Chin-To Fong
| Title | Associate Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Pediatrics |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 777
Rochester NY 14642
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| Title | Associate Professor |
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| Institution | University of Rochester Medical Center |
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| Department | Center for Pediatric Biomedical Research |
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| Title | Associate Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Medical Humanities |
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| Title | Associate Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Biochemistry and Biophysics |
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| 1993 |
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| 1994 | Outstanding Faculty Teaching Award given by the Pediatrics Housestaff | Strong Memorial Hospital | | 2001 |
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| Ruth A. Lawrence Academic Faculty Service Award, Department of Pediatrics, | URSMD | | 2002 |
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| 2003 | DeWitt Brower Dean's Teaching Fellowship | URSMD | | 2002 |
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| Manuel D. Goldman Prize for Excellence in First Year Teaching | URSMD | | 2003 |
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| URSMD Nominee of the American Association of Medical Colleges Award for Humanism in Medicine | Received commendation from the American Assoc. Medical Colleges | | 2003 |
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| Commendation for First Year Teaching | URSMD | | 2004 |
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| Elected Faculty Commencement Speaker | the URSMD Class of 2004 | | 2004 |
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| Outstanding Faculty Teaching Award | Medical Students Class of 2005 | | 2004 |
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| First Annual Loss Science Lecturer | St. John Fisher College | | 2004 |
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| Elected member of Alpha Omega Alpha Zeta Chapter | Class of 2005, URSMD | | 2004 |
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| 2005 | Manuel D. Goldman Prize for Excellence in First Year Teaching | University of Rochester School of Med. and Dent. | | 2007 |
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| Leonard Tow Humanism in Medicine Award | Arnold P. Gold Foundation | | 2007 |
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| Gold Medal Award for Excellence in Teaching | Alumni Association, URSMD |
Dr. Fong's primary research interest is Genetics of orofacial clefts. Cleft lip and palate is a common birth defect that affects one in 700 children in the U. S. and around the world. Children with this birth defect face multiple challenges, such as feeding difficulty, hearing impairment, speech defects and many dental abnormalities. These problems, along with the cosmetic changes associated with the clefts, often result in life-long physical, educational and psychological handicaps. Caring of these children thus requires a team approach over long periods of time.
Cleft lip and palate is a familial trait, but the genetic factors that result in this abnormality have not been clearly identified. Recent calculations have led to the belief that as many as a couple dozen genetic factors may act together to cause cleft lip and palate, with a few of the factors being more important than the rest. Moreover, there is convincing evidence that environment factors, such as cigarette smoking by the pregnant mother, play a role in the development of cleft lip and palate in the fetus.
In these situations, the environmental and genetic factors act together to cause the birth defect. Therefore, cleft lip and palate is considered a multifactorial genetic disorder. The work in our laboratory is focused on finding the genetic factors for cleft lip and palate through linkage disequilibrium analyses. We believe that better treatment and prevention of cleft lip and palate will come from a better understanding of these genetic and environmental factors.
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Newman DL, Fisher LM, Ohmen J, Parody R, Fong CT, Frisina ST, Mapes F, Eddins DA, Robert Frisina D, Frisina RD, Friedman RA. GRM7 variants associated with age-related hearing loss based on auditory perception. Hear Res. 2012 Dec; 294(1-2):125-32.
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Digiovanni BF, Ward DS, O'Donnell SM, Fong CT, Gross RA, Grady-Weliky T, Lambert DR. Process of discovery: A fourth-year translational science course. Med Educ Online. 2011; 16.
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Ryckman KK, Feenstra B, Shaffer JR, Bream EN, Geller F, Feingold E, Weeks DE, Gadow E, Cosentino V, Saleme C, Simhan HN, Merrill D, Fong CT, Busch T, Berends SK, Comas B, Camelo JL, Boyd H, Laurie CC, Crosslin D, Zhang Q, Doheny KF, Pugh E, Melbye M, Marazita ML, Dagle JM, Murray JC. Replication of a genome-wide association study of birth weight in preterm neonates. J Pediatr. 2012 Jan; 160(1):19-24.e4.
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Ton TG, Fogg TT, Fong CT, John C, Li SX, Marshall JA, Peters K, Neal W, Pearson TA. Knowledge, perception, and behaviors of relatives of people with premature heart disease: a systematic literature review. Circulation. 2011 Aug 23; 124(8):958-64.
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Thienpont B, Béna F, Breckpot J, Philip N, Menten B, Van Esch H, Scalais E, Salamone JM, Fong CT, Kussmann JL, Grange DK, Gorski JL, Zahir F, Yong SL, Morris MM, Gimelli S, Fryns JP, Mortier G, Friedman JM, Villard L, Bottani A, Vermeesch JR, Cheung SW, Devriendt K. Duplications of the critical Rubinstein-Taybi deletion region on chromosome 16p13.3 cause a novel recognisable syndrome. J Med Genet. 2010 Mar; 47(3):155-61.
