Gary Paige
| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Neurobiology and Anatomy |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 603
Rochester NY 14642
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| Title | Chairman |
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| Institution | School of Medicine and Dentistry |
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| Department | Neurobiology and Anatomy |
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| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Ophthalmology |
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| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Biomedical Engineering |
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| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Otolaryngology |
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| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Neurology |
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| Division | Neurology - Cognitive Behavioral Neurology |
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| 1966 |
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| 1970 | Dow Foundation Scholarship | Interlochen Arts Academy | | 1970 |
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| Academic Honors Award | Interlochen Arts Academy | | 1972 |
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| National Science Foundation Research Participation Award | Department of Psychobiology, University of California - Irvine | | 1974 |
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| 1975 | J. Franks Fund Scholarship Award | University of Chicago Pritzker School of Medicine | | 1974 |
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| B.S. Cum Laude and With Honors | University of California - Irvine | | 1975 |
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| 1981 | Medical Scientist Training Program (MD, PhD) | | 1984 |
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| Michael J. Hogan Award | Dept. Opthalmology, University of California | | 1991 |
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| Traveling Fellowship | Royal College of Surgeons Foundation | | 1995 |
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| Honory Life Member | Neuro-Otological Society of Australia | | 1997 |
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| Arthur Kornberg Research Award | University of Rochester | | 1999 |
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| Stadium Generale (keynote) Presentation | | 2002 |
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| 2004 | President | Association of Medical School Neuroscience Department Chairs. | | 2007 |
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| Vice President and Program Director | Society for the Neural Control of Movement. |
Research:
Multisensory Interaction and Adaptive Plasticity in Spatial Localization and Orientation.
The sensori-neural processes underlying our abilities to localize, track, and interact with a cluttered environment are crucial attributes of daily life, and are among the most fundamental tasks of the nervous system. The integration of multiple sensory inputs are required to guide spatial behaviors, ranging from mundane tasks such as reaching for objects to complex ones such as navigating to and from the workplace. These functions are also among the first (and often most subtle) to register problems after head trauma, neurological disease, and aging. The goal of our research is to understand how the brain integrates sensory inputs from the outside world (location and motion of visual and auditory targets) with those of the internal senses (vestibular and somatosensory depictions of orientation and motion of the body and its parts,) to achieve meaningful spatial perceptions and behaviors (eye, head and postural movements and reflexes). An equally important interest is how plastic neural mechanisms register errors and adaptively adjust performance in order to maintain proper spatial calibration across sensory modalities, or analogously, recover normal function after suffering pathologic loss. Finally, an important translational concern is how the neural degeneration of natural aging affects spatial behavior and plasticity.
Current experiments address two intriguing areas of interest. One is understanding how the brain utilizes auditory and visual information about target location and motion in order to maintain accurate and congruent spatial calibration across modalities, as assessed through different forms of orienting movements ("pointing"). These include visually-guided manual pointing by laser joystick, and more natural gaze (eye and head) pointing. Since gaze shifts activate vestibular reflexes (vestibulo-ocular and –collic reflexes: VOR and VCR) as well as somatosensory feedback from the neck, we are studying how the senses interact with each other and with volitional and reflex motor control. We are also investigating the important challenges of spatial memory when targets are transient, as occurs frequently in nature. Finally, we are interested in how spatial sensory modalities are plastically co-calibrated by cross-sensory experience--an essential feature normal spatial behavior over a lifetime.
A second focus is how vestibular inputs during both angular (from the semicircular canals) and linear (from the otoliths) head motion interact with each other, despite an intriguing limitation in the physics of the linear form (Einstein's "equivalency principle"). As biological linear accelerometers, the otolith organs cannot readily distinguish accelerations due to head tilt (relative to gravity) from those arising during translational (as opposed to angular) motion, and yet relevant behaviors and perceptions associated with these two forms of motion differ greatly. We are characterizing the compromised but fascinating solutions that have evolved to help resolve (albeit imperfectly) this sensory ambiguity.
Our research environment is unique in structure and instrumentation, as well as broad and translational in character. We benefit from a collegiate and multi-disciplinary group of faculty working on problems of common interest.
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Dobreva MS, O'Neill WE, Paige GD. Influence of age, spatial memory, and ocular fixation on localization of auditory, visual, and bimodal targets by human subjects. Exp Brain Res. 2012 Dec; 223(4):441-55.
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Greene NT, Paige GD. Influence of sound source width on human sound localization. Conf Proc IEEE Eng Med Biol Soc. 2012 Aug; 2012:6455-8.
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Dobreva MS, O'Neill WE, Paige GD. Influence of aging on human sound localization. J Neurophysiol. 2011 May; 105(5):2471-86.
