Ronnie Guillet
| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Pediatrics |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 651
Rochester NY 14642
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| 1992 |
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| Member, Society for Pediatric Research | | 2003 |
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| Department of Pediatrics "Above and Beyond" Award | | 2007 |
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| Member, American Pediatric Society | | 2007 |
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| Ruth A. Lawrence Faculty Service Award in Fellowship Training | | 2010 |
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| URMC Mentoring of Junior Faculty Award |
Dr. Guillet's primary research focus is in the area of neonatal brain development and injury. The developing brain is at risk from the effects of centrally-acting agents, including hypoxia, seizures, and medications. This risk is due in part to the fact that the brain may be more vulnerable during times of rapid maturational change. She has an active clinical research program, focused on the neonatal brain. Dr. Guillet is the recent recipient of a 5 year multimillion dollar grant from NIH for a multicenter clinical trial to determine if treatment with phenobarbital compared with treatment with placebo for four months after resolution of neonatal seizures alters neurodevelopmental outcome or changes the incidence of recurrent seizures. In addition, she is the overall Primary Investigator for long term follow-up of children around the world who were enrolled in the CoolCap Study (head cooling with systemic hypothermia for infants with neonatal encephalopathy). She has served as site investigator on national studies of hypothermia in the treatment of neonatal asphyxia and of phototherapy in extremely low birthweight neonates, including a substudy on the potential effect of hyperbilirubinemia and phototherapy on the maturation of the brainstem evoked response, a marker of brainstem development in premature infants.
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Shankaran S, Barnes PD, Hintz SR, Laptook AR, Zaterka-Baxter KM, McDonald SA, Ehrenkranz RA, Walsh MC, Tyson JE, Donovan EF, Goldberg RN, Bara R, Das A, Finer NN, Sanchez PJ, Poindexter BB, Van Meurs KP, Carlo WA, Stoll BJ, Duara S, Guillet R, Higgins RD. Brain injury following trial of hypothermia for neonatal hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed. 2012 Nov; 97(6):F398-404.
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Shankaran S, Pappas A, McDonald SA, Vohr BR, Hintz SR, Yolton K, Gustafson KE, Leach TM, Green C, Bara R, Huitema CM, Ehrenkranz RA, Tyson JE, Das A, Hammond J, Peralta-Carcelen M, Evans PW, Heyne RJ, Wilson-Costello DE, Vaucher YE, Bauer CR, Dusick AM, Adams-Chapman I, Goldstein RF, Guillet R, Papile LA, Higgins RD. Childhood outcomes after hypothermia for neonatal encephalopathy. N Engl J Med. 2012 May 31; 366(22):2085-92.
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Lasky RE, Church MW, Orlando MS, Morris BH, Parikh NA, Tyson JE, McDavid GE, Oh W, Stevenson DK, Van Meurs KP, Guillet R, Phelps DL. The effects of aggressive vs. conservative phototherapy on the brainstem auditory evoked responses of extremely-low-birth-weight infants. Pediatr Res. 2012 Jan; 71(1):77-84.
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Guillet R, Edwards AD, Thoresen M, Ferriero DM, Gluckman PD, Whitelaw A, Gunn AJ. Seven- to eight-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy. Pediatr Res. 2012 Feb; 71(2):205-9.
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Schor NF, Guillet R, McAnarney ER. Anticipatory guidance as a principle of faculty development: managing transition and change. Acad Med. 2011 Oct; 86(10):1235-40.
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Guillet R, Kwon JM, Chen S, McDermott MP. Urine phenobarbital drug screening: potential use for compliance assessment in neonates. J Child Neurol. 2012 Feb; 27(2):200-3.
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Higgins RD, Raju T, Edwards AD, Azzopardi DV, Bose CL, Clark RH, Ferriero DM, Guillet R, Gunn AJ, Hagberg H, Hirtz D, Inder TE, Jacobs SE, Jenkins D, Juul S, Laptook AR, Lucey JF, Maze M, Palmer C, Papile L, Pfister RH, Robertson NJ, Rutherford M, Shankaran S, Silverstein FS, Soll RF, Thoresen M, Walsh WF. Hypothermia and other treatment options for neonatal encephalopathy: an executive summary of the Eunice Kennedy Shriver NICHD workshop. J Pediatr. 2011 Nov; 159(5):851-858.e1.
