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Chin-To Fong

TitleAssociate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentPediatrics
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 777
Rochester NY 14642
Other Positions
TitleAssociate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentBiochemistry and Biophysics

TitleAssociate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentMedical Humanities and Bioethics

 
 Awards And Honors
1993 - 1994Outstanding Faculty Teaching Award given by the Pediatrics Housestaff  | Strong Memorial Hospital
2001     Ruth A. Lawrence Academic Faculty Service Award, Department of Pediatrics,  | URSMD
2002 - 2003DeWitt Brower Dean's Teaching Fellowship  | URSMD
2002     Manuel D. Goldman Prize for Excellence in First Year Teaching  | URSMD
2003     URSMD Nominee of the American Association of Medical Colleges Award for Humanism in Medicine  | Received commendation from the American Assoc. Medical Colleges
2003     Commendation for First Year Teaching  | URSMD
2004     Elected Faculty Commencement Speaker  | the URSMD Class of 2004
2004     Outstanding Faculty Teaching Award  | Medical Students Class of 2005
2004     First Annual Loss Science Lecturer  | St. John Fisher College
2004     Elected member of Alpha Omega Alpha Zeta Chapter  | Class of 2005, URSMD
2004 - 2005Manuel D. Goldman Prize for Excellence in First Year Teaching  | University of Rochester School of Med. and Dent.
2007     Leonard Tow Humanism in Medicine Award  | Arnold P. Gold Foundation
2007     Gold Medal Award for Excellence in Teaching  | Alumni Association, URSMD
 
 Overview
Dr. Fong's primary research interest is Genetics of orofacial clefts. Cleft lip and palate is a common birth defect that affects one in 700 children in the U. S. and around the world. Children with this birth defect face multiple challenges, such as feeding difficulty, hearing impairment, speech defects and many dental abnormalities. These problems, along with the cosmetic changes associated with the clefts, often result in life-long physical, educational and psychological handicaps. Caring of these children thus requires a team approach over long periods of time.

Cleft lip and palate is a familial trait, but the genetic factors that result in this abnormality have not been clearly identified. Recent calculations have led to the belief that as many as a couple dozen genetic factors may act together to cause cleft lip and palate, with a few of the factors being more important than the rest. Moreover, there is convincing evidence that environment factors, such as cigarette smoking by the pregnant mother, play a role in the development of cleft lip and palate in the fetus.

In these situations, the environmental and genetic factors act together to cause the birth defect. Therefore, cleft lip and palate is considered a multifactorial genetic disorder. The work in our laboratory is focused on finding the genetic factors for cleft lip and palate through linkage disequilibrium analyses. We believe that better treatment and prevention of cleft lip and palate will come from a better understanding of these genetic and environmental factors.