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Cui QN, O'Neill WE, Paige GD. Advancing age alters the influence of eye position on sound localization. Exp Brain Res. 2010 Oct; 206(4):371-9.
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Cui QN, Razavi B, O'Neill WE, Paige GD. Perception of auditory, visual, and egocentric spatial alignment adapts differently to changes in eye position. J Neurophysiol. 2010 Feb; 103(2):1020-35.
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Seidman SH, Au Yong N, Paige GD. The perception of translational motion: what is vestibular and what is not. Ann N Y Acad Sci. 2009 May; 1164:222-8.
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Cui QN, Bachus L, Knoth E, O'Neill WE, Paige GD. Eye position and cross-sensory learning both contribute to prism adaptation of auditory space. Prog Brain Res. 2008; 171:265-70.
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Razavi B, O'Neill WE, Paige GD. Auditory spatial perception dynamically realigns with changing eye position. J Neurosci. 2007 Sep 19; 27(38):10249-58.
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Au Yong N, Paige GD, Seidman SH. Multiple sensory cues underlying the perception of translation and path. J Neurophysiol. 2007 Feb; 97(2):1100-13.
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Barnes GR, Paige GD. Anticipatory VOR suppression induced by visual and nonvisual stimuli in humans. J Neurophysiol. 2004 Sep; 92(3):1501-11.
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Zwiers MP, Van Opstal AJ, Paige GD. Plasticity in human sound localization induced by compressed spatial vision. Nat Neurosci. 2003 Feb; 6(2):175-81.
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Seidman SH, Paige GD, Tomlinson RD, Schmitt N. Linearity of canal-otolith interaction during eccentric rotation in humans. Exp Brain Res. 2002 Nov; 147(1):29-37.
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Paige GD. Otolith function: basis for modern testing. Ann N Y Acad Sci. 2002 Apr; 956:314-23.
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Paige GD, Seidman SH. Characteristics of the VOR in response to linear acceleration. Ann N Y Acad Sci. 1999 May 28; 871:123-35.
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Seidman SH, Paige GD, Tomko DL. Adaptive plasticity in the naso-occipital linear vestibulo-ocular reflex. Exp Brain Res. 1999 Apr; 125(4):485-94.
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Paige GD, Telford L, Seidman SH, Barnes GR. Human vestibuloocular reflex and its interactions with vision and fixation distance during linear and angular head movement. J Neurophysiol. 1998 Nov; 80(5):2391-404.
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Seidman SH, Telford L, Paige GD. Tilt perception during dynamic linear acceleration. Exp Brain Res. 1998 Apr; 119(3):307-14.
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Telford L, Seidman SH, Paige GD. Canal-otolith interactions in the squirrel monkey vestibulo-ocular reflex and the influence of fixation distance. Exp Brain Res. 1998 Jan; 118(1):115-25.
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Telford L, Seidman SH, Paige GD. Dynamics of squirrel monkey linear vestibuloocular reflex and interactions with fixation distance. J Neurophysiol. 1997 Oct; 78(4):1775-90.
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Paige GD, Barnes GR, Telford L, Seidman SH. Influence of sensorimotor context on the linear vestibulo-ocular reflex. Ann N Y Acad Sci. 1996 Jun 19; 781:322-31.
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Seidman SH, Paige GD. Perception and eye movement during low-frequency centripetal acceleration. Ann N Y Acad Sci. 1996 Jun 19; 781:693-5.
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Telford L, Seidman SH, Paige GD. Canal-otolith interactions driving vertical and horizontal eye movements in the squirrel monkey. Exp Brain Res. 1996 Jun; 109(3):407-18.
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Panosian MS, Paige GD. Nystagmus and postural instability after headshake in patients with vestibular dysfunction. Otolaryngol Head Neck Surg. 1995 Mar; 112(3):399-404.
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Seidman SH, Telford L, Paige GD. Vertical, horizontal, and torsional eye movement responses to head roll in the squirrel monkey. Exp Brain Res. 1995; 104(2):218-26.
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King WM, Zhou W, Tomlinson RD, McConville KM, Page WK, Paige GD, Maxwell JS. Eye position signals in the abducens and oculomotor nuclei of monkeys during ocular convergence. J Vestib Res. 1994 Sep-Oct; 4(5):401-8.
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McConville K, Tomlinson RD, King WM, Paige G, Na EQ. Eye position signals in the vestibular nuclei: consequences for models of integrator function. J Vestib Res. 1994 Sep-Oct; 4(5):391-400.
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Paige GD. Senescence of human visual-vestibular interactions: smooth pursuit, optokinetic, and vestibular control of eye movements with aging. Exp Brain Res. 1994; 98(2):355-72.
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Merfeld DM, Young LR, Paige GD, Tomko DL. Three dimensional eye movements of squirrel monkeys following postrotatory tilt. J Vestib Res. 1993; 3(2):123-39.
