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John Leddy

TitleProfessor Emeritus
InstitutionSchool of Medicine and Dentistry
DepartmentMedicine
Address8 Charleston Drive
Mendon NY 14506
 
 Awards And Honors
1956     Alpha Omega Alpha  | Columbia University
1962 - 1965Special Fellow  | The National Foundation
1965 - 1970Senior Investigator  | Arthritis Foundation
1969 - 1970Russell L. Cecil Fellow  | Arthritis Foundation
1974     Excellence in Teaching Award  | University of Rochester School of Medicine and Dentistry
1977 - 1981Member, Allergy-Immunology Research Committee  | NIAID
1978 - 1984Director, Center for Interdisciplinary Research on Immunologic Diseases  | NIAID, NIH
1981     Buswell Faculty Award  | University of Rochester
1981 - 1995Advisory Commettee, The Ernest Witebsky Center for Immunology
1983     Excellence in Teaching Award  | University of Rochester School of Medicine and Dentistry
1983 - 1986Member, Center Grants Review Committee  | The Arthritis Foundation
1988     Excellence in Teaching Award  | University of Rochester School of Medicine and Dentistry
1996     Excellence in Teaching Award  | University of Rochester School of Medicine and Dentistry
 
 Selected Publications
List All   |   Timeline
  1. Epstein LH, Wright SM, Paluch RA, Leddy J, Hawk LW, Jaroni JL, Saad FG, Crystal-Mansour S, Lerman C. Food hedonics and reinforcement as determinants of laboratory food intake in smokers. Physiol Behav. 2004 May; 81(3):511-7.
    View in: PubMed
  2. Vladutiu GD, Bennett MJ, Fisher NM, Smail D, Boriack R, Leddy J, Pendergast DR. Phenotypic variability among first-degree relatives with carnitine palmitoyltransferase II deficiency. Muscle Nerve. 2002 Oct; 26(4):492-8.
    View in: PubMed
  3. Stamos BD, Leddy JP. Closed flexor tendon disruption in athletes. Hand Clin. 2000 Aug; 16(3):359-65.
    View in: PubMed
  4. Feldweg AM, Leddy JP. Drug interactions affecting the efficacy of corticosteroid therapy a brief review with an illustrative case. J Clin Rheumatol. 1999 Jun; 5(3):143-50.
    View in: PubMed
  5. Popescu NA, Sheehan MG, Kouides PA, Loughner JE, Condemi JJ, Looney RJ, Leddy JP. Allergic reactions to cyclophosphamide: delayed clinical expression associated with positive immediate skin tests to drug metabolites in five patients. J Allergy Clin Immunol. 1996 Jan; 97(1 Pt 1):26-33.
    View in: PubMed
  6. Wang X, Fleischer DT, Whitehead WT, Haviland DL, Rosenfeld SI, Leddy JP, Snyderman R, Wetsel RA. Inherited human complement C5 deficiency. Nonsense mutations in exons 1 (Gln1 to Stop) and 36 (Arg1458 to Stop) and compound heterozygosity in three African-American families. J Immunol. 1995 May 15; 154(10):5464-71.
    View in: PubMed
  7. Leddy JP, Wilkinson SL, Kissel GE, Passador ST, Falany JL, Rosenfeld SI. Erythrocyte membrane proteins reactive with IgG (warm-reacting) anti-red blood cell autoantibodies: II. Antibodies coprecipitating band 3 and glycophorin A. Blood. 1994 Jul 15; 84(2):650-6.
    View in: PubMed
  8. Kafka SP, Condemi JJ, Marsh DO, Leddy JP. Mononeuritis multiplex and vasculitis. Association with anti-neutrophil cytoplasmic autoantibody. Arch Neurol. 1994 Jun; 51(6):565-8.
    View in: PubMed
  9. Leddy JP, Falany JL, Kissel GE, Passador ST, Rosenfeld SI. Erythrocyte membrane proteins reactive with human (warm-reacting) anti-red cell autoantibodies. J Clin Invest. 1993 Apr; 91(4):1672-80.
    View in: PubMed
  10. Francis CW, Brenner B, Leddy JP, Marder VJ. Angioedema during therapy with recombinant tissue plasminogen activator. Br J Haematol. 1991 Apr; 77(4):562-3.
    View in: PubMed
  11. Houle JJ, Leddy JP, Rosenfeld SI. Secretion of the terminal complement proteins, C5-C9, by human platelets. Clin Immunol Immunopathol. 1989 Mar; 50(3):385-93.
