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Patricia Hinkle

TitleProfessor Emeritus
InstitutionSchool of Medicine and Dentistry
DepartmentPharmacology and Physiology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 711
Rochester NY 14642
 
 Selected Publications
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  1. Wheeler SG, Hammond CL, Jornayvaz FR, Samuel VT, Shulman GI, Soroka CJ, Boyer JL, Hinkle PM, Ballatori N. Osta-/- mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity. Am J Physiol Gastrointest Liver Physiol. 2014 Mar; 306(5):G425-38.
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  2. Sebag JA, Zhang C, Hinkle PM, Bradshaw AM, Cone RD. Developmental control of the melanocortin-4 receptor by MRAP2 proteins in zebrafish. Science. 2013 Jul 19; 341(6143):278-81.
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  3. Gehret AU, Hinkle PM. siRNA Screen Identifies the Phosphatase Acting on the G Protein-Coupled Thyrotropin-Releasing Hormone Receptor. ACS Chem Biol. 2013 Mar 15; 8(3):588-98.
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  4. Hinkle PM, Gehret AU, Jones BW. Desensitization, trafficking, and resensitization of the pituitary thyrotropin-releasing hormone receptor. Front Neurosci. 2012; 6:180.
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  5. Thal DM, Homan KT, Chen J, Wu EK, Hinkle PM, Huang ZM, Chuprun JK, Song J, Gao E, Cheung JY, Sklar LA, Koch WJ, Tesmer JJ. Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. ACS Chem Biol. 2012 Nov 16; 7(11):1830-9.
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  6. Christian WV, Li N, Hinkle PM, Ballatori N. ß-Subunit of the Osta-Ostß organic solute transporter is required not only for heterodimerization and trafficking but also for function. J Biol Chem. 2012 Jun 15; 287(25):21233-43.
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  7. Liang L, Sebag JA, Eagelston L, Serasinghe MN, Veo K, Reinick C, Angleson J, Hinkle PM, Dores RM. Functional expression of frog and rainbow trout melanocortin 2 receptors using heterologous MRAP1s. Gen Comp Endocrinol. 2011 Oct 1; 174(1):5-14.
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  8. Hinkle PM, Serasinghe MN, Jakabowski A, Sebag JA, Wilson KR, Haskell-Luevano C. Use of chimeric melanocortin-2 and -4 receptors to identify regions responsible for ligand specificity and dependence on melanocortin 2 receptor accessory protein. Eur J Pharmacol. 2011 Jun 11; 660(1):94-102.
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  9. Gehret AU, Hinkle PM. Importance of regions outside the cytoplasmic tail of G-protein-coupled receptors for phosphorylation and dephosphorylation. Biochem J. 2010 Jun 1; 428(2):235-45.
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  10. Sebag JA, Hinkle PM. Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2. Sci Signal. 2010; 3(116):ra28.
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  11. Gehret AU, Jones BW, Tran PN, Cook LB, Greuber EK, Hinkle PM. Role of helix 8 of the thyrotropin-releasing hormone receptor in phosphorylation by G protein-coupled receptor kinase. Mol Pharmacol. 2010 Feb; 77(2):288-97.
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  12. Jones BW, Hinkle PM. Subcellular trafficking of the TRH receptor: effect of phosphorylation. Mol Endocrinol. 2009 Sep; 23(9):1466-78.
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  13. Sebag JA, Hinkle PM. Opposite effects of the melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking. J Biol Chem. 2009 Aug 21; 284(34):22641-8.
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  14. Hinkle PM, Sebag JA. Structure and function of the melanocortin2 receptor accessory protein (MRAP). Mol Cell Endocrinol. 2009 Mar 5; 300(1-2):25-31.
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  15. Sebag JA, Hinkle PM. Regions of melanocortin 2 (MC2) receptor accessory protein necessary for dual topology and MC2 receptor trafficking and signaling. J Biol Chem. 2009 Jan 2; 284(1):610-8.
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  16. Jones BW, Hinkle PM. Arrestin binds to different phosphorylated regions of the thyrotropin-releasing hormone receptor with distinct functional consequences. Mol Pharmacol. 2008 Jul; 74(1):195-202.
