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A. William Tank

TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentPharmacology and Physiology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 711
Rochester NY 14642
Other Positions
TitleChair
InstitutionSchool of Medicine and Dentistry
DepartmentPharmacology and Physiology

 
 Awards And Honors
      Arnold K. Balls Award, Purdue University (for outstanding research as a graduate student).
      David Ross Fellowship, Purdue University.
1976 - 1979NRSA Post-doctoral Fellowship 5 F32 NS 05567.
1995     Herbert W. Mapstone Award for Excellence in Teaching Second Year Medical Students; University of Rochester Medical School.
1996     Special commendation for Excellence in Teaching Second Year Medical Students; University of Rochester Medical School.
2000 - 2003Dean's Senior Teaching Scholar Award.
2000     Paul Stark Professor of Pharmacology (endowed chair).
2011     Lewis Pratt Ross Professor and Chair
 
 Selected Publications
List All   |   Timeline
  1. Xu L, Sterling CR, Tank AW. cAMP-mediated stimulation of tyrosine hydroxylase mRNA translation is mediated by polypyrimidine-rich sequences within its 3'-untranslated region and poly(C)-binding protein 2. Mol Pharmacol. 2009 Oct; 76(4):872-83.
    View in: PubMed
  2. Noh T, Gabet Y, Cogan J, Shi Y, Tank A, Sasaki T, Criswell B, Dixon A, Lee C, Tam J, Kohler T, Segev E, Kockeritz L, Woodgett J, Müller R, Chai Y, Smith E, Bab I, Frenkel B. Lef1 haploinsufficient mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner. PLoS One. 2009; 4(5):e5438.
    View in: PubMed
  3. Radcliffe PM, Sterling CR, Tank AW. Induction of tyrosine hydroxylase mRNA by nicotine in rat midbrain is inhibited by mifepristone. J Neurochem. 2009 Jun; 109(5):1272-84.
    View in: PubMed
  4. Tank AW, Xu L, Chen X, Radcliffe P, Sterling CR. Post-transcriptional regulation of tyrosine hydroxylase expression in adrenal medulla and brain. Ann N Y Acad Sci. 2008 Dec; 1148:238-48.
    View in: PubMed
  5. Chen X, Xu L, Radcliffe P, Sun B, Tank AW. Activation of tyrosine hydroxylase mRNA translation by cAMP in midbrain dopaminergic neurons. Mol Pharmacol. 2008 Jun; 73(6):1816-28.
    View in: PubMed
  6. Chen X, Rzhetskaya M, Kareva T, Bland R, During MJ, Tank AW, Kholodilov N, Burke RE. Antiapoptotic and trophic effects of dominant-negative forms of dual leucine zipper kinase in dopamine neurons of the substantia nigra in vivo. J Neurosci. 2008 Jan 16; 28(3):672-80.
    View in: PubMed
  7. Xu L, Chen X, Sun B, Sterling C, Tank AW. Evidence for regulation of tyrosine hydroxylase mRNA translation by stress in rat adrenal medulla. Brain Res. 2007 Jul 16; 1158:1-10.
    View in: PubMed
  8. Nagase H, Yamakuni T, Matsuzaki K, Maruyama Y, Kasahara J, Hinohara Y, Kondo S, Mimaki Y, Sashida Y, Tank AW, Fukunaga K, Ohizumi Y. Mechanism of neurotrophic action of nobiletin in PC12D cells. Biochemistry. 2005 Oct 25; 44(42):13683-91.
    View in: PubMed
  9. Osterhout CA, Sterling CR, Chikaraishi DM, Tank AW. Induction of tyrosine hydroxylase in the locus coeruleus of transgenic mice in response to stress or nicotine treatment: lack of activation of tyrosine hydroxylase promoter activity. J Neurochem. 2005 Aug; 94(3):731-41.
    View in: PubMed
  10. Yoshimura R, Xu L, Sun B, Tank AW. Nicotinic and muscarinic acetylcholine receptors are essential for the long-term response of tyrosine hydroxylase gene expression to chronic nicotine treatment in rat adrenal medulla. Brain Res Mol Brain Res. 2004 Jul 26; 126(2):188-97.
