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George Abraham

TitleProfessor Emeritus
InstitutionSchool of Medicine and Dentistry
DepartmentMedicine
Address146 Kilbourn Road
Rochester NY 14618
Other Positions
TitleProfessor Emeritus
InstitutionSchool of Medicine and Dentistry
DepartmentMicrobiology and Immunology

TitleProfessor Emeritus
InstitutionSchool of Medicine and Dentistry
DepartmentPediatrics

 
 Selected Publications
  • Chakravarti B, Abraham GN. Effect of age and oxidative stress on tyrosine phosphorylation of ZAP-70. Mech Ageing Dev. 2002 Feb; 123(4):297-311.
    View in: PubMed
  • Falsey AR, Walsh EE, Francis CW, Looney RJ, Kolassa JE, Hall WJ, Abraham GN. Response of C-reactive protein and serum amyloid A to influenza A infection in older adults. J Infect Dis. 2001 Apr 1; 183(7):995-9.
    View in: PubMed
  • Looney RJ, Hasan MS, Coffin D, Campbell D, Falsey AR, Kolassa J, Agosti JM, Abraham GN, Evans TG. Hepatitis B immunization of healthy elderly adults: relationship between naïve CD4+ T cells and primary immune response and evaluation of GM-CSF as an adjuvant. J Clin Immunol. 2001 Jan; 21(1):30-6.
    View in: PubMed
  • Chakravarti B, Abraham GN. Aging and T-cell-mediated immunity. Mech Ageing Dev. 1999 May 17; 108(3):183-206.
    View in: PubMed
  • Looney RJ, Falsey A, Campbell D, Torres A, Kolassa J, Brower C, McCann R, Menegus M, McCormick K, Frampton M, Hall W, Abraham GN. Role of cytomegalovirus in the T cell changes seen in elderly individuals. Clin Immunol. 1999 Feb; 90(2):213-9.
    View in: PubMed
  • Chakravarti B, Chakravarti DN, Devecis J, Seshi B, Abraham GN. Effect of age on mitogen induced protein tyrosine phosphorylation in human T cell and its subsets: down-regulation of tyrosine phosphorylation of ZAP-70. Mech Ageing Dev. 1998 Aug 1; 104(1):41-58.
    View in: PubMed
  • Thornton CA, Welle S, Griggs RC, Abraham GN. Human IgG production in vivo: determination of synthetic rate by nonradioactive tracer incorporation. J Immunol. 1996 Jul 15; 157(2):950-5.
    View in: PubMed
  • Freeman SM, McCune C, Robinson W, Abboud CN, Abraham GN, Angel C, Marrogi A. The treatment of ovarian cancer with a gene modified cancer vaccine: a phase I study. Hum Gene Ther. 1995 Jul; 6(7):927-39.
    View in: PubMed
  • Whartenby KA, Abraham GN, Calabresi PA, Abboud CN, Calabresi P, Marrogi A, Freeman SM. Gene-modified cells for the treatment of cancer. Pharmacol Ther. 1995 Apr; 66(1):175-90.
    View in: PubMed
  • Freeman SM, Abboud CN, Whartenby KA, Packman CH, Koeplin DS, Moolten FL, Abraham GN. The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res. 1993 Nov 1; 53(21):5274-83.
    View in: PubMed
  • Whartenby KA, Insel RA, Freeman SM, Keng P, Abraham GN. Oncogene elements within an endogenous retrovirus. Acta Virol. 1993 Apr-Jun; 37(2-3):113-22.
    View in: PubMed
  • Perl A, Gorevic PD, Condemi JJ, Papsidero L, Poiesz BJ, Abraham GN. Antibodies to retroviral proteins and reverse transcriptase activity in patients with essential cryoglobulinemia. Arthritis Rheum. 1991 Oct; 34(10):1313-8.
    View in: PubMed
  • Smalley HB, Todd J, Barnes RM, Thompson RN, Abraham GN, Johnson PM. Estimation of serum V kappa IIIb light chains in rheumatoid arthritis and correlation with CD5-positive B-cells. Br J Rheumatol. 1990 Oct; 29(5):325-30.
    View in: PubMed
  • Abraham GN, Khan AS. Human endogenous retroviruses and immune disease. Clin Immunol Immunopathol. 1990 Jul; 56(1):1-8.
    View in: PubMed
  • Perl A, Abraham GN. [Clonal immunoglobulin rearrangement in patients with essential cryoglobulinemia]. Orv Hetil. 1990 May 13; 131(19):1019-22.