    View in: PubMed
  12. Rosenfeld SI, Ryan DH, Looney RJ, Anderson CL, Abraham GN, Leddy JP. Human Fc gamma receptors: stable inter-donor variation in quantitative expression on platelets correlates with functional responses. J Immunol. 1987 May 1; 138(9):2869-73.
    View in: PubMed
  13. Rosenfeld SI, Jenkins DE, Leddy JP. Enhanced reactive lysis of paroxysmal nocturnal hemoglobinuria erythrocytes. Studies on C9 binding and incorporation into high molecular weight complexes. J Exp Med. 1986 Oct 1; 164(4):981-97.
    View in: PubMed
  14. Rosenfeld SI, Looney RJ, Leddy JP, Phipps DC, Abraham GN, Anderson CL. Human platelet Fc receptor for immunoglobulin G. Identification as a 40,000-molecular-weight membrane protein shared by monocytes. J Clin Invest. 1985 Dec; 76(6):2317-22.
    View in: PubMed
  15. Packman CH, Rosenfeld SI, Leddy JP. High-density lipoprotein and its apolipoproteins inhibit cytolytic activity of complement. Studies on the nature of inhibitory moiety. Biochim Biophys Acta. 1985 Jan 10; 812(1):107-15.
    View in: PubMed
  16. Rosenfeld SI, Jenkins DE, Leddy JP. Enhanced reactive lysis of paroxysmal nocturnal hemoglobinuria erythrocytes by C5b-9 does not involve increased C7 binding or cell-bound C3b. J Immunol. 1985 Jan; 134(1):506-11.
    View in: PubMed
  17. Marinetti GV, Rosenfeld SI, Thiem PA, Condemi JJ, Leddy JP. Beta-adrenergic receptors of human leukocytes. Studies with intact mononuclear and polymorphonuclear cells and membranes comparing two radioligands in the presence and absence of chloroquine. Biochem Pharmacol. 1983 Jul 1; 32(13):2033-43.
    View in: PubMed
  18. Rosenfeld SI, Packman CH, Leddy JP. Inhibition of the lytic action of cell-bound terminal complement components by human high density lipoproteins and apoproteins. J Clin Invest. 1983 Apr; 71(4):795-808.
    View in: PubMed
  19. Heal JM, Bailey G, Helphingstine C, Thiem PA, Leddy JP, Buchholz DH, Nusbacher J. Non-centrifugal plasma collection using cross-flow membrane plasmapheresis. Vox Sang. 1983 Mar; 44(3):156-66.
    View in: PubMed
  20. Suchman AL, Condemi JJ, Leddy JP. Seizure after pulse therapy with methyl prednisolone. Arthritis Rheum. 1983 Jan; 26(1):117.
    View in: PubMed
  21. Rosenfeld SI, Packman CH, Jenkins DE, Countryman JK, Leddy JP. Complement lysis of human erythrocytes. III. Differing effectiveness of human and guinea pig C9 on normal and paroxysmal nocturnal hemoglobinuria cells. J Immunol. 1980 Nov; 125(5):2063-8.
    View in: PubMed
  22. Packman CH, Rosenfeld SI, Jenkins DE, Leddy JP. Complement lysis of human erythrocytes. II. A unique interaction of human C8 and C9 with paroxysmal nocturnal hemoglobinuria erythrocytes. J Immunol. 1980 Jun; 124(6):2818-23.
    View in: PubMed
  23. Packman CH, Rosenfeld SI, Jenkins DE, Thiem PA, Leddy JP. Complement lysis of human erythrocytes. Differeing susceptibility of two types of paroxysmal nocturnal hemoglobinuria cells to C5b-9. J Clin Invest. 1979 Aug; 64(2):428-33.
    View in: PubMed
  24. Leddy JP, Steigbigel RT. Complement, serum bactericidal activity, and disseminated gram-negative infection. Ann Intern Med. 1979 Jun; 90(6):984-5.
    View in: PubMed
  25. Nusbacher J, Rosenfeld SI, Leddy JP, Klemperer MR, MacPherson JL. The leukokinetic changes and complement activation associated with filtration leukapheresis. Exp Hematol. 1979; 7(4 Suppl):24-30.
    View in: PubMed
  26. Nusbacher J, Rosenfeld SI, MacPherson JL, Thiem PA, Leddy JP. Nylon fiber leukapheresis: associated complement component changes and cranulocytopenia. Blood. 1978 Feb; 51(2):359-65.