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Brunetti-Pierri N, Berg JS, Scaglia F, Belmont J, Bacino CA, Sahoo T, Lalani SR, Graham B, Lee B, Shinawi M, Shen J, Kang SH, Pursley A, Lotze T, Kennedy G, Lansky-Shafer S, Weaver C, Roeder ER, Grebe TA, Arnold GL, Hutchison T, Reimschisel T, Amato S, Geragthy MT, Innis JW, Obersztyn E, Nowakowska B, Rosengren SS, Bader PI, Grange DK, Naqvi S, Garnica AD, Bernes SM, Fong CT, Summers A, Walters WD, Lupski JR, Stankiewicz P, Cheung SW, Patel A. Recurrent reciprocal 1q21.1 deletions and duplications associated with microcephaly or macrocephaly and developmental and behavioral abnormalities. Nat Genet. 2008 Dec; 40(12):1466-71.
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Robinson DM, Meagher CC, Orlowski CC, Lagoe EC, Fong CT. Young-Simpson syndrome (YSS), a variant of del(1)(p36) syndrome? Am J Med Genet A. 2008 Jun 15; 146A(12):1571-4.
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Robinson DM, Fong CT. Genetics in medical school curriculum: a look at the University of Rochester School of Medicine and Dentistry. J Zhejiang Univ Sci B. 2008 Jan; 9(1):10-5.
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Berg JS, Brunetti-Pierri N, Peters SU, Kang SH, Fong CT, Salamone J, Freedenberg D, Hannig VL, Prock LA, Miller DT, Raffalli P, Harris DJ, Erickson RP, Cunniff C, Clark GD, Blazo MA, Peiffer DA, Gunderson KL, Sahoo T, Patel A, Lupski JR, Beaudet AL, Cheung SW. Speech delay and autism spectrum behaviors are frequently associated with duplication of the 7q11.23 Williams-Beuren syndrome region. Genet Med. 2007 Jul; 9(7):427-41.
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Yoon YJ, Perkiomaki MR, Tallents RH, Barillas I, Herrera-Guido R, Fong CT, Kyrkanides S. Transverse craniofacial features and their genetic predisposition in families with nonsyndromic unilateral cleft lip and palate. Cleft Palate Craniofac J. 2004 May; 41(3):256-61.
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Yoon YJ, Perkiomaki MR, Tallents RH, Barillas I, Herrera-Guido R, Fong CT, Kyrkanides S. Association of nasomaxillary asymmetry in children with unilateral cleft lip and palate and their parents. Cleft Palate Craniofac J. 2003 Sep; 40(5):493-7.
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Perkiomaki MR, Yoon YJ, Tallents RH, Barillas I, Herrera-Guido R, Moss ME, Fong CT, Kyrkanides S. Association of distinct craniofacial features in nonsyndromic cleft lip and palate family members. Cleft Palate Craniofac J. 2003 Jul; 40(4):397-402.
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Suzuki T, Li W, Zhang Q, Karim A, Novak EK, Sviderskaya EV, Hill SP, Bennett DC, Levin AV, Nieuwenhuis HK, Fong CT, Castellan C, Miterski B, Swank RT, Spritz RA. Hermansky-Pudlak syndrome is caused by mutations in HPS4, the human homolog of the mouse light-ear gene. Nat Genet. 2002 Mar; 30(3):321-4.
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Fong CT, Wang M, Young EC, Hogan CA, Tallents RH, Kyrkanides S, Liptak GS, Sanger JA, Frisina RD. Microtia associated with the Kabuki (Niikawa-Kuroki) syndrome. Otolaryngol Head Neck Surg. 2001 Nov; 125(5):557-8.
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Cao Q, Abeysinghe H, Chow O, Xu J, Kaung H, Fong C, Keng P, Insel RA, Lee WM, Barrett JC, Wang N. Suppression of tumorigenicity in human ovarian carcinoma cell line SKOV-3 by microcell-mediated transfer of chromosome 11. Cancer Genet Cytogenet. 2001 Sep; 129(2):131-7.
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Kaczorowski JM, Halterman JS, Spitalnik P, Mannick E, Fong CT, Seaman JM. Pathology teach and tell: congenital hepatic fibrosis and autosomal dominant polycystic kidney disease. Pediatr Pathol Mol Med. 2001 May-Jun; 20(3):245-8.
