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Peter Gibbs

TitleResearch Associate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentBiochemistry and Biophysics
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester NY 14642
 
 Selected Publications
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  1. Christensen LL, Tobiasen H, Holm A, Schepeler T, Ostenfeld MS, Thorsen K, Rasmussen MH, Birkenkamp-Demtroeder K, Sieber OM, Gibbs P, Lubinski J, Lamy P. MiRNA-362-3p induces cell cycle arrest through targeting of E2F1, USF2 and PTPN1 and is associated with recurrence of colorectal cancer. Int J Cancer. 2013 Jul; 133(1):67-78.
    View in: PubMed
  2. Miralem T, Lerner-Marmarosh N, Gibbs PE, Tudor C, Hagen FK, Maines MD. The human biliverdin reductase-based peptide fragments and biliverdin regulate protein kinase Cd activity: the peptides are inhibitors or substrate for the protein kinase C. J Biol Chem. 2012 Jul 13; 287(29):24698-712.
    View in: PubMed
  3. Gibbs PE, Tudor C, Maines MD. Biliverdin reductase: more than a namesake - the reductase, its Peptide fragments, and biliverdin regulate activity of the three classes of protein kinase C. Front Pharmacol. 2012; 3:31.
    View in: PubMed
  4. Gibbs PE, Miralem T, Lerner-Marmarosh N, Tudor C, Maines MD. Formation of ternary complex of human biliverdin reductase-protein kinase Cd-ERK2 protein is essential for ERK2-mediated activation of Elk1 protein, nuclear factor-?B, and inducible nitric-oxidase synthase (iNOS). J Biol Chem. 2012 Jan 6; 287(2):1066-79.
    View in: PubMed
  5. Tie J, Gibbs P, Lipton L, Christie M, Jorissen RN, Burgess AW, Croxford M, Jones I, Langland R, Kosmider S, McKay D, Bollag G, Nolop K, Sieber OM, Desai J. Optimizing targeted therapeutic development: analysis of a colorectal cancer patient population with the BRAF(V600E) mutation. Int J Cancer. 2011 May 1; 128(9):2075-84.
    View in: PubMed
  6. Ding B, Gibbs PE, Brookes PS, Maines MD. The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters ß-adrenergic receptor ligand-mediated cardiac dysfunction. FASEB J. 2011 Jan; 25(1):301-13.
    View in: PubMed
  7. Gibbs PE, Miralem T, Maines MD. Characterization of the human biliverdin reductase gene structure and regulatory elements: promoter activity is enhanced by hypoxia and suppressed by TNF-alpha-activated NF-kappaB. FASEB J. 2010 Sep; 24(9):3239-54.
    View in: PubMed
  8. Miralem T, Gibbs PE, Revert F, Saus J, Maines MD. Human biliverdin reductase suppresses Goodpasture antigen-binding protein (GPBP) kinase activity: the reductase regulates tumor necrosis factor-alpha-NF-kappaB-dependent GPBP expression. J Biol Chem. 2010 Apr 23; 285(17):12551-8.
    View in: PubMed
  9. Terrab A, Ortiz MA, Talavera M, Ariza MJ, Moriana Mdel C, García-Castaño JL, Tremetsberger K, Stuessy TF, Baeza CM, Urtubey E, Ruas Cde F, Casimiro-Soriguer R, Balao F, Gibbs PE, Talavera S. AFLP and breeding system studies indicate vicariance origin for scattered populations and enigmatic low fecundity in the Moroccan endemic Hypochaeris angustifolia (Asteraceae), sister taxon to all of the South American Hypochaeris species. Mol Phylogenet Evol. 2009 Oct; 53(1):13-22.
    View in: PubMed
  10. Tudor C, Lerner-Marmarosh N, Engelborghs Y, Gibbs PE, Maines MD. Biliverdin reductase is a transporter of haem into the nucleus and is essential for regulation of HO-1 gene expression by haematin. Biochem J. 2008 Aug 1; 413(3):405-16.
    View in: PubMed
  11. Ortiz MA, Tremetsberger K, Terrab A, Stuessy TF, García-Castaño JL, Urtubey E, Baeza CM, Ruas CF, Gibbs PE, Talavera S. Phylogeography of the invasive weed Hypochaeris radicata (Asteraceae): from Moroccan origin to worldwide introduced populations. Mol Ecol. 2008 Aug; 17(16):3654-67.
