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Glynis Scott

TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentDermatology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 697
Rochester NY 14642
Other Positions
TitleProfessor
InstitutionUniversity of Rochester Medical Center
DepartmentCancer Center

 
 Overview
There are two major projects on going in my laboratory--the first is the investigation into signaling pathways of prostaglandins in human melanocytes and melanoma, and the second is the role of Plexin receptors in melanocyte and melanoma biology.
Melanocytes are pigment producing cells within the epidermis that are progenitor cells for a deadly cancer, melanoma. The production of melanin by melanocytes is a key function of melanocytes and provides photoprotection to the skin. Prostaglandins (PG) are lipid signaling molecules released by keratinocytes and melanocytes in response to ultraviolet irradiation. Our research focus is on defining signaling intermediates that mediate the effect of the two primary PG in the skin, PGE2 & PGF2?? on melanocyte dendrite extension, growth and pigment production. Our laboratory is also investigating the role of sempahorins and their receptors on melanocyte growth, differentiation, and progression to melanoma. Semaphorins are membrane bound and secreted proteins involved in neuronal pathfinding, that we have recently shown to be involved in melanocyte adhesion and dendrite formation. Our particular focus is on Semaphorin 7A and Semaphorin 4D, and their cognate receptors Plexin C1 and Plexin B1, which are lost during progression of melanocytes to melanoma. Integration of signaling intermediates with biologic functions such as proliferation, apoptosis and migration, allow us to dissect the function of PG and semaphorins in melanocyte, and to link signaling by specific receptors to downstream biologic targets important for skin pigmentation and melanoma progression.

 
 Selected Publications
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  1. Scott G. Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and cholera toxin by Eisinger and Marko. Exp Dermatol. 2014 Jan; 23(1):18-9.
    View in: PubMed
  2. Soong J, Scott G. Plexin B1 inhibits MET through direct association and regulates Shp2 expression in melanocytes. J Cell Sci. 2013 Jan 15; 126(Pt 2):688-95.
    View in: PubMed
  3. Kennedy BS, Bedard B, Younge M, Tuttle D, Ammerman E, Ricci J, Doniger AS, Escuyer VE, Mitchell K, Noble-Wang JA, O'Connell HA, Lanier WA, Katz LM, Betts RF, Mercurio MG, Scott GA, Lewis MA, Goldgeier MH. Outbreak of Mycobacterium chelonae infection associated with tattoo ink. N Engl J Med. 2012 Sep 13; 367(11):1020-4.
    View in: PubMed
  4. Somers K, Iorizzo L, Scott G, Mercurio MG. Extramammary Paget disease of the penis as a manifestation of recurrent transitional cell carcinoma. Dermatol Online J. 2012 Aug; 18(8):3.
    View in: PubMed
  5. Scott G. Demonstration of melanosome transfer by a shedding microvesicle mechanism. J Invest Dermatol. 2012 Apr; 132(4):1073-4.
    View in: PubMed
  6. Iorizzo LJ, Scott G, Tausk FA. Gianotti-Crosti syndrome: a case report in an adult. Cutis. 2012 Apr; 89(4):169-72.
    View in: PubMed
  7. Lai KW, Brodell LA, Lambert E, Menegus M, Scott GA, Tu JH. Primary cutaneous Nocardia brasiliensis infection isolated in an immunosuppressed patient: a case report. Cutis. 2012 Feb; 89(2):75-7.
    View in: PubMed
  8. Soong J, Chen Y, Shustef EM, Scott GA. Sema4D, the ligand for Plexin B1, suppresses c-Met activation and migration and promotes melanocyte survival and growth. J Invest Dermatol. 2012 Apr; 132(4):1230-8.
    View in: PubMed
  9. Pryor JG, Brown-Kipphut BA, Iqbal A, Scott GA. Microarray comparative genomic hybridization detection of copy number changes in desmoplastic melanoma and malignant peripheral nerve sheath tumor. Am J Dermatopathol. 2011 Dec; 33(8):780-5.