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Gupta P, Mick G, Fong CT, Jospe N, McCormick K. Hyponatremia secondary to reset osmostat in a child with a central nervous system midline defect and a chromosomal abnormality. J Pediatr Endocrinol Metab. 2000 Nov-Dec; 13(9):1637-41.
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Index of suspicion. Pediatr Rev. 2000 Sep; 21(9):315-20.
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LaPoint SF, Powers JM, Woodruff JM, MacCollin M, Jacoby LB, Vortmeyer AO, Zhuang Z, Fong CT, Ifthikharuddin SF, Teot L, Coniglio JU, Sullivan RP. Schwann cell-onion bulb tumor of the trigeminal nerve: hyperplasia, dysplasia or neoplasia? Acta Neuropathol. 2000 Jan; 99(1):67-72.
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Xu J, Fong CT, Cedrone E, Sullivan J, Wang N. Prenatal identification of de novo marker chromosomes using micro-FISH approach. Clin Genet. 1998 Jun; 53(6):490-6.
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Berg MJ, Schifitto G, Powers JM, Martinez-Capolino C, Fong CT, Myers GJ, Epstein LG, Walsh CA. X-linked female band heterotopia-male lissencephaly syndrome. Neurology. 1998 Apr; 50(4):1143-6.
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Oh J, Ho L, Ala-Mello S, Amato D, Armstrong L, Bellucci S, Carakushansky G, Ellis JP, Fong CT, Green JS, Heon E, Legius E, Levin AV, Nieuwenhuis HK, Pinckers A, Tamura N, Whiteford ML, Yamasaki H, Spritz RA. Mutation analysis of patients with Hermansky-Pudlak syndrome: a frameshift hot spot in the HPS gene and apparent locus heterogeneity. Am J Hum Genet. 1998 Mar; 62(3):593-8.
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Chitayat D, Grix A, Balfe JW, Abramowicz JS, Garza J, Fong CT, Silver MM, Saller DN, Bresnick GH, Giedion A, Lachman RS, Rimoin DL. Brachydactyly-short stature-hypertension (Bilginturan) syndrome: report on two families. Am J Med Genet. 1997 Dec 19; 73(3):279-85.
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Fong CT. Principles of inborn errors of metabolism: an exercise. Pediatr Rev. 1995 Oct; 16(10):390-5.
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Fong CT. Molecular diagnosis of genetic diseases. Pediatr Ann. 1993 May; 22(5):304-10.
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Fong CT. Clinical diagnosis of genetic diseases. Pediatr Ann. 1993 May; 22(5):277-81.
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Marchuk DA, Tavakkol R, Wallace MR, Brownstein BH, Taillon-Miller P, Fong CT, Legius E, Andersen LB, Glover TW, Collins FS. A yeast artificial chromosome contig encompassing the type 1 neurofibromatosis gene. Genomics. 1992 Jul; 13(3):672-80.
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Fong CT, White PS, Peterson K, Sapienza C, Cavenee WK, Kern SE, Vogelstein B, Cantor AB, Look AT, Brodeur GM. Loss of heterozygosity for chromosomes 1 or 14 defines subsets of advanced neuroblastomas. Cancer Res. 1992 Apr 1; 52(7):1780-5.
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Moley JF, Brother MB, Fong CT, White PS, Baylin SB, Nelkin B, Wells SA, Brodeur GM. Consistent association of 1p loss of heterozygosity with pheochromocytomas from patients with multiple endocrine neoplasia type 2 syndromes. Cancer Res. 1992 Feb 15; 52(4):770-4.
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Brodeur GM, Fong CT. Molecular biology and genetics of human neuroblastoma. Cancer Genet Cytogenet. 1989 Sep; 41(2):153-74.
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Fong CT, Dracopoli NC, White PS, Merrill PT, Griffith RC, Housman DE, Brodeur GM. Loss of heterozygosity for the short arm of chromosome 1 in human neuroblastomas: correlation with N-myc amplification. Proc Natl Acad Sci U S A. 1989 May; 86(10):3753-7.
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Brodeur GM, Fong CT, Morita M, Griffith R, Hayes FA, Seeger RC. Molecular analysis and clinical significance of N-myc amplification and chromosome 1p monosomy in human neuroblastomas. Prog Clin Biol Res. 1988; 271:3-15.
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Fong CT, Brodeur GM. Down's syndrome and leukemia: epidemiology, genetics, cytogenetics and mechanisms of leukemogenesis. Cancer Genet Cytogenet. 1987 Sep; 28(1):55-76.
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Barton LL, Lustig RH, Fong CT, Walentik CA. Neonatal septicemia due to Pseudomonas aeruginosa. Am Fam Physician. 1986 Mar; 33(3):147-51.
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