Charlotte Ryan
| Title | Professor Emeritus |
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| Institution | School of Medicine and Dentistry |
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| Department | Pathology and Laboratory Medicine |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester NY 14642
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Dr. Ryan's research endeavors with the liver transplant program include the study of post transplant biopsies in hepatitis C patients more particularly regarding response to antiviral therapy and the treatment of acute cellular rejection. Additional projects have included liver grafts from donors with CNS tumors and analysis of outcomes in patients with primary sclerosing cholangitis. Collaboration with Oncology is ongoing and involves the association of tissue factor (TF) with VEGF expression in colorectal, pancreatic and gastric carcinomas, suggesting a link between hemostatic activation and angiogenesis. Past studies included EGFR and VEGF expression and mutated K12-ras as indicators of survival in colon cancer. Another field of investigation concerns the development and evaluation of microtubule-targeting agents as therapeutic candidates in hepatic and colorectal cancers.
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Barry CT, Mills B, Hah Z, Mooney RA, Ryan CK, Rubens DJ, Parker KJ. Shear wave dispersion measures liver steatosis. Ultrasound Med Biol. 2012 Feb; 38(2):175-82.
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Barry CT, D'Souza M, McCall M, Safadjou S, Ryan C, Kashyap R, Marroquin C, Orloff M, Almudevar A, Godfrey TE. Micro RNA expression profiles as adjunctive data to assess the risk of hepatocellular carcinoma recurrence after liver transplantation. Am J Transplant. 2012 Feb; 12(2):428-37.
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Jain A, Singhal A, Kashyap R, Safadjou S, Ryan CK, Orloff MS. Comparative analysis of hepatitis C recurrence and fibrosis progression between deceased-donor and living-donor liver transplantation: 8-year longitudinal follow-up. Transplantation. 2011 Aug 27; 92(4):453-60.
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Kashyap R, Safadjou S, Chen R, Mantry P, Sharma R, Patil V, Maloo M, Ryan C, Marroquin C, Barry C, Ramaraju G, Maliakkal B, Orloff M. Living donor and deceased donor liver transplantation for autoimmune and cholestatic liver diseases--an analysis of the UNOS database. J Gastrointest Surg. 2010 Sep; 14(9):1362-9.
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Wu MH, Ma WL, Hsu CL, Chen YL, Ou JH, Ryan CK, Hung YC, Yeh S, Chang C. Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription. Sci Transl Med. 2010 May 19; 2(32):32ra35.
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Kashyap R, Ryan C, Sharma R, Maloo MK, Safadjou S, Graham M, Tretheway D, Jain A, Orloff M. Liver grafts from donors with central nervous system tumors: a single-center perspective. Liver Transpl. 2009 Oct; 15(10):1204-8.
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Kashyap R, Mantry P, Sharma R, Maloo MK, Safadjou S, Qi Y, Jain A, Maliakkal B, Ryan C, Orloff M. Comparative analysis of outcomes in living and deceased donor liver transplants for primary sclerosing cholangitis. J Gastrointest Surg. 2009 Aug; 13(8):1480-6.
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Yao JL, Ryan CK, Francis CW, Kohli M, Taubman MB, Khorana AA. Tissue factor and VEGF expression in prostate carcinoma: a tissue microarray study. Cancer Invest. 2009 May; 27(4):430-4.
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Jain A, Sharma R, Ryan C, Safadjou S, Kashyap R, Mantry P, Maliakkal B, Orloff M. Response to antiviral therapy in liver transplant recipients with recurrent hepatitis C viral infection: a single center experience. Clin Transplant. 2010 Jan-Feb; 24(1):104-11.
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Tretheway D, Jain A, LaPoint R, Sharma R, Orloff M, Milot P, Bozorgzadeh A, Ryan C. Should trichrome stain be used on all post-liver transplant biopsies with hepatitis C virus infection to estimate the fibrosis score? Liver Transpl. 2008 May; 14(5):695-700.
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Jain A, Sharma R, Ryan C, Tsoulfas G, Orloff M, Abt P, Kashyap R, Batzold P, Sauberman L, Safadjou S, Graham M, Bozorgzadeh A. Potential immunological advantage of intravenous mycophenolate mofetil with tacrolimus and steroids in primary deceased donor liver transplantation and live donor liver transplantation without antibody induction. Liver Transpl. 2008 Feb; 14(2):202-9.
