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Laurie Steiner

TitleAssistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentPediatrics
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 651
Rochester NY 14642
 
 Awards And Honors
1998     De Kiewit Research Fellowship  | University of Rochester
1999     Phi Beta Kappa
2003     Alpha Omega Alpha
2006     Pediatric Scientist Development Program
2008     Best Basic Science Presentation  | New England Perinatal Conference
2008     NIH Loan Repayment  | NIH
2009     Fellow's Basic Research Award  | Society for Pediatric Research
 
 Overview
~Genomics
~Epigenetics
~Hematology

The Steiner laboratory utilizes genomics techniques to study the molecular mechanisms underlying erythroid maturation and development. The laboratory is particularly interested in studying how specific DNA sequences, DNA binding proteins, and chromatin structure interact during normal erythropoiesis. The laboratory is also interested in studying how those interactions are perturbed in disease states.

 
 Selected Publications
List All   |   Timeline
  1. Su MY, Steiner LA, Bogardus H, Mishra T, Schulz VP, Hardison RC, Gallagher PG. Identification of biologically relevant enhancers in human erythroid cells. J Biol Chem. 2013 Mar 22; 288(12):8433-44.
    View in: PubMed
  2. Yocum AO, Steiner LA, Seidel NE, Cline AP, Rout ED, Lin JY, Wong C, Garrett LJ, Gallagher PG, Bodine DM. A tissue-specific chromatin loop activates the erythroid ankyrin-1 promoter. Blood. 2012 Oct 25; 120(17):3586-93.
    View in: PubMed
  3. Steiner LA, Schulz VP, Maksimova Y, Wong C, Gallagher PG. Patterns of histone H3 lysine 27 monomethylation and erythroid cell type-specific gene expression. J Biol Chem. 2011 Nov 11; 286(45):39457-65.
    View in: PubMed
  4. Pilon AM, Ajay SS, Kumar SA, Steiner LA, Cherukuri PF, Wincovitch S, Anderson SM. Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation. Blood. 2011 Oct 27; 118(17):e139-48.
    View in: PubMed
  5. Li X, Wang S, Li Y, Deng C, Steiner LA, Xiao H, Wu C, Bungert J, Gallagher PG, Felsenfeld G, Qiu Y, Huang S. Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes. Blood. 2011 Aug 4; 118(5):1386-94.
    View in: PubMed
  6. Steiner LA, Ehrenkranz RA, Peterec SM, Steiner RD, Reyes-Múgica M, Gallagher PG. Perinatal onset mevalonate kinase deficiency. Pediatr Dev Pathol. 2011 Jul-Aug; 14(4):301-6.
    View in: PubMed
  7. Hopewell B, Steiner LA, Ehrenkranz RA, Bizzarro MJ, Gallagher PG. Partial exchange transfusion for polycythemia hyperviscosity syndrome. Am J Perinatol. 2011 Aug; 28(7):557-64.
    View in: PubMed
  8. Gallagher PG, Steiner LA, Liem RI, Owen AN, Cline AP, Seidel NE, Garrett LJ, Bodine DM. Mutation of a barrier insulator in the human ankyrin-1 gene is associated with hereditary spherocytosis. J Clin Invest. 2010 Dec; 120(12):4453-65.
    View in: PubMed
  9. Laflamme K, Owen AN, Devlin EE, Yang MQ, Wong C, Steiner LA, Garrett LJ, Elnitski L, Gallagher PG, Bodine DM. Functional analysis of a novel cis-acting regulatory region within the human ankyrin gene (ANK-1) promoter. Mol Cell Biol. 2010 Jul; 30(14):3493-502.
    View in: PubMed
  10. Steiner LA, Maksimova Y, Schulz V, Wong C, Raha D, Mahajan MC, Weissman SM, Gallagher PG. Chromatin architecture and transcription factor binding regulate expression of erythrocyte membrane protein genes. Mol Cell Biol. 2009 Oct; 29(20):5399-412.
    View in: PubMed
  11. Gallagher PG, Nilson DG, Steiner LA, Maksimova YD, Lin JY, Bodine DM. An insulator with barrier-element activity promotes alpha-spectrin gene expression in erythroid cells. Blood. 2009 Feb 12; 113(7):1547-54.
    View in: PubMed
  12. Di Terlizzi R, Gallagher PG, Mohandas N, Steiner LA, Dolce KS, Guo X, Wilkerson MJ, Stockham SL. Canine elliptocytosis due to a mutant beta-spectrin. Vet Clin Pathol. 2009 Mar; 38(1):52-8.
    View in: PubMed
  13. Steiner LA, Gallagher PG. Erythrocyte disorders in the perinatal period. Semin Perinatol. 2007 Aug; 31(4):254-61.
    View in: PubMed
  14. Steiner LA, Bizzarro MJ, Ehrenkranz RA, Gallagher PG. A decline in the frequency of neonatal exchange transfusions and its effect on exchange-related morbidity and mortality. Pediatrics. 2007 Jul; 120(1):27-32.
    View in: PubMed
  15. Steiner LA, Van Hoff J, Kutlar F, Gallagher PG. Aplastic crisis revealing the diagnosis of Hb Evans [alpha62(E11)Val-->Met, GTG-->ATG (alpha2)] in a Hispanic kindred: case report and review. Hemoglobin. 2007; 31(4):409-16.
    View in: PubMed
  16. Zezza DJ, Stewart SE, Steiner LA. Genes encoding Xenopus laevis Ig L chains. Implications for the evolution of kappa and lambda chains. J Immunol. 1992 Dec 15; 149(12):3968-77.
    View in: PubMed

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