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Russell Hilf

TitleProfessor Emeritus
InstitutionSchool of Medicine and Dentistry
DepartmentBiochemistry and Biophysics
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester NY 14642
 
 Overview
Hormone action is mediated by specific cell receptors, resulting in a variety of metabolic responses and/or growth. A number of hormones are implicated in the etiology and growth of mammary cancer. Our studies are directed towards elucidation of the roles of estrogens and antiestrogens, insulin and insulin-like growth factors (IGFS) as regulators of neoplastic growth. By utilizing well characterized rodent models, in vivo and in vitro, experiments are designed to gain understanding of these regulatory actions.

Mechanism of action of estrogens and antiestrogens is being studied by defining the nucleotide requirements for binding of estrogen and antiestrogen activated estrogen receptor with their DNA regulatory element (ERE) and by transfection assays. Estrogen response depends on the expression level of one or both estrogen receptor (ER) isoforms, alpha and beta, and the concentration and type of ER-ligands. Our goal is to understand how these factors contribute to the level of induction characteristic of a particular gene. We have now established that insulin affects tumor growth and regulation, both directly and in a permissive role. We have examined insulin and estrogen receptors, how they are regulated by hormones and how such regulation relates to changes in tumor growth behavior.

A second active area of study is to define the mechanisms whereby tumor cytotoxicity ensues photoradiation therapy, a treatment approach that employs hematoporphyrin photosensitizers followed by exposure of tumors to visible light. The singlet oxygen produced is cytotoxic. We reported that important cellular targets are several mitochondrial respiratory enzymes, leading to reduced ATP production. Current aims are to elucidate these actions and to evolve methods to optimize therapeutic efficacy. The role of estrogenic and antiestrogenic agents in altering production of protoporphyrin IX from 5-aminolevulinic acid and the actions of new synthetic prophyrin derivatives are ongoing projects aimed at improving PDT outcome.

 
 Selected Publications
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  1. Li X, Nott SL, Huang Y, Hilf R, Bambara RA, Qiu X, Yakovlev A, Welle S, Muyan M. Gene expression profiling reveals that the regulation of estrogen-responsive element-independent genes by 17 beta-estradiol-estrogen receptor beta is uncoupled from the induction of phenotypic changes in cell models. J Mol Endocrinol. 2008 May; 40(5):211-29.
    View in: PubMed
  2. Hilf R. Mitochondria are targets of photodynamic therapy. J Bioenerg Biomembr. 2007 Feb; 39(1):85-9.
    View in: PubMed
  3. Huang J, Li X, Qiao T, Bambara RA, Hilf R, Muyan M. A tale of two estrogen receptors (ERs): how differential ER-estrogen responsive element interactions contribute to subtype-specific transcriptional responses. Nucl Recept Signal. 2006; 4:e015.
    View in: PubMed
  4. Huang J, Li X, Hilf R, Bambara RA, Muyan M. Molecular basis of therapeutic strategies for breast cancer. Curr Drug Targets Immune Endocr Metabol Disord. 2005 Dec; 5(4):379-96.
    View in: PubMed
  5. Huang J, Li X, Maguire CA, Hilf R, Bambara RA, Muyan M. Binding of estrogen receptor beta to estrogen response element in situ is independent of estradiol and impaired by its amino terminus. Mol Endocrinol. 2005 Nov; 19(11):2696-712.
    View in: PubMed
  6. You Y, Gibson SL, Hilf R, Ohulchanskyy TY, Detty MR. Core-modified porphyrins. Part 4: Steric effects on photophysical and biological properties in vitro. Bioorg Med Chem. 2005 Mar 15; 13(6):2235-51.
    View in: PubMed
  7. Li X, Huang J, Yi P, Bambara RA, Hilf R, Muyan M. Single-chain estrogen receptors (ERs) reveal that the ERalpha/beta heterodimer emulates functions of the ERalpha dimer in genomic estrogen signaling pathways. Mol Cell Biol. 2004 Sep; 24(17):7681-94.
    View in: PubMed
  8. Gibson SL, Hilf R, Donnelly DJ, Detty MR. Analogues of tetramethylrosamine as transport molecules for and inhibitors of P-glycoprotein-mediated multidrug resistance. Bioorg Med Chem. 2004 Sep 1; 12(17):4625-31.
    View in: PubMed
  9. Detty MR, Gibson SL, Hilf R. Comparison of the dark and light-induced toxicity of thio and seleno analogues of the thiopyrylium dye AA1. Bioorg Med Chem. 2004 May 15; 12(10):2589-96.
    View in: PubMed
  10. Detty MR, Prasad PN, Donnelly DJ, Ohulchanskyy T, Gibson SL, Hilf R. Synthesis, properties, and photodynamic properties in vitro of heavy-chalcogen analogues of tetramethylrosamine. Bioorg Med Chem. 2004 May 15; 12(10):2537-44.
    View in: PubMed
  11. Huang J, Li X, Yi P, Hilf R, Bambara RA, Muyan M. Targeting estrogen responsive elements (EREs): design of potent transactivators for ERE-containing genes. Mol Cell Endocrinol. 2004 Apr 15; 218(1-2):65-78.
    View in: PubMed
  12. You Y, Gibson SL, Hilf R, Davies SR, Oseroff AR, Roy I, Ohulchanskyy TY, Bergey EJ, Detty MR. Water soluble, core-modified porphyrins. 3. Synthesis, photophysical properties, and in vitro studies of photosensitization, uptake, and localization with carboxylic acid-substituted derivatives. J Med Chem. 2003 Aug 14; 46(17):3734-47.
    View in: PubMed
  13. Brennan NK, Hall JP, Davies SR, Gollnick SO, Oseroff AR, Gibson SL, Hilf R, Detty MR. In vitro photodynamic properties of chalcogenopyrylium analogues of the thiopyrylium antitumor agent AA1. J Med Chem. 2002 Nov 7; 45(23):5123-35.
    View in: PubMed
  14. Yi P, Bhagat S, Hilf R, Bambara RA, Muyan M. Differences in the abilities of estrogen receptors to integrate activation functions are critical for subtype-specific transcriptional responses. Mol Endocrinol. 2002 Aug; 16(8):1810-27.
    View in: PubMed
  15. Sathya G, Yi P, Bhagat S, Bambara RA, Hilf R, Muyan M. Structural regions of ERalpha critical for synergistic transcriptional responses contain co-factor interacting surfaces. Mol Cell Endocrinol. 2002 Jun 28; 192(1-2):171-85.
    View in: PubMed
  16. Yi P, Driscoll MD, Huang J, Bhagat S, Hilf R, Bambara RA, Muyan M. The effects of estrogen-responsive element- and ligand-induced structural changes on the recruitment of cofactors and transcriptional responses by ER alpha and ER beta. Mol Endocrinol. 2002 Apr; 16(4):674-93.
    View in: PubMed
  17. Hilmey DG, Abe M, Nelen MI, Stilts CE, Baker GA, Baker SN, Bright FV, Davies SR, Gollnick SO, Oseroff AR, Gibson SL, Hilf R, Detty MR. Water-soluble, core-modified porphyrins as novel, longer-wavelength-absorbing sensitizers for photodynamic therapy. II. Effects of core heteroatoms and meso-substituents on biological activity. J Med Chem. 2002 Jan 17; 45(2):449-61.
    View in: PubMed
  18. Muyan M, Yi P, Sathya G, Willmert LJ, Driscoll MD, Hilf R, Bambara RA. Fusion estrogen receptor proteins: toward the development of receptor-based agonists and antagonists. Mol Cell Endocrinol. 2001 Sep; 182(2):249-63.