    View in: PubMed
  10. Laguio M, Scott G, Mercurio MG, Mariuz P. Chief complaint: "people were staring". Am J Med. 2011 Sep; 124(9):821-3.
    View in: PubMed
  11. Yang L, Chen G, Mohanty S, Scott G, Fazal F, Rahman A, Begum S, Hynes RO, Xu L. GPR56 Regulates VEGF production and angiogenesis during melanoma progression. Cancer Res. 2011 Aug 15; 71(16):5558-68.
    View in: PubMed
  12. Denby KS, Brodell LA, Fender AB, Sternberg LJ, Scott GA, Tu JH. Reaction to phosphorescent pigment in a nonprofessional tattoo. J Am Acad Dermatol. 2011 Jun; 64(6):1205-6.
    View in: PubMed
  13. McClelland L, Chen Y, Soong J, Kuo I, Scott G. Plexin B1 inhibits integrin-dependent pp125FAK and Rho activity in melanoma. Pigment Cell Melanoma Res. 2011 Feb; 24(1):165-74.
    View in: PubMed
  14. Stevens L, McClelland L, Fricke A, Williamson M, Kuo I, Scott G. Plexin B1 suppresses c-Met in melanoma: a role for plexin B1 as a tumor-suppressor protein through regulation of c-Met. J Invest Dermatol. 2010 Jun; 130(6):1636-45.
    View in: PubMed
  15. McNaughton BR, Gareiss PC, Jacobs SE, Fricke AF, Scott GA, Miller BL. A potent activator of melanogenesis identified from small-molecule screening. ChemMedChem. 2009 Oct; 4(10):1583-9.
    View in: PubMed
  16. Mentrikoski MJ, Ma L, Pryor JG, McMahon LA, Yang Q, Spaulding BO, Scott GA, Wang HL, Xu H. Diagnostic utility of IMP3 in segregating metastatic melanoma from benign nevi in lymph nodes. Mod Pathol. 2009 Dec; 22(12):1582-7.
    View in: PubMed
  17. Lai KW, Lambert E, Coleman S, Scott G, Mercurio MG. Nodular amyloidosis: differentiation from colloid milium by electron microscopy. Am J Dermatopathol. 2009 Jul; 31(5):472-4.
    View in: PubMed
  18. Gonzales UP, Scott GA, Briones AJ, Pentland AP. Remote hemorrhagic bullae occurring in a patient treated with subcutaneous heparin. Arch Dermatol. 2009 May; 145(5):604-5.
    View in: PubMed
  19. Scott GA, McClelland LA, Fricke AF, Fender A. Plexin C1, a receptor for semaphorin 7a, inactivates cofilin and is a potential tumor suppressor for melanoma progression. J Invest Dermatol. 2009 Apr; 129(4):954-63.
    View in: PubMed
  20. Pryor JG, Simon RA, Bourne PA, Spaulding BO, Scott GA, Xu H. Merkel cell carcinoma expresses K homology domain-containing protein overexpressed in cancer similar to other high-grade neuroendocrine carcinomas. Hum Pathol. 2009 Feb; 40(2):238-43.
    View in: PubMed
  21. Mentrikoski M, Johnson MD, Korones DN, Scott GA. Glioblastoma multiforme in skin: a report of 2 cases and review of the literature. Am J Dermatopathol. 2008 Aug; 30(4):381-4.
    View in: PubMed
  22. Ibrahim SF, Pryor J, Merritt RW, Scott G, Beck LA. Cutaneous myiasis arising in an eccrine adnexal neoplasm. Dermatol Online J. 2008; 14(6):6.
    View in: PubMed
  23. Sharma AK, Scott G, Westesson PL. MRI sign of nodular fasciitis: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 May; 105(5):e53-6.
    View in: PubMed
  24. Fender AB, Reale VF, Scott GA. Anetodermic pilomatricoma with perforation. J Am Acad Dermatol. 2008 Mar; 58(3):535-6.
    View in: PubMed
  25. Pryor JG, Bourne PA, Yang Q, Spaulding BO, Scott GA, Xu H. IMP-3 is a novel progression marker in malignant melanoma. Mod Pathol. 2008 Apr; 21(4):431-7.
