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Francis Gigliotti

TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentPediatrics
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 690
Rochester NY 14642
 
 Awards And Honors
1989     House Staff Teaching Award
1992 - 1995Lowell Glasgow Dean's Teaching Scholar
1995     Elected to American Society for Clinical Investigation
2006     Ruth A. Lawrence Faculty Service Award for Research
2007     American's Top Pediatricians
2007     Lindsey Distinguished Professorship for Pediatric Research  | University of Rochester Medical Center-Department of Pediatrics
2008     Best Doctor's in America
 
 Overview
Dr. Gigliotti's research interests are:

1) Pneumocystis carinii pneumonia
2) Infections in the immunocompromised host
3) Inflammatory lung injury
4) Opportunistic infections.

Pneumocystis carinii is a life-threatening cause of pneumonitis among patients who are immunocompromised because of malignancies, AIDS, or congenital immunodeficiency disorders. P. carinii pneumonia also occurs in children who are immunocompromised on the basis of malnutrition; thus the global significance of P. carinii pneumonia is potentially great. However, because this organism is difficult to work with and because it cannot be cultivated outside an animal host, almost nothing is known about its biology.

The focus of Dr. Gigliotti's laboratory is elucidating the immunopathogenesis of P. carinii pneumonia. A major area of investigation relates to studying active and passive immunity to P. carinii. This work involves production of monoclonal antibodies, cloning of P. carinii genes (in collaboration with Dr. C.G. Haidaris and Dr. P.J. Haidaris, Departments of Microbiology and Immunology and of Medicine), and extensive use of animal models of P. carinii pneumonia.

The second major area of emphasis is the study of lung injury resulting from immune-mediated inflammation in response to infection with P. carinii. Together with Dr. Terry Wright, we are trying to develop means to manipulate this inflammatory process so as to decrease the morbidity and mortality associated with P. carinii pneumonia. It is hoped that these studies will lead to a better understanding of this organism and host-parasite interactions, which in turn will result in better means of prevention, diagnosis, and treatment of P. carinii pneumonia.

 
 Selected Publications
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  1. Bello-Irizarry SN, Wang J, Johnston CJ, Gigliotti F, Wright TW. MyD88 Signaling Regulates Both Host Defense and Immunopathogenesis during Pneumocystis Infection. J Immunol. 2014 Jan 1; 192(1):282-92.
    View in: PubMed
  2. Biondi E, Evans R, Mischler M, Bendel-Stenzel M, Horstmann S, Lee V, Aldag J, Gigliotti F. Epidemiology of bacteremia in febrile infants in the United States. Pediatrics. 2013 Dec; 132(6):990-6.
    View in: PubMed
  3. Perez-Nazario N, Rangel-Moreno J, O'Reilly MA, Pasparakis M, Gigliotti F, Wright TW. Selective Ablation of Lung Epithelial IKK2 Impairs Pulmonary Th17 Responses and Delays the Clearance of Pneumocystis. J Immunol. 2013 Nov 1; 191(9):4720-30.
    View in: PubMed
  4. Biondi E, Murzycki J, Ralston S, Gigliotti F. Question from the clinician: Fever and bacteremia. Pediatr Rev. 2013 Mar; 34(3):134-6.
    View in: PubMed
  5. Gigliotti F, Wright TW. Pneumocystis: where does it live? PLoS Pathog. 2012 Nov; 8(11):e1003025.
    View in: PubMed
  6. Williams L, Malhotra Y, Murante B, Laverty S, Cook S, Topa D, Hardy D, Wang H, Gigliotti F. A single-blinded randomized clinical trial comparing polymyxin B-trimethoprim and moxifloxacin for treatment of acute conjunctivitis in children. J Pediatr. 2013 Apr; 162(4):857-61.
    View in: PubMed
  7. Bello-Irizarry SN, Wang J, Olsen K, Gigliotti F, Wright TW. The Alveolar Epithelial Cell Chemokine Response to Pneumocystis Requires Adaptor Molecule MyD88 and Interleukin-1 Receptor but Not Toll-Like Receptor 2 or 4. Infect Immun. 2012 Nov; 80(11):3912-20.