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  17. Sebag JA, Hinkle PM. Melanocortin-2 receptor accessory protein MRAP forms antiparallel homodimers. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20244-9.
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  18. Hogan N, O'Boyle KM, Hinkle PM, Kelly JA. A novel TRH analog, Glp-Asn-Pro-D-Tyr-D-TrpNH2, binds to [3H][3-Me-His2]TRH-labelled sites in rat hippocampus and cortex but not pituitary or heterologous cells expressing TRHR1 or TRHR2. Neurosci Lett. 2008 Jan 24; 431(1):26-30.
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  19. Song GJ, Jones BW, Hinkle PM. Dimerization of the thyrotropin-releasing hormone receptor potentiates hormone-dependent receptor phosphorylation. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18303-8.
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  20. Jones BW, Song GJ, Greuber EK, Hinkle PM. Phosphorylation of the endogenous thyrotropin-releasing hormone receptor in pituitary GH3 cells and pituitary tissue revealed by phosphosite-specific antibodies. J Biol Chem. 2007 Apr 27; 282(17):12893-906.
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  21. Scalabrino GA, Hogan N, O'Boyle KM, Slator GR, Gregg DJ, Fitchett CM, Draper SM, Bennett GW, Hinkle PM, Bauer K, Williams CH, Tipton KF, Kelly JA. Discovery of a dual action first-in-class peptide that mimics and enhances CNS-mediated actions of thyrotropin-releasing hormone. Neuropharmacology. 2007 Jun; 52(7):1472-81.
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  22. Sebag JA, Hinkle PM. Regulation of endogenous melanocortin-4 receptor expression and signaling by glucocorticoids. Endocrinology. 2006 Dec; 147(12):5948-55.
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  23. Jones BW, Hinkle PM. Beta-arrestin mediates desensitization and internalization but does not affect dephosphorylation of the thyrotropin-releasing hormone receptor. J Biol Chem. 2005 Nov 18; 280(46):38346-54.
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  24. Song GJ, Hinkle PM. Regulated dimerization of the thyrotropin-releasing hormone receptor affects receptor trafficking but not signaling. Mol Endocrinol. 2005 Nov; 19(11):2859-70.
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  25. Cook LB, Hinkle PM. Agonist-dependent up-regulation of thyrotrophin-releasing hormone receptor protein. Biochem J. 2004 Jun 15; 380(Pt 3):815-21.
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  26. Cook LB, Hinkle PM. Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein. Endocrinology. 2004 Jul; 145(7):3095-100.
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  27. Hinkle PM, Puskas JA. Detection of G protein-coupled receptors by immunofluorescence microscopy. Methods Mol Biol. 2004; 237:127-34.
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  28. Sattin A, Pekary AE, Lloyd RL, Paulson M, Meyerhoff JA, Hinkle PM, Faull K. TRH and related peptides: homeostatic regulators of glutamate transmission? Ann N Y Acad Sci. 2003 Nov; 1003:458-60.
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  29. Graves TK, Hinkle PM. Ca(2+)-induced Ca(2+) release in the pancreatic beta-cell: direct evidence of endoplasmic reticulum Ca(2+) release. Endocrinology. 2003 Aug; 144(8):3565-74.
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  30. Cook LB, Zhu CC, Hinkle PM. Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation. Mol Endocrinol. 2003 Sep; 17(9):1777-91.
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  31. Goubaeva F, Ghosh M, Malik S, Yang J, Hinkle PM, Griendling KK, Neubig RR, Smrcka AV. Stimulation of cellular signaling and G protein subunit dissociation by G protein betagamma subunit-binding peptides. J Biol Chem. 2003 May 30; 278(22):19634-41.
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  32. Graves TK, Hinkle PM. Endoplasmic reticulum calcium storage and release in cells expressing misfolded growth hormone. Growth Horm IGF Res. 2003 Feb; 13(1):36-43.
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  33. Zhu CC, Cook LB, Hinkle PM. Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation. J Biol Chem. 2002 Aug 2; 277(31):28228-37.
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  34. Hinkle PM, Pekary AE, Senanayaki S, Sattin A. Role of TRH receptors as possible mediators of analeptic actions of TRH-like peptides. Brain Res. 2002 May 10; 935(1-2):59-64.
