URMC Research Network - Jennifer Nayak

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Jennifer Nayak

Title	Assistant Professor
Institution	School of Medicine and Dentistry
Department	Pediatrics
Address	University of Rochester Medical Center School of Medicine and Dentistry 601 Elmwood Ave, Box 690 Rochester NY 14642

Awards And Honors

1996	-	2000	Rush Rhees Scholarship
1999			Phi Beta Kappa National Honor Society
1999			Golden Key National Honor Society

Overview

My current research interests involve understanding the role of CD4 T cells in primary and secondary influenza infection. I am currently using a murine model to determine the effect of secondary influenza infection on the magnitude and kinetics of the CD4 T cell response to individual conserved and nonconserved CD4 T cell epitopes. I am also examining the effect of increasing MHC class III diversity of the CD4 T cell response to influenza.

Selected Publications

Nayak JL, Fitzgerald TF, Richards KA, Yang H, Treanor JJ, Sant AJ. CD4+ T-Cell Expansion Predicts Neutralizing Antibody Responses to Monovalent, Inactivated 2009 Pandemic Influenza A(H1N1) Virus Subtype H1N1 Vaccine. J Infect Dis. 2013 Jan; 207(2):297-305.

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Nayak JL, Sant AJ. Loss in CD4 T-cell responses to multiple epitopes in influenza due to expression of one additional MHC class II molecule in the host. Immunology. 2012 Aug; 136(4):425-36.

View in: PubMed
Chaves FA, Lee AH, Nayak JL, Richards KA, Sant AJ. The utility and limitations of current web-available algorithms to predict peptides recognized by CD4 T cells in response to pathogen infection. J Immunol. 2012 May 1; 188(9):4235-48.

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Nayak JL, Sant AJ. T cell immunology for the clinician. Pediatr Infect Dis J. 2011 Mar; 30(3):248-50.

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Nayak JL, Richards KA, Chaves FA, Sant AJ. Analyses of the specificity of CD4 T cells during the primary immune response to influenza virus reveals dramatic MHC-linked asymmetries in reactivity to individual viral proteins. Viral Immunol. 2010 Apr; 23(2):169-80.

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Nayak JL, Treanor JJ. Antiviral treatment and prophylaxis of influenza virus in children. Pediatr Ann. 2009 Dec; 38(12):667-74.

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Varughese R, Nayak JL, LoMonaco M, O'Reilly MA, Ryan RM, D'Angio CT. Effects of hyperoxia on tumor necrosis factor alpha and Grobeta expression in newborn rabbit lungs. Lung. 2003 Nov-Dec; 181(6):335-46.

View in: PubMed