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Tomko DL, Paige GD. Linear vestibuloocular reflex during motion along axes between nasooccipital and interaural. Ann N Y Acad Sci. 1992 May 22; 656:233-41.
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Paige GD. Senescence of human visual-vestibular interactions. 1. Vestibulo-ocular reflex and adaptive plasticity with aging. J Vestib Res. 1992; 2(2):133-51.
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Merrill PT, Paige GD, Abrams RA, Jacoby RG, Clifford DB. Ocular motor abnormalities in human immunodeficiency virus infection. Ann Neurol. 1991 Aug; 30(2):130-8.
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Goebel JA, Fortin M, Paige GD. Headshake versus whole-body rotation testing of the vestibulo-ocular reflex. Laryngoscope. 1991 Jul; 101(7 Pt 1):695-8.
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Paige GD, Tomko DL. Eye movement responses to linear head motion in the squirrel monkey. I. Basic characteristics. J Neurophysiol. 1991 May; 65(5):1170-82.
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Paige GD, Tomko DL. Eye movement responses to linear head motion in the squirrel monkey. II. Visual-vestibular interactions and kinematic considerations. J Neurophysiol. 1991 May; 65(5):1183-96.
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Lach HW, Reed AT, Arfken CL, Miller JP, Paige GD, Birge SJ, Peck WA. Falls in the elderly: reliability of a classification system. J Am Geriatr Soc. 1991 Feb; 39(2):197-202.
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Merfeld DM, Young LR, Tomko DL, Paige GD. Spatial orientation of VOR to combined vestibular stimuli in squirrel monkeys. Acta Otolaryngol Suppl. 1991; 481:287-92.
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Paige GD. The aging vestibulo-ocular reflex (VOR) and adaptive plasticity. Acta Otolaryngol Suppl. 1991; 481:297-300.
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Paige GD, Sargent EW. Visually-induced adaptive plasticity in the human vestibulo-ocular reflex. Exp Brain Res. 1991; 84(1):25-34.
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Sargent EW, Paige GD. The primate vestibulo-ocular reflex during combined linear and angular head motion. Exp Brain Res. 1991; 87(1):75-84.
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Bello S, Paige GD, Highstein SM. The squirrel monkey vestibulo-ocular reflex and adaptive plasticity in yaw, pitch, and roll. Exp Brain Res. 1991; 87(1):57-66.
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Paige GD. Linear vestibulo-ocular reflex (LVOR) and modulation by vergence. Acta Otolaryngol Suppl. 1991; 481:282-6.
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Goebel JA, Paige GD. Posturography following rotation: a model of posture control during vestibular dysfunction. Otolaryngol Head Neck Surg. 1990 Jun; 102(6):722-6.
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Fox CR, Paige GD. Effect of head orientation on human postural stability following unilateral vestibular ablation. J Vestib Res. 1990-1991; 1(2):153-60.
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Paige GD. Nonlinearity and asymmetry in the human vestibulo-ocular reflex. Acta Otolaryngol. 1989 Jul-Aug; 108(1-2):1-8.
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Goebel JA, Paige GD. Dynamic posturography and caloric test results in patients with and without vertigo. Otolaryngol Head Neck Surg. 1989 Jun; 100(6):553-8.
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Paige GD. The influence of target distance on eye movement responses during vertical linear motion. Exp Brain Res. 1989; 77(3):585-93.
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Furman JM, Hain TC, Paige GD. Central adaptation models of the vestibulo-ocular and optokinetic systems. Biol Cybern. 1989; 61(4):255-64.
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Paige GD. Caloric responses after horizontal canal inactivation. Acta Otolaryngol. 1985 Nov-Dec; 100(5-6):321-7.
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Paige GD. Closed chamber iris suture for intraocular lens fixation. Ophthalmic Surg. 1985 Sep; 16(9):566-7.
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Paige GD. Plasticity in the vestibulo-ocular and optokinetic reflexes following modification of canal input. Rev Oculomot Res. 1985; 1:145-53.
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Paige GD. Vestibuloocular reflex and its interactions with visual following mechanisms in the squirrel monkey. I. Response characteristics in normal animals. J Neurophysiol. 1983 Jan; 49(1):134-51.
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Paige GD. Vestibuloocular reflex and its interactions with visual following mechanisms in the squirrel monkey. II. Response characteristics and plasticity following unilateral inactivation of horizontal canal. J Neurophysiol. 1983 Jan; 49(1):152-68.
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Westenberg IS, Paige G, Golub B, Weinberger NM. Evoked potential decrements in auditory cortex. I. Discrete-trial and continual stimulation. Electroencephalogr Clin Neurophysiol. 1976 Apr; 40(4):337-55.
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