URMC Research Network

Find People
Keyword
Last Name
 
More Search Options

Barbara Iglewski

TitleProfessor Emeritus
InstitutionSchool of Medicine and Dentistry
DepartmentMicrobiology and Immunology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 672
Rochester NY 14642
 
 Awards And Honors
1986     Fellow, American Academy of Microbiology
1987     Honorary Lifetime Member - Sigma Delta Epsilon
1992     John W. Bullard Lecturer; Uniformed Services University of Health Sciences
1994     Alice Evans Award, American Society for Microbiology
1999     Arthur Kornberg, Research Award
2001 - 2010NIH Health Merit Award R37
2001     Susan B. Anthony, Lifetime Achievement Award
2009     Lifetime Mentor Award  | URMC
 
 Overview
Dr. Iglewski has made many important contributions to the field of Pathogenic Microbiology and is best known for her elucidation of the molecular mechanism of action of Pseudomonas toxin A, the discovery of various other toxins and exoenzymes including the first type 3 secreted Pseudomonas toxin (exo S) and her landmark discovery that a type I quorum sensing system was a global regulator of virulence in a human pathogen. Dr. Iglewski has published over 150 research papers and book chapters and served as an editor of a number of books including the Encyclopedia of Microbiology. Dr. Iglewski is recognized by the Institute of Scientific Information as a highly cited scientist. This group comprises less than 0.5% of all publishing researchers. Her current research projects, supported by a merit award from the NIH, focus on the regulation of virulence and biofilm development in Pseudomonas aeruginosa.

 
 Selected Publications
List All   |   Timeline
  1. Tombline G, Schwingel JM, Lapek JD, Friedman AE, Darrah T, Maguire M, Van Alst NE, Filiatrault MJ, Iglewski BH. Pseudomonas aeruginosa PA1006 Is a Persulfide-Modified Protein That Is Critical for Molybdenum Homeostasis. PLoS One. 2013; 8(2):e55593.
    View in: PubMed
  2. Filiatrault MJ, Tombline G, Wagner VE, Van Alst N, Rumbaugh K, Sokol P, Schwingel J, Iglewski BH. Pseudomonas aeruginosa PA1006, Which Plays a Role in Molybdenum Homeostasis, Is Required for Nitrate Utilization, Biofilm Formation, and Virulence. PLoS One. 2013; 8(2):e55594.
    View in: PubMed
  3. Van Alst NE, Sherrill LA, Iglewski BH, Haidaris CG. Compensatory periplasmic nitrate reductase activity supports anaerobic growth of Pseudomonas aeruginosa PAO1 in the absence of membrane nitrate reductase. Can J Microbiol. 2009 Oct; 55(10):1133-44.
    View in: PubMed
  4. Van Alst NE, Wellington M, Clark VL, Haidaris CG, Iglewski BH. Nitrite reductase NirS is required for type III secretion system expression and virulence in the human monocyte cell line THP-1 by Pseudomonas aeruginosa. Infect Immun. 2009 Oct; 77(10):4446-54.
    View in: PubMed
  5. Wagner VE, Iglewski BH. P. aeruginosa Biofilms in CF Infection. Clin Rev Allergy Immunol. 2008 Dec; 35(3):124-34.
    View in: PubMed
  6. Morici LA, Carterson AJ, Wagner VE, Frisk A, Schurr JR, Höner zu Bentrup K, Hassett DJ, Iglewski BH, Sauer K, Schurr MJ. Pseudomonas aeruginosa AlgR represses the Rhl quorum-sensing system in a biofilm-specific manner. J Bacteriol. 2007 Nov; 189(21):7752-64.
    View in: PubMed
  7. Van Alst NE, Picardo KF, Iglewski BH, Haidaris CG. Nitrate sensing and metabolism modulate motility, biofilm formation, and virulence in Pseudomonas aeruginosa. Infect Immun. 2007 Aug; 75(8):3780-90.
    View in: PubMed
  8. Li LL, Malone JE, Iglewski BH. Regulation of the Pseudomonas aeruginosa quorum-sensing regulator VqsR. J Bacteriol. 2007 Jun; 189(12):4367-74.
    View in: PubMed
  9. Wagner VE, Li LL, Isabella VM, Iglewski BH. Analysis of the hierarchy of quorum-sensing regulation in Pseudomonas aeruginosa. Anal Bioanal Chem. 2007 Jan; 387(2):469-79.
    View in: PubMed
  10. Matsui H, Wagner VE, Hill DB, Schwab UE, Rogers TD, Button B, Taylor RM, Superfine R, Rubinstein M, Iglewski BH, Boucher RC. A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilms. Proc Natl Acad Sci U S A. 2006 Nov 28; 103(48):18131-6.
    View in: PubMed
  11. Filiatrault MJ, Picardo KF, Ngai H, Passador L, Iglewski BH. Identification of Pseudomonas aeruginosa genes involved in virulence and anaerobic growth. Infect Immun. 2006 Jul; 74(7):4237-45.
    View in: PubMed
  12. Wagner VE, Frelinger JG, Barth RK, Iglewski BH. Quorum sensing: dynamic response of Pseudomonas aeruginosa to external signals. Trends Microbiol. 2006 Feb; 14(2):55-8.