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Khorana AA, Ahrendt SA, Ryan CK, Francis CW, Hruban RH, Hu YC, Hostetter G, Harvey J, Taubman MB. Tissue factor expression, angiogenesis, and thrombosis in pancreatic cancer. Clin Cancer Res. 2007 May 15; 13(10):2870-5.
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Teeters JC, Betts R, Ryan C, Huether J, Elias K, Hartmann D, Massey T, Chen L. Rectal and cutaneous malakoplakia in an orthotopic cardiac transplant recipient. J Heart Lung Transplant. 2007 Apr; 26(4):411-3.
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Qualia CM, Brown MR, Ryan CK, Rossi TM. Oral Mucosal Neuromas Leading to the Diagnosis of Multiple Endocrine Neoplasia Type 2B in a Child With Intestinal Pseudo-obstruction. Gastroenterol Hepatol (N Y). 2007 Mar; 3(3):208-11.
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Saad WE, Davies MG, Ryan CK, Rubens DJ, Patel NC, Lee DE, Sahler LG, Waldman DL. Incidence of arterial injuries detected by arteriography following percutaneous right-lobe ultrasound-guided core liver biopsies in human subjects. Am J Gastroenterol. 2006 Nov; 101(11):2641-5.
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Jain A, Ryan C, Mohanka R, Orloff M, Abt P, Romano J, Bryan L, Batzold P, Mantry P, Bozorgzadeh A. Characterization of CD4, CD8, CD56 positive lymphocytes and C4d deposits to distinguish acute cellular rejection from recurrent hepatitis C in post-liver transplant biopsies. Clin Transplant. 2006 Sep-Oct; 20(5):624-33.
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Saad WE, Ryan CK, Davies MG, Fultz P, Rubens DJ, Patel NC, Sahler LG, Lee DE, Kitanosono T, Sasson T, Waldman DL. Safety and efficacy of fluoroscopic versus ultrasound guidance for core liver biopsies in potential living related liver transplant donors: preliminary results. J Vasc Interv Radiol. 2006 Aug; 17(8):1307-12.
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Baichi MM, Arifuddin RM, Mantry PS, Bozorgzadeh A, Ryan C. Liver transplantation in sickle cell anemia: a case of acute sickle cell intrahepatic cholestasis and a case of sclerosing cholangitis. Transplantation. 2005 Dec 15; 80(11):1630-2.
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Khorana AA, Hu YC, Ryan CK, Komorowski RA, Hostetter G, Ahrendt SA. Vascular endothelial growth factor and DPC4 predict adjuvant therapy outcomes in resected pancreatic cancer. J Gastrointest Surg. 2005 Sep-Oct; 9(7):903-11.
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Jain A, Orloff M, Kashyap R, Lansing K, Betts R, Mohanka R, Menegus M, Ryan C, Bozorgzadeh A. Does valganciclovir hydrochloride (valcyte) provide effective prophylaxis against cytomegalovirus infection in liver transplant recipients? Transplant Proc. 2005 Sep; 37(7):3182-6.
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Shunyakov L, Ryan CK, Sahasrabudhe DM, Khorana AA. The influence of host response on colorectal cancer prognosis. Clin Colorectal Cancer. 2004 May; 4(1):38-45.
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Bozorgzadeh A, Jain A, Ryan C, Ornt D, Zand M, Mantry P, Lansing K, Orloff M. Impact of hepatitis C viral infection in primary cadaveric liver allograft versus primary living-donor allograft in 100 consecutive liver transplant recipients receiving tacrolimus. Transplantation. 2004 Apr 15; 77(7):1066-70.
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Nieves DS, Phipps RP, Pollock SJ, Ochs HD, Zhu Q, Scott GA, Ryan CK, Kobayashi I, Rossi TM, Goldsmith LA. Dermatologic and immunologic findings in the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Arch Dermatol. 2004 Apr; 140(4):466-72.
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Ray EC, Avissar NE, Vukcevic D, Toia L, Ryan CK, Berlanga-Acosta J, Sax HC. Growth hormone and epidermal growth factor together enhance amino acid transport systems B0,+ and A in remnant small intestine after massive enterectomy. J Surg Res. 2003 Nov; 115(1):164-70.
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Na X, Duan HO, Messing EM, Schoen SR, Ryan CK, di Sant'Agnese PA, Golemis EA, Wu G. Identification of the RNA polymerase II subunit hsRPB7 as a novel target of the von Hippel-Lindau protein. EMBO J. 2003 Aug 15; 22(16):4249-59.