    View in: PubMed
  • Perl A, DiVincenzo JP, Ryan DH, Gergely P, Szigeti A, Feher J, Abraham GN. Rearrangement of the T-cell receptor alpha, beta and gamma chain genes in chronic lymphocytic leukemia. Leuk Res. 1990; 14(2):131-7.
    View in: PubMed
  • Perl A, Rosenblatt JD, Chen IS, DiVincenzo JP, Bever R, Poiesz BJ, Abraham GN. Detection and cloning of new HTLV-related endogenous sequences in man. Nucleic Acids Res. 1989 Sep 12; 17(17):6841-54.
    View in: PubMed
  • Perl A, Divincenzo JP, Gergely P, Condemi JJ, Abraham GN. Detection and mapping of polymorphic KpnI alleles in the human T-cell receptor constant beta-2 locus. Immunology. 1989 May; 67(1):135-8.
    View in: PubMed
  • Perl A, Gorevic PD, Ryan DH, Condemi JJ, Ruszkowski RJ, Abraham GN. Clonal B cell expansions in patients with essential mixed cryoglobulinaemia. Clin Exp Immunol. 1989 Apr; 76(1):54-60.
    View in: PubMed
  • Williams JM, Gorevic PD, Looney RJ, Abraham GN. Isoelectric focusing characterization of IgM-VKiiib immunoglobulin light chains and their association with anti-IgG autoantibodies in essential mixed cryoglobulinaemia, Sjögren's syndrome and rheumatoid arthritis. Immunology. 1987 Dec; 62(4):529-36.
    View in: PubMed
  • Perl A, Wang N, Williams JM, Hunt MJ, Rosenfeld SI, Condemi JJ, Packman CH, Abraham GN. Aberrant immunoglobulin and c-myc gene rearrangements in patients with nonmalignant monoclonal cryoglobulinemia. J Immunol. 1987 Nov 15; 139(10):3512-20.
    View in: PubMed
  • Rosenfeld SI, Ryan DH, Looney RJ, Anderson CL, Abraham GN, Leddy JP. Human Fc gamma receptors: stable inter-donor variation in quantitative expression on platelets correlates with functional responses. J Immunol. 1987 May 1; 138(9):2869-73.
    View in: PubMed
  • Podell DN, Packman CH, Maniloff J, Abraham GN. Characterization of monoclonal IgG cryoglobulins: fine-structural and morphological analysis. Blood. 1987 Feb; 69(2):677-81.
    View in: PubMed
  • Perl A, Looney RJ, Ryan DH, Abraham GN. The low affinity 40,000 Fc gamma receptor and the transferrin receptor can be alternative or simultaneous target structures on cells sensitive for natural killing. J Immunol. 1986 Jun 15; 136(12):4714-20.
    View in: PubMed
  • Looney RJ, Ryan DH, Takahashi K, Fleit HB, Cohen HJ, Abraham GN, Anderson CL. Identification of a second class of IgG Fc receptors on human neutrophils. A 40 kilodalton molecule also found on eosinophils. J Exp Med. 1986 Apr 1; 163(4):826-36.
    View in: PubMed
  • Looney RJ, Abraham GN, Anderson CL. Human monocytes and U937 cells bear two distinct Fc receptors for IgG. J Immunol. 1986 Mar 1; 136(5):1641-7.
    View in: PubMed
  • Moynihan JA, Looney RJ, Abraham GN. The V kappa IIIb light chain sub-subgroup. II. Isotype expression in acquired hypogammaglobulinaemia and as a function of age. Immunology. 1986 Feb; 57(2):325-7.
    View in: PubMed
  • Rosenfeld SI, Looney RJ, Leddy JP, Phipps DC, Abraham GN, Anderson CL. Human platelet Fc receptor for immunoglobulin G. Identification as a 40,000-molecular-weight membrane protein shared by monocytes. J Clin Invest. 1985 Dec; 76(6):2317-22.
    View in: PubMed
  • Moynihan JA, Looney RJ, Abraham GN. The VKIIIb light chain sub-subgroup: restricted association with mu heavy chain in normal human serum. Immunology. 1985 Feb; 54(2):207-13.
    View in: PubMed
  • Greenstein JL, Abraham GN. VK IIIb expression is altered in acquired and drug-induced hypogammaglobulinaemia. Immunology. 1984 Dec; 53(4):779-82.
    View in: PubMed
  • Looney RJ, Abraham GN. The Fc portion of intact IgG blocks stimulation of human PBMC by anti-T3. J Immunol. 1984 Jul; 133(1):154-6.