    View in: PubMed
  13. Gillis RJ, White KG, Choi KH, Wagner VE, Schweizer HP, Iglewski BH. Molecular basis of azithromycin-resistant Pseudomonas aeruginosa biofilms. Antimicrob Agents Chemother. 2005 Sep; 49(9):3858-67.
    View in: PubMed
  14. Filiatrault MJ, Wagner VE, Bushnell D, Haidaris CG, Iglewski BH, Passador L. Effect of anaerobiosis and nitrate on gene expression in Pseudomonas aeruginosa. Infect Immun. 2005 Jun; 73(6):3764-72.
    View in: PubMed
  15. Imamura Y, Higashiyama Y, Tomono K, Izumikawa K, Yanagihara K, Ohno H, Miyazaki Y, Hirakata Y, Mizuta Y, Kadota J, Iglewski BH, Kohno S. Azithromycin exhibits bactericidal effects on Pseudomonas aeruginosa through interaction with the outer membrane. Antimicrob Agents Chemother. 2005 Apr; 49(4):1377-80.
    View in: PubMed
  16. Wagner VE, Gillis RJ, Iglewski BH. Transcriptome analysis of quorum-sensing regulation and virulence factor expression in Pseudomonas aeruginosa. Vaccine. 2004 Dec 6; 22 Suppl 1:S15-20.
    View in: PubMed
  17. Gillis RJ, Iglewski BH. Azithromycin retards Pseudomonas aeruginosa biofilm formation. J Clin Microbiol. 2004 Dec; 42(12):5842-5.
    View in: PubMed
  18. Lamb JR, Patel H, Montminy T, Wagner VE, Iglewski BH. Functional domains of the RhlR transcriptional regulator of Pseudomonas aeruginosa. J Bacteriol. 2003 Dec; 185(24):7129-39.
    View in: PubMed
  19. Smith RS, Iglewski BH. Pseudomonas aeruginosa quorum sensing as a potential antimicrobial target. J Clin Invest. 2003 Nov; 112(10):1460-5.
    View in: PubMed
  20. Wagner VE, Bushnell D, Passador L, Brooks AI, Iglewski BH. Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment. J Bacteriol. 2003 Apr; 185(7):2080-95.
    View in: PubMed
  21. Smith RS, Iglewski BH. P. aeruginosa quorum-sensing systems and virulence. Curr Opin Microbiol. 2003 Feb; 6(1):56-60.
    View in: PubMed
  22. Yoon SS, Hennigan RF, Hilliard GM, Ochsner UA, Parvatiyar K, Kamani MC, Allen HL, DeKievit TR, Gardner PR, Schwab U, Rowe JJ, Iglewski BH, McDermott TR, Mason RP, Wozniak DJ, Hancock RE, Parsek MR, Noah TL, Boucher RC, Hassett DJ. Pseudomonas aeruginosa anaerobic respiration in biofilms: relationships to cystic fibrosis pathogenesis. Dev Cell. 2002 Oct; 3(4):593-603.
    View in: PubMed
  23. Smith RS, Kelly R, Iglewski BH, Phipps RP. The Pseudomonas autoinducer N-(3-oxododecanoyl) homoserine lactone induces cyclooxygenase-2 and prostaglandin E2 production in human lung fibroblasts: implications for inflammation. J Immunol. 2002 Sep 1; 169(5):2636-42.
    View in: PubMed
  24. de Kievit TR, Kakai Y, Register JK, Pesci EC, Iglewski BH. Role of the Pseudomonas aeruginosa las and rhl quorum-sensing systems in rhlI regulation. FEMS Microbiol Lett. 2002 Jun 18; 212(1):101-6.
    View in: PubMed
  25. Smith RS, Harris SG, Phipps R, Iglewski B. The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)homoserine lactone contributes to virulence and induces inflammation in vivo. J Bacteriol. 2002 Feb; 184(4):1132-9.
    View in: PubMed
  26. Smith RS, Fedyk ER, Springer TA, Mukaida N, Iglewski BH, Phipps RP. IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2. J Immunol. 2001 Jul 1; 167(1):366-74.
    View in: PubMed
  27. De Kievit TR, Parkins MD, Gillis RJ, Srikumar R, Ceri H, Poole K, Iglewski BH, Storey DG. Multidrug efflux pumps: expression patterns and contribution to antibiotic resistance in Pseudomonas aeruginosa biofilms. Antimicrob Agents Chemother. 2001 Jun; 45(6):1761-70.
    View in: PubMed
  28. De Kievit TR, Gillis R, Marx S, Brown C, Iglewski BH. Quorum-sensing genes in Pseudomonas aeruginosa biofilms: their role and expression patterns. Appl Environ Microbiol. 2001 Apr; 67(4):1865-73.
    View in: PubMed
  29. Bollinger N, Hassett DJ, Iglewski BH, Costerton JW, McDermott TR. Gene expression in Pseudomonas aeruginosa: evidence of iron override effects on quorum sensing and biofilm-specific gene regulation. J Bacteriol. 2001 Mar; 183(6):1990-6.
    View in: PubMed
  30. Branny P, Pearson JP, Pesci EC, Köhler T, Iglewski BH, Van Delden C. Inhibition of quorum sensing by a Pseudomonas aeruginosa dksA homologue. J Bacteriol. 2001 Mar; 183(5):1531-9.
