RESEARCH: Neuroinflammation in CNS Injury and Alzheimer's Disease.

Twenty years ago evidence from epidemiological studies and investigations of human brain pathology suggested the hypothesis that innate immune activation of the brain, a term now referred to as neuroinflammation, might contribute to the pathogenesis of Alzheimer's and other brain diseases. Based on our pioneering work in the area of cyclooxygenase-2 and inflammation, we initiated a research program that focuses on understanding the role of neuroinflammation in Alzheimer's and other neurodegenerative diseases. Studies conducted in the laboratory with human brain tissue, neuronal cell culture models and mouse models of acute injury and neurodegeneration have pointed to a prominent role for specific proinflammatory cytokines and bioactive prostaglandins in promoting neuroinflammation. Interestingly, our current work in Alzheimer's disease has revealed a potential protective role for neuroinflammation and has led to a focus on the influence of glial expressed cytokines and infiltrating peripheral cells on brain pathology, utilizing genetic and pharmacological approaches in a variety of mouse models. In complementary work, we also have active preclinical projects in the area of brain radiation injury, a critical problem for individuals receiving radiotherapy for brain tumors or bone marrow transplantation. The main goal is to understand the role of neuroinflammation and oxidative stress in promoting injury and to determine whether therapeutic interventions targeting these processes can alleviate late radiation effects, including cognitive changes

RECENT PUBLICATIONS:

Cherry, J.D., B. Liu, J.L. Frost, C.A. Lemere, J.P. Williams, J.A. Olschowka and M.K. O'Banion. 2012. Galactic cosmic radiation leads to cognitive impairment and increased Ab plaque accumulation in a mouse model of Alzheimer's disease. PLOS ONE 7:e53275. PMCID in process.

Dilmanian, F.A., A.L. Jenkins, J. Olschowka, Z. Zhong, J.Y. Park, N.R. Desnoyers, S. Sobotka, G.R. Fois, C.R. Messina, M. Morales, S.D. Hurley, L.A. Trojanczyk, S. Ahmad, N. Shahrabi, P.K. Coyle, A.G. Meek and M.K. O'Banion. 2012. X-ray microbeam irradiation of the contusion-injured rat spinal cord temporarily improves hind-limb function. Rad. Res. Dec 5 [Epub ahead of print]. PMCID in process.

Wu, M.D., A.M. Hein, M.J. Moravan, S.S. Shaftel, J.A. Olschowka and M.K. O'Banion. 2012. Adult murine hippocampal neurogenesis is inhibited by sustained IL-1? and not rescued by voluntary running. Brain Behav. Immun. 26:292-300. PMCID: PMC3258353

Matousek, S.B., S. Ghosh, S.S. Shaftel, S. Kyrkanides, J.A. Olschowka and M.K. O'Banion. 2012. Chronic IL-1?-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration. J. Neuroimmune Pharmacol. 7:156-164. PMCID: PMC3302720

Hein, A. M., T. J. Zarcone, D. B. Parfitt, S. B. Matousek, D. M. Carbonari, J. A. Olschowka and M. K. O'Banion. 2012. Behavioral, structural and molecular changes following long-term hippocampal IL-1? overexpression in transgenic mice. J. Neuroimmune Pharmacol. 7:145-155. PMCID: PMC3214690

Kyrkanides S., R.H. Tallents, J.N. Miller, M.E. Olschowka, R. Johnson, M. Yang, J.A. Olschowka, S.M. Brouxhon and M.K. O'Banion. 2011. Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice. J. Neuroinflammation 8:112. PMCID: PMC3179730

Moravan, M.J., D.A. Olschowka, J.P. Williams and M.K. O'Banion. 2011. Cranial irradiation leads to acute and persistent neuroinflammation with delayed increases in T-cell infiltration and CD11c expression in C57BL/6 mouse brain. Radiat. Res. 176:459-473. PMCID: PMC3191189.

