Dr. Campbell's research focuses on childhood lead toxicity, with two major projects underway:
Lead exposure and bone development: Basic-science research and our own preliminary studies show that lead exposure can adversely affect the development of bone density. The current study, being conducted with the Department of Orthopedics, is investigating whether lead exposure is a risk factor for the development of osteoporosis. We are conducting cross-sectional studies on 8-9 year old children, 18-19 year-old adolescents and 60-65 year old adults. All subjects are having their bone density measured by DEXA, and their bone lead level measured by KXRF; the URMC is one of the few institutions in the country to have KXRF technology. This project is funded by the National Institute of Environmental Health Sciences of the NIH.

Lead exposure and humoral immunity: Basic-science research studies show that lead exposure can adversely affect the development of antibodies after an infection or immunization. The current study, being conducted with the Cancer Institute, is investigating whether lead exposure is associated with lowered humoral response after vaccination with the HPV vaccine. We will enroll 11-12 year old girls with a broad-range of past lead exposure based on blood lead levels obtained at ages 1-3 years. All will have blood drawn before the vaccine is administered and at 1, 2, and 6 months after the first vaccine. This project is funded by the National Institute of Environmental Health Sciences at NIH.

• Eisenberg KW, van Wijngaarden E, Fisher SG, Korfmacher KS, Campbell JR, Fernandez ID, Cochran J, Geltman PL. Blood lead levels of refugee children resettled in Massachusetts, 2000 to 2007. Am J Public Health. 2011 Jan; 101(1):48-54.
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• van Wijngaarden E, Campbell JR, Cory-Slechta DA. Bone lead levels are associated with measures of memory impairment in older adults. Neurotoxicology. 2009 Jul; 30(4):572-80.
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• Campbell JR, Auinger P. The association between blood lead levels and osteoporosis among adults--results from the third national health and nutrition examination survey (NHANES III). Environ Health Perspect. 2007 Jul; 115(7):1018-22.
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• Agtini MD, Soeharno R, Lesmana M, Punjabi NH, Simanjuntak C, Wangsasaputra F, Nurdin D, Pulungsih SP, Rofiq A, Santoso H, Pujarwoto H, Sjahrurachman A, Sudarmono P, von Seidlein L, Deen JL, Ali M, Lee H, Kim DR, Han O, Park JK, Suwandono A. The burden of diarrhoea, shigellosis, and cholera in North Jakarta, Indonesia: findings from 24 months surveillance. BMC Infect Dis. 2005; 5:89.
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• Campbell JR, Rosier RN, Novotny L, Puzas JE. The association between environmental lead exposure and bone density in children. Environ Health Perspect. 2004 Aug; 112(11):1200-3.
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• Tjaniadi P, Lesmana M, Subekti D, Machpud N, Komalarini S, Santoso W, Simanjuntak CH, Punjabi N, Campbell JR, Alexander WK, Beecham HJ, Corwin AL, Oyofo BA. Antimicrobial resistance of bacterial pathogens associated with diarrheal patients in Indonesia. Am J Trop Med Hyg. 2003 Jun; 68(6):666-70.
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• Oyofo BA, Lesmana M, Subekti D, Tjaniadi P, Larasati W, Putri M, Simanjuntak CH, Punjabi NH, Santoso W. Surveillance of bacterial pathogens of diarrhea disease in Indonesia. Diagn Microbiol Infect Dis. 2002 Nov; 44(3):227-34.
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• Lesmana M, Subekti DS, Tjaniadi P, Simanjuntak CH, Punjabi NH, Campbell JR, Oyofo BA. Spectrum of vibrio species associated with acute diarrhea in North Jakarta, Indonesia. Diagn Microbiol Infect Dis. 2002 Jun; 43(2):91-7.
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• Chanpong GF, Laras K, Sulaiman HA, Soeprapto W, Purnamawati S, Sukri N, Sie A, Tan R, Campbell JR, Corwin AL. Hepatitis C among child transfusion and adult renal dialysis patients in Indonesia. Am J Trop Med Hyg. 2002 Mar; 66(3):317-20.
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• Schaffer SJ, Campbell JR, Szilagyi PG, Weitzman M. Lead screening practices of pediatric residents. Arch Pediatr Adolesc Med. 1998 Feb; 152(2):185-9.
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• Campbell JR, Paris M, Schaffer SJ. A comparison of screening strategies for elevated blood lead levels. Arch Pediatr Adolesc Med. 1996 Nov; 150(11):1205-8.
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• Campbell JR, Schaffer SJ, Szilagyi PG, O'Connor KG, Briss P, Weitzman M. Blood lead screening practices among US pediatricians. Pediatrics. 1996 Sep; 98(3 Pt 1):372-7.
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• Campbell JR, McConnochie KM, Weitzman M. Lead screening among high-risk urban children. Are the 1991 Centers for Disease Control and Prevention guidelines feasible? Arch Pediatr Adolesc Med. 1994 Jul; 148(7):688-93.
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• Szilagyi PG, Roghmann KJ, Campbell JR, Humiston SG, Winter NL, Raubertas RF, Rodewald LE. Immunization practices of primary care practitioners and their relation to immunization levels. Arch Pediatr Adolesc Med. 1994 Feb; 148(2):158-66.
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• Rodewald LE, Roghmann KJ, Szilagyi PG, Winter NL, Campbell JR, Humiston SG. The school-based immunization survey: an inexpensive tool for measuring vaccine coverage. Am J Public Health. 1993 Dec; 83(12):1749-51.
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