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Guillet R, Dees R. Will my baby walk?: The predictive value of cranial imaging. Neurology. 2011 Jun 14; 76(24):2048-9.
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Shankaran S, Pappas A, McDonald SA, Laptook AR, Bara R, Ehrenkranz RA, Tyson JE, Goldberg R, Donovan EF, Fanaroff AA, Das A, Poole WK, Walsh M, Higgins RD, Welsh C, Salhab W, Carlo WA, Poindexter B, Stoll BJ, Guillet R, Finer NN, Stevenson DK, Bauer CR. Predictive value of an early amplitude integrated electroencephalogram and neurologic examination. Pediatrics. 2011 Jul; 128(1):e112-20.
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Jaacks LM, Young MF, Essley BV, McNanley TJ, Cooper EM, Pressman EK, McIntyre AW, Orlando MS, Abkowitz JL, Guillet R, O'Brien KO. Placental expression of the heme transporter, feline leukemia virus subgroup C receptor, is related to maternal iron status in pregnant adolescents. J Nutr. 2011 Jul; 141(7):1267-72.
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Kwon JM, Guillet R, Shankaran S, Laptook AR, McDonald SA, Ehrenkranz RA, Tyson JE, O'Shea TM, Goldberg RN, Donovan EF, Fanaroff AA, Poole WK, Higgins RD, Walsh MC. Clinical seizures in neonatal hypoxic-ischemic encephalopathy have no independent impact on neurodevelopmental outcome: secondary analyses of data from the neonatal research network hypothermia trial. J Child Neurol. 2011 Mar; 26(3):322-8.
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Young MF, Pressman E, Foehr ML, McNanley T, Cooper E, Guillet R, Orlando M, McIntyre AW, Lafond J, O'Brien KO. Impact of maternal and neonatal iron status on placental transferrin receptor expression in pregnant adolescents. Placenta. 2010 Nov; 31(11):1010-4.
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Wilson-Costello D, Walsh MC, Langer JC, Guillet R, Laptook AR, Stoll BJ, Shankaran S, Finer NN, Van Meurs KP, Engle WA, Das A. Impact of postnatal corticosteroid use on neurodevelopment at 18 to 22 months' adjusted age: effects of dose, timing, and risk of bronchopulmonary dysplasia in extremely low birth weight infants. Pediatrics. 2009 Mar; 123(3):e430-7.
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Morris BH, Oh W, Tyson JE, Stevenson DK, Phelps DL, O'Shea TM, McDavid GE, Perritt RL, Van Meurs KP, Vohr BR, Grisby C, Yao Q, Pedroza C, Das A, Poole WK, Carlo WA, Duara S, Laptook AR, Salhab WA, Shankaran S, Poindexter BB, Fanaroff AA, Walsh MC, Rasmussen MR, Stoll BJ, Cotten CM, Donovan EF, Ehrenkranz RA, Guillet R, Higgins RD. Aggressive vs. conservative phototherapy for infants with extremely low birth weight. N Engl J Med. 2008 Oct 30; 359(18):1885-96.
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Guillet R, Kwon JM. Prophylactic phenobarbital administration after resolution of neonatal seizures: survey of current practice. Pediatrics. 2008 Oct; 122(4):731-5.
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Thingvoll ES, Guillet R, Caserta M, Dicenzo R. Observational trial of a 48-hour gentamicin dosing regimen derived from Monte Carlo simulations in infants born at less than 28 weeks' gestation. J Pediatr. 2008 Oct; 153(4):530-4.
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Gantz M, Roy J, Guillet R. Analyzing retrospective data with time-varying exposure: a cautionary tale of H2 blockers in ELBW neonates. Am J Perinatol. 2008 Feb; 25(2):93-100.
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Guillet R, Kwon J. Seizure recurrence and developmental disabilities after neonatal seizures: outcomes are unrelated to use of phenobarbital prophylaxis. J Child Neurol. 2007 Apr; 22(4):389-95.
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Amin SB, Guillet R. Auditory neural maturation after exposure to multiple courses of antenatal betamethasone in premature infants as evaluated by auditory brainstem response. Pediatrics. 2007 Mar; 119(3):502-8.
