URMC Research Network - Karen Bentley

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Karen Bentley

Title	Associate
Institution	School of Medicine and Dentistry
Department	Pathology and Laboratory Medicine
Address	University of Rochester Medical Center School of Medicine and Dentistry 601 Elmwood Ave, Box 626 Rochester NY 14642

Overview

Ms. Bentley oversees the Electron Microscope Research Core. The Core provides services for processing and morphological assessment at the EM level. Researchers' requests often involve methods for pre- and post-embedding immunoelectron microscopy using biotin-, HRP, or gold conjugated markers for precise localization of antigens at the ultrastructural level. Other methods include: negative staining techniques for visualization of viral particles; a published innovative EM Research Core technique, "The large block tissue embedding direct off the slide/pop-off technique", to find "needle in a haystack" cells to be examined by EM; as well as customized techniques.

Selected Publications

Kim SC, Chen DR, Qi C, Gelein RM, Finkelstein JN, Elder A, Bentley K, Oberdörster G, Pui DY. A nanoparticle dispersion method for in vitro and in vivo nanotoxicity study. Nanotoxicology. 2010 Mar; 4(1):42-51.

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Miano JM, Ramanan N, Georger MA, de Mesy Bentley KL, Emerson RL, Balza RO, Xiao Q, Weiler H, Ginty DD, Misra RP. Restricted inactivation of serum response factor to the cardiovascular system. Proc Natl Acad Sci U S A. 2004 Dec 7; 101(49):17132-7.

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Sowden MP, Ballatori N, Jensen KL, Reed LH, Smith HC. The editosome for cytidine to uridine mRNA editing has a native complexity of 27S: identification of intracellular domains containing active and inactive editing factors. J Cell Sci. 2002 Mar 1; 115(Pt 5):1027-39.

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O'Reilly MA, Staversky RJ, Watkins RH, Reed CK, de Mesy Jensen KL, Finkelstein JN, Keng PC. The cyclin-dependent kinase inhibitor p21 protects the lung from oxidative stress. Am J Respir Cell Mol Biol. 2001 Jun; 24(6):703-10.

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