    View in: PubMed
  26. Fender AB, Gust A, Wang N, Scott GA, Mercurio MG. Congenital leukemia cutis. Pediatr Dermatol. 2008 Jan-Feb; 25(1):34-7.
    View in: PubMed
  27. Pryor JG, Scott GA. Nephrogenic systemic fibrosis: a clinicopathologic study of 6 cases. J Am Acad Dermatol. 2007 Nov; 57(5):902-3.
    View in: PubMed
  28. Scott G, Fricke A, Fender A, McClelland L, Jacobs S. Prostaglandin E2 regulates melanocyte dendrite formation through activation of PKCzeta. Exp Cell Res. 2007 Nov 1; 313(18):3840-50.
    View in: PubMed
  29. Brouxhon S, Kyrkanides S, O'Banion MK, Johnson R, Pearce DA, Centola GM, Miller JN, McGrath KH, Erdle B, Scott G, Schneider S, VanBuskirk J, Pentland AP. Sequential down-regulation of E-cadherin with squamous cell carcinoma progression: loss of E-cadherin via a prostaglandin E2-EP2 dependent posttranslational mechanism. Cancer Res. 2007 Aug 15; 67(16):7654-64.
    View in: PubMed
  30. Scott GA, McClelland LA, Fricke AF. Semaphorin 7a promotes spreading and dendricity in human melanocytes through beta1-integrins. J Invest Dermatol. 2008 Jan; 128(1):151-61.
    View in: PubMed
  31. Hanjani NM, Foster DC, Scott GA, Mercurio MG. A genital mass due to herpes simplex virus in a renal transplant recipient. J Low Genit Tract Dis. 2007 Jul; 11(3):173-6.
    View in: PubMed
  32. Kaufmann WK, Nevis KR, Qu P, Ibrahim JG, Zhou T, Zhou Y, Simpson DA, Helms-Deaton J, Cordeiro-Stone M, Moore DT, Thomas NE, Hao H, Liu Z, Shields JM, Scott GA, Sharpless NE. Defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression. J Invest Dermatol. 2008 Jan; 128(1):175-87.
    View in: PubMed
  33. Pryor JG, Poggioli G, Galaria N, Gust A, Robison J, Samie F, Hanjani NM, Scott GA. Nephrogenic systemic fibrosis: a clinicopathologic study of six cases. J Am Acad Dermatol. 2007 Jul; 57(1):105-11.
    View in: PubMed
  34. Scott GA, Arioka M, Jacobs SE. Lysophosphatidylcholine mediates melanocyte dendricity through PKCzeta activation. J Invest Dermatol. 2007 Mar; 127(3):668-75.
    View in: PubMed
  35. Brouxhon S, Konger RL, VanBuskirk J, Sheu TJ, Ryan J, Erdle B, Almudevar A, Breyer RM, Scott G, Pentland AP. Deletion of prostaglandin E2 EP2 receptor protects against ultraviolet-induced carcinogenesis, but increases tumor aggressiveness. J Invest Dermatol. 2007 Feb; 127(2):439-46.
    View in: PubMed
  36. Scott GA, Jacobs SE, Pentland AP. sPLA2-X stimulates cutaneous melanocyte dendricity and pigmentation through a lysophosphatidylcholine-dependent mechanism. J Invest Dermatol. 2006 Apr; 126(4):855-61.
    View in: PubMed
  37. Cooper JZ, Newman SR, Scott GA, Brown MD. Metastasizing atypical fibroxanthoma (cutaneous malignant histiocytoma): report of five cases. Dermatol Surg. 2005 Feb; 31(2):221-5; discussion 225.
    View in: PubMed
  38. Dib EG, Ifthikharuddin JJ, Scott GA, Partilo SR. Neutrophilic eccrine hidradenitis induced by imatinib mesylate (Gleevec) therapy. Leuk Res. 2005 Feb; 29(2):233-4.
