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Viktor Yarotskyy

TitleResearch Assistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentPharmacology and Physiology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 711
Rochester NY 14642
 
 Selected Publications
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  1. Yarotskyy V, Protasi F, Dirksen RT. Accelerated Activation of SOCE Current in Myotubes from Two Mouse Models of Anesthetic- and Heat-Induced Sudden Death. PLoS One. 2013; 8(10):e77633.
    View in: PubMed
  2. Yarotskyy V, Dirksen RT. Temperature and RyR1 regulate the activation rate of store-operated Ca²+ entry current in myotubes. Biophys J. 2012 Jul 18; 103(2):202-11.
    View in: PubMed
  3. Lanner JT, Georgiou DK, Dagnino-Acosta A, Ainbinder A, Cheng Q, Joshi AD, Chen Z, Yarotskyy V, Oakes JM, Lee CS, Monroe TO, Santillan A, Dong K, Goodyear L, Ismailov II, Rodney GG, Dirksen RT, Hamilton SL. AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation. Nat Med. 2012 Feb; 18(2):244-51.
    View in: PubMed
  4. Yarotskyy V, Gao G, Peterson BZ, Elmslie KS. Domain III regulates N-type (CaV2.2) calcium channel closing kinetics. J Neurophysiol. 2012 Apr; 107(7):1942-51.
    View in: PubMed
  5. Tang ZZ, Yarotskyy V, Wei L, Sobczak K, Nakamori M, Eichinger K, Moxley RT, Dirksen RT, Thornton CA. Muscle weakness in myotonic dystrophy associated with misregulated splicing and altered gating of Ca(V)1.1 calcium channel. Hum Mol Genet. 2012 Mar 15; 21(6):1312-24.
    View in: PubMed
  6. Yarotskyy V, Elmslie KS. Roscovitine inhibits CaV3.1 (T-type) channels by preferentially affecting closed-state inactivation. J Pharmacol Exp Ther. 2012 Feb; 340(2):463-72.
    View in: PubMed
  7. Fedorenko O, Yarotskyy V, Duzhyy D, Marchenko S. The large-conductance ion channels in the nuclear envelope of central neurons. Pflugers Arch. 2010 Nov; 460(6):1045-50.
    View in: PubMed
  8. Fassl J, High KM, Stephenson ER, Yarotskyy V, Elmslie KS. The intravenous anesthetic propofol inhibits human L-type calcium channels by enhancing voltage-dependent inactivation. J Clin Pharmacol. 2011 May; 51(5):719-30.
    View in: PubMed
  9. Yarotskyy V, Elmslie KS. Interference between two modulators of N-type (CaV2.2) calcium channel gating demonstrates that omega-conotoxin GVIA disrupts open state gating. Biochim Biophys Acta. 2010 Sep; 1798(9):1821-8.
    View in: PubMed
  10. Wang X, Gao G, Guo K, Yarotskyy V, Huang C, Elmslie KS, Peterson BZ. Phospholemman modulates the gating of cardiac L-type calcium channels. Biophys J. 2010 Apr 7; 98(7):1149-59.
    View in: PubMed
  11. Gowd KH, Yarotskyy V, Elmslie KS, Skalicky JJ, Olivera BM, Bulaj G. Site-specific effects of diselenide bridges on the oxidative folding of a cystine knot peptide, omega-selenoconotoxin GVIA. Biochemistry. 2010 Mar 30; 49(12):2741-52.
    View in: PubMed
  12. Yarotskyy V, Elmslie KS. Open-state occupancy prevents gating charge relaxation of N-type (CaV2.2) calcium channels. Biophys J. 2009 Nov 4; 97(9):2446-55.
    View in: PubMed
  13. Yarotskyy V, Gao G, Du L, Ganapathi SB, Peterson BZ, Elmslie KS. Roscovitine binds to novel L-channel (CaV1.2) sites that separately affect activation and inactivation. J Biol Chem. 2010 Jan 1; 285(1):43-53.
    View in: PubMed
  14. Yarotskyy V, Gao G, Peterson BZ, Elmslie KS. The Timothy syndrome mutation of cardiac CaV1.2 (L-type) channels: multiple altered gating mechanisms and pharmacological restoration of inactivation. J Physiol. 2009 Feb 1; 587(Pt 3):551-65.
    View in: PubMed
  15. Yarotskyy V, Elmslie KS. omega-conotoxin GVIA alters gating charge movement of N-type (CaV2.2) calcium channels. J Neurophysiol. 2009 Jan; 101(1):332-40.
    View in: PubMed
  16. Yarotskyy V, Elmslie KS. Roscovitine, a cyclin-dependent kinase inhibitor, affects several gating mechanisms to inhibit cardiac L-type (Ca(V)1.2) calcium channels. Br J Pharmacol. 2007 Oct; 152(3):386-95.
    View in: PubMed
  17. Martynyuk AE, Seubert CN, Yarotskyy V, Glushakov AV, Gravenstein N, Sumners C, Dennis DM. Halogenated derivatives of aromatic amino acids exhibit balanced antiglutamatergic actions: potential applications for the treatment of neurological and neuropsychiatric disorders. Recent Pat CNS Drug Discov. 2006 Nov; 1(3):261-70.
    View in: PubMed
  18. Marchenko SM, Yarotskyy VV, Kovalenko TN, Kostyuk PG, Thomas RC. Spontaneously active and InsP3-activated ion channels in cell nuclei from rat cerebellar Purkinje and granule neurones. J Physiol. 2005 Jun 15; 565(Pt 3):897-910.
    View in: PubMed
  19. Yarotskyy V, Glushakov AV, Sumners C, Gravenstein N, Dennis DM, Seubert CN, Martynyuk AE. Differential modulation of glutamatergic transmission by 3,5-dibromo-L-phenylalanine. Mol Pharmacol. 2005 May; 67(5):1648-54.
    View in: PubMed

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