 
 Selected Publications
List All   |   Timeline
  1. Petersen AK, Ahmad A, Shafiq M, Brown-Kipphut B, Fong CT, Anwar Iqbal M. Deletion 1q43 encompassing only CHRM3 in a patient with autistic disorder. Eur J Med Genet. 2013 Feb; 56(2):118-22.
    View in: PubMed
  2. Bream EN, Leppellere CR, Cooper ME, Dagle JM, Merrill DC, Christensen K, Simhan HN, Fong CT, Hallman M, Muglia LJ, Marazita ML, Murray JC. Candidate gene linkage approach to identify DNA variants that predispose to preterm birth. Pediatr Res. 2013 Feb; 73(2):135-41.
    View in: PubMed
  3. Newman DL, Fisher LM, Ohmen J, Parody R, Fong CT, Frisina ST, Mapes F, Eddins DA, Robert Frisina D, Frisina RD, Friedman RA. GRM7 variants associated with age-related hearing loss based on auditory perception. Hear Res. 2012 Dec; 294(1-2):125-32.
    View in: PubMed
  4. DiGiovanni BF, Ward DS, O'Donnell SM, Fong CT, Gross RA, Grady-Weliky T, Lambert DR. Process of discovery: a fourth-year translational science course. Med Educ Online. 2011; 16.
    View in: PubMed
  5. Ryckman KK, Feenstra B, Shaffer JR, Bream EN, Geller F, Feingold E, Weeks DE, Gadow E, Cosentino V, Saleme C, Simhan HN, Merrill D, Fong CT, Busch T, Berends SK, Comas B, Camelo JL, Boyd H, Laurie CC, Crosslin D, Zhang Q, Doheny KF, Pugh E, Melbye M, Marazita ML, Dagle JM, Murray JC. Replication of a genome-wide association study of birth weight in preterm neonates. J Pediatr. 2012 Jan; 160(1):19-24.e4.
    View in: PubMed
  6. Ton TG, Fogg TT, Fong CT, John C, Li SX, Marshall JA, Peters K, Neal W, Pearson TA. Knowledge, perception, and behaviors of relatives of people with premature heart disease: a systematic literature review. Circulation. 2011 Aug 23; 124(8):958-64.
    View in: PubMed
  7. Thienpont B, Béna F, Breckpot J, Philip N, Menten B, Van Esch H, Scalais E, Salamone JM, Fong CT, Kussmann JL, Grange DK, Gorski JL, Zahir F, Yong SL, Morris MM, Gimelli S, Fryns JP, Mortier G, Friedman JM, Villard L, Bottani A, Vermeesch JR, Cheung SW, Devriendt K. Duplications of the critical Rubinstein-Taybi deletion region on chromosome 16p13.3 cause a novel recognisable syndrome. J Med Genet. 2010 Mar; 47(3):155-61.
    View in: PubMed
  8. Nagamani SC, Zhang F, Shchelochkov OA, Bi W, Ou Z, Scaglia F, Probst FJ, Shinawi M, Eng C, Hunter JV, Sparagana S, Lagoe E, Fong CT, Pearson M, Doco-Fenzy M, Landais E, Mozelle M, Chinault AC, Patel A, Bacino CA, Sahoo T, Kang SH, Cheung SW, Lupski JR, Stankiewicz P. Microdeletions including YWHAE in the Miller-Dieker syndrome region on chromosome 17p13.3 result in facial dysmorphisms, growth restriction, and cognitive impairment. J Med Genet. 2009 Dec; 46(12):825-33.
    View in: PubMed
  9. Brunetti-Pierri N, Berg JS, Scaglia F, Belmont J, Bacino CA, Sahoo T, Lalani SR, Graham B, Lee B, Shinawi M, Shen J, Kang SH, Pursley A, Lotze T, Kennedy G, Lansky-Shafer S, Weaver C, Roeder ER, Grebe TA, Arnold GL, Hutchison T, Reimschisel T, Amato S, Geragthy MT, Innis JW, Obersztyn E, Nowakowska B, Rosengren SS, Bader PI, Grange DK, Naqvi S, Garnica AD, Bernes SM, Fong CT, Summers A, Walters WD, Lupski JR, Stankiewicz P, Cheung SW, Patel A. Recurrent reciprocal 1q21.1 deletions and duplications associated with microcephaly or macrocephaly and developmental and behavioral abnormalities. Nat Genet. 2008 Dec; 40(12):1466-71.
    View in: PubMed
