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Paul Coleman

TitleProfessor Emeritus
InstitutionSchool of Medicine and Dentistry
DepartmentNeurobiology and Anatomy in the Center for Neural Development & Disease
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 645
Rochester NY 14642
 
 Selected Publications
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  1. Chouliaras L, Mastroeni D, Delvaux E, Grover A, Kenis G, Hof PR, Steinbusch HW, Coleman PD, Rutten BP, van den Hove DL. Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients. Neurobiol Aging. 2013 Sep; 34(9):2091-9.
    View in: PubMed
  2. Mastroeni D, Chouliaras L, Grover A, Liang WS, Hauns K, Rogers J, Coleman PD. Reduced RAN Expression and Disrupted Transport between Cytoplasm and Nucleus; A Key Event in Alzheimer's Disease Pathophysiology. PLoS One. 2013; 8(1):e53349.
    View in: PubMed
  3. Delvaux E, Bentley K, Stubbs V, Sabbagh M, Coleman PD. Differential processing of amyloid precursor protein in brain and in peripheral blood leukocytes. Neurobiol Aging. 2013 Jun; 34(6):1680-6.
    View in: PubMed
  4. Berchtold NC, Coleman PD, Cribbs DH, Rogers J, Gillen DL, Cotman CW. Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease. Neurobiol Aging. 2013 Jun; 34(6):1653-61.
    View in: PubMed
  5. Cribbs DH, Berchtold NC, Perreau V, Coleman PD, Rogers J, Tenner AJ, Cotman CW. Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study. J Neuroinflammation. 2012; 9:179.
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  6. Patel S, Shah RJ, Coleman P, Sabbagh M. Potential peripheral biomarkers for the diagnosis of Alzheimer's disease. Int J Alzheimers Dis. 2011; 2011:572495.
    View in: PubMed
  7. Rogers J, Mastroeni D, Grover A, Delvaux E, Whiteside C, Coleman PD. The epigenetics of Alzheimer's disease--additional considerations. Neurobiol Aging. 2011 Jul; 32(7):1196-7.
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  8. Mastroeni D, Grover A, Delvaux E, Whiteside C, Coleman PD, Rogers J. Epigenetic mechanisms in Alzheimer's disease. Neurobiol Aging. 2011 Jul; 32(7):1161-80.
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  9. Coleman PD. What's next? Neurobiol Aging. 2010 Aug; 31(8):1493.
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  10. Mastroeni D, McKee A, Grover A, Rogers J, Coleman PD. Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease. PLoS One. 2009; 4(8):e6617.
    View in: PubMed
  11. Mastroeni D, Grover A, Delvaux E, Whiteside C, Coleman PD, Rogers J. Epigenetic changes in Alzheimer's disease: decrements in DNA methylation. Neurobiol Aging. 2010 Dec; 31(12):2025-37.
    View in: PubMed
  12. Berchtold NC, Cribbs DH, Coleman PD, Rogers J, Head E, Kim R, Beach T, Miller C, Troncoso J, Trojanowski JQ, Zielke HR, Cotman CW. Gene expression changes in the course of normal brain aging are sexually dimorphic. Proc Natl Acad Sci U S A. 2008 Oct 7; 105(40):15605-10.
    View in: PubMed
  13. Mastroeni D, Grover A, Leonard B, Joyce JN, Coleman PD, Kozik B, Bellinger DL, Rogers J. Microglial responses to dopamine in a cell culture model of Parkinson's disease. Neurobiol Aging. 2009 Nov; 30(11):1805-17.
    View in: PubMed
  14. Baskerville KA, Kent C, Personett D, Lai WR, Park PJ, Coleman P, McKinney M. Aging elevates metabolic gene expression in brain cholinergic neurons. Neurobiol Aging. 2008 Dec; 29(12):1874-93.
    View in: PubMed
  15. Mhyre TR, Loy R, Tariot PN, Profenno LA, Maguire-Zeiss KA, Zhang D, Coleman PD, Federoff HJ. Proteomic analysis of peripheral leukocytes in Alzheimer's disease patients treated with divalproex sodium. Neurobiol Aging. 2008 Nov; 29(11):1631-43.
