Alin Vonica
| Title | Research Assistant Professor |
|---|
| Institution | School of Medicine and Dentistry |
|---|
| Department | Biomedical Genetics in the Center for Oral Biology |
|---|
| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 611
Rochester NY 14642
|
|---|
|
|
|
| 1997 |
-
| 2000 | Jack and Susan Rudin Scholar in the Biomedical Sciences | | 2002 |
-
| 2005 | Ruth L Kirschstein National Research Service Award | NICHD training grant | | 2006 |
|
| Best Talk Prize | Northeast Society for Developmental Biology |
The salivary glands are important for their physiological role in digestion and oral health, and the site of pathological processes, from autoimmune diseases to cancer. I am using my experience in vertebrate embryology and signal transduction to understand the molecular processes underlying the development, maintenance, and regeneration of normal salivary glands, as well as their pathological alteration in oncogenesis.
-
Gao H, Chakraborty G, Lee-Lim AP, Mo Q, Decker M, Vonica A, Shen R, Brogi E, Brivanlou AH, Giancotti FG. The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites. Cell. 2012 Aug 17; 150(4):764-79.
-
Warmflash A, Zhang Q, Sorre B, Vonica A, Siggia ED, Brivanlou AH. Dynamics of TGF-ß signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):E1947-56.
-
Vonica A, Rosa A, Arduini BL, Brivanlou AH. APOBEC2, a selective inhibitor of TGFß signaling, regulates left-right axis specification during early embryogenesis. Dev Biol. 2011 Feb 1; 350(1):13-23.
-
Shimomura Y, Agalliu D, Vonica A, Luria V, Wajid M, Baumer A, Belli S, Petukhova L, Schinzel A, Brivanlou AH, Barres BA, Christiano AM. APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex. Nature. 2010 Apr 15; 464(7291):1043-7.
-
Francois P, Vonica A, Brivanlou AH, Siggia ED. Scaling of BMP gradients in Xenopus embryos. Nature. 2009 Sep 3; 461(7260):E1; discussion E2.
-
Vonica A, Gumbiner BM. The Xenopus Nieuwkoop center and Spemann-Mangold organizer share molecular components and a requirement for maternal Wnt activity. Dev Biol. 2007 Dec 1; 312(1):90-102.
-
Vonica A, Brivanlou AH. The left-right axis is regulated by the interplay of Coco, Xnr1 and derrière in Xenopus embryos. Dev Biol. 2007 Mar 1; 303(1):281-94.
-
Vonica A, Brivanlou AH. An obligatory caravanserai stop on the silk road to neural induction: inhibition of BMP/GDF signaling. Semin Cell Dev Biol. 2006 Feb; 17(1):117-32.
-
Chamorro MN, Schwartz DR, Vonica A, Brivanlou AH, Cho KR, Varmus HE. FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development. EMBO J. 2005 Jan 12; 24(1):73-84.
-
Bell E, Muñoz-Sanjuán I, Altmann CR, Vonica A, Brivanlou AH. Cell fate specification and competence by Coco, a maternal BMP, TGFbeta and Wnt inhibitor. Development. 2003 Apr; 130(7):1381-9.
-
Muñoz-Sanjuán I, Bell E, Altmann CR, Vonica A, Brivanlou AH. Gene profiling during neural induction in Xenopus laevis: regulation of BMP signaling by post-transcriptional mechanisms and TAB3, a novel TAK1-binding protein. Development. 2002 Dec; 129(23):5529-40.
-
Vonica A, Gumbiner BM. Zygotic Wnt activity is required for Brachyury expression in the early Xenopus laevis embryo. Dev Biol. 2002 Oct 1; 250(1):112-27.
-
Vonica A, Weng W, Gumbiner BM, Venuti JM. TCF is the nuclear effector of the beta-catenin signal that patterns the sea urchin animal-vegetal axis. Dev Biol. 2000 Jan 15; 217(2):230-43.
-
Lesnik P, Dentan C, Vonica A, Moreau M, Chapman MJ. Tissue factor pathway inhibitor activity associated with LDL is inactivated by cell- and copper-mediated oxidation. Arterioscler Thromb Vasc Biol. 1995 Aug; 15(8):1121-30.
-
Lesnik P, Vonica A, Guérin M, Moreau M, Chapman MJ. Anticoagulant activity of tissue factor pathway inhibitor in human plasma is preferentially associated with dense subspecies of LDL and HDL and with Lp(a). Arterioscler Thromb. 1993 Jul; 13(7):1066-75.
-
Dumitrascu DL, Radu D, Vonica A. The significance of low antithrombin III levels in cirrhosis. Rom J Intern Med. 1991 Jul-Dec; 29(3-4):151-4.
-
Gilles AM, Presecan E, Vonica A, Lascu I. Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme. J Biol Chem. 1991 May 15; 266(14):8784-9.
-
Lacombe ML, Sastre-Garau X, Lascu I, Vonica A, Wallet V, Thiery JP, Véron M. Overexpression of nucleoside diphosphate kinase (Nm23) in solid tumours. Eur J Cancer. 1991; 27(10):1302-7.
-
Vonica A, Vagaonescu T, Cristea A, Stancioiu N. Functional and antigenic antithrombin III in angina pectoris and acute myocardial infarction patients. Med Interne. 1990 Oct-Dec; 28(4):311-7.
-
Presecan E, Vonica A, Lascu I. Nucleoside diphosphate kinase from human erythrocytes: purification, molecular mass and subunit structure. FEBS Lett. 1989 Jul 3; 250(2):629-32.
-
Cucuianu M, Cristea A, Vonica A, Lascu I. Clinical studies on plasma antithrombin III using an antiserum prepared in our laboratories. Med Interne. 1988 Jul-Sep; 26(3):191-7.
|
Vonica's Networks
Concepts  Derived automatically from this person's publications. _
Similar People People who share similar concepts with this person. _
Same Department
People who are also in this person's primary department.
|