• Cherry JD, Liu B, Frost JL, Lemere CA, Williams JP, Olschowka JA, O'Banion MK. Galactic cosmic radiation leads to cognitive impairment and increased aß plaque accumulation in a mouse model of Alzheimer's disease. PLoS One. 2012; 7(12):e53275.
  View in: PubMed
• Dilmanian FA, Jenkins AL, Olschowka JA, Zhong Z, Park JY, Desnoyers NR, Sobotka S, Fois GR, Messina CR, Morales M, Hurley SD, Trojanczyk L, Ahmad S, Shahrabi N, Coyle PK, Meek AG, O'Banion MK. X-ray microbeam irradiation of the contusion-injured rat spinal cord temporarily improves hind-limb function. Radiat Res. 2013 Jan; 179(1):76-88.
  View in: PubMed
• Kyrkanides S, Brouxhon SM, Tallents RH, Miller JN, Olschowka JA, O'Banion MK. Conditional expression of human ß-hexosaminidase in the neurons of Sandhoff disease rescues mice from neurodegeneration but not neuroinflammation. J Neuroinflammation. 2012; 9:186.
  View in: PubMed
• Dilmanian FA, Rusek A, Fois GR, Olschowka J, Desnoyers NR, Park JY, Dioszegi I, Dane B, Wang R, Tomasi D, Lee H, Hurley SD, Coyle PK, Meek AG, O'Banion MK. Interleaved carbon minibeams: an experimental radiosurgery method with clinical potential. Int J Radiat Oncol Biol Phys. 2012 Oct 1; 84(2):514-9.
  View in: PubMed
• Hein AM, O'Banion MK. Neuroinflammation and cognitive dysfunction in chronic disease and aging. J Neuroimmune Pharmacol. 2012 Mar; 7(1):3-6.
  View in: PubMed
• Matousek SB, Ghosh S, Shaftel SS, Kyrkanides S, Olschowka JA, O'Banion MK. Chronic IL-1ß-Mediated Neuroinflammation Mitigates Amyloid Pathology in a Mouse Model of Alzheimer's Disease without Inducing Overt Neurodegeneration. J Neuroimmune Pharmacol. 2012 Mar; 7(1):156-64.
  View in: PubMed
• O'Banion MK. Acute neuroinflammation and neurogenesis: A role for microglial COX-1. Cell Cycle. 2011 Nov 15; 10(22):3819.
  View in: PubMed
• Wu MD, Hein AM, Moravan MJ, Shaftel SS, Olschowka JA, O'Banion MK. Adult murine hippocampal neurogenesis is inhibited by sustained IL-1ß and not rescued by voluntary running. Brain Behav Immun. 2012 Feb; 26(2):292-300.
  View in: PubMed
• Kyrkanides S, Tallents RH, Miller JN, Olschowka ME, Johnson R, Yang M, Olschowka JA, Brouxhon SM, O'Banion MK. Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice. J Neuroinflammation. 2011; 8:112.
  View in: PubMed
• Moravan MJ, Olschowka JA, Williams JP, O'Banion MK. Cranial irradiation leads to acute and persistent neuroinflammation with delayed increases in T-cell infiltration and CD11c expression in C57BL/6 mouse brain. Radiat Res. 2011 Oct; 176(4):459-73.
  View in: PubMed
• Hein AM, Zarcone TJ, Parfitt DB, Matousek SB, Carbonari DM, Olschowka JA, O'Banion MK. Behavioral, Structural and Molecular Changes following Long-term Hippocampal IL-1ß Overexpression in Transgenic Mice. J Neuroimmune Pharmacol. 2012 Mar; 7(1):145-55.
  View in: PubMed
• Andersen OS, O'Banion MK. Medical Scientist Training Programs: federal funding offers support and drives innovation. Acad Med. 2010 Oct; 85(10):1559.
  View in: PubMed
• Heneka MT, O'Banion MK, Terwel D, Kummer MP. Neuroinflammatory processes in Alzheimer's disease. J Neural Transm. 2010 Aug; 117(8):919-47.
  View in: PubMed
• Matousek SB, Hein AM, Shaftel SS, Olschowka JA, Kyrkanides S, O'Banion MK. Cyclooxygenase-1 mediates prostaglandin E(2) elevation and contextual memory impairment in a model of sustained hippocampal interleukin-1beta expression. J Neurochem. 2010 Jul; 114(1):247-58.
  View in: PubMed
• Hein AM, Stasko MR, Matousek SB, Scott-McKean JJ, Maier SF, Olschowka JA, Costa AC, O'Banion MK. Sustained hippocampal IL-1beta overexpression impairs contextual and spatial memory in transgenic mice. Brain Behav Immun. 2010 Feb; 24(2):243-53.