    View in: PubMed
  8. Wang J, Wright TW, Gigliotti F. Immune Modulation as Adjunctive Therapy for Pneumocystis pneumonia. Interdiscip Perspect Infect Dis. 2011; 2011:918038.
    View in: PubMed
  9. Wang J, Gigliotti F, Bhagwat SP, George TC, Wright TW. Immune modulation with sulfasalazine attenuates immunopathogenesis but enhances macrophage-mediated fungal clearance during Pneumocystis pneumonia. PLoS Pathog. 2010; 6(8):e1001058.
    View in: PubMed
  10. Bhagwat SP, Wright TW, Gigliotti F. Anti-CD3 antibody decreases inflammation and improves outcome in a murine model of Pneumocystis pneumonia. J Immunol. 2010 Jan 1; 184(1):497-502.
    View in: PubMed
  11. Pryhuber GS, Huyck HL, Bhagwat S, O'Reilly MA, Finkelstein JN, Gigliotti F, Wright TW. Parenchymal cell TNF receptors contribute to inflammatory cell recruitment and respiratory failure in Pneumocystis carinii-induced pneumonia. J Immunol. 2008 Jul 15; 181(2):1409-19.
    View in: PubMed
  12. Wang J, Gigliotti F, Bhagwat SP, Maggirwar SB, Wright TW. Pneumocystis stimulates MCP-1 production by alveolar epithelial cells through a JNK-dependent mechanism. Am J Physiol Lung Cell Mol Physiol. 2007 Jun; 292(6):L1495-505.
    View in: PubMed
  13. Gigliotti F, Crow EL, Bhagwat SP, Wright TW. Sensitized CD8+ T cells fail to control organism burden but accelerate the onset of lung injury during Pneumocystis carinii pneumonia. Infect Immun. 2006 Nov; 74(11):6310-6.
    View in: PubMed
  14. Bhagwat SP, Gigliotti F, Xu H, Wright TW. Contribution of T cell subsets to the pathophysiology of Pneumocystis-related immunorestitution disease. Am J Physiol Lung Cell Mol Physiol. 2006 Dec; 291(6):L1256-66.
    View in: PubMed
  15. Bruckner L, Gigliotti F. Viridans group streptococcal infections among children with cancer and the importance of emerging antibiotic resistance. Semin Pediatr Infect Dis. 2006 Jul; 17(3):153-60.
    View in: PubMed
  16. Gigliotti F. Pneumocystis carinii nomenclature: response to Cushion and Stringer. Clin Infect Dis. 2006 Apr 15; 42(8):1208-9.
    View in: PubMed
  17. Wells J, Haidaris CG, Wright TW, Gigliotti F. Active immunization against Pneumocystis carinii with a recombinant P. carinii antigen. Infect Immun. 2006 Apr; 74(4):2446-8.
    View in: PubMed
  18. Bruckner L, Gigliotti F, Wright T, Harmsen A, Notter RH, Chess P, Wang Z, Finkelstein J. Pneumocystis carinii infection sensitizes lung to radiation-induced injury after syngeneic marrow transplantation: role of CD4+ T cells. Am J Physiol Lung Cell Mol Physiol. 2006 Jun; 290(6):L1087-96.
    View in: PubMed
  19. Wells J, Haidaris CG, Wright TW, Gigliotti F. Complement and Fc function are required for optimal antibody prophylaxis against Pneumocystis carinii pneumonia. Infect Immun. 2006 Jan; 74(1):390-3.
    View in: PubMed
  20. Gigliotti F, Wright TW. Immunopathogenesis of Pneumocystis carinii pneumonia. Expert Rev Mol Med. 2005; 7(26):1-16.
    View in: PubMed
  21. Gigliotti F. Pneumocystis carinii: has the name really been changed? Clin Infect Dis. 2005 Dec 15; 41(12):1752-5.
    View in: PubMed
  22. Wang Z, Foye A, Chang Y, Chess PR, Wright TW, Bhagwat S, Gigliotti F, Notter RH. Inhibition of surfactant activity by Pneumocystis carinii organisms and components in vitro. Am J Physiol Lung Cell Mol Physiol. 2005 Jun; 288(6):L1124-31.
