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Nicholas Jospe

TitleProfessor (Part-Time)
InstitutionSchool of Medicine and Dentistry
DepartmentPediatrics
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 777
Rochester NY 14642
 
 Awards And Honors
2002     American Diabetes Association Certificate of Recognition  | American Diabetes Association
2002     JDRF "Inspiration Award"  | JDRF
2003     Diabetes Award in Adolescent Health  | Society for Adolescent Medicine and Carlotta Simons
 
 Overview
Dr. Jospe is engaged in clinical research aimed at preventing Type 1 diabetes and studying the underlying mechanisms causing Type 1 diabetes. He is an investigator in "TrialNet", an international study funded by the NIH and other organizations, investigating the natural history of Type 1 diabetes and possible interventions to prevent diabetes in individuals at high risk. He has partnered locally with the "Autoimmunity Center of Excellence" at the University of Rochester, as well as the Benaroya Research Institute, Virginia Mason Medical Center, Seattle WA, where he is currently on sabbatical. He is co-investigator in a multi-center industry sponsored study investigating the utility of continuous glucose sensor technology in the care of children with Type 1 diabetes.

 
 Selected Publications
List All   |   Timeline
  1. Mallone R, Scotto M, Janicki CN, James EA, Fitzgerald-Miller L, Wagner R, Gottlieb P, Thorpe J, Jospe N, Durinovic-Bellò I, Boitard C, Lou O, Dayan CM, Wong FS. Immunology of Diabetes Society T-Cell Workshop: HLA class I tetramer-directed epitope validation initiative T-Cell Workshop Report-HLA Class I Tetramer Validation Initiative. Diabetes Metab Res Rev. 2011 Nov; 27(8):720-6.
    View in: PubMed
  2. James EA, Mallone R, Schloot NC, Gagnerault MC, Thorpe J, Fitzgerald-Miller L, Reichow J, Wagner R, Pham MN, Jospe N, Lou O, Gottlieb PA, Brooks-Worrell BM, Durinovic-Belló I. Immunology of Diabetes Society T-Cell Workshop: HLA class II tetramer-directed epitope validation initiative. Diabetes Metab Res Rev. 2011 Nov; 27(8):727-36.
    View in: PubMed
  3. Hughson A, Bromberg I, Johnson B, Quataert S, Jospe N, Fowell DJ. Uncoupling of proliferation and cytokines from suppression within the CD4+CD25+Foxp3+ T-cell compartment in the 1st year of human type 1 diabetes. Diabetes. 2011 Aug; 60(8):2125-33.
    View in: PubMed
  4. Weinberg GA, Jospe N. Growth hormone deficiency and HIV infection. J Pediatr. 2005 Oct; 147(4):559-60.
    View in: PubMed
  5. Skyler JS, Weinstock RS, Raskin P, Yale JF, Barrett E, Gerich JE, Gerstein HC. Use of inhaled insulin in a basal/bolus insulin regimen in type 1 diabetic subjects: a 6-month, randomized, comparative trial. Diabetes Care. 2005 Jul; 28(7):1630-5.
    View in: PubMed
  6. Skyler JS, Krischer JP, Wolfsdorf J, Cowie C, Palmer JP, Greenbaum C, Cuthbertson D, Rafkin-Mervis LE, Chase HP, Leschek E. Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1. Diabetes Care. 2005 May; 28(5):1068-76.
    View in: PubMed
  7. Mack-Fogg JE, Orlowski CC, Jospe N. Continuous subcutaneous insulin infusion in toddlers and children with type 1 diabetes mellitus is safe and effective. Pediatr Diabetes. 2005 Mar; 6(1):17-21.
    View in: PubMed
  8. Jospe N, Florence M. Hermaphroditus in Greco-Roman myth: lessons and hypotheses for intersex today. J Pediatr Endocrinol Metab. 2004 Nov; 17(11):1471-9.
    View in: PubMed
  9. Epstein RM, Dannefer EF, Nofziger AC, Hansen JT, Schultz SH, Jospe N, Connard LW, Meldrum SC, Henson LC. Comprehensive assessment of professional competence: the Rochester experiment. Teach Learn Med. 2004; 16(2):186-96.
    View in: PubMed
  10. Effects of insulin in relatives of patients with type 1 diabetes mellitus. N Engl J Med. 2002 May 30; 346(22):1685-91.
    View in: PubMed
  11. Yu L, Cuthbertson DD, Maclaren N, Jackson R, Palmer JP, Orban T, Eisenbarth GS, Krischer JP. Expression of GAD65 and islet cell antibody (ICA512) autoantibodies among cytoplasmic ICA+ relatives is associated with eligibility for the Diabetes Prevention Trial-Type 1. Diabetes. 2001 Aug; 50(8):1735-40.
    View in: PubMed
  12. Jospe N, Kaplowitz PB, McCurdy FA, Gottlieb RP, Harris MA, Boyle R. Third-year medical student survey of office preceptorships during the pediatric clerkship. Arch Pediatr Adolesc Med. 2001 May; 155(5):592-6.