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  35. Graves TK, Patel S, Dannies PS, Hinkle PM. Misfolded growth hormone causes fragmentation of the Golgi apparatus and disrupts endoplasmic reticulum-to-Golgi traffic. J Cell Sci. 2001 Oct; 114(Pt 20):3685-94.
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  36. Smith J, Yu R, Hinkle PM. Activation of MAPK by TRH requires clathrin-dependent endocytosis and PKC but not receptor interaction with beta-arrestin or receptor endocytosis. Mol Endocrinol. 2001 Sep; 15(9):1539-48.
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  37. Rapoport AP, Simons-Evelyn M, Chen T, Sidell R, Luhowskyj S, Rosell K, Obrig T, Hicks D, Hinkle PM, Nahm M, Insel RA, Abboud CN. Flavopiridol induces apoptosis and caspase-3 activation of a newly characterized Burkitt's lymphoma cell line containing mutant p53 genes. Blood Cells Mol Dis. 2001 May-Jun; 27(3):610-24.
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  38. Romoser VA, Graves TK, Wu D, Jiang H, Hinkle PM. Calcium responses to thyrotropin-releasing hormone, gonadotropin-releasing hormone and somatostatin in phospholipase css3 knockout mice. Mol Endocrinol. 2001 Jan; 15(1):125-35.
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  39. Yu R, Hinkle PM. Rapid turnover of calcium in the endoplasmic reticulum during signaling. Studies with cameleon calcium indicators. J Biol Chem. 2000 Aug 4; 275(31):23648-53.
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  40. Xie W, Samoriski GM, McLaughlin JP, Romoser VA, Smrcka A, Hinkle PM, Bidlack JM, Gross RA, Jiang H, Wu D. Genetic alteration of phospholipase C beta3 expression modulates behavioral and cellular responses to mu opioids. Proc Natl Acad Sci U S A. 1999 Aug 31; 96(18):10385-90.
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  41. Yu R, Hinkle PM. Signal transduction and hormone-dependent internalization of the thyrotropin-releasing hormone receptor in cells lacking Gq and G11. J Biol Chem. 1999 May 28; 274(22):15745-50.
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  42. Fliss MS, Hinkle PM, Bancroft C. Expression cloning and characterization of PREB (prolactin regulatory element binding), a novel WD motif DNA-binding protein with a capacity to regulate prolactin promoter activity. Mol Endocrinol. 1999 Apr; 13(4):644-57.
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  43. Yu R, Ashworth R, Hinkle PM. Receptors for thyrotropin-releasing hormone on rat lactotropes and thyrotropes. Thyroid. 1998 Oct; 8(10):887-94.
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  44. Yu R, Hinkle PM. Signal transduction, desensitization, and recovery of responses to thyrotropin-releasing hormone after inhibition of receptor internalization. Mol Endocrinol. 1998 May; 12(5):737-49.
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  45. Nelson EJ, Zinkin NT, Hinkle PM. Fluorescence methods to assess multidrug resistance in individual cells. Cancer Chemother Pharmacol. 1998; 42(4):292-9.
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  46. Yu R, Hinkle PM. Desensitization of thyrotropin-releasing hormone receptor-mediated responses involves multiple steps. J Biol Chem. 1997 Nov 7; 272(45):28301-7.
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  47. Kerper LE, Hinkle PM. Lead uptake in brain capillary endothelial cells: activation by calcium store depletion. Toxicol Appl Pharmacol. 1997 Sep; 146(1):127-33.
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  48. Romoser VA, Hinkle PM, Persechini A. Detection in living cells of Ca2+-dependent changes in the fluorescence emission of an indicator composed of two green fluorescent protein variants linked by a calmodulin-binding sequence. A new class of fluorescent indicators. J Biol Chem. 1997 May 16; 272(20):13270-4.
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  49. Yu R, Hinkle PM. Effect of cell type on the subcellular localization of the thyrotropin-releasing hormone receptor. Mol Pharmacol. 1997 May; 51(5):785-93.
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  50. Kerper LE, Hinkle PM. Cellular uptake of lead is activated by depletion of intracellular calcium stores. J Biol Chem. 1997 Mar 28; 272(13):8346-52.