    View in: PubMed
  19. Gibson SL, Havens JJ, Metz L, Hilf R. Is delta-aminolevulinic acid dehydratase rate limiting in heme biosynthesis following exposure of cells to delta-aminolevulinic acid? Photochem Photobiol. 2001 Mar; 73(3):312-7.
    View in: PubMed
  20. Leonard KA, Hall JP, Nelen MI, Davies SR, Gollnick SO, Camacho S, Oseroff AR, Gibson SL, Hilf R, Detty MR. A selenopyrylium photosensitizer for photodynamic therapy related in structure to the antitumor agent AA1 with potent in vivo activity and no long-term skin photosensitization. J Med Chem. 2000 Nov 16; 43(23):4488-98.
    View in: PubMed
  21. Stilts CE, Nelen MI, Hilmey DG, Davies SR, Gollnick SO, Oseroff AR, Gibson SL, Hilf R, Detty MR. Water-soluble, core-modified porphyrins as novel, longer-wavelength-absorbing sensitizers for photodynamic therapy. J Med Chem. 2000 Jun 15; 43(12):2403-10.
    View in: PubMed
  22. Gibson SL, Anderson LT, Havens JJ, Hilf R. Effect of estrogenic perturbations on delta-aminolevulinic acid-induced porphobilinogen deaminase and protoporphyrin IX levels in rat Harderian glands, liver, and R3230AC tumors. Biochem Pharmacol. 1999 Dec 1; 58(11):1821-9.
    View in: PubMed
  23. Gibson SL, Nguyen ML, Havens JJ, Barbarin A, Hilf R. Relationship of delta-aminolevulinic acid-induced protoporphyrin IX levels to mitochondrial content in neoplastic cells in vitro. Biochem Biophys Res Commun. 1999 Nov 19; 265(2):315-21.
    View in: PubMed
  24. Leonard KA, Nelen MI, Anderson LT, Gibson SL, Hilf R, Detty MR. 2,4,6-triarylchalcogenopyrylium dyes related in structure to the antitumor agent AA1 as in vitro sensitizers for the photodynamic therapy of cancer. J Med Chem. 1999 Sep 23; 42(19):3942-52.
    View in: PubMed
  25. Leonard KA, Nelen MI, Simard TP, Davies SR, Gollnick SO, Oseroff AR, Gibson SL, Hilf R, Chen LB, Detty MR. Synthesis and evaluation of chalcogenopyrylium dyes as potential sensitizers for the photodynamic therapy of cancer. J Med Chem. 1999 Sep 23; 42(19):3953-64.
    View in: PubMed
  26. Hilf R, Havens JJ, Gibson SL. Effect of delta-aminolevulinic acid on protoporphyrin IX accumulation in tumor cells transfected with plasmids containing porphobilinogen deaminase DNA. Photochem Photobiol. 1999 Sep; 70(3):334-40.
    View in: PubMed
  27. Driscoll MD, Sathya G, Saidi LF, DeMott MS, Hilf R, Bambara RA. An explanation for observed estrogen receptor binding to single-stranded estrogen-responsive element DNA. Mol Endocrinol. 1999 Jun; 13(6):958-68.
    View in: PubMed
  28. Gibson SL, Havens JJ, Nguyen ML, Hilf R. Delta-aminolaevulinic acid-induced photodynamic therapy inhibits protoporphyrin IX biosynthesis and reduces subsequent treatment efficacy in vitro. Br J Cancer. 1999 Jun; 80(7):998-1004.
    View in: PubMed
  29. Driscoll MD, Sathya G, Muyan M, Klinge CM, Hilf R, Bambara RA. Sequence requirements for estrogen receptor binding to estrogen response elements. J Biol Chem. 1998 Nov 6; 273(45):29321-30.
    View in: PubMed
  30. Klinge CM, Studinski-Jones AL, Kulakosky PC, Bambara RA, Hilf R. Comparison of tamoxifen ligands on estrogen receptor interaction with estrogen response elements. Mol Cell Endocrinol. 1998 Aug 25; 143(1-2):79-90.
    View in: PubMed
  31. Gibson SL, Cupriks DJ, Havens JJ, Nguyen ML, Hilf R. A regulatory role for porphobilinogen deaminase (PBGD) in delta-aminolaevulinic acid (delta-ALA)-induced photosensitization? Br J Cancer. 1998; 77(2):235-42.
    View in: PubMed
  32. Klinge CM, Silver BF, Driscoll MD, Sathya G, Bambara RA, Hilf R. Chicken ovalbumin upstream promoter-transcription factor interacts with estrogen receptor, binds to estrogen response elements and half-sites, and inhibits estrogen-induced gene expression. J Biol Chem. 1997 Dec 12; 272(50):31465-74.
    View in: PubMed
  33. Sathya G, Li W, Klinge CM, Anolik JH, Hilf R, Bambara RA. Effects of multiple estrogen responsive elements, their spacing, and location on estrogen response of reporter genes. Mol Endocrinol. 1997 Dec; 11(13):1994-2003.
    View in: PubMed
  34. Klinge CM, Brolly CL, Bambara RA, Hilf R. hsp70 is not required for high affinity binding of purified calf uterine estrogen receptor to estrogen response element DNA in vitro. J Steroid Biochem Mol Biol. 1997 Nov-Dec; 63(4-6):283-301.
    View in: PubMed
  35. Gibson SL, Havens JJ, Foster TH, Hilf R. Time-dependent intracellular accumulation of delta-aminolevulinic acid, induction of porphyrin synthesis and subsequent phototoxicity. Photochem Photobiol. 1997 Mar; 65(3):416-21.
    View in: PubMed
  36. Anolik JH, Klinge CM, Brolly CL, Bambara RA, Hilf R. Stability of the ligand-estrogen receptor interaction depends on estrogen response element flanking sequences and cellular factors. J Steroid Biochem Mol Biol. 1996 Dec; 59(5-6):413-29.
    View in: PubMed
  37. Klinge CM, Traish AM, Driscoll MD, Hilf R, Bambara RA. Site-directed estrogen receptor antibodies stabilize 4-hydroxytamoxifen ligand, but not estradiol, and indicate ligand-specific differences in the recognition of estrogen response element DNA in vitro. Steroids. 1996 May; 61(5):278-89.
    View in: PubMed
  38. Driscoll MD, Klinge CM, Hilf R, Bambara RA. Footprint analysis of estrogen receptor binding to adjacent estrogen response elements. J Steroid Biochem Mol Biol. 1996 Apr; 58(1):45-61.
    View in: PubMed
  39. Korc-Grodzicki B, Ren N, Hilf R. Effects of estradiol on the expression and production of IGFBP-2 by R3230AC mammary tumor cells. Oncol Res. 1996; 8(12):473-83.
    View in: PubMed
  40. Klinge CM, Traish AM, Bambara RA, Hilf R. Dissociation of 4-hydroxytamoxifen, but not estradiol or tamoxifen aziridine, from the estrogen receptor as the receptor binds estrogen response element DNA. J Steroid Biochem Mol Biol. 1996 Jan; 57(1-2):51-66.
    View in: PubMed
  41. Hua Z, Gibson SL, Foster TH, Hilf R. Effectiveness of delta-aminolevulinic acid-induced protoporphyrin as a photosensitizer for photodynamic therapy in vivo. Cancer Res. 1995 Apr 15; 55(8):1723-31.
    View in: PubMed
  42. Gibson SL, al-Shawi MK, Senior AE, Hile R. Inhibition of the ATPase activity of P-glycoprotein by porphyrin photosensitization of multidrug-resistant cells in vitro. Photochem Photobiol. 1995 Apr; 61(4):390-6.
