URMC Research Network

Find People
Keyword
Last Name
 
More Search Options

Mark Frampton

TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentMedicine
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 692
Rochester NY 14642
Other Positions
TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentEnvironmental Medicine

 
 Awards And Honors
1974     Fellow, American College of Physicians
 
 Overview
Each day the average person breathes about 15,000 liters, or approximately 35 pounds, of air. Gaseous and particulate contaminants in that air gain access to the body with each breath, and may have both short and long-term effects on human health. Our ongoing studies examine the effects of particle exposure on lung function, airway inflammation, and cardiovascular function. Utilizing both environmental chamber and mouthpiece exposure systems, subjects are exposed to environmentally relevant concentrations of pollutants, with or without exercise. Respiratory and systemic effects are determined using measures of lung function, examination for markers of inflammation in exhaled air, characterization of blood leukocyte and platelet responses using 3-color flow cytometry, and detailed cardiovascular monitoring.

Ultrafine particles (UFP, <100 nm diameter) may be particularly important with regard to cardiovascular effects because of their potential for evading clearance mechanisms and entering the lung interstitium and vascular space. We have demonstrated in healthy nonsmokers that inhalation of low concentrations of UFP causes changes in leukocyte expression of adhesion molecules, and reductions in the pulmonary diffusing capacity, that are consistent with altered endothelial function. The elderly and people with underlying vascular disease, such as diabetics, may be more susceptible to vascular effects of particle exposure because of impaired endothelial function and increased risk for atherosclerosis. Our studies explore the hypothesis that inhalation of ultrafine particles alters endothelial function in healthy and susceptible people. Endothelial dysfunction is critically linked to the pathogenesis of atherosclerotic vascular disease. Data from these human clinical studies of exposure to air pollutants help to elucidate the mechanisms responsible for pollutant health effects, and assist in establishing rational air quality standards.

 
 Selected Publications
List All   |   Timeline
  1. Gardner B, Ling F, Hopke PK, Frampton MW, Utell MJ, Zareba W, Cameron SJ, Chalupa D, Kane C, Kulandhaisamy S, Topf MC, Rich DQ. Ambient fine particulate air pollution triggers ST-elevation myocardial infarction, but not non-ST elevation myocardial infarction: a case-crossover study. Part Fibre Toxicol. 2014; 11(1):1.
    View in: PubMed
  2. Wexler O, M Morgan MA, Gough MS, Steinmetz SD, Mack CM, Darling DC, Doolin KP, Apostolakos MJ, Graves BT, Frampton MW, Chen X, Pietropaoli AP. Brachial artery reactivity in patients with severe sepsis: an observational study. Crit Care. 2012; 16(2):R38.
    View in: PubMed
  3. Frampton MW, Bausch J, Chalupa D, Hopke PK, Little EL, Oakes D, Stewart JC, Utell MJ. Effects of outdoor air pollutants on platelet activation in people with type 2 diabetes. Inhal Toxicol. 2012 Oct; 24(12):831-8.
    View in: PubMed
  4. Rich DQ, Zareba W, Beckett W, Hopke PK, Oakes D, Frampton MW, Bisognano J, Chalupa D, Bausch J, O'Shea K, Wang Y, Utell MJ. Are ambient ultrafine, accumulation mode, and fine particles associated with adverse cardiac responses in patients undergoing cardiac rehabilitation? Environ Health Perspect. 2012 Aug; 120(8):1162-9.
    View in: PubMed
  5. Frampton MW. Ozone air pollution: how low can you go? Am J Respir Crit Care Med. 2011 Jul 15; 184(2):150-1.
    View in: PubMed
  6. Gough MS, Morgan MA, Mack CM, Darling DC, Frasier LM, Doolin KP, Apostolakos MJ, Stewart JC, Graves BT, Arning E, Bottiglieri T, Mooney RA, Frampton MW, Pietropaoli AP. The ratio of arginine to dimethylarginines is reduced and predicts outcomes in patients with severe sepsis. Crit Care Med. 2011 Jun; 39(6):1351-8.