    View in: PubMed
  • Greenstein JL, Solomon A, Abraham GN. Monoclonal antibodies reactive with idiotypic and variable-region specific determinants on human immunoglobulins. Immunology. 1984 Jan; 51(1):17-25.
    View in: PubMed
  • Abraham GN, Podell DN, Welch EH, Johnston SL. Idiotypic relatedness of human monoclonal IgG cryoglobulins. Immunology. 1983 Feb; 48(2):315-20.
    View in: PubMed
  • Goldberger G, Thomas ML, Tack BF, Williams J, Colten HR, Abraham GN. NH2-terminal structure and cleavage of guinea pig pro-C3, the precursor of the third complement component. J Biol Chem. 1981 Dec 25; 256(24):12617-9.
    View in: PubMed
  • Goldberger G, Abraham GN, Williams J, Colten HR. NH2-terminal sequence analysis of pro-C4, the precursor of the fourth component of guinea pig complement. J Biol Chem. 1980 Aug 10; 255(15):7071-4.
    View in: PubMed
  • Johnston SL, Abraham GN. Studies of human anti-IgM anti-IgG cryoglobulins. I. Patterns of reactivity with autologous and isologous human IgG and its subunits. Immunology. 1979 Apr; 36(4):671-83.
    View in: PubMed
  • Johnston SL, Jorizzo JR, Liberman DF, Abraham GN. Studies of human IgM anti-IgG cryoglobulins: II. Isoelectric focusing characteristics of the reactive antigen and residual serum IgG pools. Immunology. 1979 Apr; 36(4):707-10.
    View in: PubMed
  • Abraham GN, Podell DN, Wistar R, johnston SL, Welch EH. Immunological and structural properties of human monoclonal IgG cryoglobulins. Clin Exp Immunol. 1979 Apr; 36(1):63-70.
    View in: PubMed
  • Abraham GN, Waterhouse C, Condemi JJ. In vivo metabolism of a monoclonal IgG cryoglobulin. Clin Exp Immunol. 1979 Jan; 35(1):89-95.
    View in: PubMed
  • Abraham GN, Welch E, Trieshmann HW. Human triclonal anti-IgG gammopathy. II. Determination of the antigenic specificity patterns of the IgG, IgA and IgM autoantibodies for the subclasses of IgG. Immunology. 1978 Sep; 35(3):437-45.
    View in: PubMed
  • Abraham GN, Brown P, Johnston SL, Nellis L, Marks S, Welch EH. Human triclonal anti-IgG gammopathy. III. Determination of the clonal persistence of the IgM autoantibody for a four and one-half year period. Immunology. 1978 Sep; 35(3):447-53.
    View in: PubMed
  • Abraham GN. Human triclonal anti-IgG gammopathy. I. Iso-electric focusing characteristics of the IgG, IgA and IgM anti-IgG and their heavy and light chains. Immunology. 1978 Sep; 35(3):429-36.
    View in: PubMed
  • Yocum MW, Grossman J, Waterhouse C, Abraham GN, May AG, Condemi JJ. Monozygotic twins discordant for systemic lupus erythematosus. Arthritis Rheum. 1975 May-Jun; 18(3):193-9.
    View in: PubMed
  • Trieshmann HW, Abraham GN, Santucci EA. The characterization of human anti-IgG autoantibodies by liquid isoelectric focussing. J Immunol. 1975 Jan; 114(1 Pt 1):176-81.
    View in: PubMed
  • Clark RA, Abraham GN, Kyle R, Vaughan JH. Gamma globulin complexes in rheumatoid arthritis and hypergammaglobulinemic purpura. J Rheumatol. 1974 Mar; 1(1):54-65.
    View in: PubMed
  • Abraham GN, Santucci E, Jacox RF. Evidence for a common synthetic origin for secretory and serum IgA. Adv Exp Med Biol. 1974; 45(0):233-40.
    View in: PubMed
  • Taylor H, Abraham GN. Characterization of a monoclonal IgA rheumatoid factor. II. Evidence for reactivity with a specific IgG Fc fragment determinant. Clin Exp Immunol. 1973 Apr; 13(4):529-36.
    View in: PubMed
  • Abraham GN, Leddy JP, Grossman J, Condemi JJ. Properties of crystalline IgG3 globulin. Biochem Biophys Res Commun. 1972 Jan 14; 46(1):162-6.
    View in: PubMed
  • Abraham GN, Petz LD, Fudenberg HH. Immunohaematological cross-allergenicity between penicillin and cephalothin in humans. Clin Exp Immunol. 1968 May; 3(4):343-57.
    View in: PubMed

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