  View in: PubMed
• Moore AH, Wu M, Shaftel SS, Graham KA, O'Banion MK. Sustained expression of interleukin-1beta in mouse hippocampus impairs spatial memory. Neuroscience. 2009 Dec 29; 164(4):1484-95.
  View in: PubMed
• O'Banion MK. Prostaglandin E2 synthases in neurologic homeostasis and disease. Prostaglandins Other Lipid Mediat. 2010 Apr; 91(3-4):113-7.
  View in: PubMed
• Hein AM, O'Banion MK. Neuroinflammation and memory: the role of prostaglandins. Mol Neurobiol. 2009 Aug; 40(1):15-32.
  View in: PubMed
• Ahn J, Nguyen FT, Mann JR, O'Banion MK. Restructuring MD-PhD programs: career training or broad education? Acad Med. 2009 Apr; 84(4):407; author reply 407-8.
  View in: PubMed
• Kyrkanides S, Miller AW, Miller JN, Tallents RH, Brouxhon SM, Olschowka ME, O'Banion MK, Olschowka JA. Peripheral blood mononuclear cell infiltration and neuroinflammation in the HexB-/- mouse model of neurodegeneration. J Neuroimmunol. 2008 Oct 15; 203(1):50-7.
  View in: PubMed
• Fiorentino PM, Tallents RH, Miller JN, Brouxhon SM, O'Banion MK, Puzas JE, Kyrkanides S. Spinal interleukin-1beta in a mouse model of arthritis and joint pain. Arthritis Rheum. 2008 Oct; 58(10):3100-9.
  View in: PubMed
• Zhong Z, Deane R, Ali Z, Parisi M, Shapovalov Y, O'Banion MK, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV. ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat Neurosci. 2008 Apr; 11(4):420-2.
  View in: PubMed
• Shaftel SS, Griffin WS, O'Banion MK. The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective. J Neuroinflammation. 2008; 5:7.
  View in: PubMed
• Shaftel SS, Carlson TJ, Olschowka JA, Kyrkanides S, Matousek SB, O'Banion MK. Chronic interleukin-1beta expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration. J Neurosci. 2007 Aug 29; 27(35):9301-9.
  View in: PubMed
• Brouxhon S, Kyrkanides S, O'Banion MK, Johnson R, Pearce DA, Centola GM, Miller JN, McGrath KH, Erdle B, Scott G, Schneider S, VanBuskirk J, Pentland AP. Sequential down-regulation of E-cadherin with squamous cell carcinoma progression: loss of E-cadherin via a prostaglandin E2-EP2 dependent posttranslational mechanism. Cancer Res. 2007 Aug 15; 67(16):7654-64.
  View in: PubMed
• Shaftel SS, Kyrkanides S, Olschowka JA, Miller JN, Johnson RE, O'Banion MK. Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. J Clin Invest. 2007 Jun; 117(6):1595-604.
  View in: PubMed
• Kyrkanides S, Fiorentino PM, Miller JN, Gan Y, Lai YC, Shaftel SS, Puzas JE, Piancino MG, O'Banion MK, Tallents RH. Amelioration of pain and histopathologic joint abnormalities in the Col1-IL-1beta(XAT) mouse model of arthritis by intraarticular induction of mu-opioid receptor into the temporomandibular joint. Arthritis Rheum. 2007 Jun; 56(6):2038-48.
  View in: PubMed
• Heneka MT, O'Banion MK. Inflammatory processes in Alzheimer's disease. J Neuroimmunol. 2007 Mar; 184(1-2):69-91.
  View in: PubMed
• Maida ME, Hurley SD, Daeschner JA, Moore AH, O'Banion MK. Cytosolic prostaglandin E2 synthase (cPGES) expression is decreased in discrete cortical regions in psychiatric disease. Brain Res. 2006 Aug 4; 1103(1):164-72.
  View in: PubMed
• Joseph SA, Lynd-Balta E, O'Banion MK, Rappold PM, Daschner J, Allen A, Padowski J. Enhanced cyclooxygenase-2 expression in olfactory-limbic forebrain following kainate-induced seizures. Neuroscience. 2006 Jul 7; 140(3):1051-65.
  View in: PubMed
• Lai YC, Shaftel SS, Miller JN, Tallents RH, Chang Y, Pinkert CA, Olschowka JA, Dickerson IM, Puzas JE, O'Banion MK, Kyrkanides S. Intraarticular induction of interleukin-1beta expression in the adult mouse, with resultant temporomandibular joint pathologic changes, dysfunction, and pain. Arthritis Rheum. 2006 Apr; 54(4):1184-97.
