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Constantine Haidaris

TitleAssociate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentMicrobiology and Immunology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 672
Rochester NY 14642
Other Positions
TitleAssociate Professor
InstitutionUniversity of Rochester Medical Center
DepartmentCenter for Oral Biology

 
 Overview
Research Description:

Research in my lab focuses on infections in the immunocompromised host. We examine mechanisms of pathogenesis, host-microbe interactions and approaches to therapy. Much of our recent work centers on a novel approach to treat of infections termed photodynamic therapy, in which a chemical agent termed a photosensitizer is activated by light to convert molecular oxygen to reactive oxygen species that are toxic for the target cell. In collaboration with colleagues in the Departments of Physics and Imaging Sciences, we are exploring mechanisms to increase the sensitivity of pathogens to antimicrobial photodynamic therapy and developing methods to treat experimental infections using this technology.

 
 Selected Publications
List All   |   Timeline
  1. Haidaris CG, Foster TH, Waldman DL, Mathes EJ, McNamara J, Curran T. Effective photodynamic therapy against microbial populations in human deep tissue abscess aspirates. Lasers Surg Med. 2013 Oct; 45(8):509-16.
    View in: PubMed
  2. Snell SB, Foster TH, Haidaris CG. Miconazole induces fungistasis and increases killing of Candida albicans subjected to photodynamic therapy. Photochem Photobiol. 2012 May-Jun; 88(3):596-603.
    View in: PubMed
  3. Mitra S, Haidaris CG, Snell SB, Giesselman BR, Hupcher SM, Foster TH. Effective photosensitization and selectivity in vivo of Candida Albicans by meso-tetra (N-methyl-4-pyridyl) porphine tetra tosylate. Lasers Surg Med. 2011 Apr; 43(4):324-32.
    View in: PubMed
  4. Chabrier-Roselló Y, Giesselman BR, De Jesús-Andino FJ, Foster TH, Mitra S, Haidaris CG. Inhibition of electron transport chain assembly and function promotes photodynamic killing of Candida. J Photochem Photobiol B. 2010 Jun 1; 99(3):117-25.
    View in: PubMed
  5. Van Alst NE, Sherrill LA, Iglewski BH, Haidaris CG. Compensatory periplasmic nitrate reductase activity supports anaerobic growth of Pseudomonas aeruginosa PAO1 in the absence of membrane nitrate reductase. Can J Microbiol. 2009 Oct; 55(10):1133-44.
    View in: PubMed
  6. Van Alst NE, Wellington M, Clark VL, Haidaris CG, Iglewski BH. Nitrite reductase NirS is required for type III secretion system expression and virulence in the human monocyte cell line THP-1 by Pseudomonas aeruginosa. Infect Immun. 2009 Oct; 77(10):4446-54.
    View in: PubMed
  7. Chabrier-Roselló Y, Foster TH, Mitra S, Haidaris CG. Respiratory deficiency enhances the sensitivity of the pathogenic fungus Candida to photodynamic treatment. Photochem Photobiol. 2008 Sep-Oct; 84(5):1141-8.
    View in: PubMed
  8. Wellington M, Dolan K, Haidaris CG. Monocyte responses to Candida albicans are enhanced by antibody in cooperation with antibody-independent pathogen recognition. FEMS Immunol Med Microbiol. 2007 Oct; 51(1):70-83.
    View in: PubMed
  9. Van Alst NE, Picardo KF, Iglewski BH, Haidaris CG. Nitrate sensing and metabolism modulate motility, biofilm formation, and virulence in Pseudomonas aeruginosa. Infect Immun. 2007 Aug; 75(8):3780-90.
    View in: PubMed
  10. Foster DC, Piekarz KH, Murant TI, LaPoint R, Haidaris CG, Phipps RP. Enhanced synthesis of proinflammatory cytokines by vulvar vestibular fibroblasts: implications for vulvar vestibulitis. Am J Obstet Gynecol. 2007 Apr; 196(4):346.e1-8.
    View in: PubMed
  11. Wells J, Haidaris CG, Wright TW, Gigliotti F. Active immunization against Pneumocystis carinii with a recombinant P. carinii antigen. Infect Immun. 2006 Apr; 74(4):2446-8.
    View in: PubMed
  12. Wells J, Haidaris CG, Wright TW, Gigliotti F. Complement and Fc function are required for optimal antibody prophylaxis against Pneumocystis carinii pneumonia. Infect Immun. 2006 Jan; 74(1):390-3.
    View in: PubMed
  13. Chabrier-Roselló Y, Foster TH, Pérez-Nazario N, Mitra S, Haidaris CG. Sensitivity of Candida albicans germ tubes and biofilms to photofrin-mediated phototoxicity. Antimicrob Agents Chemother. 2005 Oct; 49(10):4288-95.