    View in: PubMed
  7. Stewart JC, Chalupa DC, Devlin RB, Frasier LM, Huang LS, Little EL, Lee SM, Phipps RP, Pietropaoli AP, Taubman MB, Utell MJ, Frampton MW. Vascular effects of ultrafine particles in persons with type 2 diabetes. Environ Health Perspect. 2010 Dec; 118(12):1692-8.
    View in: PubMed
  8. Huang YC, Schmitt M, Yang Z, Que LG, Stewart JC, Frampton MW, Devlin RB. Gene expression profile in circulating mononuclear cells after exposure to ultrafine carbon particles. Inhal Toxicol. 2010 Aug; 22(10):835-46.
    View in: PubMed
  9. Morgan MA, Frasier LM, Stewart JC, Mack CM, Gough MS, Graves BT, Apostolakos MJ, Doolin KP, Darling DC, Frampton MW, Pietropaoli AP. Artery-to-vein differences in nitric oxide metabolites are diminished in sepsis. Crit Care Med. 2010 Apr; 38(4):1069-77.
    View in: PubMed
  10. Hampel R, Breitner S, Rückerl R, Frampton MW, Koenig W, Phipps RP, Wichmann HE, Peters A, Schneider A. Air temperature and inflammatory and coagulation responses in men with coronary or pulmonary disease during the winter season. Occup Environ Med. 2010 Jun; 67(6):408-16.
    View in: PubMed
  11. Hildebrandt K, Rückerl R, Koenig W, Schneider A, Pitz M, Heinrich J, Marder V, Frampton M, Oberdörster G, Wichmann HE, Peters A. Short-term effects of air pollution: a panel study of blood markers in patients with chronic pulmonary disease. Part Fibre Toxicol. 2009; 6:25.
    View in: PubMed
  12. McClellan RO, Frampton MW, Koutrakis P, McDonnell WF, Moolgavkar S, North DW, Smith AE, Smith RL, Utell MJ. Critical considerations in evaluating scientific evidence of health effects of ambient ozone: a conference report. Inhal Toxicol. 2009 Sep; 21 Suppl 2:1-36.
    View in: PubMed
  13. Frampton MW, Greaves IA. NOx--NOx: who's there? Am J Respir Crit Care Med. 2009 Jun 15; 179(12):1077-8.
    View in: PubMed
  14. Zareba W, Couderc JP, Oberdörster G, Chalupa D, Cox C, Huang LS, Peters A, Utell MJ, Frampton MW. ECG parameters and exposure to carbon ultrafine particles in young healthy subjects. Inhal Toxicol. 2009 Feb; 21(3):223-33.
    View in: PubMed
  15. Fanning EW, Froines JR, Utell MJ, Lippmann M, Oberdörster G, Frampton M, Godleski J, Larson TV. Particulate matter (PM) research centers (1999-2005) and the role of interdisciplinary center-based research. Environ Health Perspect. 2009 Feb; 117(2):167-74.
    View in: PubMed
  16. Shah AP, Pietropaoli AP, Frasier LM, Speers DM, Chalupa DC, Delehanty JM, Huang LS, Utell MJ, Frampton MW. Effect of inhaled carbon ultrafine particles on reactive hyperemia in healthy human subjects. Environ Health Perspect. 2008 Mar; 116(3):375-80.
    View in: PubMed
  17. Stewart JC, Villasmil ML, Frampton MW. Changes in fluorescence intensity of selected leukocyte surface markers following fixation. Cytometry A. 2007 Jun; 71(6):379-85.
    View in: PubMed
  18. Pietropaoli AP, Perillo IB, Perkins PT, Frasier LM, Speers DM, Frampton MW, Utell MJ, Hyde RW. Smokers have reduced nitric oxide production by conducting airways but normal levels in the alveoli. Inhal Toxicol. 2007 May; 19(6-7):533-41.
    View in: PubMed
  19. Rückerl R, Phipps RP, Schneider A, Frampton M, Cyrys J, Oberdörster G, Wichmann HE, Peters A. Ultrafine particles and platelet activation in patients with coronary heart disease--results from a prospective panel study. Part Fibre Toxicol. 2007; 4:1.
    View in: PubMed
  20. Frampton MW. Does inhalation of ultrafine particles cause pulmonary vascular effects in humans? Inhal Toxicol. 2007; 19 Suppl 1:75-9.