    View in: PubMed
  11. Sun B, Chen X, Xu L, Sterling C, Tank AW. Chronic nicotine treatment leads to induction of tyrosine hydroxylase in locus ceruleus neurons: the role of transcriptional activation. Mol Pharmacol. 2004 Oct; 66(4):1011-21.
    View in: PubMed
  12. Thiruchelvam M, McCormack A, Richfield EK, Baggs RB, Tank AW, Di Monte DA, Cory-Slechta DA. Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype. Eur J Neurosci. 2003 Aug; 18(3):589-600.
    View in: PubMed
  13. Sun B, Tank AW. c-Fos is essential for the response of the tyrosine hydroxylase gene to depolarization or phorbol ester. J Neurochem. 2003 Jun; 85(6):1421-30.
    View in: PubMed
  14. Sun B, Sterling CR, Tank AW. Chronic nicotine treatment leads to sustained stimulation of tyrosine hydroxylase gene transcription rate in rat adrenal medulla. J Pharmacol Exp Ther. 2003 Feb; 304(2):575-88.
    View in: PubMed
  15. Sun B, Tank AW. Overexpression of c-Fos is sufficient to stimulate tyrosine hydroxylase (TH) gene transcription in rat pheochromocytoma PC18 cells. J Neurochem. 2002 Jan; 80(2):295-306.
    View in: PubMed
  16. Piech-Dumas KM, Best JA, Chen Y, Nagamoto-Combs K, Osterhout CA, Tank AW. The cAMP responsive element and CREB partially mediate the response of the tyrosine hydroxylase gene to phorbol ester. J Neurochem. 2001 Mar; 76(5):1376-85.
    View in: PubMed
  17. Sterling CR, Tank AW. Adrenal tyrosine hydroxylase activity and gene expression are increased by intraventricular administration of nicotine. J Pharmacol Exp Ther. 2001 Jan; 296(1):15-21.
    View in: PubMed
  18. Thiruchelvam M, Richfield EK, Baggs RB, Tank AW, Cory-Slechta DA. The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implications for Parkinson's disease. J Neurosci. 2000 Dec 15; 20(24):9207-14.
    View in: PubMed
  19. Piech-Dumas KM, Tank AW. CREB mediates the cAMP-responsiveness of the tyrosine hydroxylase gene: use of an antisense RNA strategy to produce CREB-deficient PC12 cell lines. Brain Res Mol Brain Res. 1999 Jul 5; 70(2):219-30.
    View in: PubMed
  20. Piech-Dumas KM, Sterling CR, Tank AW. Regulation of tyrosine hydroxylase gene expression by muscarinic agonists in rat adrenal medulla. J Neurochem. 1999 Jul; 73(1):153-61.
    View in: PubMed
  21. Nankova BB, Tank AW, Sabban EL. Transient or sustained transcriptional activation of the genes encoding rat adrenomedullary catecholamine biosynthetic enzymes by different durations of immobilization stress. Neuroscience. 1999; 94(3):803-8.
    View in: PubMed
  22. Best JA, Tank AW. The THCRE2 site in the rat tyrosine hydroxylase gene promoter is responsive to phorbol ester. Neurosci Lett. 1998 Dec 24; 258(3):131-4.
    View in: PubMed
  23. Tank AW, Osterhout CA, Sterling CR. Regulation of tyrosine hydroxylase activity by muscarinic agonists in rat adrenal medulla. J Pharmacol Exp Ther. 1998 Aug; 286(2):848-54.
    View in: PubMed
  24. Bowyer JF, Frame LT, Clausing P, Nagamoto-Combs K, Osterhout CA, Sterling CR, Tank AW. Long-term effects of amphetamine neurotoxicity on tyrosine hydroxylase mRNA and protein in aged rats. J Pharmacol Exp Ther. 1998 Aug; 286(2):1074-85.
    View in: PubMed
  25. Tank AW, Piech KM, Osterhout CA, Sun B, Sterling C. Regulation of tyrosine hydroxylase gene expression by transsynaptic mechanisms and cell-cell contact. Adv Pharmacol. 1998; 42:25-9.