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  51. Ashworth R, Hinkle PM. Thyrotropin-releasing hormone-induced intracellular calcium responses in individual rat lactotrophs and thyrotrophs. Endocrinology. 1996 Dec; 137(12):5205-12.
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  52. Hinkle PM, Nelson EJ, Ashworth R. Characterization of the calcium response to thyrotropin-releasing hormone in lactotrophs and GH cells. Trends Endocrinol Metab. 1996 Dec; 7(10):370-4.
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  53. Shupnik MA, Weck J, Hinkle PM. Thyrotropin (TSH)-releasing hormone stimulates TSH beta promoter activity by two distinct mechanisms involving calcium influx through L type Ca2+ channels and protein kinase C. Mol Endocrinol. 1996 Jan; 10(1):90-9.
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  54. Ashworth R, Yu R, Nelson EJ, Dermer S, Gershengorn MC, Hinkle PM. Visualization of the thyrotropin-releasing hormone receptor and its ligand during endocytosis and recycling. Proc Natl Acad Sci U S A. 1995 Jan 17; 92(2):512-6.
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  55. Nelson EJ, Hinkle PM. Thyrotropin-releasing hormone activates Ca2+ efflux. Evidence suggesting that a plasma membrane Ca2+ pump is an effector for a G-protein-coupled Ca(2+)-mobilizing receptor. J Biol Chem. 1994 Dec 9; 269(49):30854-60.
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  56. Nelson EJ, Hinkle PM. Characteristics of the Ca2+ spike and oscillations induced by different doses of thyrotropin-releasing hormone (TRH) in individual pituitary cells and nonexcitable cells transfected with TRH receptor complementary deoxyribonucleic acid. Endocrinology. 1994 Sep; 135(3):1084-92.
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  57. Nelson EJ, Li CC, Bangalore R, Benson T, Kass RS, Hinkle PM. Inhibition of L-type calcium-channel activity by thapsigargin and 2,5-t-butylhydroquinone, but not by cyclopiazonic acid. Biochem J. 1994 Aug 15; 302 ( Pt 1):147-54.
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  58. Gershengorn MC, Heinflink M, Nussenzveig DR, Hinkle PM, Falck-Pedersen E. Thyrotropin-releasing hormone (TRH) receptor number determines the size of the TRH-responsive phosphoinositide pool. Demonstration using controlled expression of TRH receptors by adenovirus mediated gene transfer. J Biol Chem. 1994 Mar 4; 269(9):6779-83.
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  59. Hinkle PM, Osborne ME. Cadmium toxicity in rat pheochromocytoma cells: studies on the mechanism of uptake. Toxicol Appl Pharmacol. 1994 Jan; 124(1):91-8.
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  60. Yan Z, Hinkle PM. Saturable, stereospecific transport of 3,5,3'-triiodo-L-thyronine and L-thyroxine into GH4C1 pituitary cells. J Biol Chem. 1993 Sep 25; 268(27):20179-84.
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  61. Straight SW, Hinkle PM, Jewers RJ, McCance DJ. The E5 oncoprotein of human papillomavirus type 16 transforms fibroblasts and effects the downregulation of the epidermal growth factor receptor in keratinocytes. J Virol. 1993 Aug; 67(8):4521-32.
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  62. Hinkle PM, Nelson EJ, Haymes AA. Regulation of L-type voltage-gated calcium channels by epidermal growth factor. Endocrinology. 1993 Jul; 133(1):271-6.
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  63. Haymes AA, Hinkle PM. Activation of protein kinase C increases Ca2+ sensitivity of secretory response of GH3 pituitary cells. Am J Physiol. 1993 Apr; 264(4 Pt 1):C1020-8.
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  64. Hinkle PM, Shanshala ED, Nelson EJ. Measurement of intracellular cadmium with fluorescent dyes. Further evidence for the role of calcium channels in cadmium uptake. J Biol Chem. 1992 Dec 15; 267(35):25553-9.
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  65. Li P, Thaw CN, Sempowski GD, Gershengorn MC, Hinkle PM. Characterization of the calcium response to thyrotropin-releasing hormone (TRH) in cells transfected with TRH receptor complementary DNA: importance of voltage-sensitive calcium channels. Mol Endocrinol. 1992 Sep; 6(9):1393-402.
