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James Corsetti

TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentPathology and Laboratory Medicine
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 608
Rochester NY 14642
 
 Awards And Honors
2000     Member, Who's Who in Science and Engineering
 
 Overview
My current research interests focus on studies of cardiovascular disease risk in human populations using non-traditional statistical approaches, especially as related to risk associations involving novel biomarkers as well as genetic markers. Underlying our approach is the hypothesis that particular blood and genetic risk markers are most efficacious in particular patient subgroups and that, in general, different patient subgroups have different markers of risk. As such, we have recently developed a 3-dimensional graphical exploratory data analysis technique that we call "outcome event mapping" that allows identification of high-risk patient subgroups not constrained by traditional rectilinear approaches to subgroup identification and allowing subgroup identification even in unexpected regions of risk parameter domains. With it, we have demonstrated a high-risk subgroup in post-MI patients based upon high levels of serum C-reactive protein (CRP) and total cholesterol. Interestingly, we have shown the counter-intuitive result that within this subgroup elevated high-density lipoprotein (HDL) cholesterol, the so-called "good cholesterol", is a risk factor for recurrent events, a finding that we ascribe to transformation of the usual anti-inflammatory HDL into pro-inflammatory HDL. We have also been able to adapt outcome event mapping to delineate subgroup-specific risk in association with single-nucleotide polymorphism (SNP) variants. For example, we have shown that a variant of a SNP in the p22phox subunit of NAD(P)H oxidase (an enzyme playing a critical role in generation of reactive oxygen species and thus potentially in the transformation of HDL) is associated with risk along with elevated HDL in this subgroup. We plan future studies to delineate mechanisms involved in elevated HDL-associated risk using outcome event mapping with additional genetic markers together with advanced statistical techniques to elucidate causal pathways; and to fully characterize the physico-chemical nature of changes at the molecular level in HDL mediating transformation of HDL from anti-inflammatory to pro-inflammatory in nature.