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Na X, Wu G, Ryan CK, Schoen SR, di'Santagnese PA, Messing EM. Overproduction of vascular endothelial growth factor related to von Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1 alpha expression in renal cell carcinomas. J Urol. 2003 Aug; 170(2 Pt 1):588-92.
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Ray EC, Avissar NE, Vukcevic D, Toia L, Ryan CK, Berlanga-Acosta J, Sax HC. Growth hormone and epidermal growth factor together enhance amino acid transport systems B(0,+) and A in remnant small intestine after massive enterectomy. J Surg Res. 2003 Aug; 113(2):257-63.
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Elias KR, Ryan CK. Epithelioid hemangioendothelioma and the elusive vacuole. Liver Transpl. 2003 Mar; 9(3):310-2.
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Khorana AA, Ryan CK, Cox C, Eberly S, Sahasrabudhe DM. Vascular endothelial growth factor, CD68, and epidermal growth factor receptor expression and survival in patients with Stage II and Stage III colon carcinoma: a role for the host response in prognosis. Cancer. 2003 Feb 15; 97(4):960-8.
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Daikh BE, Ryan CK, Schwartz RH. Montelukast reduces peripheral blood eosinophilia but not tissue eosinophilia or symptoms in a patient with eosinophilic gastroenteritis and esophageal stricture. Ann Allergy Asthma Immunol. 2003 Jan; 90(1):23-7.
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Ryan CK, Johnson LA, Germin BI, Marcos A. One hundred consecutive hepatic biopsies in the workup of living donors for right lobe liver transplantation. Liver Transpl. 2002 Dec; 8(12):1114-22.
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Burton JR, Ryan C, Shaw-Stiffel TA. Liver transplantation in mushroom poisoning. J Clin Gastroenterol. 2002 Sep; 35(3):276-80.
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Avissar NE, Ryan CK, Ganapathy V, Sax HC. Na(+)-dependent neutral amino acid transporter ATB(0) is a rabbit epithelial cell brush-border protein. Am J Physiol Cell Physiol. 2001 Sep; 281(3):C963-71.
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Chey WY, Hussain A, Ryan C, Potter GD, Shah A. Infliximab for refractory ulcerative colitis. Am J Gastroenterol. 2001 Aug; 96(8):2373-81.
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Belly RT, Rosenblatt JD, Steinmann M, Toner J, Sun J, Shehadi J, Peacock JL, Raubertas RF, Jani N, Ryan CK. Detection of mutated K12-ras in histologically negative lymph nodes as an indicator of poor prognosis in stage II colorectal cancer. Clin Colorectal Cancer. 2001 Aug; 1(2):110-6.
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Ifthikharuddin JJ, Mieles LA, Rosenblatt JD, Ryan CK, Sahasrabudhe DM. CD-20 expression in post-transplant lymphoproliferative disorders: treatment with rituximab. Am J Hematol. 2000 Oct; 65(2):171-3.
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Siafakas CG, Ryan CK, Brown MR, Miller TL. Multiple esophageal rings: an association with eosinophilic esophagitis: case report and review of the literature. Am J Gastroenterol. 2000 Jun; 95(6):1572-5.
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Moran SL, Ryan CK, Orlando GS, Pratt CE, Michalko KB. Effects of 5-fluorouracil on flexor tendon repair. J Hand Surg Am. 2000 Mar; 25(2):242-51.
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Bili A, Condemi JJ, Bottone SM, Ryan CK. Seven cases of complete and incomplete forms of Churg-Strauss syndrome not related to leukotriene receptor antagonists. J Allergy Clin Immunol. 1999 Nov; 104(5):1060-5.
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Hofgärtner WT, Thorp M, Ramus MW, Delorefice G, Chey WY, Ryan CK, Takahashi GW, Lobitz JR. Gastric adenocarcinoma associated with fundic gland polyps in a patient with attenuated familial adenomatous polyposis. Am J Gastroenterol. 1999 Aug; 94(8):2275-81.
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Morrissey NJ, Blom D, Ryan CK, Fisher T, Bronsther O, Orloff MS. Tolerance induction permits the development of graft-versus-host disease: donor-mediated attack following small bowel transplantation in mixed chimeras. Transpl Immunol. 1999 Mar; 7(1):19-25.
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Iannoli P, Miller JH, Ryan CK, Sax HC. Enterocyte nutrient transport is preserved in a rabbit model of acute intestinal ischemia. JPEN J Parenter Enteral Nutr. 1998 Nov-Dec; 22(6):387-92.