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  16. Coleman P, Federoff H, Kurlan R. A focus on the synapse for neuroprotection in Alzheimer disease and other dementias. Neurology. 2004 Oct 12; 63(7):1155-62.
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  17. Coleman P, Kurlan R, Crook R, Werner J, Hardy J. A new presenilin Alzheimer's disease case confirms the helical alignment of pathogenic mutations in transmembrane domain 5. Neurosci Lett. 2004 Jul 8; 364(3):139-40.
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  18. Bishop G, Coleman P, Crutcher K, David D, Kinoshita J, LaFerla F, Leissring M, Shepherd J, Therianos S, Wang R, Wilson A, Zhu M. Live discussion: how the other half lives - or the what, how, and where, of the AbetaPP intracellular domain. J Alzheimers Dis. 2004 Apr; 6(2):193-9.
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  19. Therianos S, Zhu M, Pyun E, Coleman PD. Single-channel quantitative multiplex reverse transcriptase-polymerase chain reaction for large numbers of gene products differentiates nondemented from neuropathological Alzheimer's disease. Am J Pathol. 2004 Mar; 164(3):795-806.
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  20. Coleman PD. How old is old? Neurobiol Aging. 2004 Jan; 25(1):1.
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  21. Coleman P, Finch C, Joseph J. The need for multiple time points in aging studies. Neurobiol Aging. 2004 Jan; 25(1):3-4.
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  22. Coleman PD, Yao PJ. Synaptic slaughter in Alzheimer's disease. Neurobiol Aging. 2003 Dec; 24(8):1023-7.
    View in: PubMed
  23. Hurley SD, Coleman PD. Facial nerve axotomy in aged and young adult rats: analysis of the glial response. Neurobiol Aging. 2003 May-Jun; 24(3):511-8.
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  24. Yao PJ, Zhu M, Pyun EI, Brooks AI, Therianos S, Meyers VE, Coleman PD. Defects in expression of genes related to synaptic vesicle trafficking in frontal cortex of Alzheimer's disease. Neurobiol Dis. 2003 Mar; 12(2):97-109.
    View in: PubMed
  25. Yao PJ, O'Herron TM, Coleman PD. Immunohistochemical characterization of clathrin assembly protein AP180 and synaptophysin in human brain. Neurobiol Aging. 2003 Jan-Feb; 24(1):173-8.
    View in: PubMed
  26. Coleman PD, Lerttamrab M, Gao J. Generation of single-frequency coherent transition radiation by a prebunched electron beam traversing a vacuum beam tunnel in a periodic medium. Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Dec; 66(6 Pt 2):066502.
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  27. Yao PJ, Coleman PD, Calkins DJ. High-resolution localization of clathrin assembly protein AP180 in the presynaptic terminals of mammalian neurons. J Comp Neurol. 2002 May 27; 447(2):152-62.
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  28. Callahan LM, Vaules WA, Coleman PD. Progressive reduction of synaptophysin message in single neurons in Alzheimer disease. J Neuropathol Exp Neurol. 2002 May; 61(5):384-95.
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  29. Kelz MB, Dent GW, Therianos S, Marciano PG, McIntosh TK, Coleman PD, Eberwine JH. Single-cell antisense RNA amplification and microarray analysis as a tool for studying neurological degeneration and restoration. Sci Aging Knowledge Environ. 2002 Jan 9; 2002(1):re1.
    View in: PubMed
  30. Chang JW, Young DA, Coleman PD, O'Banion MK. Two-dimensional gel analysis of secreted proteins induced by interleukin-1 beta in rat astrocytes. Neurochem Int. 2001 Nov-Dec; 39(5-6):349-59.
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  31. Yao PJ, Weimer JM, O'Herron TM, Coleman PD. Clathrin assembly protein AP-2 is detected in both neurons and glia, and its reduction is prominent in layer II of frontal cortex in Alzheimer's disease. Neurobiol Aging. 2000 Nov-Dec; 21(6):921-9.
    View in: PubMed
  32. Utal AK, Coleman PD. Non-HPLC separation of water-soluble choline metabolites by two-dimensional high voltage electrophoresis and thin layer chromatography. J Neurosci Methods. 1999 Aug 1; 90(1):13-21.