    View in: PubMed
  14. Filiatrault MJ, Wagner VE, Bushnell D, Haidaris CG, Iglewski BH, Passador L. Effect of anaerobiosis and nitrate on gene expression in Pseudomonas aeruginosa. Infect Immun. 2005 Jun; 73(6):3764-72.
    View in: PubMed
  15. Disney MD, Stephenson R, Wright TW, Haidaris CG, Turner DH, Gigliotti F. Activity of Hoechst 33258 against Pneumocystis carinii f. sp. muris, Candida albicans, and Candida dubliniensis. Antimicrob Agents Chemother. 2005 Apr; 49(4):1326-30.
    View in: PubMed
  16. Burns R, Luzina I, Nasir A, Haidaris CG, Barth RK, Gaspari AA. Keratinocyte-derived, CD80-mediated costimulation is associated with hapten-specific IgE production during contact hypersensitivity to TH1 haptens. J Allergy Clin Immunol. 2005 Feb; 115(2):383-90.
    View in: PubMed
  17. Bliss JM, Bigelow CE, Foster TH, Haidaris CG. Susceptibility of Candida species to photodynamic effects of photofrin. Antimicrob Agents Chemother. 2004 Jun; 48(6):2000-6.
    View in: PubMed
  18. Wells J, Gigliotti F, Simpson-Haidaris PJ, Haidaris CG. Epitope mapping of a protective monoclonal antibody against Pneumocystis carinii with shared reactivity to Streptococcus pneumoniae surface antigen PspA. Infect Immun. 2004 Mar; 72(3):1548-56.
    View in: PubMed
  19. Wellington M, Bliss JM, Haidaris CG. Enhanced phagocytosis of Candida species mediated by opsonization with a recombinant human antibody single-chain variable fragment. Infect Immun. 2003 Dec; 71(12):7228-31.
    View in: PubMed
  20. Bliss JM, Sullivan MA, Malone J, Haidaris CG. Differentiation of Candida albicans and Candida dubliniensis by using recombinant human antibody single-chain variable fragments specific for hyphae. J Clin Microbiol. 2003 Mar; 41(3):1152-60.
    View in: PubMed
  21. Board KF, Patil S, Lebedeva I, Capuano S, Trichel AM, Murphey-Corb M, Rajakumar PA, Flynn JL, Haidaris CG, Norris KA. Experimental Pneumocystis carinii pneumonia in simian immunodeficiency virus-infected rhesus macaques. J Infect Dis. 2003 Feb 15; 187(4):576-88.
    View in: PubMed
  22. Disney MD, Haidaris CG, Turner DH. Uptake and antifungal activity of oligonucleotides in Candida albicans. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1530-4.
    View in: PubMed
  23. Croix DA, Board K, Capuano S, Murphey-Corb M, Haidaris CG, Flynn JL, Reinhart T, Norris KA. Alterations in T lymphocyte profiles of bronchoalveolar lavage fluid from SIV- and Pneumocystis carinii-coinfected rhesus macaques. AIDS Res Hum Retroviruses. 2002 Mar 20; 18(5):391-401.
    View in: PubMed
  24. Gigliotti F, Haidaris CG, Wright TW, Harmsen AG. Passive intranasal monoclonal antibody prophylaxis against murine Pneumocystis carinii pneumonia. Infect Immun. 2002 Mar; 70(3):1069-74.
    View in: PubMed
  25. Haidaris CG, Malone J, Sherrill LA, Bliss JM, Gaspari AA, Insel RA, Sullivan MA. Recombinant human antibody single chain variable fragments reactive with Candida albicans surface antigens. J Immunol Methods. 2001 Nov 1; 257(1-2):185-202.
    View in: PubMed
  26. Disney MD, Haidaris CG, Turner DH. Recognition elements for 5' exon substrate binding to the Candida albicans group I intron. Biochemistry. 2001 May 29; 40(21):6507-19.
    View in: PubMed
  27. Odrljin TM, Haidaris CG, Lerner NB, Simpson-Haidaris PJ. Integrin alphavbeta3-mediated endocytosis of immobilized fibrinogen by A549 lung alveolar epithelial cells. Am J Respir Cell Mol Biol. 2001 Jan; 24(1):12-21.
    View in: PubMed
  28. Wakem P, Burns RP, Ramirez F, Zlotnick D, Ferbel B, Haidaris CG, Gaspari AA. Allergens and irritants transcriptionally upregulate CD80 gene expression in human keratinocytes. J Invest Dermatol. 2000 Jun; 114(6):1085-92.
    View in: PubMed
  29. Lee LH, Gigliotti F, Wright TW, Simpson-Haidaris PJ, Weinberg GA, Haidaris CG. Molecular characterization of KEX1, a kexin-like protease in mouse Pneumocystis carinii. Gene. 2000 Jan 25; 242(1-2):141-50.