    View in: PubMed
  23. Wang J, Gigliotti F, Maggirwar S, Johnston C, Finkelstein JN, Wright TW. Pneumocystis carinii activates the NF-kappaB signaling pathway in alveolar epithelial cells. Infect Immun. 2005 May; 73(5):2766-77.
    View in: PubMed
  24. Disney MD, Stephenson R, Wright TW, Haidaris CG, Turner DH, Gigliotti F. Activity of Hoechst 33258 against Pneumocystis carinii f. sp. muris, Candida albicans, and Candida dubliniensis. Antimicrob Agents Chemother. 2005 Apr; 49(4):1326-30.
    View in: PubMed
  25. Empey KM, Hollifield M, Schuer K, Gigliotti F, Garvy BA. Passive immunization of neonatal mice against Pneumocystis carinii f. sp. muris enhances control of infection without stimulating inflammation. Infect Immun. 2004 Nov; 72(11):6211-20.
    View in: PubMed
  26. Swain SD, Wright TW, Degel PM, Gigliotti F, Harmsen AG. Neither neutrophils nor reactive oxygen species contribute to tissue damage during Pneumocystis pneumonia in mice. Infect Immun. 2004 Oct; 72(10):5722-32.
    View in: PubMed
  27. Elhassan NO, Stevens TP, Gigliotti F, Hardy DJ, Cole CA, Sinkin RA. Vancomycin usage in central venous catheters in a neonatal intensive care unit. Pediatr Infect Dis J. 2004 Mar; 23(3):201-6.
    View in: PubMed
  28. Wells J, Gigliotti F, Simpson-Haidaris PJ, Haidaris CG. Epitope mapping of a protective monoclonal antibody against Pneumocystis carinii with shared reactivity to Streptococcus pneumoniae surface antigen PspA. Infect Immun. 2004 Mar; 72(3):1548-56.
    View in: PubMed
  29. Wright TW, Pryhuber GS, Chess PR, Wang Z, Notter RH, Gigliotti F. TNF receptor signaling contributes to chemokine secretion, inflammation, and respiratory deficits during Pneumocystis pneumonia. J Immunol. 2004 Feb 15; 172(4):2511-21.
    View in: PubMed
  30. Bliss JM, Wellington M, Gigliotti F. Antifungal pharmacotherapy for neonatal candidiasis. Semin Perinatol. 2003 Oct; 27(5):365-74.
    View in: PubMed
  31. Gigliotti F, Harmsen AG, Wright TW. Characterization of transmission of Pneumocystis carinii f. sp. muris through immunocompetent BALB/c mice. Infect Immun. 2003 Jul; 71(7):3852-6.
    View in: PubMed
  32. An CL, Gigliotti F, Harmsen AG. Exposure of immunocompetent adult mice to Pneumocystis carinii f. sp. muris by cohousing: growth of P. carinii f. sp. muris and host immune response. Infect Immun. 2003 Apr; 71(4):2065-70.
    View in: PubMed
  33. Koval CE, Gigliotti F, Nevins D, Demeter LM. Immune reconstitution syndrome after successful treatment of Pneumocystis carinii pneumonia in a man with human immunodeficiency virus type 1 infection. Clin Infect Dis. 2002 Aug 15; 35(4):491-3.
    View in: PubMed
  34. Bruckner L, Gigliotti F. Alpha-hemolytic streptococcal infections among immunocompromised hosts: increasing incidence, severity and antibiotic resistance. Pediatr Infect Dis J. 2002 Apr; 21(4):343-5.
    View in: PubMed
  35. Gigliotti F, Haidaris CG, Wright TW, Harmsen AG. Passive intranasal monoclonal antibody prophylaxis against murine Pneumocystis carinii pneumonia. Infect Immun. 2002 Mar; 70(3):1069-74.