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  33. Callahan LM, Vaules WA, Coleman PD. Quantitative decrease in synaptophysin message expression and increase in cathepsin D message expression in Alzheimer disease neurons containing neurofibrillary tangles. J Neuropathol Exp Neurol. 1999 Mar; 58(3):275-87.
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  34. Morsch R, Simon W, Coleman PD. Neurons may live for decades with neurofibrillary tangles. J Neuropathol Exp Neurol. 1999 Feb; 58(2):188-97.
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  35. Yao PJ, Morsch R, Callahan LM, Coleman PD. Changes in synaptic expression of clathrin assembly protein AP180 in Alzheimer's disease analysed by immunohistochemistry. Neuroscience. 1999; 94(2):389-94.
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  36. Smith ML, Johanson RA, Rogers KE, Coleman PD, Slemmon JR. Identification of a neuronal calmodulin-binding peptide, CAP-19, containing an IQ motif. Brain Res Mol Brain Res. 1998 Nov 12; 62(1):12-24.
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  37. Utal AK, Stopka AL, Roy M, Coleman PD. PEP-19 immunohistochemistry defines the basal ganglia and associated structures in the adult human brain, and is dramatically reduced in Huntington's disease. Neuroscience. 1998 Oct; 86(4):1055-63.
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  38. Yao PJ, Coleman PD. Reduced O-glycosylated clathrin assembly protein AP180: implication for synaptic vesicle recycling dysfunction in Alzheimer's disease. Neurosci Lett. 1998 Aug 7; 252(1):33-6.
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  39. Chow N, Cox C, Callahan LM, Weimer JM, Guo L, Coleman PD. Expression profiles of multiple genes in single neurons of Alzheimer's disease. Proc Natl Acad Sci U S A. 1998 Aug 4; 95(16):9620-5.
    View in: PubMed
  40. Anderton BH, Callahan L, Coleman P, Davies P, Flood D, Jicha GA, Ohm T, Weaver C. Dendritic changes in Alzheimer's disease and factors that may underlie these changes. Prog Neurobiol. 1998 Aug; 55(6):595-609.
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  41. Combs CK, Coleman PD, O'Banion MK. Developmental regulation and PKC dependence of Alzheimer's-type tau phosphorylations in cultured fetal rat hippocampal neurons. Brain Res Dev Brain Res. 1998 Apr 17; 107(1):143-58.
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  42. Yao PJ, Coleman PD. Reduction of O-linked N-acetylglucosamine-modified assembly protein-3 in Alzheimer's disease. J Neurosci. 1998 Apr 1; 18(7):2399-411.
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  43. Utal AK, Stopka AL, Coleman PD. Interleukin-1 beta stimulates mitogen-activated protein kinase in U373 astrocytoma cells without the production of lipid second messengers. Neurochem Res. 1998 Feb; 23(2):235-42.
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  44. Callahan LM, Chow N, Cheetham JE, Cox C, Coleman PD. Analysis of message expression in single neurons of Alzheimer's disease brain. Neurobiol Aging. 1998 Jan-Feb; 19(1 Suppl):S99-105.
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  45. Cheetham JE, Coleman PD, Chow N. Isolation of single immunohistochemically identified whole neuronal cell bodies from post-mortem human brain for simultaneous analysis of multiple gene expression. J Neurosci Methods. 1997 Nov 7; 77(1):43-8.
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  46. Song J, Combs CK, Pilcher WH, Song LY, Utal AK, Coleman PD. Low initial tau phosphorylation in human brain biopsy samples. Neurobiol Aging. 1997 Sep-Oct; 18(5):475-81.
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  47. Coleman PD. Research uses of neuropathological data. Neurobiol Aging. 1997 Jul-Aug; 18(4 Suppl):S97-8.
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  48. O'Banion MK, Chang JW, Kaplan MD, Yermakova A, Coleman PD. Glial and neuronal expression of cyclooxygenase-2: relevance to Alzheimer's disease. Adv Exp Med Biol. 1997; 433:177-80.
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  49. O'Banion MK, Chang JW, Coleman PD. Decreased expression of prostaglandin G/H synthase-2 (PGHS-2) in Alzheimer's disease brain. Adv Exp Med Biol. 1997; 407:171-7.