    View in: PubMed
  31. de Kievit TR, Iglewski BH. Bacterial quorum sensing in pathogenic relationships. Infect Immun. 2000 Sep; 68(9):4839-49.
    View in: PubMed
  32. Rashid MH, Rumbaugh K, Passador L, Davies DG, Hamood AN, Iglewski BH, Kornberg A. Polyphosphate kinase is essential for biofilm development, quorum sensing, and virulence of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2000 Aug 15; 97(17):9636-41.
    View in: PubMed
  33. Pearson JP, Feldman M, Iglewski BH, Prince A. Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection. Infect Immun. 2000 Jul; 68(7):4331-4.
    View in: PubMed
  34. McKnight SL, Iglewski BH, Pesci EC. The Pseudomonas quinolone signal regulates rhl quorum sensing in Pseudomonas aeruginosa. J Bacteriol. 2000 May; 182(10):2702-8.
    View in: PubMed
  35. Kline T, Bowman J, Iglewski BH, de Kievit T, Kakai Y, Passador L. Novel synthetic analogs of the Pseudomonas autoinducer. Bioorg Med Chem Lett. 1999 Dec 20; 9(24):3447-52.
    View in: PubMed
  36. Hassett DJ, Ma JF, Elkins JG, McDermott TR, Ochsner UA, West SE, Huang CT, Fredericks J, Burnett S, Stewart PS, McFeters G, Passador L, Iglewski BH. Quorum sensing in Pseudomonas aeruginosa controls expression of catalase and superoxide dismutase genes and mediates biofilm susceptibility to hydrogen peroxide. Mol Microbiol. 1999 Dec; 34(5):1082-93.
    View in: PubMed
  37. Rumbaugh KP, Griswold JA, Iglewski BH, Hamood AN. Contribution of quorum sensing to the virulence of Pseudomonas aeruginosa in burn wound infections. Infect Immun. 1999 Nov; 67(11):5854-62.
    View in: PubMed
  38. Pesci EC, Milbank JB, Pearson JP, McKnight S, Kende AS, Greenberg EP, Iglewski BH. Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20):11229-34.
    View in: PubMed
  39. de Kievit T, Seed PC, Nezezon J, Passador L, Iglewski BH. RsaL, a novel repressor of virulence gene expression in Pseudomonas aeruginosa. J Bacteriol. 1999 Apr; 181(7):2175-84.
    View in: PubMed
  40. Glessner A, Smith RS, Iglewski BH, Robinson JB. Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of twitching motility. J Bacteriol. 1999 Mar; 181(5):1623-9.
    View in: PubMed
  41. Pearson JP, Van Delden C, Iglewski BH. Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals. J Bacteriol. 1999 Feb; 181(4):1203-10.
    View in: PubMed
  42. De Kievit TR, Iglewski BH. Quorum sensing, gene expression, and Pseudomonas biofilms. Methods Enzymol. 1999; 310:117-28.
    View in: PubMed
  43. Van Delden C, Iglewski BH. Cell-to-cell signaling and Pseudomonas aeruginosa infections. Emerg Infect Dis. 1998 Oct-Dec; 4(4):551-60.
    View in: PubMed
  44. Van Delden C, Pesci EC, Pearson JP, Iglewski BH. Starvation selection restores elastase and rhamnolipid production in a Pseudomonas aeruginosa quorum-sensing mutant. Infect Immun. 1998 Sep; 66(9):4499-502.
    View in: PubMed
  45. Davies DG, Parsek MR, Pearson JP, Iglewski BH, Costerton JW, Greenberg EP. The involvement of cell-to-cell signals in the development of a bacterial biofilm. Science. 1998 Apr 10; 280(5361):295-8.
    View in: PubMed
  46. Pearson JP, Pesci EC, Iglewski BH. Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes. J Bacteriol. 1997 Sep; 179(18):5756-67.
    View in: PubMed
  47. Preston MJ, Seed PC, Toder DS, Iglewski BH, Ohman DE, Gustin JK, Goldberg JB, Pier GB. Contribution of proteases and LasR to the virulence of Pseudomonas aeruginosa during corneal infections. Infect Immun. 1997 Aug; 65(8):3086-90.
    View in: PubMed
  48. Albus AM, Pesci EC, Runyen-Janecky LJ, West SE, Iglewski BH. Vfr controls quorum sensing in Pseudomonas aeruginosa. J Bacteriol. 1997 Jun; 179(12):3928-35.
    View in: PubMed
  49. Pesci EC, Pearson JP, Seed PC, Iglewski BH. Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa. J Bacteriol. 1997 May; 179(10):3127-32.
    View in: PubMed
  50. Pesci EC, Iglewski BH. The chain of command in Pseudomonas quorum sensing. Trends Microbiol. 1997 Apr; 5(4):132-4; discussion 134-5.
    View in: PubMed
  51. Passador L, Tucker KD, Guertin KR, Journet MP, Kende AS, Iglewski BH. Functional analysis of the Pseudomonas aeruginosa autoinducer PAI. J Bacteriol. 1996 Oct; 178(20):5995-6000.
    View in: PubMed
  52. Rust L, Pesci EC, Iglewski BH. Analysis of the Pseudomonas aeruginosa elastase (lasB) regulatory region. J Bacteriol. 1996 Feb; 178(4):1134-40.
