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Patricia White

TitleAssistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentNeurobiology and Anatomy
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 603
Rochester NY 14642
 
 Awards And Honors
      ARCS Scholar
      Hearst Scholar
 
 Overview
Scientific Goals

I want to realize the promise of developmental biology for human medicine. If we can define, describe, and understand the molecular mechanisms that regulate cell division and differentiation, then in principle, we can manipulate cells and tissues to rebuild damaged or diseased organs.

We have begun this process for human deafness, which impacts one quarter of adults over the age of 65. For many of these individuals, decades of noise exposure results in the progressive loss of mechanosensory hair cells, which detect sound vibration in the cochlea. In mammals, lost hair cells are not replaced; consequently, damage accumulates as people age. Surprisingly, when we tested the developmental capacities of nearby cells to divide and create new sensory cells, we found a latent ability for regeneration. My work here at Rochester centers on identifying what molecules regulate inner ear regeneration in mammals. My goal is to find a biological treatment for noise-induced hearing loss.

 
 Selected Publications
List All   |   Timeline
  1. Gilels F, Paquette ST, Zhang J, Rahman I, White PM. Mutation of foxo3 causes adult onset auditory neuropathy and alters cochlear synapse architecture in mice. J Neurosci. 2013 Nov 20; 33(47):18409-24.
    View in: PubMed
  2. White PM, Stone JS, Groves AK, Segil N. EGFR signaling is required for regenerative proliferation in the cochlea: conservation in birds and mammals. Dev Biol. 2012 Mar 1; 363(1):191-200.
    View in: PubMed
  3. Yee CM, Williams TJ, White PM, Nuechterlein KH, Ames D, Subotnik KL. Attentional modulation of the P50 suppression deficit in recent-onset and chronic schizophrenia. J Abnorm Psychol. 2010 Feb; 119(1):31-9.
    View in: PubMed
  4. Siram S, Oyetunji T, Johnson SM, Khoury AL, White PM, Chang DC, Greene WR, Frederick WA. Predictors for survival of penetrating trauma using emergency department thoracotomy in an urban trauma center: the Cardiac Instability Score. J Natl Med Assoc. 2010 Feb; 102(2):126-30.
    View in: PubMed
  5. Kwan T, White PM, Segil N. Development and regeneration of the inner ear. Ann N Y Acad Sci. 2009 Jul; 1170:28-33.
    View in: PubMed
  6. Stewart LP, White PM. Sensory filtering phenomenology in PTSD. Depress Anxiety. 2008; 25(1):38-45.
    View in: PubMed
  7. Leskin LP, White PM. Attentional networks reveal executive function deficits in posttraumatic stress disorder. Neuropsychology. 2007 May; 21(3):275-84.
    View in: PubMed
  8. Jeng JC, Fidler PE, Sokolich JC, Jaskille AD, Khan S, White PM, Street JH, Light TD, Jordan MH. Seven years' experience with Integra as a reconstructive tool. J Burn Care Res. 2007 Jan-Feb; 28(1):120-6.
    View in: PubMed
  9. Kanazawa A, White PM, Hampson SE. Ethnic variation in depressive symptoms in a community sample in Hawaii. Cultur Divers Ethnic Minor Psychol. 2007 Jan; 13(1):35-44.
    View in: PubMed
  10. Graver CJ, White PM. Neuropsychological effects of stress on social phobia with and without comorbid depression. Behav Res Ther. 2007 Jun; 45(6):1193-206.
    View in: PubMed
  11. White PM, Doetzlhofer A, Lee YS, Groves AK, Segil N. Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells. Nature. 2006 Jun 22; 441(7096):984-7.
    View in: PubMed
  12. White PM, Yee CM. P50 sensitivity to physical and psychological state influences. Psychophysiology. 2006 May; 43(3):320-8.
    View in: PubMed
  13. White PM, Kanazawa A, Yee CM. Gender and suppression of mid-latency ERP components during stress. Psychophysiology. 2005 Nov; 42(6):720-5.
    View in: PubMed
  14. Doetzlhofer A, White PM, Johnson JE, Segil N, Groves AK. In vitro growth and differentiation of mammalian sensory hair cell progenitors: a requirement for EGF and periotic mesenchyme. Dev Biol. 2004 Aug 15; 272(2):432-47.
    View in: PubMed
  15. White PM, Morrison SJ, Orimoto K, Kubu CJ, Verdi JM, Anderson DJ. Neural crest stem cells undergo cell-intrinsic developmental changes in sensitivity to instructive differentiation signals. Neuron. 2001 Jan; 29(1):57-71.
    View in: PubMed
  16. White PM, Anderson DJ. In vivo transplantation of mammalian neural crest cells into chick hosts reveals a new autonomic sublineage restriction. Development. 1999 Oct; 126(19):4351-63.
    View in: PubMed
  17. Morrison SJ, White PM, Zock C, Anderson DJ. Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells. Cell. 1999 Mar 5; 96(5):737-49.
    View in: PubMed

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