  10. Robinson DM, Meagher CC, Orlowski CC, Lagoe EC, Fong CT. Young-Simpson syndrome (YSS), a variant of del(1)(p36) syndrome? Am J Med Genet A. 2008 Jun 15; 146A(12):1571-4.
    View in: PubMed
  11. Robinson DM, Fong CT. Genetics in medical school curriculum: a look at the University of Rochester School of Medicine and Dentistry. J Zhejiang Univ Sci B. 2008 Jan; 9(1):10-5.
    View in: PubMed
  12. Berg JS, Brunetti-Pierri N, Peters SU, Kang SH, Fong CT, Salamone J, Freedenberg D, Hannig VL, Prock LA, Miller DT, Raffalli P, Harris DJ, Erickson RP, Cunniff C, Clark GD, Blazo MA, Peiffer DA, Gunderson KL, Sahoo T, Patel A, Lupski JR, Beaudet AL, Cheung SW. Speech delay and autism spectrum behaviors are frequently associated with duplication of the 7q11.23 Williams-Beuren syndrome region. Genet Med. 2007 Jul; 9(7):427-41.
    View in: PubMed
  13. Yoon YJ, Perkiomaki MR, Tallents RH, Barillas I, Herrera-Guido R, Fong CT, Kyrkanides S. Transverse craniofacial features and their genetic predisposition in families with nonsyndromic unilateral cleft lip and palate. Cleft Palate Craniofac J. 2004 May; 41(3):256-61.
    View in: PubMed
  14. Yoon YJ, Perkiomaki MR, Tallents RH, Barillas I, Herrera-Guido R, Fong CT, Kyrkanides S. Association of nasomaxillary asymmetry in children with unilateral cleft lip and palate and their parents. Cleft Palate Craniofac J. 2003 Sep; 40(5):493-7.
    View in: PubMed
  15. Perkiomaki MR, Yoon YJ, Tallents RH, Barillas I, Herrera-Guido R, Moss ME, Fong CT, Kyrkanides S. Association of distinct craniofacial features in nonsyndromic cleft lip and palate family members. Cleft Palate Craniofac J. 2003 Jul; 40(4):397-402.
    View in: PubMed
  16. Suzuki T, Li W, Zhang Q, Karim A, Novak EK, Sviderskaya EV, Hill SP, Bennett DC, Levin AV, Nieuwenhuis HK, Fong CT, Castellan C, Miterski B, Swank RT, Spritz RA. Hermansky-Pudlak syndrome is caused by mutations in HPS4, the human homolog of the mouse light-ear gene. Nat Genet. 2002 Mar; 30(3):321-4.
    View in: PubMed
  17. Fong CT, Wang M, Young EC, Hogan CA, Tallents RH, Kyrkanides S, Liptak GS, Sanger JA, Frisina RD. Microtia associated with the Kabuki (Niikawa-Kuroki) syndrome. Otolaryngol Head Neck Surg. 2001 Nov; 125(5):557-8.
    View in: PubMed
  18. Cao Q, Abeysinghe H, Chow O, Xu J, Kaung H, Fong C, Keng P, Insel RA, Lee WM, Barrett JC, Wang N. Suppression of tumorigenicity in human ovarian carcinoma cell line SKOV-3 by microcell-mediated transfer of chromosome 11. Cancer Genet Cytogenet. 2001 Sep; 129(2):131-7.
    View in: PubMed
  19. Kaczorowski JM, Halterman JS, Spitalnik P, Mannick E, Fong CT, Seaman JM. Pathology teach and tell: congenital hepatic fibrosis and autosomal dominant polycystic kidney disease. Pediatr Pathol Mol Med. 2001 May-Jun; 20(3):245-8.
    View in: PubMed
  20. Gupta P, Mick G, Fong CT, Jospe N, McCormick K. Hyponatremia secondary to reset osmostat in a child with a central nervous system midline defect and a chromosomal abnormality. J Pediatr Endocrinol Metab. 2000 Nov-Dec; 13(9):1637-41.
    View in: PubMed
  21. Index of suspicion. Pediatr Rev. 2000 Sep; 21(9):315-20.
    View in: PubMed
  22. LaPoint SF, Powers JM, Woodruff JM, MacCollin M, Jacoby LB, Vortmeyer AO, Zhuang Z, Fong CT, Ifthikharuddin SF, Teot L, Coniglio JU, Sullivan RP. Schwann cell-onion bulb tumor of the trigeminal nerve: hyperplasia, dysplasia or neoplasia? Acta Neuropathol. 2000 Jan; 99(1):67-72.