    View in: PubMed
  53. Tang HB, DiMango E, Bryan R, Gambello M, Iglewski BH, Goldberg JB, Prince A. Contribution of specific Pseudomonas aeruginosa virulence factors to pathogenesis of pneumonia in a neonatal mouse model of infection. Infect Immun. 1996 Jan; 64(1):37-43.
    View in: PubMed
  54. Pearson JP, Passador L, Iglewski BH, Greenberg EP. A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1490-4.
    View in: PubMed
  55. Seed PC, Passador L, Iglewski BH. Activation of the Pseudomonas aeruginosa lasI gene by LasR and the Pseudomonas autoinducer PAI: an autoinduction regulatory hierarchy. J Bacteriol. 1995 Feb; 177(3):654-9.
    View in: PubMed
  56. Gray KM, Passador L, Iglewski BH, Greenberg EP. Interchangeability and specificity of components from the quorum-sensing regulatory systems of Vibrio fischeri and Pseudomonas aeruginosa. J Bacteriol. 1994 May; 176(10):3076-80.
    View in: PubMed
  57. Toder DS, Ferrell SJ, Nezezon JL, Rust L, Iglewski BH. lasA and lasB genes of Pseudomonas aeruginosa: analysis of transcription and gene product activity. Infect Immun. 1994 Apr; 62(4):1320-7.
    View in: PubMed
  58. West SE, Kaye SA, Hamood AN, Iglewski BH. Characterization of Pseudomonas aeruginosa mutants that are deficient in exotoxin A synthesis and are altered in expression of regA, a positive regulator of exotoxin A. Infect Immun. 1994 Mar; 62(3):897-903.
    View in: PubMed
  59. Pearson JP, Gray KM, Passador L, Tucker KD, Eberhard A, Iglewski BH, Greenberg EP. Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes. Proc Natl Acad Sci U S A. 1994 Jan 4; 91(1):197-201.
    View in: PubMed
  60. Rust L, Messing CR, Iglewski BH. Elastase assays. Methods Enzymol. 1994; 235:554-62.
    View in: PubMed
  61. Passador L, Cook JM, Gambello MJ, Rust L, Iglewski BH. Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication. Science. 1993 May 21; 260(5111):1127-30.
    View in: PubMed
  62. Gambello MJ, Kaye S, Iglewski BH. LasR of Pseudomonas aeruginosa is a transcriptional activator of the alkaline protease gene (apr) and an enhancer of exotoxin A expression. Infect Immun. 1993 Apr; 61(4):1180-4.
    View in: PubMed
  63. Wick MJ, Cook JM, Iglewski BH. Structure-function analysis of exotoxin A proteins with mutations at histidine 426. Infect Immun. 1992 Mar; 60(3):1128-39.
    View in: PubMed
  64. Hamood AN, Ohman DE, West SE, Iglewski BH. Isolation and characterization of toxin A excretion-deficient mutants of Pseudomonas aeruginosa PAO1. Infect Immun. 1992 Feb; 60(2):510-7.
    View in: PubMed
  65. Frank DW, Iglewski BH. Cloning and sequence analysis of a trans-regulatory locus required for exoenzyme S synthesis in Pseudomonas aeruginosa. J Bacteriol. 1991 Oct; 173(20):6460-8.
    View in: PubMed
  66. Storey DG, Raivio TL, Frank DW, Wick MJ, Kaye S, Iglewski BH. Effect of regB on expression from the P1 and P2 promoters of the Pseudomonas aeruginosa regAB operon. J Bacteriol. 1991 Oct; 173(19):6088-94.
    View in: PubMed
  67. Toder DS, Gambello MJ, Iglewski BH. Pseudomonas aeruginosa LasA: a second elastase under the transcriptional control of lasR. Mol Microbiol. 1991 Aug; 5(8):2003-10.
    View in: PubMed
  68. Gambello MJ, Iglewski BH. Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression. J Bacteriol. 1991 May; 173(9):3000-9.
    View in: PubMed
  69. Mohr CD, Rust L, Albus AM, Iglewski BH, Deretic V. Expression patterns of genes encoding elastase and controlling mucoidy: co-ordinate regulation of two virulence factors in Pseudomonas aeruginosa isolates from cystic fibrosis. Mol Microbiol. 1990 Dec; 4(12):2103-10.
    View in: PubMed
  70. Olson JC, Hamood AN, Vincent TS, Beachey EH, Iglewski BH. Identification of functional epitopes of Pseudomonas aeruginosa exotoxin A using synthetic peptides and subclone products. Mol Immunol. 1990 Oct; 27(10):981-93.
    View in: PubMed
  71. Hamood AN, Wick MJ, Iglewski BH. Secretion of toxin A from Pseudomonas aeruginosa PAO1, PAK, and PA103 by Escherichia coli. Infect Immun. 1990 May; 58(5):1133-40.
    View in: PubMed
  72. Wick MJ, Hamood AN, Iglewski BH. Analysis of the structure-function relationship of Pseudomonas aeruginosa exotoxin A. Mol Microbiol. 1990 Apr; 4(4):527-35.
    View in: PubMed
  73. Wick MJ, Frank DW, Storey DG, Iglewski BH. Identification of regB, a gene required for optimal exotoxin A yields in Pseudomonas aeruginosa. Mol Microbiol. 1990 Mar; 4(3):489-97.