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Pulsifer-Anderson E, Guillet R. National Institues of Health recommends the routine use of H2 blockers in preterm infants be carefully evaluated. Neonatal Netw. 2006 May-Jun; 25(3):223-4.
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Guillet R, Stoll BJ, Cotten CM, Gantz M, McDonald S, Poole WK, Phelps DL. Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants. Pediatrics. 2006 Feb; 117(2):e137-42.
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Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF, Fanaroff AA, Poole WK, Wright LL, Higgins RD, Finer NN, Carlo WA, Duara S, Oh W, Cotten CM, Stevenson DK, Stoll BJ, Lemons JA, Guillet R, Jobe AH. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med. 2005 Oct 13; 353(15):1574-84.
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Amin SB, Charafeddine L, Guillet R. Transient bilirubin encephalopathy and apnea of prematurity in 28 to 32 weeks gestational age infants. J Perinatol. 2005 Jun; 25(6):386-90.
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Elhassan NO, Stevens TP, Sorbero ME, Dick AW, Guillet R, Hall CB. Guidelines for palivizumab prophylaxis: are they based on infant's risk of hospitalization for respiratory syncytial viral disease? Pediatr Infect Dis J. 2003 Nov; 22(11):939-43.
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Amin SB, Orlando MS, Dalzell LE, Merle KS, Guillet R. Brainstem maturation after antenatal steroids exposure in premature infants as evaluated by auditory brainstem-evoked response. J Perinatol. 2003 Jun; 23(4):307-11.
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DiCenzo R, Forrest A, Slish JC, Cole C, Guillet R. A gentamicin pharmacokinetic population model and once-daily dosing algorithm for neonates. Pharmacotherapy. 2003 May; 23(5):585-91.
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Hashim MJ, Guillet R. Common issues in the care of sick neonates. Am Fam Physician. 2002 Nov 1; 66(9):1685-92.
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Uy IP, D'Angio CT, Menegus M, Guillet R. Changes in early-onset group B beta hemolytic streptococcus disease with changing recommendations for prophylaxis. J Perinatol. 2002 Oct-Nov; 22(7):516-22.
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Stevens TP, Chess PR, McConnochie KM, Sinkin RA, Guillet R, Maniscalco WM, Fisher SG. Survival in early- and late-term infants with congenital diaphragmatic hernia treated with extracorporeal membrane oxygenation. Pediatrics. 2002 Sep; 110(3):590-6.
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Amin SB, Ahlfors C, Orlando MS, Dalzell LE, Merle KS, Guillet R. Bilirubin and serial auditory brainstem responses in premature infants. Pediatrics. 2001 Apr; 107(4):664-70.
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McBride MC, Laroia N, Guillet R. Electrographic seizures in neonates correlate with poor neurodevelopmental outcome. Neurology. 2000 Aug 22; 55(4):506-13.
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Amin SB, Merle KS, Orlando MS, Dalzell LE, Guillet R. Brainstem maturation in premature infants as a function of enteral feeding type. Pediatrics. 2000 Aug; 106(2 Pt 1):318-22.
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Sinkin RA, Dweck HS, Horgan MJ, Gallaher KJ, Cox C, Maniscalco WM, Chess PR, D'Angio CT, Guillet R, Kendig JW, Ryan RM, Phelps DL. Early dexamethasone-attempting to prevent chronic lung disease. Pediatrics. 2000 Mar; 105(3 Pt 1):542-8.
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Amin SB, Orlando MS, Dalzell LE, Merle KS, Guillet R. Morphological changes in serial auditory brain stem responses in 24 to 32 weeks' gestational age infants during the first week of life. Ear Hear. 1999 Oct; 20(5):410-8.
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Kendig JW, Ryan RM, Sinkin RA, Maniscalco WM, Notter RH, Guillet R, Cox C, Dweck HS, Horgan MJ, Reubens LJ, Risemberg H, Phelps DL. Comparison of two strategies for surfactant prophylaxis in very premature infants: a multicenter randomized trial. Pediatrics. 1998 Jun; 101(6):1006-12.
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Laroia N, Guillet R, Burchfiel J, McBride MC. EEG background as predictor of electrographic seizures in high-risk neonates. Epilepsia. 1998 May; 39(5):545-51.
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Butler-O'Hara M, LeMoine C, Guillet R. Analgesia for neonatal circumcision: a randomized controlled trial of EMLA cream versus dorsal penile nerve block. Pediatrics. 1998 Apr; 101(4):E5.