    View in: PubMed
  23. Xu J, Fong CT, Cedrone E, Sullivan J, Wang N. Prenatal identification of de novo marker chromosomes using micro-FISH approach. Clin Genet. 1998 Jun; 53(6):490-6.
    View in: PubMed
  24. Berg MJ, Schifitto G, Powers JM, Martinez-Capolino C, Fong CT, Myers GJ, Epstein LG, Walsh CA. X-linked female band heterotopia-male lissencephaly syndrome. Neurology. 1998 Apr; 50(4):1143-6.
    View in: PubMed
  25. Oh J, Ho L, Ala-Mello S, Amato D, Armstrong L, Bellucci S, Carakushansky G, Ellis JP, Fong CT, Green JS, Heon E, Legius E, Levin AV, Nieuwenhuis HK, Pinckers A, Tamura N, Whiteford ML, Yamasaki H, Spritz RA. Mutation analysis of patients with Hermansky-Pudlak syndrome: a frameshift hot spot in the HPS gene and apparent locus heterogeneity. Am J Hum Genet. 1998 Mar; 62(3):593-8.
    View in: PubMed
  26. Chitayat D, Grix A, Balfe JW, Abramowicz JS, Garza J, Fong CT, Silver MM, Saller DN, Bresnick GH, Giedion A, Lachman RS, Rimoin DL. Brachydactyly-short stature-hypertension (Bilginturan) syndrome: report on two families. Am J Med Genet. 1997 Dec 19; 73(3):279-85.
    View in: PubMed
  27. Fong CT. Principles of inborn errors of metabolism: an exercise. Pediatr Rev. 1995 Oct; 16(10):390-5.
    View in: PubMed
  28. Fong CT. Molecular diagnosis of genetic diseases. Pediatr Ann. 1993 May; 22(5):304-10.
    View in: PubMed
  29. Fong CT. Clinical diagnosis of genetic diseases. Pediatr Ann. 1993 May; 22(5):277-81.
    View in: PubMed
  30. Marchuk DA, Tavakkol R, Wallace MR, Brownstein BH, Taillon-Miller P, Fong CT, Legius E, Andersen LB, Glover TW, Collins FS. A yeast artificial chromosome contig encompassing the type 1 neurofibromatosis gene. Genomics. 1992 Jul; 13(3):672-80.
    View in: PubMed
  31. Fong CT, White PS, Peterson K, Sapienza C, Cavenee WK, Kern SE, Vogelstein B, Cantor AB, Look AT, Brodeur GM. Loss of heterozygosity for chromosomes 1 or 14 defines subsets of advanced neuroblastomas. Cancer Res. 1992 Apr 1; 52(7):1780-5.
    View in: PubMed
  32. Moley JF, Brother MB, Fong CT, White PS, Baylin SB, Nelkin B, Wells SA, Brodeur GM. Consistent association of 1p loss of heterozygosity with pheochromocytomas from patients with multiple endocrine neoplasia type 2 syndromes. Cancer Res. 1992 Feb 15; 52(4):770-4.
    View in: PubMed
  33. Brodeur GM, Fong CT. Molecular biology and genetics of human neuroblastoma. Cancer Genet Cytogenet. 1989 Sep; 41(2):153-74.
    View in: PubMed
  34. Fong CT, Dracopoli NC, White PS, Merrill PT, Griffith RC, Housman DE, Brodeur GM. Loss of heterozygosity for the short arm of chromosome 1 in human neuroblastomas: correlation with N-myc amplification. Proc Natl Acad Sci U S A. 1989 May; 86(10):3753-7.
    View in: PubMed
  35. Brodeur GM, Fong CT, Morita M, Griffith R, Hayes FA, Seeger RC. Molecular analysis and clinical significance of N-myc amplification and chromosome 1p monosomy in human neuroblastomas. Prog Clin Biol Res. 1988; 271:3-15.
    View in: PubMed
  36. Fong CT, Brodeur GM. Down's syndrome and leukemia: epidemiology, genetics, cytogenetics and mechanisms of leukemogenesis. Cancer Genet Cytogenet. 1987 Sep; 28(1):55-76.
    View in: PubMed
  37. Barton LL, Lustig RH, Fong CT, Walentik CA. Neonatal septicemia due to Pseudomonas aeruginosa. Am Fam Physician. 1986 Mar; 33(3):147-51.
    View in: PubMed

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