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Iannoli P, Miller JH, Ryan CK, Sax HC. Glucocorticoids upregulate intestinal nutrient transport in a time-dependent and substrate-specific fashion. J Gastrointest Surg. 1998 Sep-Oct; 2(5):449-57.
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Iannoli P, Miller JH, Ryan CK, Gu LH, Ziegler TR, Sax HC. Epidermal growth factor and human growth hormone accelerate adaptation after massive enterectomy in an additive, nutrient-dependent, and site-specific fashion. Surgery. 1997 Oct; 122(4):721-8; discussion 728-9.
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Ryan CK, Miller JH, Seydel AS, de Mesy Jensen K, Sax HC. Epidermal growth factor and neurotensin induce microvillus hypertrophy following massive enterectomy. J Gastrointest Surg. 1997 Sep-Oct; 1(5):467-73.
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Zwick A, Munir M, Ryan CK, Gian J, Burt RW, Leppert M, Spirio L, Chey WY. Gastric adenocarcinoma and dysplasia in fundic gland polyps of a patient with attenuated adenomatous polyposis coli. Gastroenterology. 1997 Aug; 113(2):659-63.
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Morrissey NJ, Blom D, Ryan C, Fisher T, Bronsther O, Orloff M. Graft versus host disease in rats made tolerant for organ allografts. J Surg Res. 1997 May; 69(2):307-15.
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Joseph D, Jin H, Ryan C, Chey WY. Resolution of anorectal incontinence in herpes proctitis confirmed by anorectal manometry. Gastrointest Endosc. 1997 May; 45(5):429-32.
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Iannoli P, Miller JH, Ryan CK, Gu LH, Ziegler TR, Sax HC. Human growth hormone induces system B transport in short bowel syndrome. J Surg Res. 1997 Apr; 69(1):150-8.
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Seydel AS, Miller JH, Sarac TP, Ryan CK, Chey WY, Sax HC. Octreotide diminishes luminal nutrient transport activity, which is reversed by epidermal growth factor. Am J Surg. 1996 Sep; 172(3):267-71.
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Sarac TP, Seydel AS, Ryan CK, Bessey PQ, Miller JH, Souba WW, Sax HC. Sequential alterations in gut mucosal amino acid and glucose transport after 70% small bowel resection. Surgery. 1996 Sep; 120(3):503-8.
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Sax HC, Illig KA, Ryan CK, Hardy DJ. Low-dose enteral feeding is beneficial during total parenteral nutrition. Am J Surg. 1996 Jun; 171(6):587-90.
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Ryan CK, Potter GD. Disinfectant colitis. Rinse as well as you wash. J Clin Gastroenterol. 1995 Jul; 21(1):6-9.
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Ryan CK, Sax HC. Evaluation of a carboxymethylcellulose sponge for prevention of postoperative adhesions. Am J Surg. 1995 Jan; 169(1):154-9; discussion 159-60.
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Sarac TP, Souba WW, Miller JH, Ryan CK, Koch M, Bessey PQ, Sax HC. Starvation induces differential small bowel luminal amino acid transport. Surgery. 1994 Oct; 116(4):679-85; discussion 685-6.
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Reed A, Ryan C, Schwartz SI. Xanthogranulomatous cholecystitis. J Am Coll Surg. 1994 Aug; 179(2):249-52.
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Panosian MS, Hengerer AS, Ryan CK. Pathologic quiz case 2. Chondrosarcoma of the maxilla. Arch Otolaryngol Head Neck Surg. 1993 Feb; 119(2):246-7, 249-50.
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Illig KA, Ryan CK, Hardy DJ, Rhodes J, Locke W, Sax HC. Total parenteral nutrition-induced changes in gut mucosal function: atrophy alone is not the issue. Surgery. 1992 Oct; 112(4):631-7.
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Di Sant'Agnese PA, Ettinger LJ, Ryan CK, Jensen KL, Anderson VM, Biro FM, Emmens RW. Histiomonocytic malignancy. A spectrum of disease in an 11-month-old infant. Cancer. 1983 Oct 15; 52(8):1417-22.
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Muechler EK, Gillette MB, Cary D, Ryan CK, di Sant' Agnese PA, Markham RE, Jacobs LS. Ovarian lipoid cell tumor. Steroid hormones and ultrastructure. Diagn Gynecol Obstet. 1982; 4(4):309-15.
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