    View in: PubMed
  21. Elder A, Couderc JP, Gelein R, Eberly S, Cox C, Xia X, Zareba W, Hopke P, Watts W, Kittelson D, Frampton M, Utell M, Oberdörster G. Effects of on-road highway aerosol exposures on autonomic responses in aged, spontaneously hypertensive rats. Inhal Toxicol. 2007 Jan; 19(1):1-12.
    View in: PubMed
  22. Stewart JC, Hyde RW, Boscia J, Chow MY, O'Mara RE, Perillo I, Pietropaoli A, Smith CJ, Torres A, Utell MJ, Frampton MW. Changes in markers of epithelial permeability and inflammation in chronic smokers switching to a nonburning tobacco device (Eclipse). Nicotine Tob Res. 2006 Dec; 8(6):773-83.
    View in: PubMed
  23. Frampton MW. Inflammation and airborne particles. Clin Occup Environ Med. 2006; 5(4):797-815.
    View in: PubMed
  24. Frampton MW, Stewart JC, Oberdörster G, Morrow PE, Chalupa D, Pietropaoli AP, Frasier LM, Speers DM, Cox C, Huang LS, Utell MJ. Inhalation of ultrafine particles alters blood leukocyte expression of adhesion molecules in humans. Environ Health Perspect. 2006 Jan; 114(1):51-8.
    View in: PubMed
  25. Rückerl R, Ibald-Mulli A, Koenig W, Schneider A, Woelke G, Cyrys J, Heinrich J, Marder V, Frampton M, Wichmann HE, Peters A. Air pollution and markers of inflammation and coagulation in patients with coronary heart disease. Am J Respir Crit Care Med. 2006 Feb 15; 173(4):432-41.
    View in: PubMed
  26. Beckett WS, Chalupa DF, Pauly-Brown A, Speers DM, Stewart JC, Frampton MW, Utell MJ, Huang LS, Cox C, Zareba W, Oberdörster G. Comparing inhaled ultrafine versus fine zinc oxide particles in healthy adults: a human inhalation study. Am J Respir Crit Care Med. 2005 May 15; 171(10):1129-35.
    View in: PubMed
  27. Frampton MW, Utell MJ, Zareba W, Oberdörster G, Cox C, Huang LS, Morrow PE, Lee FE, Chalupa D, Frasier LM, Speers DM, Stewart J. Effects of exposure to ultrafine carbon particles in healthy subjects and subjects with asthma. Res Rep Health Eff Inst. 2004 Dec; (126):1-47; discussion 49-63.
    View in: PubMed
  28. Chalupa DC, Morrow PE, Oberdörster G, Utell MJ, Frampton MW. Ultrafine particle deposition in subjects with asthma. Environ Health Perspect. 2004 Jun; 112(8):879-82.
    View in: PubMed
  29. Elder AC, Gelein R, Azadniv M, Frampton M, Finkelstein J, Oberdörster G. Systemic effects of inhaled ultrafine particles in two compromised, aged rat strains. Inhal Toxicol. 2004 Jun; 16(6-7):461-71.
    View in: PubMed
  30. Elder A, Gelein R, Finkelstein J, Phipps R, Frampton M, Utell M, Kittelson DB, Watts WF, Hopke P, Jeong CH, Kim E, Liu W, Zhao W, Zhuo L, Vincent R, Kumarathasan P, Oberdörster G. On-road exposure to highway aerosols. 2. Exposures of aged, compromised rats. Inhal Toxicol. 2004; 16 Suppl 1:41-53.
    View in: PubMed
  31. Pietropaoli AP, Frampton MW, Hyde RW, Morrow PE, Oberdörster G, Cox C, Speers DM, Frasier LM, Chalupa DC, Huang LS, Utell MJ. Pulmonary function, diffusing capacity, and inflammation in healthy and asthmatic subjects exposed to ultrafine particles. Inhal Toxicol. 2004; 16 Suppl 1:59-72.
    View in: PubMed
  32. Hjort MR, Brenyo AJ, Finkelstein JN, Frampton MW, LoMonaco MB, Stewart JC, Johnston CJ, D'Angio CT. Alveolar epithelial cell-macrophage interactions affect oxygen-stimulated interleukin-8 release. Inflammation. 2003 Jun; 27(3):137-45.