    View in: PubMed
  26. Osterhout CA, Chikaraishi DM, Tank AW. Induction of tyrosine hydroxylase protein and a transgene containing tyrosine hydroxylase 5' flanking sequences by stress in mouse adrenal gland. J Neurochem. 1997 Mar; 68(3):1071-7.
    View in: PubMed
  27. Nagamoto-Combs K, Piech KM, Best JA, Sun B, Tank AW. Tyrosine hydroxylase gene promoter activity is regulated by both cyclic AMP-responsive element and AP1 sites following calcium influx. Evidence for cyclic amp-responsive element binding protein-independent regulation. J Biol Chem. 1997 Feb 28; 272(9):6051-8.
    View in: PubMed
  28. Chen Y, Best JA, Nagamoto K, Tank AW. Regulation of tyrosine hydroxylase gene expression by the m1 muscarinic acetylcholine receptor in rat pheochromocytoma cells. Brain Res Mol Brain Res. 1996 Aug; 40(1):42-54.
    View in: PubMed
  29. Best JA, Chen Y, Piech KM, Tank AW. The response of the tyrosine hydroxylase gene to cyclic AMP is mediated by two cyclic AMP-response elements. J Neurochem. 1995 Nov; 65(5):1934-43.
    View in: PubMed
  30. Carlson CD, Tank AW. Increased cell-cell contact stimulates the transcription rate of the tyrosine hydroxylase gene in rat pheochromocytoma PC18 cells. J Neurochem. 1994 Mar; 62(3):844-53.
    View in: PubMed
  31. Fossom LH, Sterling CR, Tank AW. Regulation of tyrosine hydroxylase gene transcription rate and tyrosine hydroxylase mRNA stability by cyclic AMP and glucocorticoid. Mol Pharmacol. 1992 Nov; 42(5):898-908.
    View in: PubMed
  32. Bowyer JF, Nakanishi A, Houchi H, Dreyer E, Sterling C, Masserano JS, Tank AW, Weiner N. Phosphorylation and activation of tyrosine hydroxylase in PC18 cells: a cell line derived from rat pheochromocytoma PC12 cells. Brain Res. 1992 Sep 25; 591(2):261-70.
    View in: PubMed
  33. Goldstein ME, Tank AW, Fossom LH, Hamill RW. Molecular aspects of the regulation of tyrosine hydroxylase by testosterone. Brain Res Mol Brain Res. 1992 Jun; 14(1-2):79-86.
    View in: PubMed
  34. Bowyer JF, Tank AW, Newport GD, Slikker W, Ali SF, Holson RR. The influence of environmental temperature on the transient effects of methamphetamine on dopamine levels and dopamine release in rat striatum. J Pharmacol Exp Ther. 1992 Feb; 260(2):817-24.
    View in: PubMed
  35. Fossom LH, Sterling C, Tank AW. Activation of tyrosine hydroxylase by nicotine in rat adrenal gland. J Neurochem. 1991 Dec; 57(6):2070-7.
    View in: PubMed
  36. Fossom LH, Carlson CD, Tank AW. Stimulation of tyrosine hydroxylase gene transcription rate by nicotine in rat adrenal medulla. Mol Pharmacol. 1991 Aug; 40(2):193-202.
    View in: PubMed
  37. Gupta M, Stoler MH, Fossom LH, Tank AW. Tyrosine hydroxylase mRNA in the dopaminergic neurons of young adult and aged mice by in situ hybridization. Neurosci Lett. 1990 Oct 30; 119(1):49-52.
    View in: PubMed
  38. Tachikawa E, Tank AW, Weiner DH, Mosimann WF, Yanagihara N, Weiner N. Tyrosine hydroxylase is activated and phosphorylated on different sites in rat pheochromocytoma PC12 cells treated with phorbol ester and forskolin. J Neurochem. 1987 May; 48(5):1366-76.
    View in: PubMed
  39. Tank AW, Weiner N. Tyrosine 3-monooxygenase from rat pheochromocytoma. Methods Enzymol. 1987; 142:71-82.
    View in: PubMed
  40. Tank AW, Deitrich RA, Weiner H. Effects of induction of rat liver cytosolic aldehyde dehydrogenase on the oxidation of biogenic aldehydes. Biochem Pharmacol. 1986 Dec 15; 35(24):4563-9.
