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Oksana Polesskaya

TitleResearch Assistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentMicrobiology and Immunology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 672
Rochester NY 14642
Other Positions
TitleAssistant Professor of Clinical
InstitutionSchool of Nursing
DepartmentNursing

 
 Overview
I earned Ph.D. from Institute of Medical Genetics (Moscow, Russia). My research there was focused on studying changes in genome which are associated with schizophrenia.
During my work in Molecular Neurobiology Branch in NIDA/NIH I analyzed the effect of amphetamine on mouse brain using expression microarrays, and participated in the large-scale SNP genotyping project of multisubstance abuse patients which led to identification of several genomic loci responsible for increased drug abuse vulnerability.
My postdoctoral research in George Mason University (Virginia) was related to the biology of drug abuse, focusing on the expression changes caused in brain of adolescent rats by exposure to nicotine.
My current research focuses on neurological complications of HIV-1 infection. These complications include cognitive, motor and behavioral abnormalities. It is thought that the cause of these complications is a low-grade inflammation going on in central nervous system (CNS). Clinical observation had shown that use of addictive drugs, especially methamphetamine, is associated with accelerated progression of neurological complications of AIDS. We hypothesize that both maladies affect brain vasculature and change cerebral blood flow therefore aggravating the toxic effect of each other. We use mouse model of neuroAIDS to study the effect of MA on brain vasculature.
The data obtained in Dewhurst lab and in other labs suggested that mixed lineage kinase 3 (MLK3) mediates different aspects of HIV-1-related neuroinflammation, and that blockage of MLK3 may reduce both microglila activation and neuronal damage. I work on further characterization of role of MLK3 in neuroinflammation and on developing new pharmacological inhibitors of MLK3 aiming to create a drug which could curb the neurological complications of AIDS.