    View in: PubMed
  36. Bruckner LB, Korones DN, Karnauchow T, Hardy DJ, Gigliotti F. High incidence of penicillin resistance among alpha-hemolytic streptococci isolated from the blood of children with cancer. J Pediatr. 2002 Jan; 140(1):20-6.
    View in: PubMed
  37. McFarland EJ, Borkowsky W, Fenton T, Wara D, McNamara J, Samson P, Kang M, Mofenson L, Cunningham C, Duliege AM, Sinangil F, Spector SA, Jimenez E, Bryson Y, Burchett S, Frenkel LM, Yogev R, Gigliotti F, Luzuriaga K, Livingston RA. Human immunodeficiency virus type 1 (HIV-1) gp120-specific antibodies in neonates receiving an HIV-1 recombinant gp120 vaccine. J Infect Dis. 2001 Nov 15; 184(10):1331-5.
    View in: PubMed
  38. Wellington M, Gigliotti F. Update on antifungal agents. Pediatr Infect Dis J. 2001 Oct; 20(10):993-5.
    View in: PubMed
  39. Gigliotti F, Murante BL, Weinberg GA. Short course directly observed therapy to monitor compliance with antiretroviral therapy in human immunodeficiency virus-infected children. Pediatr Infect Dis J. 2001 Jul; 20(7):716-8.
    View in: PubMed
  40. Vargas SL, Hughes WT, Santolaya ME, Ulloa AV, Ponce CA, Cabrera CE, Cumsille F, Gigliotti F. Search for primary infection by Pneumocystis carinii in a cohort of normal, healthy infants. Clin Infect Dis. 2001 Mar 15; 32(6):855-61.
    View in: PubMed
  41. Morgan DJ, Vargas SL, Reyes-Mugica M, Walterspiel JN, Carver W, Gigliotti F. Identification of Pneumocystis carinii in the lungs of infants dying of sudden infant death syndrome. Pediatr Infect Dis J. 2001 Mar; 20(3):306-9.
    View in: PubMed
  42. Wright TW, Notter RH, Wang Z, Harmsen AG, Gigliotti F. Pulmonary inflammation disrupts surfactant function during Pneumocystis carinii pneumonia. Infect Immun. 2001 Feb; 69(2):758-64.
    View in: PubMed
  43. Vargas SL, Ponce CA, Gigliotti F, Ulloa AV, Prieto S, Muñoz MP, Hughes WT. Transmission of Pneumocystis carinii DNA from a patient with P. carinii pneumonia to immunocompetent contact health care workers. J Clin Microbiol. 2000 Apr; 38(4):1536-8.
    View in: PubMed
  44. Lee LH, Gigliotti F, Wright TW, Simpson-Haidaris PJ, Weinberg GA, Haidaris CG. Molecular characterization of KEX1, a kexin-like protease in mouse Pneumocystis carinii. Gene. 2000 Jan 25; 242(1-2):141-50.
    View in: PubMed
  45. Wright TW, Gigliotti F, Finkelstein JN, McBride JT, An CL, Harmsen AG. Immune-mediated inflammation directly impairs pulmonary function, contributing to the pathogenesis of Pneumocystis carinii pneumonia. J Clin Invest. 1999 Nov; 104(9):1307-17.
    View in: PubMed
  46. Gigliotti F, Haidaris CG. Antigenic characterization of Pneumocystis carinii. Semin Respir Infect. 1998 Dec; 13(4):313-22.
    View in: PubMed
  47. Simpson-Haidaris PJ, Courtney MA, Wright TW, Goss R, Harmsen A, Gigliotti F. Induction of fibrinogen expression in the lung epithelium during Pneumocystis carinii pneumonia. Infect Immun. 1998 Sep; 66(9):4431-9.
    View in: PubMed
  48. Gigliotti F, Wiley JA, Harmsen AG. Immunization with Pneumocystis carinii gpA is immunogenic but not protective in a mouse model of P. carinii pneumonia. Infect Immun. 1998 Jul; 66(7):3179-82.
