URMC Research Network - Elena Bulgac

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Elena Bulgac

Title	Research Associate Prof (Part-Time)
Institution	School of Medicine and Dentistry
Department	Biochemistry and Biophysics
Address	University of Rochester Medical Center School of Medicine and Dentistry 601 Elmwood Ave, Box 712 Rochester NY 14642

Overview

Chromosomes instability of human fungal pathogen Candida albicans. Survival due to specific chromosome rearrangements.

Candida albicans is a unicellular budding fungus that forms part of normal gut or genitalia microflora. In immunocompromized humans, however, C. albicans becomes an important opportunistic pathogen that can cause mortality. C. albicans is unique among other fungal pathogens by having an ability to infect divers sites of human body, including skin, nails, mucosal surfaces, as well as any other tissues or inner organs. In the laboratory, this fungus demonstrates an impressive ability to flourish under extreme pH and temperatures, as well as in other extreme environments. C. albicans possesses an acute ability to counter act the environmental stresses and to mount adequate phenotypic responses.

Selected Publications

Ahmad A, Kravets A, Rustchenko E. Transcriptional Regulatory Circuitries in the Human Pathogen Candida albicans Involving Sense-Antisense Interactions. Genetics. 2012 Feb; 190(2):537-47.

View in: PubMed
Yang F, Yan TH, Rustchenko E, Gao PH, Wang Y, Yan L, Cao YY, Wang QJ, Ji H, Cao YB, Jiang YY. High-frequency genetic contents variations in clinical Candida albicans isolates. Biol Pharm Bull. 2011; 34(5):624-31.

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Kravets A, Qin H, Ahmad A, Bethlendy G, Gao Q, Rustchenko E. Widespread occurrence of dosage compensation in Candida albicans. PLoS One. 2010; 5(6):e10856.

View in: PubMed
Rustchenko E. Chromosome instability in Candida albicans. FEMS Yeast Res. 2007 Jan; 7(1):2-11.

View in: PubMed