    View in: PubMed
  13. Chase HP, Cuthbertson DD, Dolan LM, Kaufman F, Krischer JP, Schatz DA, White NH, Wilson DM, Wolfsdorf J. First-phase insulin release during the intravenous glucose tolerance test as a risk factor for type 1 diabetes. J Pediatr. 2001 Feb; 138(2):244-9.
    View in: PubMed
  14. Greenbaum CJ, Cuthbertson D, Krischer JP. Type I diabetes manifested solely by 2-h oral glucose tolerance test criteria. Diabetes. 2001 Feb; 50(2):470-6.
    View in: PubMed
  15. Gupta P, Mick G, Fong CT, Jospe N, McCormick K. Hyponatremia secondary to reset osmostat in a child with a central nervous system midline defect and a chromosomal abnormality. J Pediatr Endocrinol Metab. 2000 Nov-Dec; 13(9):1637-41.
    View in: PubMed
  16. Jospe N, Lane A, Greenlaw J, Sulkes SB. Ambiguity of the external genitalia in an infant with Down syndrome: gender assignment and ethical implications. Ment Retard. 1999 Jun; 37(3):232-6.
    View in: PubMed
  17. Jospe N, Forbes G. Fluids and electrolytes--clinical aspects. Pediatr Rev. 1996 Nov; 17(11):395-403; quiz 404.
    View in: PubMed
  18. Jospe N, Kaplowitz PB, Furlanetto RW. Homozygous nonsense mutation in the insulin receptor gene of a patient with severe congenital insulin resistance: leprechaunism and the role of the insulin-like growth factor receptor. Clin Endocrinol (Oxf). 1996 Aug; 45(2):229-35.
    View in: PubMed
  19. Jospe N, Orlowski CC, Furlanetto RW. Comparison of transdermal and oral estrogen therapy in girls with Turner's syndrome. J Pediatr Endocrinol Metab. 1995 Apr-Jun; 8(2):111-6.
    View in: PubMed
  20. Liu R, Zhu J, Jospe N, Furlanetto RW, Bastian W, Livingston JN. Deletion of lysine 121 creates a temperature-sensitive alteration in insulin binding by the insulin receptor. J Biol Chem. 1995 Jan 6; 270(1):476-82.
    View in: PubMed
  21. Jospe N, Zhu J, Liu R, Livingston JN, Furlanetto RW. Deletion of 3 basepairs resulting in the loss of lysine-121 in the insulin receptor alpha-subunit in a patient with leprechaunism: binding, phosphorylation, and biological activity. J Clin Endocrinol Metab. 1994 Nov; 79(5):1294-302.
    View in: PubMed
  22. Becker B, Jospe N, Goldsmith LA. Melanocytic nevi in Turner syndrome. Pediatr Dermatol. 1994 Jun; 11(2):120-4.
    View in: PubMed
  23. Sandrini R, Jospe N, Migeon CJ. Temporal and individual variations in the dose of glucocorticoid used for the treatment of salt-losing congenital virilizing adrenal hyperplasia due to 21-hydroxylase deficiency. Acta Paediatr Suppl. 1993 Mar; 388:56-60; discussion 61.
    View in: PubMed
  24. Jospe N, Powell KR. Growth hormone deficiency in an 8-year-old girl with human immunodeficiency virus infection. Pediatrics. 1990 Aug; 86(2):309-12.
    View in: PubMed
  25. Donohoue PA, Jospe N, Migeon CJ, Van Dop C. Two distinct areas of unequal crossingover within the steroid 21-hydroxylase genes produce absence of CYP21B. Genomics. 1989 Oct; 5(3):397-406.
    View in: PubMed
  26. Jospe N, Berkovitz GD, Corcoran LE, Humphrey RL. Factitious transient neonatal hyperthyrotropinemia. J Endocrinol Invest. 1988 Feb; 11(2):129-32.
    View in: PubMed
  27. McLean RH, Donohoue PA, Jospe N, Bias WB, Van Dop C, Migeon CJ. Restriction fragment analysis of duplication of the fourth component of complement (C4A). Genomics. 1988 Jan; 2(1):76-85.
    View in: PubMed
  28. Jospe N, Donohoue PA, Van Dop C, McLean RH, Bias WB, Migeon CJ. Prevalence of polymorphic 21-hydroxylase gene (CA21HB) mutations in salt-losing congenital adrenal hyperplasia. Biochem Biophys Res Commun. 1987 Feb 13; 142(3):798-804.
    View in: PubMed
  29. Donohoue PA, van Dop C, McLean RH, White PC, Jospe N, Migeon CJ. Gene conversion in salt-losing congenital adrenal hyperplasia with absent complement C4B protein. J Clin Endocrinol Metab. 1986 May; 62(5):995-1002.
    View in: PubMed
  30. Donohoue PA, Jospe N, Migeon CJ, McLean RH, Bias WB, White PC, Van Dop C. Restriction maps and restriction fragment length polymorphisms of the human 21-hydroxylase genes. Biochem Biophys Res Commun. 1986 Apr 29; 136(2):722-9.
    View in: PubMed
  31. Donohoue PA, Van Dop C, Jospe N, Migeon CJ. Congenital adrenal hyperplasia: molecular mechanisms resulting in 21-hydroxylase deficiency. Acta Endocrinol Suppl (Copenh). 1986; 279:315-20.
    View in: PubMed

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