URMC Research Network - Laurie Steiner

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Laurie Steiner

Title	Assistant Professor
Institution	School of Medicine and Dentistry
Department	Pediatrics
Address	University of Rochester Medical Center School of Medicine and Dentistry 601 Elmwood Ave, Box 651 Rochester NY 14642

Awards And Honors

1998			De Kiewit Research Fellowship \| University of Rochester
1999			Phi Beta Kappa
2003			Alpha Omega Alpha
2006			Pediatric Scientist Development Program
2008			Best Basic Science Presentation \| New England Perinatal Conference
2008			NIH Loan Repayment \| NIH
2009			Fellow's Basic Research Award \| Society for Pediatric Research

Overview

~Genomics
~Epigenetics
~Hematology

The Steiner laboratory utilizes genomics techniques to study the molecular mechanisms underlying erythroid maturation and development. The laboratory is particularly interested in studying how specific DNA sequences, DNA binding proteins, and chromatin structure interact during normal erythropoiesis. The laboratory is also interested in studying how those interactions are perturbed in disease states.

Selected Publications

Yocum AO, Steiner LA, Seidel NE, Cline AP, Rout ED, Lin JY, Wong C, Garrett LJ, Gallagher PG, Bodine DM. A tissue-specific chromatin loop activates the erythroid ankyrin-1 promoter. Blood. 2012 Oct 25; 120(17):3586-93.

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Steiner LA, Schulz VP, Maksimova Y, Wong C, Gallagher PG. Patterns of Histone H3 Lysine 27 Monomethylation and Erythroid Cell Type-specific Gene Expression. J Biol Chem. 2011 Nov 11; 286(45):39457-65.

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Pilon AM, Ajay SS, Kumar SA, Steiner LA, Cherukuri PF, Wincovitch S, Anderson SM. Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation. Blood. 2011 Oct 27; 118(17):e139-48.

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Li X, Wang S, Li Y, Deng C, Steiner LA, Xiao H, Wu C, Bungert J, Gallagher PG, Felsenfeld G, Qiu Y, Huang S. Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes. Blood. 2011 Aug 4; 118(5):1386-94.

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Steiner LA, Ehrenkranz RA, Peterec SM, Steiner RD, Reyes-Múgica M, Gallagher PG. Perinatal onset mevalonate kinase deficiency. Pediatr Dev Pathol. 2011 Jul-Aug; 14(4):301-6.

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Hopewell B, Steiner LA, Ehrenkranz RA, Bizzarro MJ, Gallagher PG. Partial exchange transfusion for polycythemia hyperviscosity syndrome. Am J Perinatol. 2011 Aug; 28(7):557-64.

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Gallagher PG, Steiner LA, Liem RI, Owen AN, Cline AP, Seidel NE, Garrett LJ, Bodine DM. Mutation of a barrier insulator in the human ankyrin-1 gene is associated with hereditary spherocytosis. J Clin Invest. 2010 Dec 1; 120(12):4453-65.

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Laflamme K, Owen AN, Devlin EE, Yang MQ, Wong C, Steiner LA, Garrett LJ, Elnitski L, Gallagher PG, Bodine DM. Functional analysis of a novel cis-acting regulatory region within the human ankyrin gene (ANK-1) promoter. Mol Cell Biol. 2010 Jul; 30(14):3493-502.

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Steiner LA, Maksimova Y, Schulz V, Wong C, Raha D, Mahajan MC, Weissman SM, Gallagher PG. Chromatin architecture and transcription factor binding regulate expression of erythrocyte membrane protein genes. Mol Cell Biol. 2009 Oct; 29(20):5399-412.

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Gallagher PG, Nilson DG, Steiner LA, Maksimova YD, Lin JY, Bodine DM. An insulator with barrier-element activity promotes alpha-spectrin gene expression in erythroid cells. Blood. 2009 Feb 12; 113(7):1547-54.

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Di Terlizzi R, Gallagher PG, Mohandas N, Steiner LA, Dolce KS, Guo X, Wilkerson MJ, Stockham SL. Canine elliptocytosis due to a mutant beta-spectrin. Vet Clin Pathol. 2009 Mar; 38(1):52-8.

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Steiner LA, Gallagher PG. Erythrocyte disorders in the perinatal period. Semin Perinatol. 2007 Aug; 31(4):254-61.

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Steiner LA, Bizzarro MJ, Ehrenkranz RA, Gallagher PG. A decline in the frequency of neonatal exchange transfusions and its effect on exchange-related morbidity and mortality. Pediatrics. 2007 Jul; 120(1):27-32.

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Steiner LA, Van Hoff J, Kutlar F, Gallagher PG. Aplastic crisis revealing the diagnosis of Hb Evans [alpha62(E11)Val-->Met, GTG-->ATG (alpha2)] in a Hispanic kindred: case report and review. Hemoglobin. 2007; 31(4):409-16.

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Zezza DJ, Stewart SE, Steiner LA. Genes encoding Xenopus laevis Ig L chains. Implications for the evolution of kappa and lambda chains. J Immunol. 1992 Dec 15; 149(12):3968-77.

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