    View in: PubMed
  41. Tank AW, Ham L, Curella P. Induction of tyrosine hydroxylase by cyclic AMP and glucocorticoids in a rat pheochromocytoma cell line: effect of the inducing agents alone or in combination on the enzyme levels and rate of synthesis of tyrosine hydroxylase. Mol Pharmacol. 1986 Nov; 30(5):486-96.
    View in: PubMed
  42. Tank AW, Curella P, Ham L. Induction of mRNA for tyrosine hydroxylase by cyclic AMP and glucocorticoids in a rat pheochromocytoma cell line: evidence for the regulation of tyrosine hydroxylase synthesis by multiple mechanisms in cells exposed to elevated levels of both inducing agents. Mol Pharmacol. 1986 Nov; 30(5):497-503.
    View in: PubMed
  43. Tachikawa E, Tank AW, Yanagihara N, Mosimann W, Weiner N. Phosphorylation of tyrosine hydroxylase on at least three sites in rat pheochromocytoma PC12 cells treated with 56 mM K+: determination of the sites on tyrosine hydroxylase phosphorylated by cyclic AMP-dependent and calcium/calmodulin-dependent protein kinases. Mol Pharmacol. 1986 Nov; 30(5):476-85.
    View in: PubMed
  44. Yanagihara N, Tank AW, Langan TA, Weiner N. Enhanced phosphorylation of tyrosine hydroxylase at more than one site is induced by 56 mM K+ in rat pheochromocytoma PC12 cells in culture. J Neurochem. 1986 Feb; 46(2):562-8.
    View in: PubMed
  45. Tank AW, Lewis EJ, Chikaraishi DM, Weiner N. Elevation of RNA coding for tyrosine hydroxylase in rat adrenal gland by reserpine treatment and exposure to cold. J Neurochem. 1985 Oct; 45(4):1030-3.
    View in: PubMed
  46. Tank AW, Meligeni J, Weiner N. Cyclic AMP-dependent protein kinase is not involved in the in vivo activation of tyrosine hydroxylase in the adrenal gland after decapitation. J Biol Chem. 1984 Jul 25; 259(14):9269-76.
    View in: PubMed
  47. Yanagihara N, Tank AW, Weiner N. Relationship between activation and phosphorylation of tyrosine hydroxylase by 56 mm K+ in PC12 cells in culture. Mol Pharmacol. 1984 Jul; 26(1):141-7.
    View in: PubMed
  48. Lewis EJ, Tank AW, Weiner N, Chikaraishi DM. Regulation of tyrosine hydroxylase mRNA by glucocorticoid and cyclic AMP in a rat pheochromocytoma cell line. Isolation of a cDNA clone for tyrosine hydroxylase mRNA. J Biol Chem. 1983 Dec 10; 258(23):14632-7.
    View in: PubMed
  49. Tank AW, Weiner N. Induction of tyrosine hydroxylase by glucocorticoids in mouse neuroblastoma cells. Enhancement of the induction by cyclic AMP. Mol Pharmacol. 1982 Sep; 22(2):421-30.
    View in: PubMed
  50. Tank AW, Weiner H, Thurman JA. Enzymology and subcellular localization of aldehyde oxidation in rat liver. Oxidation of 3,4-dihydroxyphenylacetaldehyde derived from dopamine to 3,4-dihydroxyphenylacetic acid. Biochem Pharmacol. 1981 Dec 15; 30(24):3265-75.
    View in: PubMed
  51. Tank AW, Weiner N. Effect of carbachol and 56 mm-potassium chloride on the cyclic AMP-mediated induction of tyrosine hydroxylase in neuroblastoma cells in culture. J Neurochem. 1981 Feb; 36(2):518-31.
    View in: PubMed
  52. Tank AW, Weiner H. Ethanol-induced alteration of dopamine metabolism in rat liver. Biochem Pharmacol. 1979 Oct 15; 28(20):3139-47.
    View in: PubMed

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