    View in: PubMed
  49. Gigliotti F, Garvy BA, Haidaris CG, Harmsen AG. Recognition of Pneumocystis carinii antigens by local antibody-secreting cells following resolution of P. carinii pneumonia in mice. J Infect Dis. 1998 Jul; 178(1):235-42.
    View in: PubMed
  50. Haidaris CG, Medzihradsky OF, Gigliotti F, Simpson-Haidaris PJ. Molecular characterization of mouse Pneumocystis carinii surface glycoprotein A. DNA Res. 1998 Apr 30; 5(2):77-85.
    View in: PubMed
  51. Haidaris CG, Fisher DJ, Gigliotti F, Simpson-Haidaris PJ. Antigenic properties of recombinant glycosylated and nonglycosylated Pneumocystis carinii glycoprotein A polypeptides expressed in baculovirus-infected insect cells. Mol Biotechnol. 1998 Apr; 9(2):91-7.
    View in: PubMed
  52. Sobel JD, Hasegawa A, Debernardis F, Adriani D, Pellegrini G, Cassone A, Fidel PL, Haidaris CG, Gigliotti F, Harmsen AG, Fujita S, Yamamoto K, Makimura K, Shibuya K, Uchida K, Yamaguchi H. Selected animal models: vaginal candidosis, Pneumocystis pneumonia, dermatophytosis and trichosporosis. Med Mycol. 1998; 36 Suppl 1:129-36.
    View in: PubMed
  53. Testa SM, Haidaris CG, Gigliotti F, Turner DH. A Pneumocystis carinii group I intron ribozyme that does not require 2' OH groups on its 5' exon mimic for binding to the catalytic core. Biochemistry. 1997 Dec 9; 36(49):15303-14.
    View in: PubMed
  54. Garvy BA, Wiley JA, Gigliotti F, Harmsen AG. Protection against Pneumocystis carinii pneumonia by antibodies generated from either T helper 1 or T helper 2 responses. Infect Immun. 1997 Dec; 65(12):5052-6.
    View in: PubMed
  55. Gigliotti F, Harmsen AG. Pneumocystis carinii host origin defines the antibody specificity and protective response induced by immunization. J Infect Dis. 1997 Nov; 176(5):1322-6.
    View in: PubMed
  56. Weinberg GA, Gigliotti F, Stroncek DF, Eiber G, Kassmann B, Murante B, Korones DN. Lack of relation of granulocyte antibodies (antineutrophil antibodies) to neutropenia in children with human immunodeficiency virus infection. Pediatr Infect Dis J. 1997 Sep; 16(9):881-4.
    View in: PubMed
  57. Garvy BA, Gigliotti F, Harmsen AG. Neutralization of interferon-gamma exacerbates pneumocystis-driven interstitial pneumonitis after bone marrow transplantation in mice. J Clin Invest. 1997 Apr 1; 99(7):1637-44.
    View in: PubMed
  58. Gigliotti F, Garvy BA, Harmsen AG. Antibody-mediated shift in the profile of glycoprotein A phenotypes observed in a mouse model of Pneumocystis carinii pneumonia. Infect Immun. 1996 Jun; 64(6):1892-9.
    View in: PubMed
  59. Gingras TM, Powell KR, Ringrose K, Gigliotti F. Delayed type hypersensitivity testing in hospitalized children: a retrospective chart review. Pediatr Infect Dis J. 1996 Mar; 15(3):267-9.
    View in: PubMed
  60. Gigliotti F, McCool T. Glycoprotein A is the immunodominant antigen of Pneumocystis carinii in mice following immunization. Parasitol Res. 1996; 82(1):90-1.
    View in: PubMed
  61. Wright TW, Gigliotti F, Haidaris CG, Simpson-Haidaris PJ. Cloning and characterization of a conserved region of human and rhesus macaque Pneumocystis carinii gpA. Gene. 1995 Dec 29; 167(1-2):185-9.
    View in: PubMed
  62. Harmsen AG, Chen W, Gigliotti F. Active immunity to Pneumocystis carinii reinfection in T-cell-depleted mice. Infect Immun. 1995 Jul; 63(7):2391-5.