    View in: PubMed
  74. Storey DG, Frank DW, Farinha MA, Kropinski AM, Iglewski BH. Multiple promoters control the regulation of the Pseudomonas aeruginosa regA gene. Mol Microbiol. 1990 Mar; 4(3):499-503.
    View in: PubMed
  75. Hamood AN, Iglewski BH. Expression of the Pseudomonas aeruginosa toxA positive regulatory gene (regA) in Escherichia coli. J Bacteriol. 1990 Feb; 172(2):589-94.
    View in: PubMed
  76. Wick MJ, Frank DW, Storey DG, Iglewski BH. Structure, function, and regulation of Pseudomonas aeruginosa exotoxin A. Annu Rev Microbiol. 1990; 44:335-63.
    View in: PubMed
  77. Smith AW, Iglewski BH. Transformation of Pseudomonas aeruginosa by electroporation. Nucleic Acids Res. 1989 Dec 25; 17(24):10509.
    View in: PubMed
  78. Frank DW, Storey DG, Hindahl MS, Iglewski BH. Differential regulation by iron of regA and toxA transcript accumulation in Pseudomonas aeruginosa. J Bacteriol. 1989 Oct; 171(10):5304-13.
    View in: PubMed
  79. Zimniak L, Dayn A, Iglewski BH. Identification of RegA protein from Pseudomonas aeruginosa using anti-RegA antibody. Biochem Biophys Res Commun. 1989 Sep 29; 163(3):1312-8.
    View in: PubMed
  80. Coburn J, Wyatt RT, Iglewski BH, Gill DM. Several GTP-binding proteins, including p21c-H-ras, are preferred substrates of Pseudomonas aeruginosa exoenzyme S. J Biol Chem. 1989 May 25; 264(15):9004-8.
    View in: PubMed
  81. Hamood AN, Olson JC, Vincent TS, Iglewski BH. Regions of toxin A involved in toxin A excretion in Pseudomonas aeruginosa. J Bacteriol. 1989 Apr; 171(4):1817-24.
    View in: PubMed
  82. Coburn J, Dillon ST, Iglewski BH, Gill DM. Exoenzyme S of Pseudomonas aeruginosa ADP-ribosylates the intermediate filament protein vimentin. Infect Immun. 1989 Mar; 57(3):996-8.
    View in: PubMed
  83. Wick MJ, Iglewski BH. Determination of the amino acid change responsible for the nontoxic, cross-reactive exotoxin A protein (CRM 66) of Pseudomonas aeruginosa PAO-PR1. J Bacteriol. 1988 Nov; 170(11):5385-8.
    View in: PubMed
  84. West SE, Iglewski BH. Codon usage in Pseudomonas aeruginosa. Nucleic Acids Res. 1988 Oct 11; 16(19):9323-35.
    View in: PubMed
  85. Frank DW, Iglewski BH. Kinetics of toxA and regA mRNA accumulation in Pseudomonas aeruginosa. J Bacteriol. 1988 Oct; 170(10):4477-83.
    View in: PubMed
  86. Bever RA, Iglewski BH. Molecular characterization and nucleotide sequence of the Pseudomonas aeruginosa elastase structural gene. J Bacteriol. 1988 Sep; 170(9):4309-14.
    View in: PubMed
  87. Hindahl MS, Frank DW, Hamood A, Iglewski BH. Characterization of a gene that regulates toxin A synthesis in Pseudomonas aeruginosa. Nucleic Acids Res. 1988 Jun 24; 16(12):5699.
    View in: PubMed
  88. Schad PA, Iglewski BH. Nucleotide sequence and expression in Escherichia coli of the Pseudomonas aeruginosa lasA gene. J Bacteriol. 1988 Jun; 170(6):2784-9.
    View in: PubMed
  89. Schad PA, Bever RA, Nicas TI, Leduc F, Hanne LF, Iglewski BH. Cloning and characterization of elastase genes from Pseudomonas aeruginosa. J Bacteriol. 1987 Jun; 169(6):2691-6.
    View in: PubMed
  90. Elsheikh LE, Kronevi T, Wretlind B, Abaas S, Iglewski BH. Assessment of elastase as a Pseudomonas aeruginosa virulence factor in experimental lung infection in mink. Vet Microbiol. 1987 Mar; 13(3):281-9.
    View in: PubMed
  91. Hindahl MS, Iglewski BH. Cloning and expression of a common Legionella outer membrane antigen in Escherichia coli. Microb Pathog. 1987 Feb; 2(2):91-9.
    View in: PubMed
  92. Hindahl MS, Frank DW, Iglewski BH. Molecular studies of a positive regulator of toxin A synthesis in Pseudomonas aeruginosa. Antibiot Chemother. 1987; 39:279-89.
    View in: PubMed
  93. Parmely MJ, Horvat RT, Iglewski BH, Kanarek J, Furtado D, Van Enk R. The antigenicity of a pulmonary pathogen defined by monoclonal T cells. Adv Exp Med Biol. 1987; 216B:1043-51.
    View in: PubMed
  94. Woodruff WA, Parr TR, Hancock RE, Hanne LF, Nicas TI, Iglewski BH. Expression in Escherichia coli and function of Pseudomonas aeruginosa outer membrane porin protein F. J Bacteriol. 1986 Aug; 167(2):473-9.