    View in: PubMed
  43. Anolik JH, Klinge CM, Hilf R, Bambara RA. Cooperative binding of estrogen receptor to DNA depends on spacing of binding sites, flanking sequence, and ligand. Biochemistry. 1995 Feb 28; 34(8):2511-20.
    View in: PubMed
  44. Gibson SL, Nguyen ML, Foster TH, White G, Hilf R. Efficacy of photodynamic therapy on original and recurrent rat mammary tumors. Photochem Photobiol. 1995 Feb; 61(2):196-9.
    View in: PubMed
  45. Lawrence DS, Gibson SL, Nguyen ML, Whittemore KR, Whitten DG, Hilf R. Photosensitization and tissue distribution studies of the picket fence porphyrin, 3,1-TPro, a candidate for photodynamic therapy. Photochem Photobiol. 1995 Jan; 61(1):90-8.
    View in: PubMed
  46. Kennedy SD, Szczepaniak LS, Gibson SL, Hilf R, Foster TH, Bryant RG. Quantitative MRI of Gd-DTPA uptake in tumors: response to photodynamic therapy. Magn Reson Med. 1994 Mar; 31(3):292-301.
    View in: PubMed
  47. Gibson SL, Foster TH, Feins RH, Raubertas RF, Fallon MA, Hilf R. Effects of photodynamic therapy on xenografts of human mesothelioma and rat mammary carcinoma in nude mice. Br J Cancer. 1994 Mar; 69(3):473-81.
    View in: PubMed
  48. Anolik JH, Klinge CM, Bambara RA, Hilf R. Differential impact of flanking sequences on estradiol- vs 4-hydroxytamoxifen-liganded estrogen receptor binding to estrogen responsive element DNA. J Steroid Biochem Mol Biol. 1993 Dec; 46(6):713-30.
    View in: PubMed
  49. Korc-Grodzicki B, Ren N, Hilf R. Insulin-like growth factor-binding proteins in R3230AC mammary tumors of intact and diabetic rats. Endocrinology. 1993 Nov; 133(5):2362-70.
    View in: PubMed
  50. Foster TH, Hartley DF, Nichols MG, Hilf R. Fluence rate effects in photodynamic therapy of multicell tumor spheroids. Cancer Res. 1993 Mar 15; 53(6):1249-54.
    View in: PubMed
  51. Narayanan U, Hilf R. Effects of diabetes and insulin on phosphoinositide metabolism in R3230AC mammary tumors. Cancer Biochem Biophys. 1992 Nov; 13(2):93-101.
    View in: PubMed
  52. Klinge CM, Bambara RA, Hilf R. Antiestrogen-liganded estrogen receptor interaction with estrogen responsive element DNA in vitro. J Steroid Biochem Mol Biol. 1992 Oct; 43(4):249-62.
    View in: PubMed
  53. Klinge CM, Peale FV, Hilf R, Bambara RA, Zain S. Cooperative estrogen receptor interaction with consensus or variant estrogen responsive elements in vitro. Cancer Res. 1992 Mar 1; 52(5):1073-81.
    View in: PubMed
  54. Klinge CM, Bambara RA, Hilf R. What differentiates antiestrogen-liganded vs estradiol-liganded estrogen receptor action? Oncol Res. 1992; 4(4-5):137-44.
    View in: PubMed
  55. Ryan PD, Hilf R. EGF receptors in R3230AC rat mammary carcinomas: characteristics and regulation in vitro and in vivo. Oncol Res. 1992; 4(4-5):181-92.
    View in: PubMed
  56. Detty MR, Merkel PB, Gibson SL, Hilf R. Chalcogenapyrylium dyes as dual-action sensitizers for photodynamic therapy. Oncol Res. 1992; 4(8-9):367-73.
    View in: PubMed
  57. Dao TL, Hilf R. Dietary fat and breast cancer: a search for mechanisms. Adv Exp Med Biol. 1992; 322:223-37.
    View in: PubMed
  58. Korc-Grodzicki B, Furlanetto RW, Hilf R. Characterization of insulin-like growth factor receptors in the insulin-responsive R3230AC mammary adenocarcinoma. Oncol Res. 1992; 4(3):109-19.
    View in: PubMed
  59. Foster TH, Primavera MC, Marder VJ, Hilf R, Sporn LA. Photosensitized release of von Willebrand factor from cultured human endothelial cells. Cancer Res. 1991 Jun 15; 51(12):3261-6.
    View in: PubMed
  60. Ceckler TL, Gibson SL, Kennedy SD, Hill R, Bryant RG. Hetergeneous tumour response to photodynamic therapy assessed by in vivo localised 31P NMR spectroscopy. Br J Cancer. 1991 Jun; 63(6):916-22.
    View in: PubMed
  61. Foster TH, Murant RS, Bryant RG, Knox RS, Gibson SL, Hilf R. Oxygen consumption and diffusion effects in photodynamic therapy. Radiat Res. 1991 Jun; 126(3):296-303.
    View in: PubMed
  62. Ishibe Y, Klinge CM, Hilf R, Bambara RA. Estrogen receptor alters the topology of plasmid DNA containing estrogen responsive elements. Biochem Biophys Res Commun. 1991 Apr 15; 176(1):486-91.
    View in: PubMed
  63. Barber DC, VanDerMeid KR, Gibson SL, Hilf R, Whitten DG. Photosensitizing activities of picket fence porphyrins in vitro and in vivo. Cancer Res. 1991 Apr 1; 51(7):1836-45.
    View in: PubMed
  64. Chazen MD, Baggs RB, Gibson SL, Albert MS, Hilf R. Gross and microscopic changes in the viscera induced by photodynamic therapy applied to the lower abdomen of intact rats. Lasers Surg Med. 1991; 11(1):43-50.
    View in: PubMed
  65. Gibson SL, VanDerMeid KR, Murant RS, Raubertas RF, Hilf R. Effects of various photoradiation regimens on the antitumor efficacy of photodynamic therapy for R3230AC mammary carcinomas. Cancer Res. 1990 Nov 15; 50(22):7236-41.
    View in: PubMed
  66. Feins RH, Hilf R, Ross H, Gibson SL. Photodynamic therapy for human malignant mesothelioma in the nude mouse. J Surg Res. 1990 Oct; 49(4):311-4.
    View in: PubMed
  67. Ludwig LB, Klinge CM, Peale FV, Bambara RA, Zain S, Hilf R. A microtiter well assay for quantitative measurement of estrogen receptor binding to estrogen-responsive elements. Mol Endocrinol. 1990 Jul; 4(7):1027-33.
    View in: PubMed
  68. Klinge CM, Bambara RA, Zain S, Hilf R. Nuclease sensitivity of estradiol-charged estrogen receptor binding sites in nuclei isolated from normal and neoplastic rat mammary tissues. J Steroid Biochem. 1990 Jun; 36(1-2):7-14.
    View in: PubMed
  69. Gibson SL, van der Meid KR, Murant RS, Hilf R. Increased efficacy of photodynamic therapy of R3230AC mammary adenocarcinoma by intratumoral injection of Photofrin II. Br J Cancer. 1990 Apr; 61(4):553-7.
    View in: PubMed
  70. Detty MR, Merkel PB, Hilf R, Gibson SL, Powers SK. Chalcogenapyrylium dyes as photochemotherapeutic agents. 2. Tumor uptake, mitochondrial targeting, and singlet-oxygen-induced inhibition of cytochrome c oxidase. J Med Chem. 1990 Apr; 33(4):1108-16.