    View in: PubMed
  12. Lerner-Marmarosh N, Miralem T, Gibbs PE, Maines MD. Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling. Proc Natl Acad Sci U S A. 2008 May 13; 105(19):6870-5.
    View in: PubMed
  13. Gibbs PE, Maines MD. Biliverdin inhibits activation of NF-kappaB: reversal of inhibition by human biliverdin reductase. Int J Cancer. 2007 Dec 1; 121(11):2567-74.
    View in: PubMed
  14. Lerner-Marmarosh N, Miralem T, Gibbs PE, Maines MD. Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase. FASEB J. 2007 Dec; 21(14):3949-62.
    View in: PubMed
  15. Maines MD, Miralem T, Lerner-Marmarosh N, Shen J, Gibbs PE. Human biliverdin reductase, a previously unknown activator of protein kinase C betaII. J Biol Chem. 2007 Mar 16; 282(11):8110-22.
    View in: PubMed
  16. Zhang H, Gibbs PE, Lawrence CW. The Saccharomyces cerevisiae rev6-1 mutation, which inhibits both the lesion bypass and the recombination mode of DNA damage tolerance, is an allele of POL30, encoding proliferating cell nuclear antigen. Genetics. 2006 Aug; 173(4):1983-9.
    View in: PubMed
  17. Maines MD, Gibbs PE. 30 some years of heme oxygenase: from a "molecular wrecking ball" to a "mesmerizing" trigger of cellular events. Biochem Biophys Res Commun. 2005 Dec 9; 338(1):568-77.
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  18. Gibbs PE, McDonald J, Woodgate R, Lawrence CW. The relative roles in vivo of Saccharomyces cerevisiae Pol eta, Pol zeta, Rev1 protein and Pol32 in the bypass and mutation induction of an abasic site, T-T (6-4) photoadduct and T-T cis-syn cyclobutane dimer. Genetics. 2005 Feb; 169(2):575-82.
    View in: PubMed
  19. Gibbs P, Bianchi MB, Taroda Ranga N. Effects of self-, chase and mixed self/cross-pollinations on pistil longevity and fruit set in Ceiba species (Bombacaceae) with late-acting self-incompatibility. Ann Bot. 2004 Aug; 94(2):305-10.
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  20. Bittencourt NS, Gibbs PE, Semir J. Histological study of post-pollination events in Spathodea campanulata beauv. (Bignoniaceae), a species with late-acting self-incompatibility. Ann Bot. 2003 Jun; 91(7):827-34.
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  21. Talavera S, Gibbs PE, Fernández-Piedra MP, Ortiz-Herrera MA. Genetic control of self-incompatibility in Anagallis monelli (Primulaceae: Myrsinaceae). Heredity (Edinb). 2001 Nov; 87(Pt 5):589-97.
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  22. Nelson JR, Gibbs PE, Nowicka AM, Hinkle DC, Lawrence CW. Evidence for a second function for Saccharomyces cerevisiae Rev1p. Mol Microbiol. 2000 Aug; 37(3):549-54.
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  23. Gibbs PE, Wang XD, Li Z, McManus TP, McGregor WG, Lawrence CW, Maher VM. The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4186-91.
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  24. Lawrence CW, Gibbs PE, Murante RS, Wang XD, Li Z, McManus TP, McGregor WG, Nelson JR, Hinkle DC, Maher VM. Roles of DNA polymerase zeta and Rev1 protein in eukaryotic mutagenesis and translesion replication. Cold Spring Harb Symp Quant Biol. 2000; 65:61-9.
    View in: PubMed
  25. Gibbs PE, McGregor WG, Maher VM, Nisson P, Lawrence CW. A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta. Proc Natl Acad Sci U S A. 1998 Jun 9; 95(12):6876-80.
    View in: PubMed
  26. Gibbs PE, Witke WF, Dugaiczyk A. The molecular clock runs at different rates among closely related members of a gene family. J Mol Evol. 1998 May; 46(5):552-61.
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  27. Nishio H, Gibbs PE, Minghetti PP, Zielinski R, Dugaiczyk A. The chimpanzee alpha-fetoprotein-encoding gene shows structural similarity to that of gorilla but distinct differences from that of human. Gene. 1995 Sep 11; 162(2):213-20.
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  28. Gibbs PE, Lawrence CW. Novel mutagenic properties of abasic sites in Saccharomyces cerevisiae. J Mol Biol. 1995 Aug 11; 251(2):229-36.