 
 Selected Publications
List All   |   Timeline
  1. Sparks CE, Corsetti JP, Sparks JD. High-density lipoproteins: taking the good with the bad. Curr Opin Lipidol. 2014 Jun; 25(3):230-2.
    View in: PubMed
  2. Corsetti JP, Salzman P, Ryan D, Moss AJ, Zareba W, Sparks CE. Plasminogen Activator Inhibitor-2 Polymorphism Associates with Recurrent Coronary Event Risk in Patients with High HDL and C-Reactive Protein Levels. PLoS One. 2013; 8(7):e68920.
    View in: PubMed
  3. Le NT, Corsetti JP, Dehoff-Sparks JL, Sparks CE, Fujiwara K, Abe J. Reactive Oxygen Species, SUMOylation, and Endothelial Inflammation. Int J Inflam. 2012; 2012:678190.
    View in: PubMed
  4. Corsetti JP, Bakker SJ, Sparks CE, Dullaart RP. Apolipoprotein A-II influences apolipoprotein E-linked cardiovascular disease risk in women with high levels of HDL cholesterol and C-reactive protein. PLoS One. 2012; 7(6):e39110.
    View in: PubMed
  5. Corsetti JP, Gansevoort RT, Bakker SJ, Navis G, Sparks CE, Dullaart RP. Apolipoprotein E predicts incident cardiovascular disease risk in women but not in men with concurrently high levels of high-density lipoprotein cholesterol and C-reactive protein. Metabolism. 2012 Jul; 61(7):996-1002.
    View in: PubMed
  6. Corsetti JP, Ryan D, Moss AJ, McCarthy J, Goldenberg I, Zareba W, Sparks CE. Thrombospondin-4 polymorphism (A387P) predicts cardiovascular risk in postinfarction patients with high HDL cholesterol and C-reactive protein levels. Thromb Haemost. 2011 Dec; 106(6):1170-8.
    View in: PubMed
  7. Corsetti JP, Sterry J, Sakpal M, Lefevre BH, Ryan D. Glycerol as a reference material for fecal fat quantitation using low-resolution time domain ¹H NMR spectroscopy. Clin Biochem. 2011 Nov; 44(16):1352-4.
    View in: PubMed
  8. Refaai MA, Fialkow LB, Heal JM, Henrichs KF, Spinelli SL, Phipps RP, Masel E, Smith BH, Corsetti JP, Francis CW, Bankey PE, Blumberg N. An association of ABO non-identical platelet and cryoprecipitate transfusions with altered red cell transfusion needs in surgical patients. Vox Sang. 2011 Jul; 101(1):55-60.
    View in: PubMed
  9. Corsetti JP, Gansevoort RT, Navis G, Sparks CE, Dullaart RP. LPL polymorphism (D9N) predicts cardiovascular disease risk directly and through interaction with CETP polymorphism (TaqIB) in women with high HDL cholesterol and CRP. Atherosclerosis. 2011 Feb; 214(2):373-6.
    View in: PubMed
  10. Corsetti JP, Ryan D, Rainwater DL, Moss AJ, Zareba W, Sparks CE. Cholesteryl ester transfer protein polymorphism (TaqIB) associates with risk in postinfarction patients with high C-reactive protein and high-density lipoprotein cholesterol levels. Arterioscler Thromb Vasc Biol. 2010 Aug; 30(8):1657-64.
    View in: PubMed
  11. Casas JP, Ninio E, Panayiotou A, Palmen J, Cooper JA, Ricketts SL, Sofat R, Nicolaides AN, Corsetti JP, Fowkes FG, Tzoulaki I, Kumari M, Brunner EJ, Kivimaki M, Marmot MG, Hoffmann MM, Winkler K, März W, Ye S, Stirnadel HA, Boekholdt SM, Khaw KT, Humphries SE, Sandhu MS, Hingorani AD, Talmud PJ. PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry. Circulation. 2010 Jun 1; 121(21):2284-93.
    View in: PubMed
  12. Corsetti JP, Gansevoort RT, Sparks CE, Dullaart RP. Inflammation reduces HDL protection against primary cardiac risk. Eur J Clin Invest. 2010 Jun; 40(6):483-9.
    View in: PubMed
  13. Block R, Corsetti J, Goldenberg I, Vorobiof G, McNitt S, Ryan D, Zareba W, Moss AJ. The common apolipoprotein A-1 polymorphism -75A>G is associated with ethnic differences in recurrent coronary events after recovery from an acute myocardial infarction. Heart Int. 2009 Jun 30; 4(1):e8.
    View in: PubMed
  14. Corsetti JP, Ryan D, Rainwater DL, Moss AJ, Zareba W, Block RC, Sparks CE. Lp(a) and risk of recurrent cardiac events in obese postinfarction patients. Obesity (Silver Spring). 2008 Dec; 16(12):2717-22.
    View in: PubMed
  15. Corsetti JP, Ryan D, Moss AJ, Rainwater DL, Zareba W, Sparks CE. Plasminogen activator inhibitor-1 polymorphism (4G/5G) predicts recurrence in nonhyperlipidemic postinfarction patients. Arterioscler Thromb Vasc Biol. 2008 Mar; 28(3):548-54.
    View in: PubMed
  16. Ryan TP, Sloand JA, Winters PC, Corsetti JP, Fisher SG. Chronic kidney disease prevalence and rate of diagnosis. Am J Med. 2007 Nov; 120(11):981-6.
    View in: PubMed
  17. Goldenberg I, Moss AJ, Block R, Ryan D, Corsetti JP, McNitt S, Eberly SW, Zareba W. Polymorphism in the cholesteryl ester transfer protein gene and the risk of early onset myocardial infarction among cigarette smokers. Ann Noninvasive Electrocardiol. 2007 Oct; 12(4):364-74.
    View in: PubMed
  18. Corsetti JP, Ryan D, Moss AJ, Rainwater DL, Zareba W, Sparks CE. Glycoprotein Ibalpha polymorphism T145M, elevated lipoprotein-associated phospholipase A2, and hypertriglyceridemia predict risk for recurrent coronary events in diabetic postinfarction patients. Diabetes. 2007 May; 56(5):1429-35.
    View in: PubMed
  19. Collaborative meta-analysis of individual participant data from observational studies of Lp-PLA2 and cardiovascular diseases. Eur J Cardiovasc Prev Rehabil. 2007 Feb; 14(1):3-11.
    View in: PubMed