    View in: PubMed
  71. Ceckler TL, Gibson SL, Hilf R, Bryant RG. In situ assessment of tumor vascularity using fluorine NMR imaging. Magn Reson Med. 1990 Mar; 13(3):416-33.
    View in: PubMed
  72. Peale FV, Ishibe Y, Klinge CM, Zain S, Hilf R, Bambara RA. Rapid purification of the estrogen receptor by sequence-specific DNA affinity chromatography. Biochemistry. 1989 Oct 31; 28(22):8671-5.
    View in: PubMed
  73. Gibson SL, Ceckler TL, Bryant TG, Hilf R. Effects of laser photodynamic therapy on tumor phosphate levels and pH assessed by 31P-NMR spectroscopy. Cancer Biochem Biophys. 1989 Oct; 10(4):319-28.
    View in: PubMed
  74. Klinge CM, Knox DT, Bambara RA, Zain S, Hilf R. Antiestrogen(4-hydroxytamoxifen)-charged estrogen receptor binding to nuclei from normal and neoplastic rat mammary tissues is not affected by host hormonal status. J Steroid Biochem. 1989 Sep; 33(3):335-40.
    View in: PubMed
  75. Hanzlik CA, Knox RS, Gibson SL, Hilf R. Picosecond fluorescence of R3230AC mammary carcinoma mitochondria after treatment with hematoporphyrin derivative and Photofrin II in vivo. Photochem Photobiol. 1989 Jul; 50(1):45-53.
    View in: PubMed
  76. Klinge CM, Bambara RA, Zain S, Hilf R. Effects of host hormonal status on binding of activated estrogen receptor to nuclei from R3230AC and 7,12-dimethylbenz[a]anthracene-induced mammary tumors. Cancer Res. 1989 Mar 1; 49(5):1165-70.
    View in: PubMed
  77. Gibson SL, Murant RS, Chazen MD, Kelly ME, Hilf R. In vitro photosensitization of tumour cell enzymes by photofrin II administered in vivo. Br J Cancer. 1989 Jan; 59(1):47-53.
    View in: PubMed
  78. Narayanan U, Keuker C, Hilf R. Membrane-associated phosphatidylinositol kinase of R3230AC mammary tumors and normal mammary glands and effects of insulin on tumor enzyme activity. Cancer Res. 1988 Dec 1; 48(23):6727-32.
    View in: PubMed
  79. Collins-Gold LC, Barber DC, Hagan WJ, Gibson SL, Hilf R, Whitten DG. Synthetic porphyrins at interfaces; photosensitization and related reactions of atropisomers of o-substituted tetraphenylporphine derivatives in films, reversed micelles and membranes. Photochem Photobiol. 1988 Aug; 48(2):165-75.
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  80. Hilf R, Livingston JN, Crofton DH. Effects of diabetes and sex steroid hormones on insulin receptor tyrosine kinase activity in R3230AC mammary adenocarcinomas. Cancer Res. 1988 Jul 1; 48(13):3742-50.
    View in: PubMed
  81. Gibson SL, Murant RS, Hilf R. Photosensitizing effects of hematoporphyrin derivative and photofrin II on the plasma membrane enzymes 5'-nucleotidase, Na+K+-ATPase, and Mg2+-ATPase in R3230AC mammary adenocarcinomas. Cancer Res. 1988 Jun 15; 48(12):3360-6.
    View in: PubMed
  82. Hagan WJ, Barber DC, Whitten DG, Kelly M, Albrecht F, Gibson SL, Hilf R. Picket-fence porphyrins as potential phototherapeutic agents. Cancer Res. 1988 Mar 1; 48(5):1148-52.
    View in: PubMed
  83. Peale FV, Ludwig LB, Zain S, Hilf R, Bambara RA. Properties of a high-affinity DNA binding site for estrogen receptor. Proc Natl Acad Sci U S A. 1988 Feb; 85(4):1038-42.
    View in: PubMed
  84. Hilf R, Gibson SL, Penney DP, Ceckler TL, Bryant RG. Early biochemical responses to photodynamic therapy monitored by NMR spectroscopy. Photochem Photobiol. 1987 Nov; 46(5):809-17.
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  85. Lerea CC, Klinge CM, Bambara RA, Zain S, Hilf R. Characterization of a cytosolic inhibitor of calf estrogen receptor binding to nuclei. Endocrinology. 1987 Sep; 121(3):1146-54.
    View in: PubMed
  86. Murant RS, Gibson SL, Hilf R. Photosensitizing effects of Photofrin II on the site-selected mitochondrial enzymes adenylate kinase and monoamine oxidase. Cancer Res. 1987 Aug 15; 47(16):4323-8.
    View in: PubMed
  87. Klinge CM, Bambara RA, Zain S, Hilf R. Estrogen receptor binding to nuclei from normal and neoplastic rat mammary tissues in vitro. Cancer Res. 1987 Jun 1; 47(11):2852-9.
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  88. Roghmann MC, Skinner KA, Hilf R. Effects of estradiol and tamoxifen on creatine kinase in rodent mammary carcinomas. Cancer Res. 1987 Mar 1; 47(5):1348-53.
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  89. Gibson SL, Murant RS, Hilf R. Photosensitizing effects of hematoporphyrin derivative immobilized on sepharose. Photochem Photobiol. 1987 Jan; 45(1):93-104.
    View in: PubMed
  90. Ceckler TL, Bryant RG, Penney DP, Gibson SL, Hilf R. 31P-NMR spectroscopy demonstrates decreased ATP levels in vivo as an early response to photodynamic therapy. Biochem Biophys Res Commun. 1986 Oct 15; 140(1):273-9.
    View in: PubMed
  91. Hilf R, Murant RS, Narayanan U, Gibson SL. Relationship of mitochondrial function and cellular adenosine triphosphate levels to hematoporphyrin derivative-induced photosensitization in R3230AC mammary tumors. Cancer Res. 1986 Jan; 46(1):211-7.
    View in: PubMed
  92. Crute JJ, Wahl AF, Bambara RA, Murant RS, Gibson SL, Hilf R. Inhibition of mammalian DNA polymerases by hematoporphyrin derivative and photoradiation. Cancer Res. 1986 Jan; 46(1):153-9.
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  93. Feldman JM, Hilf R. Failure of indomethacin to inhibit growth of the R3230AC mammary tumor in rats. J Natl Cancer Inst. 1985 Oct; 75(4):751-6.
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  94. Gibson SL, Hilf R. Interdependence of fluence, drug dose and oxygen on hematoporphyrin derivative induced photosensitization of tumor mitochondria. Photochem Photobiol. 1985 Oct; 42(4):367-73.
    View in: PubMed
  95. Narayanan U, Ribes JA, Hilf R. Effects of streptozotocin-induced diabetes and insulin on phospholipid content of R3230AC mammary tumor cells. Cancer Res. 1985 Oct; 45(10):4833-7.
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  96. Cushing CL, Bambara RA, Hilf R. Interactions of estrogen-receptor and antiestrogen-receptor complexes with nuclei in vitro. Endocrinology. 1985 Jun; 116(6):2419-29.
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  97. Feldman JM, Hilf R. Effect of estradiol-17 beta on glucose and proline uptake in plasma membrane vesicles from the R3230AC rat mammary carcinoma. Biochim Biophys Acta. 1985 May 30; 845(2):265-71.
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  98. Feldman JM, Hilf R. A role of estrogens and insulin binding in the dietary lipid alteration of R3230AC mammary carcinoma growth in rats. Cancer Res. 1985 May; 45(5):1964-72.
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  99. Feldman JM, Hilf R. Effects of diabetes on the dietary lipid alteration of R3230AC mammary carcinoma growth in rats. Proc Soc Exp Biol Med. 1985 May; 179(1):105-12.