    View in: PubMed
  33. Lippmann M, Frampton M, Schwartz J, Dockery D, Schlesinger R, Koutrakis P, Froines J, Nel A, Finkelstein J, Godleski J, Kaufman J, Koenig J, Larson T, Luchtel D, Liu LJ, Oberdorster G, Peters A, Sarnat J, Sioutas C, Suh H, Sullivan J, Utell M, Wichmann E, Zelikoff J. The U.S. Environmental Protection Agency Particulate Matter Health Effects Research Centers Program: a midcourse report of status, progress, and plans. Environ Health Perspect. 2003 Jun; 111(8):1074-92.
    View in: PubMed
  34. Daigle CC, Chalupa DC, Gibb FR, Morrow PE, Oberdörster G, Utell MJ, Frampton MW. Ultrafine particle deposition in humans during rest and exercise. Inhal Toxicol. 2003 May; 15(6):539-52.
    View in: PubMed
  35. Utell MJ, Frampton MW, Zareba W, Devlin RB, Cascio WE. Cardiovascular effects associated with air pollution: potential mechanisms and methods of testing. Inhal Toxicol. 2002 Dec; 14(12):1231-47.
    View in: PubMed
  36. Frampton MW, Boscia J, Roberts NJ, Azadniv M, Torres A, Cox C, Morrow PE, Nichols J, Chalupa D, Frasier LM, Gibb FR, Speers DM, Tsai Y, Utell MJ. Nitrogen dioxide exposure: effects on airway and blood cells. Am J Physiol Lung Cell Mol Physiol. 2002 Jan; 282(1):L155-65.
    View in: PubMed
  37. Perillo IB, Hyde RW, Olszowka AJ, Pietropaoli AP, Frasier LM, Torres A, Perkins PT, Forster RE, Utell MJ, Frampton MW. Chemiluminescent measurements of nitric oxide pulmonary diffusing capacity and alveolar production in humans. J Appl Physiol. 2001 Nov; 91(5):1931-40.
    View in: PubMed
  38. Frampton MW. Systemic and cardiovascular effects of airway injury and inflammation: ultrafine particle exposure in humans. Environ Health Perspect. 2001 Aug; 109 Suppl 4:529-32.
    View in: PubMed
  39. Voter KZ, Whitin JC, Torres A, Morrow PE, Cox C, Tsai Y, Utell MJ, Frampton MW. Ozone exposure and the production of reactive oxygen species by bronchoalveolar cells in humans. Inhal Toxicol. 2001 Jun; 13(6):465-83.
    View in: PubMed
  40. Azadniv M, Torres A, Boscia J, Speers DM, Frasier LM, Utell MJ, Frampton MW. Neutrophils in lung inflammation: Which reactive oxygen species are being measured? Inhal Toxicol. 2001 Jun; 13(6):485-95.
    View in: PubMed
  41. Avissar NE, Reed CK, Cox C, Frampton MW, Finkelstein JN. Ozone, but not nitrogen dioxide, exposure decreases glutathione peroxidases in epithelial lining fluid of human lung. Am J Respir Crit Care Med. 2000 Oct; 162(4 Pt 1):1342-7.
    View in: PubMed
  42. Utell MJ, Frampton MW. Toxicologic methods: controlled human exposures. Environ Health Perspect. 2000 Aug; 108 Suppl 4:605-13.
    View in: PubMed
  43. Crawford EL, Khuder SA, Durham SJ, Frampton M, Utell M, Thilly WG, Weaver DA, Ferencak WJ, Jennings CA, Hammersley JR, Olson DA, Willey JC. Normal bronchial epithelial cell expression of glutathione transferase P1, glutathione transferase M3, and glutathione peroxidase is low in subjects with bronchogenic carcinoma. Cancer Res. 2000 Mar 15; 60(6):1609-18.
    View in: PubMed
  44. Utell MJ, Frampton MW. Acute health effects of ambient air pollution: the ultrafine particle hypothesis. J Aerosol Med. 2000; 13(4):355-59.