    View in: PubMed
  95. Nicas TI, Iglewski BH. Production of elastase and other exoproducts by environmental isolates of Pseudomonas aeruginosa. J Clin Microbiol. 1986 May; 23(5):967-9.
    View in: PubMed
  96. Dreyfus LA, Iglewski BH. Purification and characterization of an extracellular protease of Legionella pneumophila. Infect Immun. 1986 Mar; 51(3):736-43.
    View in: PubMed
  97. Hindahl MS, Iglewski BH. Outer membrane proteins from Legionella pneumophila serogroups and other Legionella species. Infect Immun. 1986 Jan; 51(1):94-101.
    View in: PubMed
  98. Nicas TI, Bradley J, Lochner JE, Iglewski BH. The role of exoenzyme S in infections with Pseudomonas aeruginosa. J Infect Dis. 1985 Oct; 152(4):716-21.
    View in: PubMed
  99. Björklind A, Wretlind B, Möllegård I, Schad PA, Iglewski BH, Cox CD. Genetic mapping and characterization of Pseudomonas aeruginosa mutants that hyperproduce exoproteins. J Bacteriol. 1985 Jun; 162(3):1329-31.
    View in: PubMed
  100. Nicas TI, Iglewski BH. The contribution of exoproducts to virulence of Pseudomonas aeruginosa. Can J Microbiol. 1985 Apr; 31(4):387-92.
    View in: PubMed
  101. Nicas TI, Frank DW, Stenzel P, Lile JD, Iglewski BH. Role of exoenzyme S in chronic Pseudomonas aeruginosa lung infections. Eur J Clin Microbiol. 1985 Apr; 4(2):175-9.
    View in: PubMed
  102. Lochner JE, Bigley RH, Iglewski BH. Defective triggering of polymorphonuclear leukocyte oxidative metabolism by Legionella pneumophila toxin. J Infect Dis. 1985 Jan; 151(1):42-6.
    View in: PubMed
  103. Nicas TI, Iglewski BH. Contribution of exoenzyme S to the virulence of Pseudomonas aeruginosa. Antibiot Chemother. 1985; 36:40-8.
    View in: PubMed
  104. Nicas TI, Iglewski BH. Genetic approaches to study Pseudomonas aeruginosa protein antigens. Adv Exp Med Biol. 1985; 185:223-32.
    View in: PubMed
  105. Dreyfus LA, Iglewski BH. Conjugation-mediated genetic exchange in Legionella pneumophila. J Bacteriol. 1985 Jan; 161(1):80-4.
    View in: PubMed
  106. Parmely MJ, Iglewski BH, Horvat RT. Identification of the principal T lymphocyte-stimulating antigens of Pseudomonas aeruginosa. J Exp Med. 1984 Nov 1; 160(5):1338-49.
    View in: PubMed
  107. Nicas TI, Iglewski BH. Isolation and characterization of transposon-induced mutants of Pseudomonas aeruginosa deficient in production of exoenzyme S. Infect Immun. 1984 Aug; 45(2):470-4.
    View in: PubMed
  108. Hindahl MS, Iglewski BH. Isolation and characterization of the Legionella pneumophila outer membrane. J Bacteriol. 1984 Jul; 159(1):107-13.
    View in: PubMed
  109. Howe TR, Iglewski BH. Isolation and characterization of alkaline protease-deficient mutants of Pseudomonas aeruginosa in vitro and in a mouse eye model. Infect Immun. 1984 Mar; 43(3):1058-63.
    View in: PubMed
  110. Cryz SJ, Iglewski BH. Toxoids of Pseudomonas aeruginosa toxin A: production by chemical and genetic means. Rev Infect Dis. 1983 Nov-Dec; 5 Suppl 5:S992-7.
    View in: PubMed
  111. Howe TR, Wretlind B, Iglewski BH. Comparison of two methods of genetic exchange in determination of the genetic locus of the structural gene for Pseudomonas aeruginosa elastase. J Bacteriol. 1983 Oct; 156(1):58-61.
    View in: PubMed
  112. Woods DE, Iglewski BH. Toxins of Pseudomonas aeruginosa: new perspectives. Rev Infect Dis. 1983 Sep-Oct; 5 Suppl 4:S715-22.
    View in: PubMed
  113. Hanne LF, Howe TR, Iglewski BH. Locus of the Pseudomonas aeruginosa toxin A gene. J Bacteriol. 1983 Apr; 154(1):383-6.
    View in: PubMed
  114. Blackwood LL, Stone RM, Iglewski BH, Pennington JE. Evaluation of Pseudomonas aeruginosa exotoxin A and elastase as virulence factors in acute lung infection. Infect Immun. 1983 Jan; 39(1):198-201.
    View in: PubMed
  115. Lochner JE, Friedman RL, Bigley RH, Iglewski BH. Effect of oxygen-dependent antimicrobial systems on Legionella pneumophila. Infect Immun. 1983 Jan; 39(1):487-9.
    View in: PubMed
  116. Friedman RL, Lochner JE, Bigley RH, Iglewski BH. The effects of Legionella pneumophila toxin on oxidative processes and bacterial killing of human polymorphonuclear leukocytes. J Infect Dis. 1982 Sep; 146(3):328-34.