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  100. Peale FV, Bond J, Hilf R, Bambara R. An analysis of the decrease in the assayed level of charged bovine estrogen receptor observed at physiological ionic strength. J Steroid Biochem. 1985 Feb; 22(2):161-7.
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  101. Perlin DS, Murant RS, Gibson SL, Hilf R. Effects of photosensitization by hematoporphyrin derivative on mitochondrial adenosine triphosphatase-mediated proton transport and membrane integrity of R3230AC mammary adenocarcinoma. Cancer Res. 1985 Feb; 45(2):653-8.
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  102. Hilf R, Crofton DH. Effects of estradiol on insulin receptor distribution in primary cultures of R3230AC mammary adenocarcinoma of the rat. Endocrinology. 1985 Jan; 116(1):154-63.
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  103. Gibson SL, Cohen HJ, Hilf R. Evidence against the production of superoxide by photoirradiation of hematoporphyrin derivative. Photochem Photobiol. 1984 Oct; 40(4):441-8.
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  104. Lawton KG, Wierowski JV, Schechter S, Hilf R, Bambara RA. Analysis of the mechanism of ATP stimulation of calf thymus DNA alpha-polymerase. Biochemistry. 1984 Sep 11; 23(19):4294-300.
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  105. Hilf R, Warne NW, Smail DB, Gibson SL. Photodynamic inactivation of selected intracellular enzymes by hematoporphyrin derivative and their relationship to tumor cell viability in vitro. Cancer Lett. 1984 Sep; 24(2):165-72.
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  106. Pratt K, Wierowski JV, Hilf R, Bambara RA. Bovine estrogen receptor binds chromatin at pre-existing nuclease hypersensitive sites. Mol Cell Endocrinol. 1984 May; 35(2-3):205-14.
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  107. Hilf R, Smail DB, Murant RS, Leakey PB, Gibson SL. Hematoporphyrin derivative-induced photosensitivity of mitochondrial succinate dehydrogenase and selected cytosolic enzymes of R3230AC mammary adenocarcinomas of rats. Cancer Res. 1984 Apr; 44(4):1483-8.
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  108. Gibson SL, Leakey PB, Crute JJ, Hilf R. Photosensitization of mitochondrial cytochrome c oxidase by hematoporphyrin derivative (HpD) in-vitro and in-vivo. Prog Clin Biol Res. 1984; 170:323-34.
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  109. Hanzlik CA, Knox WH, Nordlund TM, Hilf R, Gibson SL. Picosecond fluorescence of hematoporphyrin derivative, its components and related porphyrins. Prog Clin Biol Res. 1984; 170:201-10.
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  110. Gibson SL, Hilf R. Photosensitization of mitochondrial cytochrome c oxidase by hematoporphyrin derivative and related porphyrins in vitro and in vivo. Cancer Res. 1983 Sep; 43(9):4191-7.
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  111. Hilf R, Leakey PB, Sollott SJ, Gibson SL. Photodynamic inactivation of R3230AC mammary carcinoma in vitro with hematoporphyrin derivative: effects of dose, time, and serum on uptake and phototoxicity. Photochem Photobiol. 1983 Jun; 37(6):633-42.
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  112. Sorge LK, Hilf R. Effect of environmental hydrogen ion concentration on regulation of insulin receptors in cultured R3230AC mammary carcinoma cells. Endocrinology. 1983 Jun; 112(6):1964-72.
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  113. Hilf R, Feldstein ML, Gibson SL, Savlov ED. A logistic model based on enzyme activities for the prediction of response of breast cancer patients to chemotherapy. Cancer. 1982 Nov 1; 50(9):1734-8.
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  114. Sorge LK, Hilf R. Down-regulation of insulin receptors in primary cultures of R3230 AC rat mammary adenocarcinoma cells. Endocrinology. 1982 Apr; 110(4):1155-63.
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  115. Hilf R, Helton DL. Effects of trypsin on binding of insulin and concanavalin A and on glucose and proline transport in the R3230AC mammary adenocarcinoma. Biochim Biophys Acta. 1982 Feb 10; 720(1):42-52.
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  116. Hilf R, Helton DL. Reduction of proline transport in R3230AC mammary carcinomas by estrogens in vitro. Biochem Pharmacol. 1982 Jan 1; 31(1):37-41.
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  117. Sorge LK, Hilf R. The hormonal regulation and interaction of concanavalin A and insulin binding in R3230AC mammary adenocarcinoma cells. Biochim Biophys Acta. 1981 Aug 17; 676(2):187-98.
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  118. Savlov ED, Hilf R, Gibson SL, Feldstein M. Low tissue enzyme activity seen in breast cancers of patients who fail adjuvant chemotherapy. Cancer. 1981 May 1; 47(9):2214-7.
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  119. Abraham S, Hillyard LA, Hansen FN, Lin CY, Hilf R. Effect of estrogen on metabolism and enzyme activities of mammary adenocarcinoma R3230AC in Fischer rats. Cancer Res. 1981 Apr; 41(4):1435-40.
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  120. Shafie SM, Hilf R. Insulin receptor levels and magnitude of insulin-induced responses in 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats. Cancer Res. 1981 Mar; 41(3):826-9.
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  121. Hilf R, Sorge LK, Gay RJ. Insulin binding and glucose transport. Int Rev Cytol. 1981; 72:147-202.
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  122. Hilf R, Feldstein ML, Savlov ED, Gibson SL, Seneca B. The lack of relationship between estrogen receptor status and response to chemotherapy. Cancer. 1980 Dec 15; 46(12 Suppl):2797-800.
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  123. Gay RJ, Hilf R. Influence of proliferative rates and A system substrate availability on proline transport in primary cell cultures of the R3230AC mammary tumor. J Cell Physiol. 1980 Nov; 105(2):287-300.
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  124. Evans IM, Hilf R, Murphy M, Bosmann HB. Correlation of serum, tumor, and liver serum glycoprotein: N-acetylneuraminic acid transferase activity with growth of the R3230AC mammary tumor in rats and relationship of the serum activity to tumor burden. Cancer Res. 1980 Sep; 40(9):3103-11.
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  125. Suojanen JN, Gay RJ, Hilf R. Influence of estrogen on glutathione levels and glutathione-metabolizing enzymes in uteri and R3230AC mammary tumors of rats. Biochim Biophys Acta. 1980 Jul 15; 630(4):485-96.
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  126. Gibson SL, Hilf R. Regulation of estrogen-binding capacity by insulin in 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats. Cancer Res. 1980 Jul; 40(7):2343-8.
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  127. Libertini LJ, Lin CY, Abraham S, Hilf R, Smith S. Medium chain fatty acid synthesis in rodent mammary adenocarcinomas in vitro. Biochim Biophys Acta. 1980 May 28; 618(2):185-91.
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  128. Hilf R, Feldstein ML, Gibson SL, Savlov ED. The relative importance of estrogen receptor analysis as a prognostic factor for recurrence or response to chemotherapy in women with breast cancer. Cancer. 1980 Apr 15; 45(8):1993-2000.
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  129. Gay RJ, Hilf R. Paradoxical effects of 17 beta-estradiol on glucose transport in primary cell cultures of a rat mammary tumor. Biochem Biophys Res Commun. 1980 Feb 27; 92(4):1180-8.
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  130. Gay RJ, Hilf R. Density-dependent and adaptive regulation of glucose transport in primary cell cultures of the R3230AC rat mammary adenocarcinoma. J Cell Physiol. 1980 Feb; 102(2):155-74.