    View in: PubMed
  30. Gigliotti F, Haidaris CG. Antigenic characterization of Pneumocystis carinii. Semin Respir Infect. 1998 Dec; 13(4):313-22.
    View in: PubMed
  31. Guadiz G, Haidaris CG, Maine GN, Simpson-Haidaris PJ. The carboxyl terminus of Pneumocystis carinii glycoprotein A encodes a functional glycosylphosphatidylinositol signal sequence. J Biol Chem. 1998 Oct 2; 273(40):26202-9.
    View in: PubMed
  32. Gaspari AA, Burns R, Nasir A, Ramirez D, Barth RK, Haidaris CG. CD86 (B7-2), but not CD80 (B7-1), expression in the epidermis of transgenic mice enhances the immunogenicity of primary cutaneous Candida albicans infections. Infect Immun. 1998 Sep; 66(9):4440-9.
    View in: PubMed
  33. Gigliotti F, Garvy BA, Haidaris CG, Harmsen AG. Recognition of Pneumocystis carinii antigens by local antibody-secreting cells following resolution of P. carinii pneumonia in mice. J Infect Dis. 1998 Jul; 178(1):235-42.
    View in: PubMed
  34. Haidaris CG, Medzihradsky OF, Gigliotti F, Simpson-Haidaris PJ. Molecular characterization of mouse Pneumocystis carinii surface glycoprotein A. DNA Res. 1998 Apr 30; 5(2):77-85.
    View in: PubMed
  35. Haidaris CG, Fisher DJ, Gigliotti F, Simpson-Haidaris PJ. Antigenic properties of recombinant glycosylated and nonglycosylated Pneumocystis carinii glycoprotein A polypeptides expressed in baculovirus-infected insect cells. Mol Biotechnol. 1998 Apr; 9(2):91-7.
    View in: PubMed
  36. Sobel JD, Hasegawa A, Debernardis F, Adriani D, Pellegrini G, Cassone A, Fidel PL, Haidaris CG, Gigliotti F, Harmsen AG, Fujita S, Yamamoto K, Makimura K, Shibuya K, Uchida K, Yamaguchi H. Selected animal models: vaginal candidosis, Pneumocystis pneumonia, dermatophytosis and trichosporosis. Med Mycol. 1998; 36 Suppl 1:129-36.
    View in: PubMed
  37. Testa SM, Haidaris CG, Gigliotti F, Turner DH. A Pneumocystis carinii group I intron ribozyme that does not require 2' OH groups on its 5' exon mimic for binding to the catalytic core. Biochemistry. 1997 Dec 9; 36(49):15303-14.
    View in: PubMed
  38. Wright TW, Gigliotti F, Haidaris CG, Simpson-Haidaris PJ. Cloning and characterization of a conserved region of human and rhesus macaque Pneumocystis carinii gpA. Gene. 1995 Dec 29; 167(1-2):185-9.
    View in: PubMed
  39. Ting LM, Hsia RC, Haidaris CG, Bavoil PM. Interaction of outer envelope proteins of Chlamydia psittaci GPIC with the HeLa cell surface. Infect Immun. 1995 Sep; 63(9):3600-8.
    View in: PubMed
  40. Wright TW, Bissoondial TY, Haidaris CG, Gigliotti F, Haidaris PJ. Isoform diversity and tandem duplication of the glycoprotein A gene in ferret Pneumocystis carinii. DNA Res. 1995; 2(2):77-88.
    View in: PubMed
  41. Thertulien R, Simpson-Haidaris PJ, Haidaris CG. Intracellular localization of a Trypanosoma cruzi kDNA minicircle transcript using RNA: RNA in situ hybridization. J Eukaryot Microbiol. 1994 Jul-Aug; 41(4):402-7.
    View in: PubMed
  42. Wright TW, Simpson-Haidaris PJ, Gigliotti F, Harmsen AG, Haidaris CG. Conserved sequence homology of cysteine-rich regions in genes encoding glycoprotein A in Pneumocystis carinii derived from different host species. Infect Immun. 1994 May; 62(5):1513-9.
    View in: PubMed
  43. Hoffman MP, Haidaris CG. Identification and characterization of a Candida albicans-binding proteoglycan secreted from rat submandibular salivary glands. Infect Immun. 1994 Mar; 62(3):828-36.
    View in: PubMed
  44. Gigliotti F, Harmsen AG, Haidaris CG, Haidaris PJ. Pneumocystis carinii is not universally transmissible between mammalian species. Infect Immun. 1993 Jul; 61(7):2886-90.
    View in: PubMed
  45. Gigliotti F, Haidaris PJ, Haidaris CG, Wright TW, Van der Meid KR. Further evidence of host species-specific variation in antigens of Pneumocystis carinii using the polymerase chain reaction. J Infect Dis. 1993 Jul; 168(1):191-4.