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  66. Nelson EJ, Hinkle PM. Characterization of multidrug-resistant pituitary tumor cells. Endocrinology. 1992 Jun; 130(6):3246-56.
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  67. Hinkle PM, Scammell JG, Shanshala ED. Prolactin and secretogranin-II, a marker for the regulated pathway, are secreted in parallel by pituitary GH4C1 cells. Endocrinology. 1992 Jun; 130(6):3503-11.
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  68. Haymes AA, Kwan YW, Arena JP, Kass RS, Hinkle PM. Activation of protein kinase C reduces L-type calcium channel activity of GH3 pituitary cells. Am J Physiol. 1992 May; 262(5 Pt 1):C1211-9.
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  69. Spaulding SW, Smith TJ, Hinkle PM, Davis FB, Kung MP, Roth JA. Studies on the biological activity of triiodothyronine sulfate. J Clin Endocrinol Metab. 1992 May; 74(5):1062-7.
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  70. Hinkle PM, Shanshala ED, Yan ZF. Epidermal growth factor decreases the concentration of thyrotropin-releasing hormone (TRH) receptors and TRH responses in pituitary GH4C1 cells. Endocrinology. 1991 Sep; 129(3):1283-8.
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  71. Hinkle PM, Shanshala ED. Pituitary thyrotropin-releasing hormone (TRH) receptors: effects of TRH, drugs mimicking TRH action, and chlordiazepoxide. Mol Endocrinol. 1989 Sep; 3(9):1337-44.
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  72. Phillips WJ, Enyeart JJ, Hinkle PM. Pituitary thyrotropin-releasing hormone receptors: local anesthetic effects on binding and responses. Mol Endocrinol. 1989 Sep; 3(9):1345-51.
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  73. Phillips WJ, Hinkle PM. Solubilization and characterization of pituitary thyrotropin-releasing hormone receptors. Mol Pharmacol. 1989 Apr; 35(4):533-40.
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  74. Kaji H, Hinkle PM. Attenuation of thyroid hormone action by 1,25-dihydroxyvitamin D3 in pituitary cells. Endocrinology. 1989 Feb; 124(2):930-6.
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  75. Hinkle PM. Pituitary TRH receptors. Ann N Y Acad Sci. 1989; 553:176-87.
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  76. Day RN, Hinkle PM. Prolactin synthesis in cultured pituitary cells is chloride-dependent. J Biol Chem. 1988 Nov 5; 263(31):15922-7.
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  77. Day RN, Hinkle PM. Osmotic regulation of prolactin secretion. Possible role of chloride. J Biol Chem. 1988 Nov 5; 263(31):15915-21.
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  78. Hinkle PM, Jackson AE, Thompson TM, Zavacki AM, Coppola DA, Bancroft C. Calcium channel agonists and antagonists: effects of chronic treatment on pituitary prolactin synthesis and intracellular calcium. Mol Endocrinol. 1988 Nov; 2(11):1132-8.
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  79. Kaji H, Casnellie JE, Hinkle PM. Thyrotropin releasing hormone action in pituitary cells. Protein kinase C-mediated effects on the epidermal growth factor receptor. J Biol Chem. 1988 Sep 25; 263(27):13588-93.
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  80. Day RN, Hinkle PM. Transient dopaminergic inhibition of prolactin release from hybrid cells derived by fusion of normal rat pituitary and GH4C1 tumor cells. Endocrinology. 1988 May; 122(5):2165-73.
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  81. Hinkle PM, Kinsella PA, Osterhoudt KC. Cadmium uptake and toxicity via voltage-sensitive calcium channels. J Biol Chem. 1987 Dec 5; 262(34):16333-7.
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  82. Kaji H, Hinkle PM. Regulation of thyroid hormone receptors and responses by thyrotropin-releasing hormone in GH4C1 cells. Endocrinology. 1987 Nov; 121(5):1697-704.
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  83. Enyeart JJ, Sheu SS, Hinkle PM. Pituitary Ca2+ channels: blockade by conventional and novel Ca2+ antagonists. Am J Physiol. 1987 Jul; 253(1 Pt 1):C162-70.