    View in: PubMed
  45. Frampton MW, Ghio AJ, Samet JM, Carson JL, Carter JD, Devlin RB. Effects of aqueous extracts of PM(10) filters from the Utah valley on human airway epithelial cells. Am J Physiol. 1999 Nov; 277(5 Pt 1):L960-7.
    View in: PubMed
  46. Frampton MW, Pryor WA, Cueto R, Cox C, Morrow PE, Utell MJ. Aldehydes (nonanal and hexanal) in rat and human bronchoalveolar lavage fluid after ozone exposure. Res Rep Health Eff Inst. 1999 Nov; (90):1-15; discussion 17-8.
    View in: PubMed
  47. Pietropaoli AP, Perillo IB, Torres A, Perkins PT, Frasier LM, Utell MJ, Frampton MW, Hyde RW. Simultaneous measurement of nitric oxide production by conducting and alveolar airways of humans. J Appl Physiol. 1999 Oct; 87(4):1532-42.
    View in: PubMed
  48. Frampton MW, Pryor WA, Cueto R, Cox C, Morrow PE, Utell MJ. Ozone exposure increases aldehydes in epithelial lining fluid in human lung. Am J Respir Crit Care Med. 1999 Apr; 159(4 Pt 1):1134-7.
    View in: PubMed
  49. Looney RJ, Falsey A, Campbell D, Torres A, Kolassa J, Brower C, McCann R, Menegus M, McCormick K, Frampton M, Hall W, Abraham GN. Role of cytomegalovirus in the T cell changes seen in elderly individuals. Clin Immunol. 1999 Feb; 90(2):213-9.
    View in: PubMed
  50. Geigel EJ, Hyde RW, Perillo IB, Torres A, Perkins PT, Pietropaoli AP, Frasier LM, Frampton MW, Utell MJ. Rate of nitric oxide production by lower alveolar airways of human lungs. J Appl Physiol. 1999 Jan; 86(1):211-21.
    View in: PubMed
  51. Crawford EL, Weaver DA, DeMuth JP, Jackson CM, Khuder SA, Frampton MW, Utell MJ, Thilly WG, Willey JC. Measurement of cytochrome P450 2A6 and 2E1 gene expression in primary human bronchial epithelial cells. Carcinogenesis. 1998 Oct; 19(10):1867-71.
    View in: PubMed
  52. Looney RJ, Frampton MW, Byam J, Kenaga C, Speers DM, Cox C, Mast R, Klykken PC, Morrow PE, Utell MJ. Acute respiratory exposure of human volunteers to octamethylcyclotetrasiloxane (D4): absence of immunological effects. Toxicol Sci. 1998 Aug; 44(2):214-20.
    View in: PubMed
  53. Coller HA, Khrapko K, Torres A, Frampton MW, Utell MJ, Thilly WG. Mutational spectra of a 100-base pair mitochondrial DNA target sequence in bronchial epithelial cells: a comparison of smoking and nonsmoking twins. Cancer Res. 1998 Mar 15; 58(6):1268-77.
    View in: PubMed
  54. Torres A, Utell MJ, Morow PE, Voter KZ, Whitin JC, Cox C, Looney RJ, Speers DM, Tsai Y, Frampton MW. Airway inflammation in smokers and nonsmokers with varying responsiveness to ozone. Am J Respir Crit Care Med. 1997 Sep; 156(3 Pt 1):728-36.
    View in: PubMed
  55. Willey JC, Coy EL, Frampton MW, Torres A, Apostolakos MJ, Hoehn G, Schuermann WH, Thilly WG, Olson DE, Hammersley JR, Crespi CL, Utell MJ. Quantitative RT-PCR measurement of cytochromes p450 1A1, 1B1, and 2B7, microsomal epoxide hydrolase, and NADPH oxidoreductase expression in lung cells of smokers and nonsmokers. Am J Respir Cell Mol Biol. 1997 Jul; 17(1):114-24.
    View in: PubMed
  56. Frampton MW, Balmes JR, Cox C, Krein PM, Speers DM, Tsai Y, Utell MJ. Effects of ozone on normal and potentially sensitive human subjects. Part III: Mediators of inflammation in bronchoalveolar lavage fluid from nonsmokers, smokers, and asthmatic subjects exposed to ozone: a collaborative study. Res Rep Health Eff Inst. 1997 Jun; (78):73-9; discussion 81-99.