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  29. Gibbs PE, Borden A, Lawrence CW. The T-T pyrimidine (6-4) pyrimidinone UV photoproduct is much less mutagenic in yeast than in Escherichia coli. Nucleic Acids Res. 1995 Jun 11; 23(11):1919-22.
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  30. Torpey LE, Gibbs PE, Nelson J, Lawrence CW. Cloning and sequence of REV7, a gene whose function is required for DNA damage-induced mutagenesis in Saccharomyces cerevisiae. Yeast. 1994 Nov; 10(11):1503-9.
    View in: PubMed
  31. Gibbs PE, Dugaiczyk A. Reading the molecular clock from the decay of internal symmetry of a gene. Proc Natl Acad Sci U S A. 1994 Apr 12; 91(8):3413-7.
    View in: PubMed
  32. Gibbs PE, Lawrence CW. U-U and T-T cyclobutane dimers have different mutational properties. Nucleic Acids Res. 1993 Aug 25; 21(17):4059-65.
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  33. Witke WF, Gibbs PE, Zielinski R, Yang F, Bowman BH, Dugaiczyk A. Complete structure of the human Gc gene: differences and similarities between members of the albumin gene family. Genomics. 1993 Jun; 16(3):751-4.
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  34. Gibbs PE, Kilbey BJ, Banerjee SK, Lawrence CW. The frequency and accuracy of replication past a thymine-thymine cyclobutane dimer are very different in Saccharomyces cerevisiae and Escherichia coli. J Bacteriol. 1993 May; 175(9):2607-12.
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  35. Lawrence CW, Gibbs PE, Borden A, Horsfall MJ, Kilbey BJ. Mutagenesis induced by single UV photoproducts in E. coli and yeast. Mutat Res. 1993 May; 299(3-4):157-63.
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  36. Gibbs PE, Strongin KB, McPherson A. Evolution of legume seed storage proteins--a domain common to legumins and vicilins is duplicated in vicilins. Mol Biol Evol. 1989 Nov; 6(6):614-23.
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  37. Minghetti PP, Gibbs PE, Norman AW. Computer analysis of 1,25-dihydroxyvitamin D3-receptor regulated promoters: identification of a candidate D3-response element. Biochem Biophys Res Commun. 1989 Jul 31; 162(2):869-75.
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  38. Gibbs PE, Dugaiczyk A. Origin of structural domains of the serum-albumin gene family and a predicted structure of the gene for vitamin D-binding protein. Mol Biol Evol. 1987 Jul; 4(4):364-79.
    View in: PubMed
  39. Gibbs PE, Zielinski R, Boyd C, Dugaiczyk A. Structure, polymorphism, and novel repeated DNA elements revealed by a complete sequence of the human alpha-fetoprotein gene. Biochemistry. 1987 Mar 10; 26(5):1332-43.
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  40. Ruffner DE, Sprung CN, Minghetti PP, Gibbs PE, Dugaiczyk A. Invasion of the human albumin-alpha-fetoprotein gene family by Alu, Kpn, and two novel repetitive DNA elements. Mol Biol Evol. 1987 Jan; 4(1):1-9.
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  41. Gibbs PE, Zouzias DC, Freedberg IM. Differential post-translational modification of human type I keratins synthesized in a rabbit reticulocyte cell-free system. Biochim Biophys Acta. 1985 Mar 20; 824(3):247-55.
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  42. Bertolino AP, Gibbs PE, Freedberg IM. In vitro biosynthesis of mouse hair keratins under the direction of follicular RNA. J Invest Dermatol. 1982 Sep; 79(3):173-7.
    View in: PubMed
  43. Gibbs PE, Freedberg IM. Epidermal keratin messenger RNAs: a heterogeneous family. Biochim Biophys Acta. 1982 Feb 26; 696(2):124-33.
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  44. Gibbs PE, Freedberg IM. Mammalian epidermal messenger RNA: identification and characterization of the keratin messengers. J Invest Dermatol. 1980 Jun; 74(6):382-8.
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  45. Freedberg IM, Gibbs PE, Gilmartin ME. Control of epidermal and hair root protein synthesis. Curr Probl Dermatol. 1980; 10:295-309.
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  46. Powell BC, Kemp DJ, Partington GA, Gibbs PE, Rogers GE. Control of feather keratin synthesis by the availability of keratin mRNA. Biochem Biophys Res Commun. 1976 Feb 23; 68(4):1263-71.
    View in: PubMed

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