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  84. Enyeart JJ, Sheu SS, Hinkle PM. Dihydropyridine modulators of voltage-sensitive Ca2+ channels specifically regulate prolactin production by GH4C1 pituitary tumor cells. J Biol Chem. 1987 Mar 5; 262(7):3154-9.
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  85. Kaji H, Hinkle PM. Epidermal growth factor decreases thyroid hormone receptors and attenuates thyroid hormone responses in GH4C1 cells. Endocrinology. 1987 Feb; 120(2):537-43.
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  86. Hinkle PM, Kinsella PA. Thyroid hormone induction of an autocrine growth factor secreted by pituitary tumor cells. Science. 1986 Dec 19; 234(4783):1549-52.
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  87. Hinkle PM, Hewlett EL, Gershengorn MC. Thyroliberin action in pituitary cells is not inhibited by pertussis toxin. Biochem J. 1986 Jul 1; 237(1):181-6.
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  88. Enyeart JJ, Aizawa T, Hinkle PM. Interaction of dihydropyridine Ca2+ agonist Bay K 8644 with normal and transformed pituitary cells. Am J Physiol. 1986 Jan; 250(1 Pt 1):C95-102.
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  89. Enyeart JJ, Aizawa T, Hinkle PM. Dihydropyridine Ca2+ antagonists: potent inhibitors of secretion from normal and transformed pituitary cells. Am J Physiol. 1985 May; 248(5 Pt 1):C510-9.
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  90. Aizawa T, Hinkle PM. Differential effects of thyrotropin-releasing hormone, vasoactive intestinal peptide, phorbol ester, and depolarization in GH4C1 rat pituitary cells. Endocrinology. 1985 Mar; 116(3):909-19.
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  91. Aizawa T, Hinkle PM. Thyrotropin-releasing hormone rapidly stimulates a biphasic secretion of prolactin and growth hormone in GH4C1 rat pituitary tumor cells. Endocrinology. 1985 Jan; 116(1):73-82.
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  92. Hinkle PM, Phillips WJ. Thyrotropin-releasing hormone stimulates GTP hydrolysis by membranes from GH4C1 rat pituitary tumor cells. Proc Natl Acad Sci U S A. 1984 Oct; 81(19):6183-7.
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  93. Enyeart JJ, Hinkle PM. The calcium agonist Bay K 8644 stimulates secretion from a pituitary cell line. Biochem Biophys Res Commun. 1984 Aug 16; 122(3):991-6.
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  94. Halpern J, Hinkle PM. Characterization of thyroid hormone stimulation of uridine uptake by rat pituitary tumor cells. Endocrinology. 1984 Jul; 115(1):95-101.
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  95. Hinkle PM, Kinsella PA. Regulation of thyrotropin-releasing hormone binding by monovalent cations and guanyl nucleotides. J Biol Chem. 1984 Mar 25; 259(6):3445-9.
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  96. Halpern J, Hinkle PM. Binding and internalization of epidermal growth factor by rat pituitary tumor cells. Mol Cell Endocrinol. 1983 Dec; 33(2-3):183-96.
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  97. Hinkle PM, Kinsella PA. Rapid temperature-dependent transformation of the thyrotropin-releasing hormone-receptor complex in rat pituitary tumor cells. J Biol Chem. 1982 May 25; 257(10):5462-70.
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  98. Hinkle PM, Goh KB. Regulation of thyrotropin-releasing hormone receptors and responses by L-triiodothyronine in dispersed rat pituitary cell cultures. Endocrinology. 1982 May; 110(5):1725-31.
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  99. Halpern J, Hinkle PM. Evidence for an active step in thyroid hormone transport to nuclei: drug inhibition of L-125I-triiodothyronine binding to nuclear receptors in rat pituitary tumor cells. Endocrinology. 1982 Mar; 110(3):1070-2.
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  100. Berk BC, Hinkle PM. Purification of a stimulator of microtubule assembly from bovine thyroid. J Biol Chem. 1981 Nov 25; 256(22):11859-65.
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  101. Hinkle PM, Perrone MH, Schonbrunn A. Mechanism of thyroid hormone inhibition of thyrotropin-releasing hormone action. Endocrinology. 1981 Jan; 108(1):199-205.