  20. Corsetti JP, Ryan D, Moss AJ, Zareba W, Sparks CE. NAD(P)H oxidase polymorphism (C242T) and high HDL cholesterol associate with recurrent coronary events in postinfarction patients. Atherosclerosis. 2008 Jan; 196(1):461-8.
    View in: PubMed
  21. Corsetti JP, Rainwater DL, Moss AJ, Zareba W, Sparks CE. High lipoprotein-associated phospholipase A2 is a risk factor for recurrent coronary events in postinfarction patients. Clin Chem. 2006 Jul; 52(7):1331-8.
    View in: PubMed
  22. Corsetti JP, Zareba W, Moss AJ, Rainwater DL, Sparks CE. Elevated HDL is a risk factor for recurrent coronary events in a subgroup of non-diabetic postinfarction patients with hypercholesterolemia and inflammation. Atherosclerosis. 2006 Jul; 187(1):191-7.
    View in: PubMed
  23. Corsetti JP, Zareba W, Moss AJ, Sparks CE. Serum glucose and triglyceride determine high-risk subgroups in non-diabetic postinfarction patients. Atherosclerosis. 2005 Dec; 183(2):293-300.
    View in: PubMed
  24. Corsetti JP, Zareba W, Moss AJ, Sparks CE. Apolipoprotein B determines risk for recurrent coronary events in postinfarction patients with metabolic syndrome. Atherosclerosis. 2004 Dec; 177(2):367-73.
    View in: PubMed
  25. Corsetti JP, Zareba W, Moss AJ, Ridker PM, Marder VJ, Rainwater DL, Sparks CE. Metabolic syndrome best defines the multivariate distribution of blood variables in postinfarction patients. Atherosclerosis. 2003 Dec; 171(2):351-8.
    View in: PubMed
  26. Chirieac DV, Chirieac LR, Corsetti JP, Cianci J, Sparks CE, Sparks JD. Glucose-stimulated insulin secretion suppresses hepatic triglyceride-rich lipoprotein and apoB production. Am J Physiol Endocrinol Metab. 2000 Nov; 279(5):E1003-11.
    View in: PubMed
  27. Sparks JD, Shaw WN, Corsetti JP, Bolognino M, Pesek JF, Sparks CE. Insulin-treated Zucker diabetic fatty rats retain the hypertriglyceridemia associated with obesity. Metabolism. 2000 Nov; 49(11):1424-30.
    View in: PubMed
  28. Corsetti JP, Sparks JD, Peterson RG, Smith RL, Sparks CE. Effect of dietary fat on the development of non-insulin dependent diabetes mellitus in obese Zucker diabetic fatty male and female rats. Atherosclerosis. 2000 Feb; 148(2):231-41.
    View in: PubMed
  29. Nieto FJ, Iribarren C, Gross MD, Comstock GW, Cutler RG. Uric acid and serum antioxidant capacity: a reaction to atherosclerosis? Atherosclerosis. 2000 Jan; 148(1):131-9.
    View in: PubMed
  30. Sparks JD, Phung TL, Bolognino M, Cianci J, Khurana R, Peterson RG, Sowden MP, Corsetti JP, Sparks CE. Lipoprotein alterations in 10- and 20-week-old Zucker diabetic fatty rats: hyperinsulinemic versus insulinopenic hyperglycemia. Metabolism. 1998 Nov; 47(11):1315-24.
    View in: PubMed
  31. Lazova RZ, Sterry JA, Corsetti JP. Pseudoparaproteinemia due to hemoglobinopathy. Clin Chem. 1995 Sep; 41(9):1321-2.
    View in: PubMed
  32. Sparks JD, Corsetti JP, Sparks CE. Liver regrowth and apolipoprotein B secretion by rat hepatocytes following partial hepatectomy. Metabolism. 1994 Jun; 43(6):681-90.
    View in: PubMed
  33. Corsetti JP, Cox C, Schulz TJ, Arvan DA. Combined serum amylase and lipase determinations for diagnosis of suspected acute pancreatitis. Clin Chem. 1993 Dec; 39(12):2495-9.
    View in: PubMed
  34. Corsetti JP, Sparks JD, Sikora B, Sparks CE. Cellular heterogeneity in binding and uptake of low-density lipoprotein in primary rat hepatocytes. Hepatology. 1993 Apr; 17(4):645-50.
    View in: PubMed
  35. Corsetti JP, Way BA, Sparks CE, Sparks JD. Immunolocalization, quantitation and cellular heterogeneity of apolipoprotein B in rat hepatocytes. Hepatology. 1992 Jun; 15(6):1117-24.
    View in: PubMed
  36. Corsetti JP, Sterry JA, Sparks JD, Sparks CE, Weintraub M. Effect of weight loss on serum lipoprotein(a) concentrations in an obese population. Clin Chem. 1991 Jul; 37(7):1191-5.
    View in: PubMed
  37. Corsetti JP, Weidner CH, Cianci J, Sparks CE. The labeling of lipoproteins for studies of cellular binding with a fluorescent lipophilic dye. Anal Biochem. 1991 May 15; 195(1):122-8.
    View in: PubMed
  38. Rattner DW, Napolitano LM, Corsetti J, Compton C, Stanford GG, Warshaw AL, Chernow B. Hypocalcemia in experimental pancreatitis occurs independently of changes in serum nonesterified fatty acid levels. Int J Pancreatol. 1990 Jun; 6(4):249-62.
    View in: PubMed
  39. Corsetti JP, Sotirchos SV, Cox C, Cowles JW, Leary JF, Blumburg N. Correction of cellular autofluorescence in flow cytometry by mathematical modeling of cellular fluorescence. Cytometry. 1988 Nov; 9(6):539-47.
    View in: PubMed
  40. Corsetti JP, Cowles JW, Cox MT, Blumberg N. A rapid and accurate single-drop modification of the acid-elution technique for detecting fetomaternal hemorrhage. Vox Sang. 1988; 54(1):39-42.
    View in: PubMed
  41. Corsetti JP, Cox C, Leary JF, Cox MT, Blumberg N, Doherty RA. Comparison of quantitative acid-elution technique and flow cytometry for detecting fetomaternal hemorrhage. Ann Clin Lab Sci. 1987 May-Jun; 17(3):197-206.
    View in: PubMed
  42. Szilagyi PG, Corsetti J, Callahan CM, McCormick K, Metlay LA. Pancreatic exocrine aplasia, clinical features of leprechaunism, and abnormal gonadotropin regulation. Pediatr Pathol. 1987; 7(1):51-61.
    View in: PubMed

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