    View in: PubMed
  63. Gigliotti F. Acute conjunctivitis. Pediatr Rev. 1995 Jun; 16(6):203-7; quiz 208.
    View in: PubMed
  64. Wright TW, Bissoondial TY, Haidaris CG, Gigliotti F, Haidaris PJ. Isoform diversity and tandem duplication of the glycoprotein A gene in ferret Pneumocystis carinii. DNA Res. 1995; 2(2):77-88.
    View in: PubMed
  65. Gigliotti F. Management of the child with conjunctivitis. Pediatr Infect Dis J. 1994 Dec; 13(12):1161-2.
    View in: PubMed
  66. Shenep JL, Feldman S, Gigliotti F, Roberson PK, Marina N, Foreschle JE, Fullen GH, Lott L, Brodkey TO. Response of immunocompromised children with solid tumors to a conjugate vaccine for Haemophilus influenzae type b. J Pediatr. 1994 Oct; 125(4):581-4.
    View in: PubMed
  67. Fanelli A, Duranti R, Gorini M, Spinelli A, Gigliotti F, Scano G. Histamine induced changes in breathing pattern may precede bronchoconstriction in selected patients with bronchial asthma. Thorax. 1994 Jul; 49(7):639-43.
    View in: PubMed
  68. Wright TW, Simpson-Haidaris PJ, Gigliotti F, Harmsen AG, Haidaris CG. Conserved sequence homology of cysteine-rich regions in genes encoding glycoprotein A in Pneumocystis carinii derived from different host species. Infect Immun. 1994 May; 62(5):1513-9.
    View in: PubMed
  69. Chen W, Gigliotti F, Harmsen AG. Latency is not an inevitable outcome of infection with Pneumocystis carinii. Infect Immun. 1993 Dec; 61(12):5406-9.
    View in: PubMed
  70. Gigliotti F, Harmsen AG, Haidaris CG, Haidaris PJ. Pneumocystis carinii is not universally transmissible between mammalian species. Infect Immun. 1993 Jul; 61(7):2886-90.
    View in: PubMed
  71. Gigliotti F, Haidaris PJ, Haidaris CG, Wright TW, Van der Meid KR. Further evidence of host species-specific variation in antigens of Pneumocystis carinii using the polymerase chain reaction. J Infect Dis. 1993 Jul; 168(1):191-4.
    View in: PubMed
  72. Gigliotti F. Acute conjunctivitis of childhood. Pediatr Ann. 1993 Jun; 22(6):353-6.
    View in: PubMed
  73. Haidaris PJ, Wright TW, Gigliotti F, Fallon MA, Whitbeck AA, Haidaris CG. In situ hybridization analysis of developmental stages of Pneumocystis carinii that are transcriptionally active for a major surface glycoprotein gene. Mol Microbiol. 1993 Mar; 7(5):647-56.
    View in: PubMed
  74. Chen W, Havell EA, Gigliotti F, Harmsen AG. Interleukin-6 production in a murine model of Pneumocystis carinii pneumonia: relation to resistance and inflammatory response. Infect Immun. 1993 Jan; 61(1):97-102.
    View in: PubMed
  75. Haidaris PJ, Wright TW, Gigliotti F, Haidaris CG. Expression and characterization of a cDNA clone encoding an immunodominant surface glycoprotein of Pneumocystis carinii. J Infect Dis. 1992 Nov; 166(5):1113-23.
    View in: PubMed
  76. Gigliotti F. Host species-specific antigenic variation of a mannosylated surface glycoprotein of Pneumocystis carinii. J Infect Dis. 1992 Feb; 165(2):329-36.
    View in: PubMed
  77. Haidaris CG, Wright TW, Gigliotti F, Haidaris PJ. Molecular cloning and characterization of ferret Pneumocystis carinii gp120. J Protozool. 1991 Nov-Dec; 38(6):5S-6S.