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  131. Hissin PJ, Hilf R. Effects of estrogen to alter amino acid transport in R3230AC mammary carcinomas and its relationship to insulin action. Cancer Res. 1979 Sep; 39(9):3381-7.
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  132. Smith RD, Hilf R, Senior AE. Prolactin binding to dissociated cells from rat mammary tumors and mammary gland. Cancer Biochem Biophys. 1979; 3(3):117-21.
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  133. Shafie SM, Cech JM, Livingston JN, Hilf R. Effect of pH and buffers on insulin binding to normal and neoplastic mammary cells, fat cells and membrane preparations. Cancer Biochem Biophys. 1979; 4(2):51-7.
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  134. Hilf R, Hissin PJ, Shafie SM. Regulatory interrelationships for insulin and estrogen action in mammary tumors. Cancer Res. 1978 Nov; 38(11 Pt 2):4076-85.
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  135. Hissin PJ, Hilf R. Effects of insulin in vivo and in vitro on amino acid transport into cells from the R3230AC mammary adenocarcinoma and their relationship to tumor growth. Cancer Res. 1978 Nov; 38(11 Pt 1):3646-55.
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  136. Hissin PJ, Hilf R. alpha-aminoisobutyrate transport into cells from R3230AC mammary adenocarcinoma. Evidence for sodium ion-dependent and -independent carrier-mediated entry and effects of diabetes. Biochem J. 1978 Oct 15; 176(1):205-15.
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  137. Smith RD, Hilf R, Senior AE. The effect of altered thyroid state on prolactin binding to liver and 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats. Proc Soc Exp Biol Med. 1978 Sep; 158(4):517-20.
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  138. Feldstein ML, Savlov ED, Hilf R. A statistical model for predicting response of breast cancer patients to cytotoxic chemotherapy. Cancer Res. 1978 Aug; 38(8):2544-8.
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  139. Hissin PJ, Hilf R. Characteristics of proline transport into R3230AC mammary tumor cells. Biochim Biophys Acta. 1978 Apr 4; 508(2):401-12.
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  140. Shafie SM, Hilf R. Relationship between insulin and estrogen binding to growth response in 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors. Cancer Res. 1978 Mar; 38(3):759-64.
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  141. Shafie SM, Gibson SL, Hilf R. Effect of insulin and estrogen on hormone binding in the R3230AC mammary adenocarcinoma. Cancer Res. 1977 Dec; 37(12):4641-9.
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  142. Smith RD, Hilf R, Senior AE. Prolactin binding to 7,12-dimethylbenz(a)anthracene-induced mammary tumors and liver in diabetic rats. Cancer Res. 1977 Nov; 37(11):4070-4.
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  143. Hilf R. RNA: DNA ratios in human tumors. J Natl Cancer Inst. 1977 Oct; 59(4):1053-4.
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  144. Smith RD, Hilf R, Senior AE. Prolactin binding to R3230AC mammary carcinoma and liver in hormone-treated and diabetic rats. Cancer Res. 1977 Feb; 37(2):595-8.
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  145. Savlov ED, Wittliff JL, Hilf R. Further studies of biochemical predictive tests in breast cancer. Cancer. 1977 Feb; 39(2):539-41.
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  146. Maggiulli MJ, Gustafson JC, Rector WD, Hilf R. Enzyme activities in human endometrium, myometrium and leiomyomas of the uterus. Enzyme. 1977; 22(1):13-8.
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  147. Harmon JT, Hilf R. Identification and characterization of the insulin receptor in the R3230AC mammary adenocarcinoma of the rat. Cancer Res. 1976 Nov; 36(11 Pt 1):3993-4000.
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  148. Harmon JT, Hilf R. Effect of insulin on glucose transport in DMBA-induced mammary tumors. Eur J Cancer. 1976 Nov; 12(11):933-4.
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  149. Gibson SL, Hilf R. Influence of hormonal alteration of host on estrogen-binding capacity in 7,12-dimethylbenz(a)anthracene-induced mammary tumors. Cancer Res. 1976 Oct; 36(10):3736-41.
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  150. Smith RD, Hilf R, Senior AE. Prolactin binding to mammary gland, 7,12-dimethylbenz(a)-anthracene-induced mammary tumors, and liver in rats. Cancer Res. 1976 Oct; 36(10):3726-31.
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  151. Harmon JT, Hilf R. Effect of insulin to decrease glucose transport in dissociated cells from the R3230AC mammary adenocarcinoma of diabetic rats. Biochim Biophys Acta. 1976 Aug 4; 443(1):114-25.
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  152. Hilf R, Savlov ED, Rector WD, Wittliff JL. Relationship of glycolytic enzyme activities and response of breast cancer patients to chemotherapy: A preliminary report. Cancer. 1976 Aug; 38(2):695-700.
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  153. Hissin PJ, Hilf R. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem. 1976 Jul; 74(1):214-26.
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  154. Hilf R, Rector WD, Orlando RA. Multiple molecular forms of lactate dehydrogenase and glucose 6-phosphate dehydrogenase in normal and abnormal human breast tissues. Cancer. 1976 Apr; 37(4):1825-30.
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  155. Matusik RJ, Hilf R. Relationship of adenosine 3',5'-cyclic monophosphate and guanosine 3',5'-cyclic monophosphate to growth of dimethylbenz(a)anthracene-induced mammary tumors in rats. J Natl Cancer Inst. 1976 Mar; 56(3):659-61.
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  156. Harmon JT, Hilf R. Insulin binding and glucose transport in the R3230AC mammary adenocarcinoma. J Supramol Struct. 1976; 4(2):233-40.
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  157. Ringler MB, Hilf R. Effect of estrogen on synthesis of glucose-6-phosphate dehydrogenase in R3230AC mammary tumors and uteri. Biochim Biophys Acta. 1975 Nov 10; 411(1):50-62.
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  158. Hilf R, Ickowicz R, Bartley JC, Abraham S. Multiple molecular forms of glucose-6-phosphate dehydrogenase in normal, preneoplastic, and neoplastic mammary tissues of mice. Cancer Res. 1975 Aug; 35(8):2109-16.
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  159. Senior AE, McGowan SE, Hilf R. A comparative study of inner membrane enzymes and transport systems in mitochondria from R3230AC mammary tumor and normal rat mammary gland. Cancer Res. 1975 Aug; 35(8):2061-7.
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  160. Cohen ND, Hilf R. Influence of insulin on estrogen-induced responses in the r3230ac mammary carcinoma. Cancer Res. 1975 Mar; 35(3):560-7.
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  161. Cohen ND, Hilf R. Effect of estrogen treatment on DMBA-induced mammary tumor growth and biochemistry in intact and diabetic rats (38535). Proc Soc Exp Biol Med. 1975 Feb; 148(2):339-43.
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  162. Cohen ND, Hilf R. Influence of insulin on growth and metabolism of 7,12-dimethylbenz(alpha)anthracene-induced mammary tumors. Cancer Res. 1974 Dec; 34(12):3245-52.
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  163. Bosmann HB, Hilf R. Elevations in serum glycoprotein-N-acetylneuraminic acid transferases in rats bearing mammary tumors. FEBS Lett. 1974 Aug 30; 44(3):313-6.
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  164. Savlov ED, Wittliff JL, Hilf R, Hall TC. Proceedings: Correlations between certain biochemical properties of breast cancer and response to therapy: a preliminary report. Cancer. 1974 Feb; 33(2):303-9.
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  165. Ringler MI, Hilf R. Kinetics of glucose-6-phosphate dehydrogenase from normal and neoplastic mammary tissue. Enzyme. 1974; 18(5):257-61.