    View in: PubMed
  27. Martin SE, Breckenridge RT, Rosenfeld SI, Leddy JP. Responses of human platelets to immunologic stimuli: independent roles for complement and IgG in zymosan activation. J Immunol. 1978 Jan; 120(1):9-14.
    View in: PubMed
  28. Schaller JG, Gilliland BG, Ochs HD, Leddy JP, Agodoa LC, Rosenfeld SI. Severe systemic lupus erythematosus with nephritis in a boy with deficiency of the fourth component of complement. Arthritis Rheum. 1977 Nov-Dec; 20(8):1519-25.
    View in: PubMed
  29. Staples PJ, Boujak J, Douglas RG, Leddy JP. Disseminated candidiasis in a previously healthy girl: implication of a leukocyte candidacidal defect. Clin Immunol Immunopathol. 1977 Mar; 7(2):157-67.
    View in: PubMed
  30. Breckenridge RT, Rosenfeld SI, Graff KS, Leddy JP. Hereditary C5 deficiency in man. III. Studies of hemostasis and platelet responses to zymosan. J Immunol. 1977 Jan; 118(1):12-6.
    View in: PubMed
  31. Leddy JP, Simons RL, Douglas RG. Effect of selective complement deficiency on the rate of neutralization of enveloped viruses by human sera. J Immunol. 1977 Jan; 118(1):28-34.
    View in: PubMed
  32. Packman CH, Rosenfeld SI, Weed RI, Leddy JP. Complement-induced ultrastructural membrane lesions: requirement for terminal components. J Immunol. 1976 Nov; 117(5 Pt.2):1883-9.
    View in: PubMed
  33. Rosenfeld SI, Kelly ME, Leddy JP. Hereditary deficiency of the fifth component of complement in man. I. Clinical, immunochemical, and family studies. J Clin Invest. 1976 Jun; 57(6):1626-34.
    View in: PubMed
  34. Rosenfeld SI, Baum J, Steigbigel RT, Leddy JP. Hereditary deficiency of the fifth component of complement in man. II. Biological properties of C5-deficient human serum. J Clin Invest. 1976 Jun; 57(6):1635-43.
    View in: PubMed
  35. Krieger H, Leddy JP, Breckenridge RT. Studies on a circulating anticoagulant in systemic lupus erythematosus: evidence for inhibition of the function of activated plasma thromboplastin antecedent (factor XIa). Blood. 1975 Aug; 46(2):189-97.
    View in: PubMed
  36. Bell DA, Thiem PA, Vaughan JH, Leddy JP. Studies with human leukocyte lysosomes. Evidence for antilysosome antibodies in lupus erythematosus and for the presence of lysosomal antigen in inflammatory diseases. J Clin Invest. 1975 Feb; 55(2):256-68.
    View in: PubMed
  37. Leddy JP, Griggs RC, Klemperer MR, Frank MM. Hereditary complement (C2) deficiency with dermatomyositis. Am J Med. 1975 Jan; 58(1):83-91.
    View in: PubMed
  38. Frank MM, Leddy JP, Gaither T, Heusinkveld RS, Breckenridge RT, Klemperer MR. Hereditary C6 deficiency in man. Birth Defects Orig Artic Ser. 1975; 11(1):318-21.
    View in: PubMed
  39. Leddy JP, Frank MM, Gaither T, Baum J, Klemperer MR. Hereditary deficiency of the sixth component of complement in man. I. Immunochemical, biologic, and family studies. J Clin Invest. 1974 Feb; 53(2):544-53.
    View in: PubMed
  40. Heusinkveld RS, Leddy JP, Klemperer MR, Breckenridge RT. Hereditary deficiency of the sixth component of complement in man. II. Studies of hemostasis. J Clin Invest. 1974 Feb; 53(2):554-8.
    View in: PubMed
  41. Taft EG, Grossman J, Abraham GN, Leddy JP, Lichtman MA. Pseudoleukocytosis due to cryoprotein crystals. Am J Clin Pathol. 1973 Nov; 60(5):669-71.
    View in: PubMed
  42. Grossman J, Abraham GN, Leddy JP, Condemi JL. Crystalglobulinemia. Ann Intern Med. 1972 Sep; 77(3):395-400.
    View in: PubMed
  43. Bell DA, Leblond PF, Leddy JP, Lauf PK, LaCelle PL, Weed RI. Immune hemolysis. I. Differing susceptibility of three genetic types of sheep red cells. J Immunol. 1972 Feb; 108(2):467-74.