    View in: PubMed
  39. Burns CA, Scott GA, Miller CC. Leukemia cutis at the site of trauma in a patient with Burkitt leukemia. Cutis. 2005 Jan; 75(1):54-6.
    View in: PubMed
  40. Scott G, Jacobs S, Leopardi S, Anthony FA, Learn D, Malaviya R, Pentland A. Effects of PGF2alpha on human melanocytes and regulation of the FP receptor by ultraviolet radiation. Exp Cell Res. 2005 Apr 1; 304(2):407-16.
    View in: PubMed
  41. Pentland AP, Scott G, VanBuskirk J, Tanck C, LaRossa G, Brouxhon S. Cyclooxygenase-1 deletion enhances apoptosis but does not protect against ultraviolet light-induced tumors. Cancer Res. 2004 Aug 15; 64(16):5587-91.
    View in: PubMed
  42. Joshi S, Scott G, Looney RJ. A successful challenge in a patient with vancomycin-induced linear IgA dermatosis. Ann Allergy Asthma Immunol. 2004 Jul; 93(1):101-3.
    View in: PubMed
  43. Cowen EW, Scott GA, Mercurio MG. Self-healing juvenile cutaneous mucinosis. J Am Acad Dermatol. 2004 May; 50(5 Suppl):S97-100.
    View in: PubMed
  44. Scott G, Leopardi S, Printup S, Malhi N, Seiberg M, Lapoint R. Proteinase-activated receptor-2 stimulates prostaglandin production in keratinocytes: analysis of prostaglandin receptors on human melanocytes and effects of PGE2 and PGF2alpha on melanocyte dendricity. J Invest Dermatol. 2004 May; 122(5):1214-24.
    View in: PubMed
  45. Nieves DS, Phipps RP, Pollock SJ, Ochs HD, Zhu Q, Scott GA, Ryan CK, Kobayashi I, Rossi TM, Goldsmith LA. Dermatologic and immunologic findings in the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Arch Dermatol. 2004 Apr; 140(4):466-72.
    View in: PubMed
  46. Leake D, Doerr TD, Scott G. Expression of urokinase-type plasminogen activator and its receptor in keloids. Arch Otolaryngol Head Neck Surg. 2003 Dec; 129(12):1334-8.
    View in: PubMed
  47. Peters EM, Maurer M, Botchkarev VA, Jensen Kd, Welker P, Scott GA, Paus R. Kit is expressed by epithelial cells in vivo. J Invest Dermatol. 2003 Nov; 121(5):976-84.
    View in: PubMed
  48. Scott G. Photo protection begins at the cellular level: microparasols on the job. J Invest Dermatol. 2003 Oct; 121(4):viii.
    View in: PubMed
  49. Scott G, Leopardi S, Parker L, Babiarz L, Seiberg M, Han R. The proteinase-activated receptor-2 mediates phagocytosis in a Rho-dependent manner in human keratinocytes. J Invest Dermatol. 2003 Sep; 121(3):529-41.
    View in: PubMed
  50. Scott G, Leopardi S. The cAMP signaling pathway has opposing effects on Rac and Rho in B16F10 cells: implications for dendrite formation in melanocytic cells. Pigment Cell Res. 2003 Apr; 16(2):139-48.
    View in: PubMed
  51. Konger RL, Scott GA, Landt Y, Ladenson JH, Pentland AP. Loss of the EP2 prostaglandin E2 receptor in immortalized human keratinocytes results in increased invasiveness and decreased paxillin expression. Am J Pathol. 2002 Dec; 161(6):2065-78.
    View in: PubMed
  52. Losee JE, Selber J, Vega S, Hall C, Scott G, Serletti JM. Primary cutaneous mucormycosis: guide to surgical management. Ann Plast Surg. 2002 Oct; 49(4):385-90.
    View in: PubMed
  53. Scott G. Rac and rho: the story behind melanocyte dendrite formation. Pigment Cell Res. 2002 Oct; 15(5):322-30.
    View in: PubMed
  54. Scott G, Leopardi S, Printup S, Madden BC. Filopodia are conduits for melanosome transfer to keratinocytes. J Cell Sci. 2002 Apr 1; 115(Pt 7):1441-51.