    View in: PubMed
  78. Fisher DJ, Gigliotti F, Zauderer M, Harmsen AG. Specific T-cell response to a Pneumocystis carinii surface glycoprotein (gp120). J Protozool. 1991 Nov-Dec; 38(6):22S-23S.
    View in: PubMed
  79. Gigliotti F. Antigenic variation of a major surface glycoprotein of Pneumocystis carinii. J Protozool. 1991 Nov-Dec; 38(6):4S-5S.
    View in: PubMed
  80. Fisher DJ, Gigliotti F, Zauderer M, Harmsen AG. Specific T-cell response to a Pneumocystis carinii surface glycoprotein (gp120) after immunization and natural infection. Infect Immun. 1991 Oct; 59(10):3372-6.
    View in: PubMed
  81. Gigliotti F, Feldman S, Wang WC, Day SW, Brunson G. Serologic follow-up of children with sickle cell disease immunized with a Haemophilus influenzae type b conjugate vaccine during early infancy. J Pediatr. 1991 Jun; 118(6):917-9.
    View in: PubMed
  82. Feldman S, Gigliotti F, Shenep JL, Roberson PK, Lott L. Risk of Haemophilus influenzae type b disease in children with cancer and response of immunocompromised leukemic children to a conjugate vaccine. J Infect Dis. 1990 May; 161(5):926-31.
    View in: PubMed
  83. Gigliotti F, Feldman S, Wang WC, Day SW, Brunson G. Immunization of young infants with sickle cell disease with a Haemophilus influenzae type b saccharide-diphtheria CRM197 protein conjugate vaccine. J Pediatr. 1989 Jun; 114(6):1006-10.
    View in: PubMed
  84. Shenep JL, Hughes WT, Roberson PK, Blankenship KR, Baker DK, Meyer WH, Gigliotti F, Sixbey JW, Santana VM, Feldman S, et al. Vancomycin, ticarcillin, and amikacin compared with ticarcillin-clavulanate and amikacin in the empirical treatment of febrile, neutropenic children with cancer. N Engl J Med. 1988 Oct 20; 319(16):1053-8.
    View in: PubMed
  85. Flynn PM, Shenep JL, Gigliotti F, Davis DS, Hildner WK. Immunolabeling of lipopolysaccharide liberated from antibiotic-treated Escherichia coli. Infect Immun. 1988 Oct; 56(10):2760-2.
    View in: PubMed
  86. Gigliotti F, Ballou LR, Hughes WT, Mosley BD. Purification and initial characterization of a ferret Pneumocystis carinii surface antigen. J Infect Dis. 1988 Oct; 158(4):848-54.
    View in: PubMed
  87. Gigliotti F. Immunodeficiency associated with recurrent infections and an isolated in vivo inability to respond to bacterial polysaccharides: follow-up immunization with pneumococcal polysaccharides. Pediatr Infect Dis J. 1988 Aug; 7(8):604.
    View in: PubMed
  88. Breda SD, Hammerschlag PE, Gigliotti F, Schinella R. Pneumocystis carinii in the temporal bone as a primary manifestation of the acquired immunodeficiency syndrome. Ann Otol Rhinol Laryngol. 1988 Jul-Aug; 97(4 Pt 1):427-31.
    View in: PubMed
  89. Flynn PM, Van Hooser B, Gigliotti F. Atypical mycobacterial infections of Hickman catheter exit sites. Pediatr Infect Dis J. 1988 Jul; 7(7):510-3.
    View in: PubMed
  90. Gigliotti F, Hughes WT. Passive immunoprophylaxis with specific monoclonal antibody confers partial protection against Pneumocystis carinii pneumonitis in animal models. J Clin Invest. 1988 Jun; 81(6):1666-8.
    View in: PubMed
  91. Gigliotti F, Herrod HG, Kalwinsky DK, Insel RA. Immunodeficiency associated with recurrent infections and an isolated in vivo inability to respond to bacterial polysaccharides. Pediatr Infect Dis J. 1988 Jun; 7(6):417-20.
