URMC Research Network

Find People
Keyword
Last Name
 
More Search Options

Christopher Seplaki

TitleAssistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentPublic Health Sciences
AddressPublic Health Sciences
265 Crittenden Blvd.
Rochester NY 14642
 
 Awards And Honors
1994     Rutgers Scholar
1994     John C. Daniel Memorial Award, Economics
1996     Distinguished Teaching Assistant
1999     Conference Student Competition, Highly Commended
1999     Conference Pre- and Post Doctoral Poster Award
2003     RAND Summer Institute Full Scholarship
2007     Mason F. Lord Poster Competition Honoring Dr. James Fries
 
 Overview
Dr. Seplaki's overarching goals are to understand how challenges in the social and physical environment interact with the biological processes of aging, and how to translate that understanding into effective interventions that reduce disability and mortality among older adults. His research, spanning both the individual and population level, encompasses physical and social characteristics of the home environment that support or challenge elders, life stressors, and socioeconomic status, and examines how these factors are related to changes in biological indicators of several physiological systems and self-reports of physical and mental health. Key themes in his work include an emphasis on measurement and estimation issues and a focus on subclinical disease processes related to geriatric frailty and allostatic load, including development of measures of health risk related to multi-system dysregulation. Taken together, Dr. Seplaki's research seeks to provide an integrated perspective on trajectories of health in late life and, ultimately, identify opportunities to reduce disability and mortality and improve the ability of older adults to continue to live independently.

Keywords: Aging, disability, environment, frailty, biomarkers, measurement, health disparities

 
 Selected Publications
List All   |   Timeline
  1. Mittal M, Stockman JK, Seplaki CL, Thevenet-Morrison K, Guido J, Carey MP. HIV Risk Among Women From Domestic Violence Agencies: Prevalence and Correlates. J Assoc Nurses AIDS Care. 2013 Jul-Aug; 24(4):322-30.
    View in: PubMed
  2. Cohen AA, Milot E, Yong J, Seplaki CL, Fülöp T, Bandeen-Roche K, Fried LP. A novel statistical approach shows evidence for multi-system physiological dysregulation during aging. Mech Ageing Dev. 2013 Mar; 134(3-4):110-7.
    View in: PubMed
  3. Kobrosly RW, Seplaki CL, Cory-Slechta DA, Moynihan J, van Wijngaarden E. Multisystem physiological dysfunction is associated with depressive symptoms in a population-based sample of older adults. Int J Geriatr Psychiatry. 2013 Jul; 28(7):718-27.
    View in: PubMed
  4. Xue QL, Bandeen-Roche K, Mielenz TJ, Seplaki CL, Szanton SL, Thorpe RJ, Kalyani RR, Chaves PH, Dam TT, Ornstein K, RoyChoudhury A, Varadhan R, Yao W, Fried LP. Patterns of 12-year change in physical activity levels in community-dwelling older women: can modest levels of physical activity help older women live longer? Am J Epidemiol. 2012 Sep 15; 176(6):534-43.
    View in: PubMed
  5. Kobrosly RW, Seplaki CL, Jones CM, van Wijngaarden E. Physiologic dysfunction scores and cognitive function test performance in U.S. adults. Psychosom Med. 2012 Jan; 74(1):81-8.
    View in: PubMed
  6. Szanton SL, Thorpe RJ, Boyd C, Tanner EK, Leff B, Agree E, Xue QL, Allen JK, Seplaki CL, Weiss CO, Guralnik JM, Gitlin LN. Community aging in place, advancing better living for elders: a bio-behavioral-environmental intervention to improve function and health-related quality of life in disabled older adults. J Am Geriatr Soc. 2011 Dec; 59(12):2314-20.
    View in: PubMed
  7. Weiss CO, Wolff JL, Egleston B, Seplaki CL, Fried LP. Incident preclinical mobility disability (PCMD) increases future risk of new difficulty walking and reduction in walking activity. Arch Gerontol Geriatr. 2012 May-Jun; 54(3):e329-33.
    View in: PubMed
  8. Agbedia OO, Varma VR, Seplaki CL, Seeman TE, Fried LP, Li L, Harris GC, Rebok GW, Xue QL, Tan EJ, Tanner E, Parisi JM, McGill S, Carlson MC. Blunted diurnal decline of cortisol among older adults with low socioeconomic status. Ann N Y Acad Sci. 2011 Aug; 1231:56-64.
    View in: PubMed
  9. Chapman BP, van Wijngaarden E, Seplaki CL, Talbot N, Duberstein P, Moynihan J. Openness and conscientiousness predict 34-week patterns of Interleukin-6 in older persons. Brain Behav Immun. 2011 May; 25(4):667-73.
    View in: PubMed
  10. Szanton SL, Seplaki CL, Thorpe RJ, Allen JK, Fried LP. Socioeconomic status is associated with frailty: the Women's Health and Aging Studies. J Epidemiol Community Health. 2010 Jan; 64(1):63-7.
    View in: PubMed
  11. Szanton SL, Allen JK, Seplaki CL, Bandeen-Roche K, Fried LP. Allostatic load and frailty in the women's health and aging studies. Biol Res Nurs. 2009 Jan; 10(3):248-56.
    View in: PubMed
  12. Varadhan R, Seplaki CL, Xue QL, Bandeen-Roche K, Fried LP. Stimulus-response paradigm for characterizing the loss of resilience in homeostatic regulation associated with frailty. Mech Ageing Dev. 2008 Nov; 129(11):666-70.
    View in: PubMed
  13. Weiss CO, Seplaki CL, Wolff JL, Kasper JD, Agree EM. Self-selected walking speed was consistent when recorded while using a cane. J Clin Epidemiol. 2008 Jun; 61(6):622-7.
    View in: PubMed
  14. Smith MA, Seplaki C, Biagtan M, DuPreez A, Cleary J. Characterizing hospice services in the United States. Gerontologist. 2008 Feb; 48(1):25-31.
    View in: PubMed
  15. Goldman N, Turra CM, Glei DA, Seplaki CL, Lin YH, Weinstein M. Predicting mortality from clinical and nonclinical biomarkers. J Gerontol A Biol Sci Med Sci. 2006 Oct; 61(10):1070-4.
    View in: PubMed
  16. Seplaki CL, Goldman N, Weinstein M, Lin YH. Measurement of cumulative physiological dysregulation in an older population. Demography. 2006 Feb; 43(1):165-83.
    View in: PubMed
  17. Seplaki CL, Goldman N, Weinstein M, Lin YH. Before and after the 1999 Chi-Chi earthquake: traumatic events and depressive symptoms in an older population. Soc Sci Med. 2006 Jun; 62(12):3121-32.
    View in: PubMed
  18. Goldman N, Glei DA, Seplaki C, Liu IW, Weinstein M. Perceived stress and physiological dysregulation in older adults. Stress. 2005 Jun; 8(2):95-105.
    View in: PubMed
  19. Seplaki CL, Goldman N, Glei D, Weinstein M. A comparative analysis of measurement approaches for physiological dysregulation in an older population. Exp Gerontol. 2005 May; 40(5):438-49.
    View in: PubMed
  20. Seplaki CL, Goldman N, Weinstein M, Lin YH. How are biomarkers related to physical and mental well-being? J Gerontol A Biol Sci Med Sci. 2004 Mar; 59(3):201-17.
    View in: PubMed
  21. Kindig DA, Seplaki CL, Libby DL. Death rate variation in US subpopulations. Bull World Health Organ. 2002; 80(1):9-15.
    View in: PubMed

Visualizations


Seplaki's Networks

Concepts
_
Co-Authors
_
Similar People
_
Same Department