    View in: PubMed
  117. Sokol PA, Cox CD, Iglewski BH. Pseudomonas aeruginosa mutants altered in their sensitivity to the effect of iron on toxin A or elastase yields. J Bacteriol. 1982 Aug; 151(2):783-7.
    View in: PubMed
  118. Sadoff JC, Buck GA, Iglewski BH, Bjorn MJ, Groman NB. Immunological cross-reactivity in the absence of DNA homology between Pseudomonas toxin A and diphtheria toxin. Infect Immun. 1982 Jul; 37(1):250-4.
    View in: PubMed
  119. Woods DE, Cryz SJ, Friedman RL, Iglewski BH. Contribution of toxin A and elastase to virulence of Pseudomonas aeruginosa in chronic lung infections of rats. Infect Immun. 1982 Jun; 36(3):1223-8.
    View in: PubMed
  120. Woods DE, Sokol PA, Iglewski BH. Modulatory effect of iron on the pathogenesis of Pseudomonas aeruginosa mouse corneal infections. Infect Immun. 1982 Feb; 35(2):461-4.
    View in: PubMed
  121. Friedman RL, Iglewski BH, Roerdink F, Alving CR. Suppression of cytotoxicity of diphtheria toxin by monoclonal antibodies against phosphatidylinositol phosphate. Biophys J. 1982 Jan; 37(1):23-4.
    View in: PubMed
  122. Hazlett LD, Iglewski BH, Berk RS. Experimental Pseudomonas exotoxin A mediated ocular damage in mouse pups: microscopic observations. Ophthalmic Res. 1982; 14(6):401-8.
    View in: PubMed
  123. Hazlett LD, Berk RS, Iglewski BH. Microscopic characterization of ocular damage produced by Pseudomonas aeruginosa toxin A. Infect Immun. 1981 Dec; 34(3):1025-35.
    View in: PubMed
  124. Sokol PA, Iglewski BH, Hager TA, Sadoff JC, Cross AS, McManus A, Farber BF, Iglewski WJ. Production of exoenzyme S by clinical isolates of Pseudomonas aeruginosa. Infect Immun. 1981 Oct; 34(1):147-53.
    View in: PubMed
  125. Thompson MR, Miller RD, Iglewski BH. In vitro production of an extracellular protease by Legionella pneumophila. Infect Immun. 1981 Oct; 34(1):299-302.
    View in: PubMed
  126. Berk RS, Iglewski BH, Hazlett LD. Age-related susceptibility of mice to ocular challenge with Pseudomonas aeruginosa exotoxin A. Infect Immun. 1981 Jul; 33(1):90-4.
    View in: PubMed
  127. Cryz SJ, Friedman RL, Pavlovskis OR, Iglewski BH. Effect of formalin toxoiding on Pseudomonas aeruginosa toxin A: biological, chemical, and immunochemical studies. Infect Immun. 1981 May; 32(2):759-68.
    View in: PubMed
  128. Cryz SJ, Friedman RL, Iglewski BH. Isolation and characterization of a Pseudomonas aeruginosa mutant producing a nontoxic, immunologically crossreactive toxin A protein. Proc Natl Acad Sci U S A. 1980 Dec; 77(12):7199-203.
    View in: PubMed
  129. Cross AS, Sadoff JC, Iglewski BH, Sokol PA. Evidence for the role of toxin A in the pathogenesis of infection with Pseudomonas aeruginosa in humans. J Infect Dis. 1980 Oct; 142(4):538-46.
    View in: PubMed
  130. Ohman DE, Burns RP, Iglewski BH. Corneal infections in mice with toxin A and elastase mutants of Pseudomonas aeruginosa. J Infect Dis. 1980 Oct; 142(4):547-55.
    View in: PubMed
  131. Cryz SJ, Iglewski BH. Production of alkaline protease by Pseudomonas aeruginosa. J Clin Microbiol. 1980 Jul; 12(1):131-3.
    View in: PubMed
  132. Friedman RL, Iglewski BH, Miller RD. Identification of a cytotoxin produced by Legionella pneumophila. Infect Immun. 1980 Jul; 29(1):271-4.
    View in: PubMed
  133. Ohman DE, Cryz SJ, Iglewski BH. Isolation and characterization of Pseudomonas aeruginosa PAO mutant that produces altered elastase. J Bacteriol. 1980 Jun; 142(3):836-42.
    View in: PubMed
  134. Ohman DE, Sadoff JC, Iglewski BH. Toxin A-deficient mutants of Pseudomonas aeruginosa PA103: isolation and characterization. Infect Immun. 1980 Jun; 28(3):899-908.
    View in: PubMed
  135. Alving CR, Iglewski BH, Urban KA, Moss J, Richards RL, Sadoff JC. Binding of diphtheria toxin to phospholipids in liposomes. Proc Natl Acad Sci U S A. 1980 Apr; 77(4):1986-90.
    View in: PubMed
  136. Brodsky WA, Sadoff JC, Durham JH, Ehrenspeck G, Schachner M, Iglewski BH. Effects of pseudomonas toxin A, diphtheria toxin, and cholera toxin on electrical characteristics of turtle bladder. Proc Natl Acad Sci U S A. 1979 Jul; 76(7):3562-6.