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  166. Sartini J, Meadows D, Rector WD, Hilf R. Response of endometrial and myometrial glucose-6-phosphate dehydrogenase isoenzymes to estrogen. Endocrinology. 1973 Oct; 93(4):990-3.
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  167. Ozols RF, Hilf R. Effect of androgen on glucose-6-phosphate dehydrogenase isoenzymes in rat ventral prostate and seminal vesicles. Proc Soc Exp Biol Med. 1973 Oct 1; 144(1):73-7.
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  168. Hilf R, Wittliff JL, Rector WD, Savlov ED, Hall TC, Orlando RA. Studies on certain cytoplasmic enzymes and specific estrogen receptors in human breast cancer and in nonmalignant diseases of the breast. Cancer Res. 1973 Sep; 33(9):2054-62.
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  169. Hilf R, Rector W, Abraham S. A glucose-6-phosphate dehydrogenase isoenzyme characteristic of preneoplastic and neoplastic mouse mammary tissue. J Natl Cancer Inst. 1973 May; 50(5):1395-8.
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  170. Zalenski D, Hilf R. Effect of dietary carbohydrate on fatty acids in the R3230AC mammary adenocarcinoma. Proc Soc Exp Biol Med. 1973 Apr; 142(4):1137-40.
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  171. Wittliff JL, Hilf R, Brooks WF, Savlov ED, Hall TC, Orlando RA. Specific estrogen-binding capacity of the cytoplasmic receptor in normal and neoplastic breast tissues of humans. Cancer Res. 1972 Sep; 32(9):1983-92.
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  172. Richards AH, Hilf R. Influence of pregnancy, lactation and involution on glucose-6-phosphate dehydrogenase and lactate dehydrogenase in the rat mammary gland. Endocrinology. 1972 Jul; 91(1):287-95.
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  173. Hilf R, McDonald E, Sartini J, Rector WD, Richards AH. Response of uterine glucose-6-phosphate dehydrogenase isoenzymes to estrogen. Endocrinology. 1972 Jul; 91(1):280-6.
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  174. Miller HC, Rector W, Hilf R. Preliminary enzymatic studies of human benign prostate hypertrophy and prostatic cancer. Invest Urol. 1972 Jul; 10(1):1-4.
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  175. Richards AH, Hilf R. Effect of estrogen administration on glucose 6-phosphate dehydrogenase and lactate dehydrogenase isoenzymes in rodent mammary tumors and normal mammary glands. Cancer Res. 1972 Mar; 32(3):611-6.
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  176. Hilf R. Will the best model of breast cancer please come forward? Natl Cancer Inst Monogr. 1971 Dec; 34:43-54.
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  177. Hilf R, Battaglini JW, Delmez JA, Cohen N, Rector WD. Some biochemical changes preceding regression of 7,12-dimethylbenz(a)anthracene-induced mammary tumors following oophorectomy. Cancer Res. 1971 Sep; 31(9):1195-200.
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  178. Hilf R, Bell C, Goldenberg H, Michel I. Effect of fluphenazine HCl on R3230AC mammary carcinoma and mammary glands of the rat. Cancer Res. 1971 Aug; 31(8):1111-7.
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  179. Richards AH, Hilf R. Glucose-6-phosphate dehydrogenase and lactate dehydrogenase isoenzynes in rodent mammary carcinomas and the effect of oophorectomy. Biochim Biophys Acta. 1971 Apr 8; 232(4):753-6.
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  180. Hilf R, Goldenberg H, Michel I, Gruenstein M, Meranze DR, Shimkin MB. Biochemicaevents associated with regression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinomas after ovariectoy. Cancer Res. 1971 Jan; 31(1):52-8.
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  181. Lerner LJ, Harris DN, Yiacas E, Hilf R, Michel I. Cholesterol synthesis inhibitor showing reduction of lipids and hormone antagonism. Am J Clin Nutr. 1970 Sep; 23(9):1241-50.
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  182. Hilf R, Goldenberg H, Michel I, Orlando RA, Archer FL. Enzymes, nucleic acids, and lipids in human breast cancer and normal breast tissue. Cancer Res. 1970 Jun; 30(6):1874-82.
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  183. Hilf R, Goldenberg H, Gruenstein M, Meranze DR, Shimkin MB. Lack of correlation between morphological and biochemical parameters in mammary adenocarcinomas of rats induced with 7, 12-dimethylbenz(a)anthracene. Cancer Res. 1970 May; 30(5):1223-30.
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  184. Wan LS, Hilf R, Shah M, Lerner LJ, Balin H. Enzymatic characteristics of the monkey endometrium during ovulatory and anovulatory cycles and under hormonal contraception treatment. J Reprod Med. 1970 Apr; 4(4):43-52.
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  185. Hilf R, Goldenberg H, Bell C, Michel I, Orlando RA, Archer FL. Some biochemical characteristics of rodent and human mammary carcinomas. Enzymol Biol Clin (Basel). 1970; 11(1):162-76.
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  186. Hilf R, Goldenberg H, Michel I, Carrington MJ, Bell C, Gruenstein M, Meranze DR, Shimkin MB. Biochemical characteristics of mammary glands and mammary tumors of rats induced by 3-methylcholanthrene and 7,12-dimethylbenz(a)anthracene. Cancer Res. 1969 May; 29(5):977-88.
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  187. Hilf R. Biochemical studies of hormone-responsive mammary tumors. Cancer Res. 1968 Sep; 28(9):1888-90.
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  188. Hilf R, Segaloff A, Lerner LJ. Influence of hormonal treatment of Fischer rats on the biochemistry of a transplantable dimethylbenz(a)anthracene-induced mammary carcinoma and its sublines. Cancer Res. 1968 Aug; 28(8):1550-8.
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  189. Turkington RW, Hilf R. Hormonal dependence of DNA synthesis in mammary carcinoma cells in vitro. Science. 1968 Jun 28; 160(3835):1457-9.
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  190. Harris DN, Lerner LJ, Hilf R. The effects of progesterone and ethamoxytriphetol on estradiol-induced changes in the immature rat uterus. Trans N Y Acad Sci. 1968 Apr; 30(6):774-82.
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  191. Hilf R, Lerner LJ, Harris DN. The effect of Actidione and actinomycin D on androgen-induced biochemical changes in the R3230AC mammary carcinoma and uterus of the rat. Trans N Y Acad Sci. 1968 Apr; 30(6):794-803.
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  192. Hilf R, Goldenberg H, Bell C. Effect of actidione (cycloheximide) on estrogen-induced biochemical changes in R3230AC mammary tumors, uteri, and mammary glands. Cancer Res. 1967 Aug; 27(8):1485-93.
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  193. Hilf R, Bell C, Michel I. Influence of the mammotropic tumor MtTF4 on the growth and biochemistry of the R3230AC mammary carcinoma and mammary glands. Cancer Res. 1967 Mar; 27(3):482-9.
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  194. Hilf R. Milk-like fluid in a mammary adenocarcinoma: biochemical characterization. Science. 1967 Feb 17; 155(3764):826-7.
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  195. Hilf R, Michel I, Bell C. Biochemical and morphological responses of normal and neoplastic mammary tissue to hormonal treatment. Recent Prog Horm Res. 1967; 23:229-95.
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  196. Hilf R, Bell C, Michel I, Freeman JJ, Borman A. Effect of hydroxyurea and related compounds on HMC mammary tumor growth and nucleic acids in Fischer rats. Cancer Res. 1966 Nov; 26(11):2286-91.
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  197. Hilf R, Michel I, Bell C, Carrington MJ. Influence of endocrine organ ablation on the growth and biochemical responses of the R3230AC mammary tumor to hormonal treatment. Cancer Res. 1966 Jul; 26(7):1365-70.