    View in: PubMed
  55. Pentland AP, Schoggins JW, Scott GA, Khan KN, Han R. Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition. Carcinogenesis. 1999 Oct; 20(10):1939-44.
    View in: PubMed
  56. Scott GA, Cassidy L, Tran H, Rao SK, Marinkovich MP. Melanocytes adhere to and synthesize laminin-5 in vitro. Exp Dermatol. 1999 Jun; 8(3):212-21.
    View in: PubMed
  57. Scott GA, Cassidy L. Rac1 mediates dendrite formation in response to melanocyte stimulating hormone and ultraviolet light in a murine melanoma model. J Invest Dermatol. 1998 Aug; 111(2):243-50.
    View in: PubMed
  58. Stadler FJ, Scott GA, Brown MD. Malignant fibrous tumors. Semin Cutan Med Surg. 1998 Jun; 17(2):141-52.
    View in: PubMed
  59. Stitt WZ, Scott GA, Caserta M, Goldsmith LA. Coexistence of incontinentia pigmenti and neonatal herpes simplex virus infection. Pediatr Dermatol. 1998 Mar-Apr; 15(2):112-5.
    View in: PubMed
  60. Stitt WZ, Scott GA, Martin RE, Gaspari AA. Multiple chemical sensitivities, including iatrogenic allergic contact dermatitis, in a patient with chronic actinic dermatitis: implications for management. Am J Contact Dermat. 1996 Sep; 7(3):166-70.
    View in: PubMed
  61. Scott GA, Liang H, Cassidy LL. Developmental regulation of focal contact protein expression in human melanocytes. Pigment Cell Res. 1995 Aug; 8(4):221-8.
    View in: PubMed
  62. Zalka AD, Goldsmith LA, Scott GA, Tunnessen WW. Picture of the month. Monilethrix. Arch Pediatr Adolesc Med. 1995 May; 149(5):549-50.
    View in: PubMed
  63. Scott GA. Report of three cases of cutaneous reactions to granulocyte macrophage-colony-stimulating factor and a review of the literature. Am J Dermatopathol. 1995 Apr; 17(2):107-14.
    View in: PubMed
  64. Scott GA, Goldsmith LA. Homeobox genes and skin development: a review. J Invest Dermatol. 1993 Jul; 101(1):3-8.
    View in: PubMed
  65. Scott GA, Trepeta R. Clear cell sarcoma of tendons and aponeuroses and malignant blue nevus arising in prepubescent children. Report of two cases and review of the literature. Am J Dermatopathol. 1993 Apr; 15(2):139-45.
    View in: PubMed
  66. Scott GA, Haake AR. Keratinocytes regulate melanocyte number in human fetal and neonatal skin equivalents. J Invest Dermatol. 1991 Nov; 97(5):776-81.
    View in: PubMed
  67. Fairley JA, Scott GA, Jensen KD, Goldsmith LA, Diaz LA. Characterization of keratocalmin, a calmodulin-binding protein from human epidermis. J Clin Invest. 1991 Jul; 88(1):315-22.
    View in: PubMed
  68. Toome BK, Bowers KE, Scott GA. Diagnosis of cutaneous cytomegalovirus infection: a review and report of a case. J Am Acad Dermatol. 1991 May; 24(5 Pt 2):860-7.
    View in: PubMed
  69. Haake AR, Scott GA. Physiologic distribution and differentiation of melanocytes in human fetal and neonatal skin equivalents. J Invest Dermatol. 1991 Jan; 96(1):71-7.
    View in: PubMed
  70. Lane AT, Scott GA, Day KH. Development of human fetal skin transplanted to the nude mouse. J Invest Dermatol. 1989 Dec; 93(6):787-91.
    View in: PubMed
  71. Scott GA, Rosai J. Spindle cell hemangioendothelioma. Report of seven additional cases of a recently described vascular neoplasm. Am J Dermatopathol. 1988 Aug; 10(4):281-8.
    View in: PubMed

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