    View in: PubMed
  92. Rehg JE, Gigliotti F, Stokes DC. Cryptosporidiosis in ferrets. Lab Anim Sci. 1988 Apr; 38(2):155-8.
    View in: PubMed
  93. Hughes WT, Gigliotti F. Nomenclature for Pneumocystis carinii. J Infect Dis. 1988 Mar; 157(3):432-3.
    View in: PubMed
  94. Feldman S, Gigliotti F, Bockhold C, Naegele R. Measles and rubella antibody status in previously vaccinated children with cancer. Med Pediatr Oncol. 1988; 16(5):308-11.
    View in: PubMed
  95. Gigliotti F, Shenep JL, Lott L, Thornton D. Induction of prostaglandin synthesis as the mechanism responsible for the chills and fever produced by infusing amphotericin B. J Infect Dis. 1987 Nov; 156(5):784-9.
    View in: PubMed
  96. Shenep JL, Gigliotti F, Davis DS, Hildner WK. Reactivity of antibodies to core glycolipid with gram-negative bacteria. Rev Infect Dis. 1987 Sep-Oct; 9 Suppl 5:S639-43.
    View in: PubMed
  97. Gigliotti F, Lee D, Insel RA, Scheld WM. IgG penetration into the cerebrospinal fluid in a rabbit model of meningitis. J Infect Dis. 1987 Aug; 156(2):394-8.
    View in: PubMed
  98. Stokes DC, Gigliotti F, Rehg JE, Snellgrove RL, Hughes WT. Experimental Pneumocystis carinii pneumonia in the ferret. Br J Exp Pathol. 1987 Apr; 68(2):267-76.
    View in: PubMed
  99. Gigliotti F, Stokes DC, Cheatham AB, Davis DS, Hughes WT. Development of murine monoclonal antibodies to Pneumocystis carinii. J Infect Dis. 1986 Aug; 154(2):315-22.
    View in: PubMed
  100. Gigliotti F, Shenep JL. Failure of monoclonal antibodies to core glycolipid to bind intact smooth strains of Escherichia coli. J Infect Dis. 1985 Jun; 151(6):1005-11.
    View in: PubMed
  101. Hughes WT, Feldman S, Gigliotti F, Shenep J, Sixbey J. Prevention of infectious complications in acute lymphoblastic leukemia. Semin Oncol. 1985 Jun; 12(2):180-91.
    View in: PubMed
  102. Connor E, Menegus M, Cecalupo A, Gigliotti F. Central nervous system toxoplasmosis mimicking a brain abscess in a compromised pediatric patient. Pediatr Infect Dis. 1984 Nov-Dec; 3(6):552-5.
    View in: PubMed
  103. Gigliotti F, Hendley JO, Morgan J, Michaels R, Dickens M, Lohr J. Efficacy of topical antibiotic therapy in acute conjunctivitis in children. J Pediatr. 1984 Apr; 104(4):623-6.
    View in: PubMed
  104. Gigliotti F, Smith L, Insel RA. Reproducible production of protective human monoclonal antibodies by fusion of peripheral blood lymphocytes with a mouse myeloma cell line. J Infect Dis. 1984 Jan; 149(1):43-7.
    View in: PubMed
  105. Insel RA, Gigliotti F. Monoclonal antibodies. Clinical relevance to pediatrics. Am J Dis Child. 1983 Jan; 137(1):69-76.
    View in: PubMed
  106. Gigliotti F, Insel RA. Protective human hybridoma antibody to tetanus toxin. J Clin Invest. 1982 Dec; 70(6):1306-9.
    View in: PubMed
  107. Gigliotti F, Insel RA. Protection from infection with Haemophilus influenzae type b by monoclonal antibody to the capsule. J Infect Dis. 1982 Aug; 146(2):249-54.
    View in: PubMed
  108. Gigliotti F, Williams WT, Hayden FG, Hendley JO, Benjamin J, Dickens M, Gleason C, Perriello VA, Wood J. Etiology of acute conjunctivitis in children. J Pediatr. 1981 Apr; 98(4):531-6.
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Gigliotti's Networks

Concepts
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Co-Authors
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Similar People
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Same Department