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William Simon

TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentBiochemistry and Biophysics
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester NY 14642
 
 Overview
Current interest is image processing applied to medical and biological data and application of information handling techniques to medical education. Prior areas of interest have been emission and transmission tomography and ultrasound. Collaborative work has included epidemiology of cancer due to radiation exposure and smoking, sodium and potassium transport and metabolic models of cell differentiation.

 
 Selected Publications
  • Segel GB, Simon W, Lichtman MA. Should we still be focused on red cell hemoglobin F as the principal explanation for the salutary effect of hydroxyurea in sickle cell disease? Pediatr Blood Cancer. 2011 Jul 15; 57(1):8-9.
    View in: PubMed
  • Das IJ, Cheng CW, Watts RJ, Ahnesjö A, Gibbons J, Li XA, Lowenstein J, Mitra RK, Simon WE, Zhu TC. Accelerator beam data commissioning equipment and procedures: report of the TG-106 of the Therapy Physics Committee of the AAPM. Med Phys. 2008 Sep; 35(9):4186-215.
    View in: PubMed
  • Simon W, Segel GB, Lichtman MA. Early allogeneic stem cell transplantation for chronic myelogenous leukemia in the imatinib era: a preliminary assessment. Blood Cells Mol Dis. 2006 Sep-Oct; 37(2):116-24; discussion 125-7.
    View in: PubMed
  • Siegel JA, Zimmerman BE, Kodimer K, Dell MA, Simon WE. Accurate dose calibrator activity measurement of 90Y-ibritumomab tiuxetan. J Nucl Med. 2004 Mar; 45(3):450-4.
    View in: PubMed
  • Custer AW, Kazarinova-Noyes K, Sakurai T, Xu X, Simon W, Grumet M, Shrager P. The role of the ankyrin-binding protein NrCAM in node of Ranvier formation. J Neurosci. 2003 Nov 5; 23(31):10032-9.
    View in: PubMed
  • Weiss B, Clarkson TW, Simon W. Silent latency periods in methylmercury poisoning and in neurodegenerative disease. Environ Health Perspect. 2002 Oct; 110 Suppl 5:851-4.
    View in: PubMed
  • Morsch R, Simon W, Coleman PD. Neurons may live for decades with neurofibrillary tangles. J Neuropathol Exp Neurol. 1999 Feb; 58(2):188-97.
    View in: PubMed
  • Simon W. A simple stereoscopic endoscope. JSLS. 1998 Jan-Mar; 2(1):67-70.
    View in: PubMed
  • Maillie HD, Simon W, Greenspan BS, Watts RJ, Quinn BR. The influence of life table corrections for smokers and nonsmokers on the health effects of radon using the BEIR (biological effects of ioniziing radiation) IV method. Health Phys. 1994 Jun; 66(6):615-20.
    View in: PubMed
  • Spar IL, Pryor KC, Simon W. Effect of debt level on the residency preferences of graduating medical students. Acad Med. 1993 Jul; 68(7):570-2.
    View in: PubMed
  • Maillie HD, Simon W, Watts RJ, Quinn BR. Determining person-years of life lost using the BEIR V method. Health Phys. 1993 May; 64(5):461-6.
    View in: PubMed
  • Maillie HD, Baker JV, Simon W, Watts RJ, Quinn BR. Age related rejoining of broken chromosomes in human leukocytes following X-irradiation. Mech Ageing Dev. 1992 Sep; 65(2-3):229-38.
    View in: PubMed
  • Forbes GB, Simon W, Amatruda JM. Is bioimpedance a good predictor of body-composition change? Am J Clin Nutr. 1992 Jul; 56(1):4-6.
    View in: PubMed
  • Simon W, Segel GB, Lichtman MA. Upper and lower time limits in the decision to recommend marrow transplantation for patients with chronic myelogenous leukaemia. Br J Haematol. 1988 Sep; 70(1):31-6.
    View in: PubMed
  • Simon W. Anatomy helper: computer-assisted anatomy instruction. Comput Methods Programs Biomed. 1988 Jan-Feb; 26(1):71-4.
    View in: PubMed
  • Segel GB, Simon W, Lichtman MA. Variables influencing the timing of marrow transplantation in patients with chronic myelogenous leukemia. Blood. 1986 Nov; 68(5):1055-64.
    View in: PubMed
  • Coleman PD, Romano J, Lapham L, Simon W. Cell counts in cerebral cortex of an autistic patient. J Autism Dev Disord. 1985 Sep; 15(3):245-55.
    View in: PubMed
  • Segel GB, Simon W, Lichtman MA. Multicomponent analysis of amino acid transport in human lymphocytes. Diminished L-system transport in chronic leukemic B lymphocytes. J Clin Invest. 1984 Jul; 74(1):17-24.
    View in: PubMed