    View in: PubMed
  46. Hoffman MP, Haidaris CG. Analysis of Candida albicans adhesion to salivary mucin. Infect Immun. 1993 May; 61(5):1940-9.
    View in: PubMed
  47. Haidaris PJ, Wright TW, Gigliotti F, Fallon MA, Whitbeck AA, Haidaris CG. In situ hybridization analysis of developmental stages of Pneumocystis carinii that are transcriptionally active for a major surface glycoprotein gene. Mol Microbiol. 1993 Mar; 7(5):647-56.
    View in: PubMed
  48. Haidaris PJ, Wright TW, Gigliotti F, Haidaris CG. Expression and characterization of a cDNA clone encoding an immunodominant surface glycoprotein of Pneumocystis carinii. J Infect Dis. 1992 Nov; 166(5):1113-23.
    View in: PubMed
  49. Vasilas A, Molina L, Hoffman M, Haidaris CG. The influence of morphological variation on Candida albicans adhesion to denture acrylic in vitro. Arch Oral Biol. 1992 Aug; 37(8):613-22.
    View in: PubMed
  50. Haidaris CG, Wright TW, Gigliotti F, Haidaris PJ. Molecular cloning and characterization of ferret Pneumocystis carinii gp120. J Protozool. 1991 Nov-Dec; 38(6):5S-6S.
    View in: PubMed
  51. Thertulien R, Harth G, Haidaris CG. Evidence that the entire length of a kinetoplast DNA minicircle is transcribed in Trypanosoma cruzi. Mol Microbiol. 1991 Jan; 5(1):207-15.
    View in: PubMed
  52. Meitner SW, Bowen WH, Haidaris CG. Oral and esophageal Candida albicans infection in hyposalivatory rats. Infect Immun. 1990 Jul; 58(7):2228-36.
    View in: PubMed
  53. Harth G, Haidaris CG, So M. Purification and characterization of stage-specific glycoproteins from Trypanosoma cruzi. Mol Biochem Parasitol. 1989 Mar 1; 33(2):143-50.
    View in: PubMed
  54. Bonventre PF, Weckbach L, Harth G, Haidaris C. Distribution and expression of toxic shock syndrome toxin 1 gene among Staphylococcus aureus isolates of toxic shock syndrome and non-toxic shock syndrome origin. Rev Infect Dis. 1989 Jan-Feb; 11 Suppl 1:S90-5.
    View in: PubMed
  55. Harth G, Haidaris CG, So M. Neuraminidase from Trypanosoma cruzi: analysis of enhanced expression of the enzyme in infectious forms. Proc Natl Acad Sci U S A. 1987 Dec; 84(23):8320-4.
    View in: PubMed
  56. Lyon JA, Haynes JD, Diggs CL, Chulay JD, Haidaris CG, Pratt-Rossiter J. Monoclonal antibody characterization of the 195-kilodalton major surface glycoprotein of Plasmodium falciparum malaria schizonts and merozoites: identification of additional processed products and a serotype-restricted repetitive epitope. J Immunol. 1987 Feb 1; 138(3):895-901.
    View in: PubMed
  57. Fields PI, Swanson RV, Haidaris CG, Heffron F. Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent. Proc Natl Acad Sci U S A. 1986 Jul; 83(14):5189-93.
    View in: PubMed
  58. Haidaris CG, Haynes JD, Meltzer MS, Allison AC. Serum containing tumor necrosis factor is cytotoxic for the human malaria parasite Plasmodium falciparum. Infect Immun. 1983 Oct; 42(1):385-93.
    View in: PubMed
  59. Haidaris CG, Bonventre PF. Efficacy of combined immunostimulation and chemotherapy in experimental visceral Leishmaniasis. Am J Trop Med Hyg. 1983 Mar; 32(2):286-95.
    View in: PubMed
  60. Haidaris CG, Bonventre PF. A role for oxygen-dependent mechanisms in killing of Leishmania donovani tissue forms by activated macrophages. J Immunol. 1982 Aug; 129(2):850-5.
    View in: PubMed
  61. Bonventre PF, Haidaris CG. Killing of Leishmania donovani. Amastigotes by murine macrophages. Adv Exp Med Biol. 1982; 141:189-98.
    View in: PubMed
  62. Haidaris CG, Bonventre PF. Elimination of Leishmania donovani amastigotes by activated macrophages. Infect Immun. 1981 Sep; 33(3):918-26.
    View in: PubMed
  63. Holder IA, Haidaris CG. Experimental studies of the pathogenesis of infections due to Pseudomonas aeruginosa: extracellular protease and elastase as in vivo virulence factors. Can J Microbiol. 1979 May; 25(5):593-9.
    View in: PubMed

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