    View in: PubMed
  57. Willey JC, Frampton MW, Utell MJ, Apostolakos MJ, Coy EL, Olson DE, Hammersley JR, Matteson D, Thilly WG. Patterns of gene expression in human airway epithelial cells. Chest. 1997 Jun; 111(6 Suppl):83S.
    View in: PubMed
  58. Frampton MW, Morrow PE, Torres A, Voter KZ, Whitin JC, Cox C, Speers DM, Tsai Y, Utell MJ. Effects of ozone on normal and potentially sensitive human subjects. Part II: Airway inflammation and responsiveness to ozone in nonsmokers and smokers. Res Rep Health Eff Inst. 1997 Jun; (78):39-72; discussion 81-99.
    View in: PubMed
  59. Hyde RW, Geigel EJ, Olszowka AJ, Krasney JA, Forster RE, Utell MJ, Frampton MW. Determination of production of nitric oxide by lower airways of humans--theory. J Appl Physiol. 1997 Apr; 82(4):1290-6.
    View in: PubMed
  60. Bascom R, Meggs WJ, Frampton M, Hudnell K, Killburn K, Kobal G, Medinsky M, Rea W. Neurogenic inflammation: with additional discussion of central and perceptual integration of nonneurogenic inflammation. Environ Health Perspect. 1997 Mar; 105 Suppl 2:531-7.
    View in: PubMed
  61. Frampton MW, Morrow PE, Torres A, Cox C, Voter KZ, Utell MJ. Ozone responsiveness in smokers and nonsmokers. Am J Respir Crit Care Med. 1997 Jan; 155(1):116-21.
    View in: PubMed
  62. Rahill AA, Weiss B, Morrow PE, Frampton MW, Cox C, Gibb R, Gelein R, Speers D, Utell MJ. Human performance during exposure to toluene. Aviat Space Environ Med. 1996 Jul; 67(7):640-7.
    View in: PubMed
  63. Willey JC, Coy E, Brolly C, Utell MJ, Frampton MW, Hammersley J, Thilly WG, Olson D, Cairns K. Xenobiotic metabolism enzyme gene expression in human bronchial epithelial and alveolar macrophage cells. Am J Respir Cell Mol Biol. 1996 Mar; 14(3):262-71.
    View in: PubMed
  64. Torres A, Voter KZ, Utell MJ, Whitin JC, Morrow PE, Frampton MW. Production of reactive oxygen intermediates following exposure to ozone. Relative contribution of alveolar macrophages. Chest. 1996 Mar; 109(3 Suppl):8S.
    View in: PubMed
  65. Avissar N, Finkelstein JN, Horowitz S, Willey JC, Coy E, Frampton MW, Watkins RH, Khullar P, Xu YL, Cohen HJ. Extracellular glutathione peroxidase in human lung epithelial lining fluid and in lung cells. Am J Physiol. 1996 Feb; 270(2 Pt 1):L173-82.
    View in: PubMed
  66. Culp DJ, Latchney LR, Frampton MW, Jahnke MR, Morrow PE, Utell MJ. Composition of human airway mucins and effects after inhalation of acid aerosol. Am J Physiol. 1995 Sep; 269(3 Pt 1):L358-70.
    View in: PubMed
  67. Frampton MW, Morrow PE, Cox C, Levy PC, Condemi JJ, Speers D, Gibb FR, Utell MJ. Sulfuric acid aerosol followed by ozone exposure in healthy and asthmatic subjects. Environ Res. 1995 Apr; 69(1):1-14.
    View in: PubMed
  68. Utell MJ, Frampton MW, Morrow PE, Cox C, Levy PC, Speers DM, Gibb FR. Oxidant and acid aerosol exposure in healthy subjects and subjects with asthma. Part II: Effects of sequential sulfuric acid and ozone exposures on the pulmonary function of healthy subjects and subjects with asthma. Res Rep Health Eff Inst. 1994 Nov; (70):37-93, discussion 95-112.