  • Segel GB, Simon W, Lichtman MA. A multicomponent analysis of amino acid transport systems in human lymphocytes. 1. Kinetic parameters of the A and L systems and pathways of uptake of naturally occurring amino acids in blood lymphocytes. J Cell Physiol. 1983 Sep; 116(3):372-8.
    View in: PubMed
  • Segel GB, Simon W, Lichtman AH, Lichtman MA. The activation of lymphocyte plasma membrane (Na,K)-ATPase by EGTA is explained better by zinc than calcium chelation. J Biol Chem. 1981 Jul 10; 256(13):6629-32.
    View in: PubMed
  • Walters TE, Simon W, Chesler DA, Correia JA. Attenuation correction in gamma emission computed tomography. J Comput Assist Tomogr. 1981 Feb; 5(1):89-94.
    View in: PubMed
  • Simon W, Blumenthal S. A high resolution interactive image scanner. IEEE Trans Biomed Eng. 1980 Aug; 27(8):468-70.
    View in: PubMed
  • Simon W. Avoiding megamouse experiments. J Toxicol Environ Health. 1980 Jul; 6(4):907-10.
    View in: PubMed
  • Simon W, Blumenthal S, Young JH, Elsbeck C. The scientific laboratory instrument to computer coupler. IEEE Trans Biomed Eng. 1980 Jan; 27(1):55-7.
    View in: PubMed
  • Segel GB, Simon W, Lichtman MA. Regulation of sodium and potassium transport in phytohemagglutinin-stimulated human blood lymphocytes. J Clin Invest. 1979 Sep; 64(3):834-41.
    View in: PubMed
  • Lichtman MA, Chamberlain JK, Simon W, Santillo PA. Parasinusoidal location of megakaryocytes in marrow: a determinant of platelet release. Am J Hematol. 1978; 4(4):303-12.
    View in: PubMed
  • Isenberg JF, Simon W. Radionuclide axial tomography by half back-projection. Phys Med Biol. 1978 Jan; 23(1):154-8.
    View in: PubMed
  • Lichtman MA, Chamberlain JK, Simon W, Santillo PA. The parasinusoidal location of megakaryocytes in marrow: a determinant of platelet release and a physiologic version of vascular invasion and metastasis. Trans Assoc Am Physicians. 1977; 90:313-23.
    View in: PubMed
  • Simon W, Eden M. Three-dimensional measurements from scanning electron micrographs by electron scribing. Rev Sci Instrum. 1976 Apr; 47(4):443-4.
    View in: PubMed
  • Neuman WF, Neuman MW, Sammon PJ, Simon W, Lane K. The metabolism of labeled parathyroid hormone. III. Studies in rats. Calcif Tissue Res. 1975 Sep 17; 18(4):251-61.
    View in: PubMed
  • Kay DB, Keyes JW, Simon W. Radionuclide tomographic image reconstruction using Fourier transform techniques. J Nucl Med. 1974 Nov; 15(11):981-6.
    View in: PubMed
  • Garvey CF, Young JH, Coleman PD, Simon W. Automated three-dimensional dendrite tracking system. Electroencephalogr Clin Neurophysiol. 1973 Aug; 35(2):199-204.
    View in: PubMed
  • Gramiak R, Waag RC, Simon W. Ciné ultrasound cardiography. Radiology. 1973 Apr; 107(1):175-80.
    View in: PubMed
  • Simon W. A scheme for accelerated floating point operation in small computers. Comput Biomed Res. 1970 Jun; 3(3):238-40.
    View in: PubMed
  • Simon W. A method of exponential separation applicable to small computers. Phys Med Biol. 1970 Apr; 15(2):355-60.
    View in: PubMed
  • Simon W. The Rochester Ultimate Weapon. A high speed real-time interpretive computer language for biologists. Med Biol Eng. 1970 Mar; 8(2):203-5.
    View in: PubMed
  • Simon W. Reaching across the void. J Med Educ. 1970 Jan; 45(1):60-1.
    View in: PubMed
  • Jones EA, Craigie A, Tavill AS, Simon W, Rosenoer VM. Urea kinetics and the direct measurement of the synthetic rate of albumin utilizing [14C]carbonate. Clin Sci. 1968 Dec; 35(3):553-64.
    View in: PubMed
  • Wright B, Simon W, Walsh BT. A kinetic model of metabolism essential to differentiation in Dictyostelium discoideum. Proc Natl Acad Sci U S A. 1968 Jun; 60(2):644-51.
    View in: PubMed
  • Simon W. SNAP an interpretive real-time computer language for biology. Med Biol Eng. 1968 Jan; 6(1):83-5.
    View in: PubMed
  • Houk J, Simon W. Responses of Golgi tendon organs to forces applied to muscle tendon. J Neurophysiol. 1967 Nov; 30(6):1466-81.
    View in: PubMed
  • Herd JA, Leclair NR, Simon W. Arterial pressure pulse contours during hemorrhage in anesthetized dogs. J Appl Physiol. 1966 Nov; 21(6):1864-8.
    View in: PubMed
  • Simon W. Photomicrography of deep fields. Rev Sci Instrum. 1965 Nov; 36(11):1654-5.
    View in: PubMed

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