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  198. Hilf R, Michel I, Gibbs CC, Bell C. NADP-linked enzymes and lipids in normal and neoplastic mammary tissue: effects of estrogen and dietary glucose. Biochim Biophys Acta. 1966 Jun 1; 116(3):589-92.
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  199. Hilf R, Michel I, Bell C. Dose responses of R3230AC mammary tumor and mammary tissue to estrogen: enzymes, nucleic acids, and lipids. Cancer Res. 1966 May; 26(5):865-70.
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  200. Lerner LJ, Hilf R, Turkheimer AR, Michel I, Engel SL. Effects of hormone antagonists on morphological and biochemical changes induced by hormonal steroids in the immature rat uterus. Endocrinology. 1966 Jan; 78(1):111-24.
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  201. Hilf R, Michel I, Silverstein G, Bell G. Effect of actinomycin D on estrogen-induced changes in enzymes and nucleic acids of R3230AC mammary tumors, uteri, and mammary glands. Cancer Res. 1965 Dec; 25(11):1854-9.
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  202. Lerner LJ, Hilf R, Turkheimer AR, Michel I. Effect of small doses of actinomycin D on oestrogen-induced uterine changes in the immature rat. J Endocrinol. 1965 Nov; 33(3):531-2.
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  203. Hilf R. The mechanism of action of ACTH. N Engl J Med. 1965 Oct 7; 273(15):798-811.
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  204. HILF R, MICHEL I, BELL C, FREEMAN JJ, BORMAN A. BIOCHEMICAL AND MORPHOLOGIC PROPERTIES OF A NEW LACTATING MAMMARY TUMOR LINE IN THE RAT. Cancer Res. 1965 Apr; 25:286-99.
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  205. HILF R, FREEMAN JJ, MICHEL I, BORMAN A. CHARACTERIZATION OF A TRANSPLANTABLE LACTATING MAMMARY TUMOR: ENDOCRINOLOGICAL, MORPHOLOGICAL, AND BIOCHEMICAL ASPECTS. Cancer Res. 1964 Jun; 24:812-23.
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  206. FREEMAN JJ, HILF R, IOVINO AJ, MICHEL I. EFFECTS OF STEROIDS UPON THE WEIGHT, PROTEIN AND NUCLEIC ACID CONCENTRATION OF THE PREPUTIAL GLANDS OF THE FEMALE RAT. Endocrinology. 1964 Jun; 74:990-3.
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  207. HILF R, BURNETT FF. TRIPHOSPHOPYRIDINE NUCLEOTIDE-LINKED ENZYMES IN THE REGENERATING RAT ADRENAL GLAND: EFFECT OF ADRENOCORTICOTROPHIN. Arch Biochem Biophys. 1964 Jan; 104:106-10.
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  208. HILF R, JOHNSON MM, BREUER C, FREEMAN JJ, BORMAN A. COMPARATIVE BIOCHEMISTRY OF THREE TRANSPLANTABLE MAMMARY TUMORS AS INFLUENCED BY STEROID THERAPY. J Natl Cancer Inst. 1963 Sep; 31:541-55.
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  209. HILF R, FREEMAN JJ, JOHNSON MM, STAGG R, BORMAN A. EFFECT OF STEROIDS ON THREE TRANSPLANTABLE MAMMARY TUMORS IN THE FISCHER RAT. Cancer Chemother Rep. 1963 Jul; 30:1-8.
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  210. HILF R, CASTANO FF. A simplified method for determination of urinary lead. Clin Chem. 1963 Apr; 9:163-7.
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  211. HILF R, LERNER LJ, LANG E, BORMAN A. The effect of progressive sarcoma 180 growth upon the uterotrophic response to estrogen in mice. Cancer Res. 1963 Feb; 23:304-9.
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  212. HILF R, BURNETT FF, BORMAN A. The effect of ACTH upon adrenal glucose-6-phosphate metabolizing enzymes. Biochem Biophys Res Commun. 1962 Jul 3; 8:191-4.
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  213. HILF R, BREUER C, BORMAN A. Adrenal glucose-6-phosphatase: alterations in intracellular distribution induced by treatment with adrenocorticotrophic hormone. Nature. 1962 Jun 2; 194:867-8.
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  214. HILF R, COWETT VW, JOHNSON ML, BORMAN A. The effect of sarcoma 180 and other stressing agents upon adrenal nucleic acids. Cancer Res. 1962 May; 22:449-55.
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  215. CALLOWAY DH, HILF R, MUNSON AH. Effects of chronic food restriction in swine. J Nutr. 1962 Apr; 76:365-74.
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  216. HILF R, BREUER C, BORMAN A. The effect of sarcoma 180 and other stressing agents upon adrenal adenine nucleotide-metabolizing enzymes. Cancer Res. 1961 Nov; 21:1439-44.
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  217. HILF R, BREUER C, BORMAN A. Adrenal adenine nucleotide-metabolizing enzymes: alterations induced by ACTH treatment. Arch Biochem Biophys. 1961 Aug; 94:319-27.
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  218. HILF R, ADACHI R, ECKFELDT G. Effect of dietary supplementation with broccoli on x-irradiation-induced enzyme changes in the guinea pig. Radiat Res. 1961 Jul; 15:86-93.
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  219. HILF R, BURNETT FF, BORMAN A. The effect of sarcoma 180 and other stressing agents upon adrenal and plasma corticosterone in mice. Cancer Res. 1960 Oct; 20:1389-93.
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  220. HILF R, CASTANO FF, LIGHTBOURN GA. Identification of alkaloids and related compounds by paper chromatography and ultraviolet spectrophotometry. J Lab Clin Med. 1959 Oct; 54:634-9.
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  221. WISE BL, HILF R, PILEGGI VJ. Fluid and electrolyte balance following in juries to the head. Am J Surg. 1959 Feb; 97(2):205-10.
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  222. WISE BL, HILF R, PILEGGI VJ. Effect of pneumoencephalography on fluid and electrolyte metabolism. AMA Arch Surg. 1958 Jul; 77(1):113-6.
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  223. HILF R, ROSEN I. Effect of reuse and temperature upon Rana pipiens as a pregnancy test animal. J Lab Clin Med. 1958 Jul; 52(1):153-7.
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  224. HILF R, ROSEN I. The effect of season on Rana pipiens as an animal for pregnancy tests. Am J Clin Pathol. 1957 Dec; 28(6):698-700.
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  225. HILF R, ROSEN I. The effect of season on Rana pipiens as an animal for pregnancy tests. Tech Bull Regist Med Technol. 1957 Nov; 27(11):256-8.
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  226. HILF R, ROSEN I. Effect of re-use of Rana pipiens upon the accuracy of the pregnancy test. J Clin Endocrinol Metab. 1957 Sep; 17(9):1088-93.
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  227. HILF R. Some effects of sulfur amino acids upon tumor-host relationship in the rat. Cancer Res. 1956 Sep; 16(8):753-5.
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  228. ALLISON JB, WANNEMACHER RW, HILF R, HETZEL CA. The effect of methionine supplementation upon the tumor-host relationship in the rat. J Nutr. 1956 May 10; 59(1):27-38.
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  229. ALLISON JB, WANNEMACHER RW, HILF R, CROSSLEY ML. Diet and TEPA therapy in sarcoma-bearing rats. Proc Soc Exp Biol Med. 1955 Dec; 90(3):728-30.
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  230. ALLISON JB, WANNEMACHER RW, HILF R, MIGLIARESE JF, CROSSLEY ML. Dietary protein and tumor-host relationship in the rat. J Nutr. 1954 Dec 10; 54(4):593-600.
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