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  50. Chang JW, Coleman PD, O'Banion MK. Prostaglandin G/H synthase-2 (cyclooxygenase-2) mRNA expression is decreased in Alzheimer's disease. Neurobiol Aging. 1996 Sep-Oct; 17(5):801-8.
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  51. O'Banion MK, Miller JC, Chang JW, Kaplan MD, Coleman PD. Interleukin-1 beta induces prostaglandin G/H synthase-2 (cyclooxygenase-2) in primary murine astrocyte cultures. J Neurochem. 1996 Jun; 66(6):2532-40.
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  52. Cheetham JE, Martzen MR, Kazee AM, Coleman PD. Gap-43 message levels in anterior cerebellum in Alzheimer's disease. Brain Res Mol Brain Res. 1996 Feb; 36(1):145-51.
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  53. DiLoreto DA, Martzen MR, del Cerro C, Coleman PD, del Cerro M. Müller cell changes precede photoreceptor cell degeneration in the age-related retinal degeneration of the Fischer 344 rat. Brain Res. 1995 Nov 6; 698(1-2):1-14.
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  54. Coleman PD. Possible pharmacological approaches to slowing down Alzheimer's disease progression. Neurobiol Aging. 1995 Nov-Dec; 16(6):873-5; discussion 875-6, 879-82.
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  55. West MJ, Coleman PD, Flood DG, Troncoso JC. [Differential neuronal loss in the hippocampus in normal aging and in patients with Alzheimer disease]. Ugeskr Laeger. 1995 May 29; 157(22):3190-3.
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  56. Callahan LM, Coleman PD. Neurons bearing neurofibrillary tangles are responsible for selected synaptic deficits in Alzheimer's disease. Neurobiol Aging. 1995 May-Jun; 16(3):311-4.
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  57. Utal AK, Coleman PD. Schmitt neurological sciences symposium: the cytoskeleton in Alzheimer's disease. Neurobiol Aging. 1995 Jan-Feb; 16(1):111-6.
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  58. West MJ, Coleman PD, Flood DG, Troncoso JC. Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet. 1994 Sep 17; 344(8925):769-72.
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  59. Callahan LM, Selski DJ, Martzen MR, Cheetham JE, Coleman PD. Preliminary evidence: decreased GAP-43 message in tangle-bearing neurons relative to adjacent tangle-free neurons in Alzheimer's disease parahippocampal gyrus. Neurobiol Aging. 1994 May-Jun; 15(3):381-6.
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  60. Wengenack TM, Slemmon JR, Ordy JM, Dunlap WP, Coleman PD. Vascular and cellular protein changes precede hippocampal pyramidal cell loss following global ischemia in the rat. Adv Exp Med Biol. 1994; 366:436-8.
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  61. Coleman PD. Toward rational therapy for Alzheimer's disease. Neurobiol Aging. 1994; 15 Suppl 2:S77-8.
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  62. Coleman PD. Report of Alzheimer's disease Working Group B. Neurobiol Aging. 1994; 15 Suppl 2:S23-7.
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  63. Martzen MR, Nagy A, Coleman PD, Zwiers H. Altered phosphorylation of growth-associated protein B50/GAP-43 in Alzheimer disease with high neurofibrillary tangle density. Proc Natl Acad Sci U S A. 1993 Dec 1; 90(23):11187-91.
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  64. Flood DG, Coleman PD. Dendritic regression dissociated from neuronal death but associated with partial deafferentation in aging rat supraoptic nucleus. Neurobiol Aging. 1993 Nov-Dec; 14(6):575-87.
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  65. Hamill RW, Markesbery WR, McDaniel K, Coleman PD. Characterization of brain samples in studies of aging, Alzheimer's, and other neurodegenerative diseases. Neurobiol Aging. 1993 Nov-Dec; 14(6):539-45.
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  66. Selski DJ, Thomas NE, Coleman PD, Rogers KE. The human brain homeogene, DLX-2: cDNA sequence and alignment with the murine homologue. Gene. 1993 Oct 15; 132(2):301-3.
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  67. Ordy JM, Wengenack TM, Bialobok P, Coleman PD, Rodier P, Baggs RB, Dunlap WP, Kates B. Selective vulnerability and early progression of hippocampal CA1 pyramidal cell degeneration and GFAP-positive astrocyte reactivity in the rat four-vessel occlusion model of transient global ischemia. Exp Neurol. 1993 Jan; 119(1):128-39.