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  102. Halpern J, Hinkle PM. Direct visualization of receptors for thyrotropin-releasing hormone with a fluorescein-labeled analog. Proc Natl Acad Sci U S A. 1981 Jan; 78(1):587-91.
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  103. Vriend J, Hinkle PM, Knigge KM. Evidence for a thyrotropin-releasing hormone inhibitor in the pineal gland. Endocrinology. 1980 Dec; 107(6):1791-7.
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  104. Berk BC, Hinkle PM. Thyroid and brain microtubules: a comparison. J Biol Chem. 1980 Apr 10; 255(7):3186-93.
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  105. Hinkle PM, Lewis DG, Greer TL. Thyrotropin-releasing hormone-receptor interaction in GH3 pituitary cells. Endocrinology. 1980 Mar; 106(3):1000-5.
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  106. Perrone MH, Greer TL, Hinkle PM. Relationships between thyroid hormone and glucocorticoid effects in GH3 pituitary cells. Endocrinology. 1980 Feb; 106(2):600-5.
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  107. Rupnow JH, Hinkle PM, Dixon JE. A macromolecule which gives rise to thyrotropin releasing-hormone. Biochem Biophys Res Commun. 1979 Jul 27; 89(2):721-8.
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  108. Hinkle PM, Perrone MH, Greer TL. Thyroid hormone action in pituitary cells. Differences in the regulation of thyrotropin-releasing hormone receptors and growth hormone synthesis. J Biol Chem. 1979 May 25; 254(10):3907-11.
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  109. Perrone MH, Hinkle PM. Regulation of pituitary receptors for thyrotropin-releasing hormone by thyroid hormones. J Biol Chem. 1978 Jul 25; 253(14):5168-73.
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  110. Hinkle PM, Lewis DG. Solubilization of pituitary receptors for thyrotropin-releasing hormone. Biochim Biophys Acta. 1978 Jul 3; 541(3):347-59.
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  111. Hinkle PM, Tashjian AH. Adenylyl cyclase and cyclic nucleotide phosphodiesterases in GH-Strains of rat pituitary cells. Endocrinology. 1977 Apr; 100(4):934-44.
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  112. Hinkle PM, Tashjian AH. Thyrotropin-releasing hormone regulates the number of its own receptors in the GH3 strain of pituitary cells in culture. Biochemistry. 1975 Aug 26; 14(17):3845-51.
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  113. Hinkle PM, Tashjian AH. Degradation of thyrotropin-releasing hormone by the GH3 strain of pituitary cells in culture. Endocrinology. 1975 Aug; 97(2):324-31.
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  114. Imae T, Fasman GD, Hinkle PM, Tashjian AH. Intrinsic tryptophan fluorescence of membranes of GH3 pituitary cells: quenching by thyrotropin-releasing hormone. Biochem Biophys Res Commun. 1975 Feb 17; 62(4):923-32.
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  115. Hinkle PM. Uses of prolactin- and growth hormone-producing rat pituitary tumor cells in culture. Lloydia. 1974 Jun; 37(2):192-5.
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  116. Hinkle PM, Woroch EL, Tashjian AH. Receptor-binding affinities and biological activities of analogs of thyrotropin-releasing hormone in prolactin-producing pituitary cells in culture. J Biol Chem. 1974 May 25; 249(10):3085-90.
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  117. Hinkle PM, Tashjian AH. Receptors for thyrotropin-releasing hormone in prolactin producing rat pituitary cells in culture. J Biol Chem. 1973 Sep 10; 248(17):6180-6.
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  118. Levine L, Hinkle PM, Voelkel EF, Tashjian AH. Prostaglandin production by mouse fibrosarcoma cells in culture: inhibition by indomethacin and aspirin. Biochem Biophys Res Commun. 1972 May 26; 47(4):888-96.
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  119. Hinkle PM, Kirsch JF. Demonstration of a change in the rate-determining step in papain- and ficin-catalyzed acyl-transfer reactions. Biochemistry. 1971 Jul 6; 10(14):2717-26.
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  120. Hinkle P. A model system for mitochondrial ion transport and respiratory control. Biochem Biophys Res Commun. 1970 Dec 24; 41(6):1375-81.
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