 
 Selected Publications
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  1. Polesskaya O, Wong C, Lebron L, Chamberlain JM, Gelbard HA, Goodfellow V, Kim M, Daiss JL, Dewhurst S. MLK3 regulates fMLP-stimulated neutrophil motility. Mol Immunol. 2014 Apr; 58(2):214-22.
    View in: PubMed
  2. Goodfellow VS, Loweth CJ, Ravula SB, Wiemann T, Nguyen T, Xu Y, Todd DE, Sheppard D, Pollack S, Polesskaya O, Marker DF, Dewhurst S, Gelbard HA. Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem. 2013 Oct 24; 56(20):8032-48.
    View in: PubMed
  3. Silva J, Polesskaya O, Knight W, Zheng JT, Granger M, Lopez T, Ontiveros F, Feng C, Yan C, Kasischke KA, Dewhurst S. Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5. J Neuroinflammation. 2012; 9:253.
    View in: PubMed
  4. Polesskaya O, Sun A, Salahura G, Silva JN, Dewhurst S, Kasischke K. Detection of microregional hypoxia in mouse cerebral cortex by two-photon imaging of endogenous NADH fluorescence. J Vis Exp. 2012; (60).
    View in: PubMed
  5. Polesskaya O, Silva J, Sanfilippo C, Desrosiers T, Sun A, Shen J, Feng C, Polesskiy A, Deane R, Zlokovic B, Kasischke K, Dewhurst S. Methamphetamine causes sustained depression in cerebral blood flow. Brain Res. 2011 Feb 10; 1373:91-100.
    View in: PubMed
  6. Polesskaya O, Cunningham LL, Francis SP, Luebke AE, Zhu X, Collins D, Vasilyeva ON, Sahler J, Desmet EA, Gelbard HA, Maggirwar SB, Walton JP, Frisina RD, Dewhurst S. Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure. Hear Res. 2010 Dec 1; 270(1-2):21-7.
    View in: PubMed
  7. Perry SW, Barbieri J, Tong N, Polesskaya O, Pudasaini S, Stout A, Lu R, Kiebala M, Maggirwar SB, Gelbard HA. Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax. J Neurosci. 2010 Oct 20; 30(42):14153-64.
    View in: PubMed
  8. Gelbard HA, Dewhurst S, Maggirwar SB, Kiebala M, Polesskaya O, Gendelman HE. Rebuilding synaptic architecture in HIV-1 associated neurocognitive disease: a therapeutic strategy based on modulation of mixed lineage kinase. Neurotherapeutics. 2010 Oct; 7(4):392-8.
    View in: PubMed
  9. Kiebala M, Polesskaya O, Yao Z, Perry SW, Maggirwar SB. Nuclear factor-kappa B family member RelB inhibits human immunodeficiency virus-1 Tat-induced tumor necrosis factor-alpha production. PLoS One. 2010; 5(7):e11875.
    View in: PubMed
  10. Myakishev M, Polesskaya O, Kulichkova V, Baranova A, Gause L, Konstantinova I. PCR-based detection of Pol III-transcribed transposons and its application to the rodent model of ultraviolet response. Cell Stress Chaperones. 2008; 13(1):111-6.
    View in: PubMed
  11. Paletzki RF, Myakishev MV, Polesskaya O, Orosz A, Hyman SE, Vinson C. Inhibiting activator protein-1 activity alters cocaine-induced gene expression and potentiates sensitization. Neuroscience. 2008 Apr 9; 152(4):1040-53.
    View in: PubMed
  12. Polesskaya OO, Fryxell KJ, Merchant AD, Locklear LL, Ker KF, McDonald CG, Eppolito AK, Smith LN, Wheeler TL, Smith RF. Nicotine causes age-dependent changes in gene expression in the adolescent female rat brain. Neurotoxicol Teratol. 2007 Jan-Feb; 29(1):126-40.
    View in: PubMed
  13. Polesskaya OO, Smith RF, Fryxell KJ. Chronic nicotine doses down-regulate PDE4 isoforms that are targets of antidepressants in adolescent female rats. Biol Psychiatry. 2007 Jan 1; 61(1):56-64.
    View in: PubMed
  14. Polesskaya OO, Aston C, Sokolov BP. Allele C-specific methylation of the 5-HT2A receptor gene: evidence for correlation with its expression and expression of DNA methylase DNMT1. J Neurosci Res. 2006 Feb 15; 83(3):362-73.
    View in: PubMed
  15. Liu QR, Walther D, Drgon T, Polesskaya O, Lesnick TG, Strain KJ, de Andrade M, Bower JH, Maraganore DM, Uhl GR. Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease. Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5; 134B(1):93-103.
    View in: PubMed
  16. Polesskaya OO, Haroutunian V, Davis KL, Hernandez I, Sokolov BP. Novel putative nonprotein-coding RNA gene from 11q14 displays decreased expression in brains of patients with schizophrenia. J Neurosci Res. 2003 Oct 1; 74(1):111-22.
    View in: PubMed
  17. Mir AA, Myakishev MV, Polesskaya OO, Moitra J, Petersen D, Miller L, Orosz A, Vinson C. A search for candidate genes for lipodystrophy, obesity and diabetes via gene expression analysis of A-ZIP/F-1 mice. Genomics. 2003 Apr; 81(4):378-90.
    View in: PubMed
  18. Sokolov BP, Polesskaya OO, Uhl GR. Mouse brain gene expression changes after acute and chronic amphetamine. J Neurochem. 2003 Jan; 84(2):244-52.
    View in: PubMed
  19. Polesskaya OO, Sokolov BP. Differential expression of the "C" and "T" alleles of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics. J Neurosci Res. 2002 Mar 15; 67(6):812-22.
    View in: PubMed
  20. Kalmykova AI, Shevelyov YY, Polesskaya OO, Dobritsa AA, Evstafieva AG, Boldyreff B, Issinger OG, Gvozdev VA. CK2(beta)tes gene encodes a testis-specific isoform of the regulatory subunit of casein kinase 2 in Drosophila melanogaster. Eur J Biochem. 2002 Mar; 269(5):1418-27.
    View in: PubMed
  21. Kramerov AA, Arbatsky NP, Rozovsky YM, Mikhaleva EA, Polesskaya OO, Gvozdev VA, Shibaev VN. Mucin-type glycoprotein from Drosophila melanogaster embryonic cells: characterization of carbohydrate component. FEBS Lett. 1996 Jan 15; 378(3):213-8.
    View in: PubMed

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