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  68. Coleman PD, Kazee AM, Lapham L, Eskin T, Rogers K. Reduced GAP-43 message levels are associated with increased neurofibrillary tangle density in the frontal association cortex (area 9) in Alzheimer's disease. Neurobiol Aging. 1992 Nov-Dec; 13(6):631-9.
    View in: PubMed
  69. Eberwine J, Yeh H, Miyashiro K, Cao Y, Nair S, Finnell R, Zettel M, Coleman P. Analysis of gene expression in single live neurons. Proc Natl Acad Sci U S A. 1992 Apr 1; 89(7):3010-4.
    View in: PubMed
  70. Collier TJ, Coleman PD. Divergence of biological and chronological aging: evidence from rodent studies. Neurobiol Aging. 1991 Nov-Dec; 12(6):685-93.
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  71. Coleman PD, Flood DG. Net dendritic stability of layer II pyramidal neurons in F344 rat entorhinal cortex from 12 to 37 months. Neurobiol Aging. 1991 Sep-Oct; 12(5):535-41.
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  72. Coleman PD, Rogers KE, Flood DG. The neuropil and GAP-43/B-50 in normally aging and Alzheimer's disease human brain. Prog Brain Res. 1991; 89:263-9.
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  73. Coleman PD, Rogers KE, Flood DG. Neuronal plasticity in normal aging and deficient plasticity in Alzheimer's disease: a proposed intercellular signal cascade. Prog Brain Res. 1990; 86:75-87.
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  74. Flood DG, Coleman PD. Hippocampal plasticity in normal aging and decreased plasticity in Alzheimer's disease. Prog Brain Res. 1990; 83:435-43.
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  75. Coleman PD. How old is old? Neurobiol Aging. 1989 Mar-Apr; 10(2):115.
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  76. Flood DG, Coleman PD. Neuron numbers and sizes in aging brain: comparisons of human, monkey, and rodent data. Neurobiol Aging. 1988 Sep-Dec; 9(5-6):453-63.
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  77. Coleman PD, Flood DG, West MJ. Volumes of the components of the hippocampus in the aging F344 rat. J Comp Neurol. 1987 Dec 8; 266(2):300-6.
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  78. Coleman PD, Flood DG. Neuron numbers and dendritic extent in normal aging and Alzheimer's disease. Neurobiol Aging. 1987 Nov-Dec; 8(6):521-45.
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  79. Felten SY, Bellinger DL, Collier TJ, Coleman PD, Felten DL. Decreased sympathetic innervation of spleen in aged Fischer 344 rats. Neurobiol Aging. 1987 Mar-Apr; 8(2):159-65.
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  80. Flood DG, Coleman PD. Failed compensatory dendritic growth as a pathophysiological process in Alzheimer's disease. Can J Neurol Sci. 1986 Nov; 13(4 Suppl):475-9.
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  81. Coleman PD, Buell SJ, Magagna L, Flood DG, Curcio CA. Stability of dendrites in cortical barrels of C57BL/6N mice between 4 and 45 months. Neurobiol Aging. 1986 Mar-Apr; 7(2):101-5.
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  82. Coleman PD, Flood DG. Dendritic proliferation in the aging brain as a compensatory repair mechanism. Prog Brain Res. 1986; 70:227-37.
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  83. Kaplan AS, Gash DM, Flood DG, Coleman PD. A Golgi study of hypothalamic transplants in young and old host rats. Neurobiol Aging. 1985; 6(3):205-11.
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  84. Hornberger JC, Buell SJ, Flood DG, McNeill TH, Coleman PD. Stability of numbers but not size of mouse forebrain cholinergic neurons to 53 months. Neurobiol Aging. 1985; 6(4):269-75.
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  85. Curcio CA, Coleman PD. Stability of neuron number in cortical barrels of aging mice. J Comp Neurol. 1982 Dec 1; 212(2):158-72.
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  86. Goldman G, Coleman PD. Neuron numbers in locus coeruleus do not change with age in Fisher 344 rat. Neurobiol Aging. 1981; 2(1):33-6.
    View in: PubMed

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