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Laroia N, McBride L, Baggs R, Guillet R. Dextromethorphan ameliorates effects of neonatal hypoxia on brain morphology and seizure threshold in rats. Brain Res Dev Brain Res. 1997 May 20; 100(1):29-34.
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Chess PR, Chess MA, Manuli MA, Guillet R. Screening head ultrasound to detect intraventricular hemorrhage in premature infants. Pediatr Radiol. 1997 Apr; 27(4):305-8.
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Fisher S, Guillet R. Neonatal caffeine alters passive avoidance retention in rats in an age- and gender-related manner. Brain Res Dev Brain Res. 1997 Jan 2; 98(1):145-9.
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Guillet R. Neonatal caffeine exposure alters seizure susceptibility in rats in an age-related manner. Brain Res Dev Brain Res. 1995 Oct 27; 89(1):124-8.
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Guillet R, Dunham L. Neonatal caffeine exposure and seizure susceptibility in adult rats. Epilepsia. 1995 Aug; 36(8):743-9.
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Stevens TP, Guillet R. Use of glucagon to treat neonatal low-output congestive heart failure after maternal labetalol therapy. J Pediatr. 1995 Jul; 127(1):151-3.
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Etzel BA, Guillet R. Effects of neonatal exposure to caffeine on adenosine A1 receptor ontogeny using autoradiography. Brain Res Dev Brain Res. 1994 Oct 14; 82(1-2):223-30.
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Guillet R, Kellogg CK. Neonatal caffeine exposure alters developmental sensitivity to adenosine receptor ligands. Pharmacol Biochem Behav. 1991 Dec; 40(4):811-7.
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Guillet R, Kellogg C. Neonatal exposure to therapeutic caffeine alters the ontogeny of adenosine A1 receptors in brain of rats. Neuropharmacology. 1991 May; 30(5):489-96.
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Miranda R, Ceckler T, Guillet R, Kellogg CK. Aging-related changes in brain metabolism are altered by early developmental exposure to diazepam. Neurobiol Aging. 1990 Mar-Apr; 11(2):117-22.
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Miranda R, Ceckler T, Guillet R, Kellogg C. Early developmental exposure to benzodiazepine ligands alters brain 31P-NMR spectra in young adult rats. Brain Res. 1990 Jan 1; 506(1):85-92.
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Guillet R. Neonatal caffeine exposure alters adenosine receptor control of locomotor activity in the developing rat. Dev Pharmacol Ther. 1990; 15(2):94-100.
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Younkin D, Medoff-Cooper B, Guillet R, Sinwell T, Chance B, Delivoria-Papadopoulos M. In vivo 31P nuclear magnetic resonance measurement of chronic changes in cerebral metabolites following neonatal intraventricular hemorrhage. Pediatrics. 1988 Sep; 82(3):331-6.
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Guillet R, Wyatt J, Baggs RB, Kellogg CK. Anesthetic-induced corneal lesions in developmentally sensitive rats. Invest Ophthalmol Vis Sci. 1988 Jun; 29(6):949-54.
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Kellogg CK, Guillet R. Developmental effects of neuroactive drugs. Prog Clin Biol Res. 1988; 281:265-77.
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Lawson B, Anday E, Guillet R, Wagerle LC, Chance B, Delivoria-Papadopoulos M. Brain oxidative phosphorylation following alteration in head position in preterm and term neonates. Pediatr Res. 1987 Sep; 22(3):302-5.
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Guillet R, Saffran M, Michaelson SM. Pituitary-adrenal response in neonatal rats. Endocrinology. 1980 Mar; 106(3):991-4.
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Guillet R, Michaelson SM. Corticotropin responsiveness in the neonatal rat. Neuroendocrinology. 1978; 27(3-4):119-25.
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Michaelson SM, Guillet R, Catallo MA, Small J, Inamine G, Heggeness FW. Proceedings: Influence of 2450 MHz CW microwaves on rats exposed in-utero. J Microw Power. 1976 Jun; 11(2):165-6.
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Guillet R, Sherman RG. Evidence for multiple inhibitory innervation of horseshoe crab muscles. Comp Biochem Physiol A Comp Physiol. 1974 Dec 1; 49(4):655-60.
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