  View in: PubMed
• Hoozemans JJ, O'Banion MK. The role of COX-1 and COX-2 in Alzheimer's disease pathology and the therapeutic potentials of non-steroidal anti-inflammatory drugs. Curr Drug Targets CNS Neurol Disord. 2005 Jun; 4(3):307-15.
  View in: PubMed
• Moore AH, Olschowka JA, Williams JP, Okunieff P, O'Banion MK. Regulation of prostaglandin E2 synthesis after brain irradiation. Int J Radiat Oncol Biol Phys. 2005 May 1; 62(1):267-72.
  View in: PubMed
• Heneka MT, Sastre M, Dumitrescu-Ozimek L, Hanke A, Dewachter I, Kuiperi C, O'Banion K, Klockgether T, Van Leuven F, Landreth GE. Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. Brain. 2005 Jun; 128(Pt 6):1442-53.
  View in: PubMed
• Moore AH, Olschowka JA, O'Banion MK. Intraparenchymal administration of interleukin-1beta induces cyclooxygenase-2-mediated expression of membrane- and cytosolic-associated prostaglandin E synthases in mouse brain. J Neuroimmunol. 2004 Mar; 148(1-2):32-40.
  View in: PubMed
• Moore AH, Olschowka JA, Williams JP, Paige SL, O'Banion MK. Radiation-induced edema is dependent on cyclooxygenase 2 activity in mouse brain. Radiat Res. 2004 Feb; 161(2):153-60.
  View in: PubMed
• Hurley SD, O'Banion MK, Song DD, Arana FS, Olschowka JA, Haber SN. Microglial response is poorly correlated with neurodegeneration following chronic, low-dose MPTP administration in monkeys. Exp Neurol. 2003 Dec; 184(2):659-68.
  View in: PubMed
• Shaftel SS, Olschowka JA, Hurley SD, Moore AH, O'Banion MK. COX-3: a splice variant of cyclooxygenase-1 in mouse neural tissue and cells. Brain Res Mol Brain Res. 2003 Nov 26; 119(2):213-5.
  View in: PubMed
• Heneka MT, Gavrilyuk V, Landreth GE, O'Banion MK, Weinberg G, Feinstein DL. Noradrenergic depletion increases inflammatory responses in brain: effects on IkappaB and HSP70 expression. J Neurochem. 2003 Apr; 85(2):387-98.
  View in: PubMed
• Moore AH, O'Banion MK. Neuroinflammation and anti-inflammatory therapy for Alzheimer's disease. Adv Drug Deliv Rev. 2002 Dec 7; 54(12):1627-56.
  View in: PubMed
• Garden JM, O'Banion MK, Bakus AD, Olson C. Viral disease transmitted by laser-generated plume (aerosol). Arch Dermatol. 2002 Oct; 138(10):1303-7.
  View in: PubMed
• Kyrkanides S, Moore AH, Olschowka JA, Daeschner JC, Williams JP, Hansen JT, Kerry O'Banion M. Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury. Brain Res Mol Brain Res. 2002 Aug 15; 104(2):159-69.
  View in: PubMed
• Heneka MT, Galea E, Gavriluyk V, Dumitrescu-Ozimek L, Daeschner J, O'Banion MK, Weinberg G, Klockgether T, Feinstein DL. Noradrenergic depletion potentiates beta -amyloid-induced cortical inflammation: implications for Alzheimer's disease. J Neurosci. 2002 Apr 1; 22(7):2434-42.
  View in: PubMed
• O'Banion MK, Kyrkanides S, Olschowka JA. Selective inhibition of cyclooxygenase-2 attenuates expression of inflammation-related genes in CNS injury. Adv Exp Med Biol. 2002; 507:155-60.
  View in: PubMed
• Hurley SD, Olschowka JA, O'Banion MK. Cyclooxygenase inhibition as a strategy to ameliorate brain injury. J Neurotrauma. 2002 Jan; 19(1):1-15.
  View in: PubMed
• Chang JW, Young DA, Coleman PD, O'Banion MK. Two-dimensional gel analysis of secreted proteins induced by interleukin-1 beta in rat astrocytes. Neurochem Int. 2001 Nov-Dec; 39(5-6):349-59.
  View in: PubMed
• Yermakova AV, O'Banion MK. Downregulation of neuronal cyclooxygenase-2 expression in end stage Alzheimer's disease. Neurobiol Aging. 2001 Nov-Dec; 22(6):823-36.
  View in: PubMed
• Kyrkanides S, O'Banion MK, Whiteley PE, Daeschner JC, Olschowka JA. Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury. J Neuroimmunol. 2001 Oct 1; 119(2):269-77.
  View in: PubMed