    View in: PubMed
  44. Leddy JP, Thiem PA, Leblond PF, Weed RI, Lauf PK. Immune hemolysis. II. Studies on the mechanism of enhanced lysis of sheep red cells in a high K + medium. J Immunol. 1972 Feb; 108(2):475-82.
    View in: PubMed
  45. Abraham GN, Leddy JP, Grossman J, Condemi JJ. Properties of crystalline IgG3 globulin. Biochem Biophys Res Commun. 1972 Jan 14; 46(1):162-6.
    View in: PubMed
  46. Leddy JP. Beyond the Coombs test. N Engl J Med. 1971 Jul 29; 285(5):289-90.
    View in: PubMed
  47. Mathison DA, Condemi JJ, Leddy JP, Callerame ML, Panner BJ, Vaughan JH. Purpura, arthralgia, and IgM-IgM cryoglobulinemia with rheumatoid factor acrivity. Response to cyclophosphamide and splenectomy. Ann Intern Med. 1971 Mar; 74(3):383-90.
    View in: PubMed
  48. Leddy JP, Whittemore NB, Weed RI. Human erythrocyte membranes: effect of lipid extraction on binding of IgG ("warm") autoantibodies and Rh isoantibodies. Vox Sang. 1970 Nov-Dec; 19(5):444-50.
    View in: PubMed
  49. Leddy JP, Peterson P, Yeaw MA, Bakemeier RF. Patterns of serologic specificity of human gamma-G erythrocyte autoantibodies. Correlation of antibody specificity with complement-fixing behavior. J Immunol. 1970 Sep; 105(3):677-86.
    View in: PubMed
  50. Gilliland BC, Leddy JP, Vaughan JH. The detection of cell-bound antibody on complement-coated human red cells. J Clin Invest. 1970 May; 49(5):898-906.
    View in: PubMed
  51. Leddy JP. Reactivity of human gamma G erythrocyte autoantibodies with fetal, autologous and maternal red cells. Vox Sang. 1969 Dec; 17(6):525-35.
    View in: PubMed
  52. Bakemeier RF, Leddy JP. Erythrocyte autoantibody associated with alpha-methyldopa: heterogeneity of structure and specificity. Blood. 1968 Jul; 32(1):1-14.
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  53. Croft JD, Swisher SN, Gilliland BC, Bakemeier RF, Leddy JP, Weed RI. Coombs'-test positivity induced by drugs. Mechanisms of immunologic reactions and red cell destruction. Ann Intern Med. 1968 Jan; 68(1):176-87.
    View in: PubMed
  54. Mongan ES, Leddy JP, Atwater EC, Barnett EV. Direct antiglobulin (Coombs) reactions in patients with connective tissue diseases. Arthritis Rheum. 1967 Dec; 10(6):502-8.
    View in: PubMed
  55. Leddy JP, Bakemeier RF. A relationship of direct Coombs test pattern to autoantibody specificity in acquired hemolytic anemia. Proc Soc Exp Biol Med. 1967 Jul; 125(3):808-11.
    View in: PubMed
  56. Swisher SN, Trabold N, Leddy JP, Vaughan J. Clinical correlations of the direct antiglobulin reaction. Ann N Y Acad Sci. 1965 Jun 30; 124(2):441-7.
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  57. Barnett EV, Leddy JP, Condemi JJ, Vaughan JH. Antinuclear factors in rheumatoid arthritis. Ann N Y Acad Sci. 1965 Jun 30; 124(2):896-903.
    View in: PubMed
  58. LEDDY JP, BAKEMEIER RF. STRUCTURAL ASPECTS OF HUMAN ERYTHROCYTE AUTOANTIBODIES. I. L CHAIN TYPES AND ELECTROPHORETIC DISPERSION. J Exp Med. 1965 Jan 1; 121:1-17.
    View in: PubMed
  59. BARNETT EV, CONDEMI JJ, LEDDY JP, VAUGHAN JH. GAMMA-2, GAMMA-1A AND GAMMA-1M ANTINUCLEAR FACTORS IN HUMAN SERA. J Clin Invest. 1964 Jun; 43:1104-15.
    View in: PubMed
  60. KAGEN LJ, LEDDY JP, BECKER EL. THE PRESENCE OF TWO PERMEABILITY GLOBULINS IN HUMAN SERUM. J Clin Invest. 1963 Aug; 42:1353-61.
    View in: PubMed
  61. LEDDY JP, TRABOLD NC, VAUGHAN JH, SWISHER SN. The unitary nature of "complete" and "incomplete" pathologic cold hemagglutinins. Blood. 1962 Mar; 19:379-98.
    View in: PubMed

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