    View in: PubMed
  137. Bjorn MJ, Pavlovskis OR, Thompson MR, Iglewski BH. Production of exoenzyme S during Pseudomonas aeruginosa infections of burned mice. Infect Immun. 1979 Jun; 24(3):837-42.
    View in: PubMed
  138. Sokol PA, Ohman DE, Iglewski BH. A more sensitive plate assay for detection of protease production by Pseudomanas aeruginosa. J Clin Microbiol. 1979 Apr; 9(4):538-40.
    View in: PubMed
  139. Bjorn MJ, Sokol PA, Iglewski BH. Influence of iron on yields of extracellular products in Pseudomonas aeruginosa cultures. J Bacteriol. 1979 Apr; 138(1):193-200.
    View in: PubMed
  140. Iglewski BH, Sadoff JC. Toxin inhibitors of protein synthesis: production, purification, and assay of Pseudomonas aeruginosa toxin A. Methods Enzymol. 1979; 60:780-93.
    View in: PubMed
  141. Vasil ML, Iglewski BH. Comparative toxicities of diphtherial toxin and Pseudomonas aeruginosa exotoxin A: evidence for different cell receptors. J Gen Microbiol. 1978 Oct; 108(2):333-7.
    View in: PubMed
  142. Iglewski BH, Sadoff J, Bjorn MJ, Maxwell ES. Pseudomonas aeruginosa exoenzyme S: an adenosine diphosphate ribosyltransferase distinct from toxin A. Proc Natl Acad Sci U S A. 1978 Jul; 75(7):3211-5.
    View in: PubMed
  143. Bjorn MJ, Iglewski BH, Ives SK, Sadoff JC, Vasil ML. Effect of iron on yields of exotoxin A in cultures of Pseudomonas aeruginosa PA-103. Infect Immun. 1978 Mar; 19(3):785-91.
    View in: PubMed
  144. Pavlovskis OR, Iglewski BH, Pollack M. Mechanism of action of Pseudomonas aeruginosa exotoxin A in experimental mouse infections: adenosine diphosphate ribosylation of elongation factor 2. Infect Immun. 1978 Jan; 19(1):29-33.
    View in: PubMed
  145. Pavlovskis OR, Pollack M, Callahan LT, Iglewski BH. Passive protection by antitoxin in experimental Pseudomonas aeruginosa burn infections. Infect Immun. 1977 Dec; 18(3):596-602.
    View in: PubMed
  146. Vasil ML, Kabat D, Iglewski BH. Structure-activity relationships of an exotoxin of Pseudomonas aeruginosa. Infect Immun. 1977 Apr; 16(1):353-61.
    View in: PubMed
  147. Bjorn MJ, Vasil ML, Sadoff JC, Iglewski BH. Incidence of exotoxin production by Pseudomonas species. Infect Immun. 1977 Apr; 16(1):362-6.
    View in: PubMed
  148. Iglewski BH, Liu PV, Kabat D. Mechanism of action of Pseudomonas aeruginosa exotoxin Aiadenosine diphosphate-ribosylation of mammalian elongation factor 2 in vitro and in vivo. Infect Immun. 1977 Jan; 15(1):138-44.
    View in: PubMed
  149. Iglewski BH, Burns RP, Gipson IK. Pathogenesis of corneal damage from pseudomonas exotoxin A. Invest Ophthalmol Vis Sci. 1977 Jan; 16(1):73-6.
    View in: PubMed
  150. Morse SA, Vaughan P, Johnson D, Iglewski BH. Inhibition of Neisseria gonorrhoeae by a bacteriocin from Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1976 Aug; 10(2):354-62.
    View in: PubMed
  151. Rittenberg MB, Pinney CT, Iglewski BH. Antigenic relationships on the diphtheria toxin molecule: antitoxin versus antitoxoid. Infect Immun. 1976 Jul; 14(1):122-8.
    View in: PubMed
  152. Vasil ML, Liu PV, Iglewski BH. Temperature-dependent inactivating factor of Pseudomonas aeruginosa exotoxin A. Infect Immun. 1976 May; 13(5):1467-72.
    View in: PubMed
  153. Iglewski BH, Kabat D. NAD-dependent inhibition of protein synthesis by Pseudomonas aeruginosa toxin,. Proc Natl Acad Sci U S A. 1975 Jun; 72(6):2284-8.
    View in: PubMed
  154. Iglewski BH, Rittenberg MB, Iglewski WJ. Preferential inhibition of growth and protein synthesis in Rous sarcoma virus transformed cells by diphtheria toxin. Virology. 1975 May; 65(1):272-5.
    View in: PubMed
  155. Iglewski BH, Rittenberg MB. Selective toxicity of diphtheria toxin for malignant cells. Proc Natl Acad Sci U S A. 1974 Jul; 71(7):2707-10.
    View in: PubMed
  156. Lightfoot HN, Iglewski BH. Synthesis of diphtheria toxin in E. coli cell-free lysate. Biochem Biophys Res Commun. 1974 Jan 23; 56(2):351-7.
    View in: PubMed
  157. Elwell LP, Iglewski BH. Diphtheria toxin: evidence for presence of fragment B in corynebacteriophage. Biochem Biophys Res Commun. 1972 Nov 1; 49(3):609-14.
    View in: PubMed

Visualizations


Iglewski's Networks

Concepts
_
Co-Authors
_
Similar People
_
Same Department