    View in: PubMed
  69. Apostolakos MJ, Schuermann WH, Frampton MW, Utell MJ, Willey JC. Measurement of gene expression by multiplex competitive polymerase chain reaction. Anal Biochem. 1993 Sep; 213(2):277-84.
    View in: PubMed
  70. Frampton MW. Asthma, lymphocytes, and dendritic cells. Chest. 1993 Apr; 103(4):986-7.
    View in: PubMed
  71. Frampton MW, Voter KZ, Morrow PE, Roberts NJ, Culp DJ, Cox C, Utell MJ. Sulfuric acid aerosol exposure in humans assessed by bronchoalveolar lavage. Am Rev Respir Dis. 1992 Sep; 146(3):626-32.
    View in: PubMed
  72. Frampton MW. An outbreak of tuberculosis among hospital personnel caring for a patient with a skin ulcer. Ann Intern Med. 1992 Aug 15; 117(4):312-3.
    View in: PubMed
  73. Morrow PE, Utell MJ, Bauer MA, Smeglin AM, Frampton MW, Cox C, Speers DM, Gibb FR. Pulmonary performance of elderly normal subjects and subjects with chronic obstructive pulmonary disease exposed to 0.3 ppm nitrogen dioxide. Am Rev Respir Dis. 1992 Feb; 145(2 Pt 1):291-300.
    View in: PubMed
  74. Frampton MW, Samet JM, Utell MJ. Environmental factors and atmospheric pollutants. Semin Respir Infect. 1991 Dec; 6(4):185-93.
    View in: PubMed
  75. Utell MJ, Frampton MW, Morrow PE. Air pollution and asthma: clinical studies with sulfuric acid aerosols. Allergy Proc. 1991 Nov-Dec; 12(6):385-8.
    View in: PubMed
  76. Utell MJ, Frampton MW, Roberts NJ, Finkelstein JN, Cox C, Morrow PE. Mechanisms of nitrogen dioxide toxicity in humans. Res Rep Health Eff Inst. 1991 Aug; (43):1-33.
    View in: PubMed
  77. Frampton MW, Morrow PE, Cox C, Gibb FR, Speers DM, Utell MJ. Effects of nitrogen dioxide exposure on pulmonary function and airway reactivity in normal humans. Am Rev Respir Dis. 1991 Mar; 143(3):522-7.
    View in: PubMed
  78. Johnson DA, Frampton MW, Winters RS, Morrow PE, Utell MJ. Inhalation of nitrogen dioxide fails to reduce the activity of human lung alpha-1-proteinase inhibitor. Am Rev Respir Dis. 1990 Oct; 142(4):758-62.
    View in: PubMed
  79. Anderson CL, Looney RJ, Culp DJ, Ryan DH, Fleit HB, Utell MJ, Frampton MW, Manganiello PD, Guyre PM. Alveolar and peritoneal macrophages bear three distinct classes of Fc receptors for IgG. J Immunol. 1990 Jul 1; 145(1):196-201.
    View in: PubMed
  80. Frampton MW, Finkelstein JN, Roberts NJ, Smeglin AM, Morrow PE, Utell MJ. Effects of nitrogen dioxide exposure on bronchoalveolar lavage proteins in humans. Am J Respir Cell Mol Biol. 1989 Dec; 1(6):499-505.
    View in: PubMed
  81. Frampton MW, Smeglin AM, Roberts NJ, Finkelstein JN, Morrow PE, Utell MJ. Nitrogen dioxide exposure in vivo and human alveolar macrophage inactivation of influenza virus in vitro. Environ Res. 1989 Apr; 48(2):179-92.
    View in: PubMed
  82. Frampton MW, Mayewski RJ. Physicians' and nurses' attitudes toward withholding treatment in a community hospital. J Gen Intern Med. 1987 Nov-Dec; 2(6):394-9.
    View in: PubMed
  83. Frampton MW. Lower extremity ischemia associated with use of military antishock trousers. Ann Emerg Med. 1984 Dec; 13(12):1155-7.
    View in: PubMed
  84. Frampton MW. Temporal arteritis. Seven variations. N Y State J Med. 1981 Jul; 81(8):1179-82.
    View in: PubMed

Visualizations


Frampton's Networks

Concepts
_
Co-Authors
_
Similar People
_
Same Department