• Matsuoka Y, Picciano M, Malester B, LaFrancois J, Zehr C, Daeschner JM, Olschowka JA, Fonseca MI, O'Banion MK, Tenner AJ, Lemere CA, Duff K. Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease. Am J Pathol. 2001 Apr; 158(4):1345-54.
  View in: PubMed
• Yermakova A, O'Banion MK. Cyclooxygenases in the central nervous system: implications for treatment of neurological disorders. Curr Pharm Des. 2000 Nov; 6(17):1755-76.
  View in: PubMed
• Kyrkanides S, O'Banion MK, Subtelny JD. Nonsteroidal anti-inflammatory drugs in orthodontic tooth movement: metalloproteinase activity and collagen synthesis by endothelial cells. Am J Orthod Dentofacial Orthop. 2000 Aug; 118(2):203-9.
  View in: PubMed
• Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, Landreth G, Lue L, Mrak R, Mackenzie IR, McGeer PL, O'Banion MK, Pachter J, Pasinetti G, Plata-Salaman C, Rogers J, Rydel R, Shen Y, Streit W, Strohmeyer R, Tooyoma I, Van Muiswinkel FL, Veerhuis R, Walker D, Webster S, Wegrzyniak B, Wenk G, Wyss-Coray T. Inflammation and Alzheimer's disease. Neurobiol Aging. 2000 May-Jun; 21(3):383-421.
  View in: PubMed
• Yermakova AV, Rollins J, Callahan LM, Rogers J, O'Banion MK. Cyclooxygenase-1 in human Alzheimer and control brain: quantitative analysis of expression by microglia and CA3 hippocampal neurons. J Neuropathol Exp Neurol. 1999 Nov; 58(11):1135-46.
  View in: PubMed
• Bohn MC, Choi-Lundberg DL, Davidson BL, Leranth C, Kozlowski DA, Smith JC, O'Banion MK, Redmond DE. Adenovirus-mediated transgene expression in nonhuman primate brain. Hum Gene Ther. 1999 May 1; 10(7):1175-84.
  View in: PubMed
• Kyrkanides S, Olschowka JA, Williams JP, Hansen JT, O'Banion MK. TNF alpha and IL-1beta mediate intercellular adhesion molecule-1 induction via microglia-astrocyte interaction in CNS radiation injury. J Neuroimmunol. 1999 Mar 1; 95(1-2):95-106.
  View in: PubMed
• O'Banion MK, Olschowka JA. Localization and distribution of cyclooxygenase-2 in brain tissue by immunohistochemistry. Methods Mol Biol. 1999; 120:55-66.
  View in: PubMed
• O'Banion MK. Cyclooxygenase-2: molecular biology, pharmacology, and neurobiology. Crit Rev Neurobiol. 1999; 13(1):45-82.
  View in: PubMed
• Huang TL, O'Banion MK. Interleukin-1 beta and tumor necrosis factor-alpha suppress dexamethasone induction of glutamine synthetase in primary mouse astrocytes. J Neurochem. 1998 Oct; 71(4):1436-42.
  View in: PubMed
• Combs CK, Coleman PD, O'Banion MK. Developmental regulation and PKC dependence of Alzheimer's-type tau phosphorylations in cultured fetal rat hippocampal neurons. Brain Res Dev Brain Res. 1998 Apr 17; 107(1):143-58.
  View in: PubMed
• Olschowka JA, Kyrkanides S, Harvey BK, O'Banion MK, Williams JP, Rubin P, Hansen JT. ICAM-1 induction in the mouse CNS following irradiation. Brain Behav Immun. 1997 Dec; 11(4):273-85.
  View in: PubMed
• Kaplan MD, Olschowka JA, O'Banion MK. Cyclooxygenase-1 behaves as a delayed response gene in PC12 cells differentiated by nerve growth factor. J Biol Chem. 1997 Jul 25; 272(30):18534-7.
  View in: PubMed
• O'Banion MK, Chang JW, Kaplan MD, Yermakova A, Coleman PD. Glial and neuronal expression of cyclooxygenase-2: relevance to Alzheimer's disease. Adv Exp Med Biol. 1997; 433:177-80.
  View in: PubMed
• Wheeler TT, O'Banion MK, Colasurdo AM, Young DA. Bovine papillomavirus E5 oncogene stimulates DNA synthesis in C127 fibroblasts without general effects on growth factor responsive protein phosphorylations. Arch Virol. 1997; 142(5):953-64.
  View in: PubMed
• O'Banion MK, Chang JW, Coleman PD. Decreased expression of prostaglandin G/H synthase-2 (PGHS-2) in Alzheimer's disease brain. Adv Exp Med Biol. 1997; 407:171-7.
  View in: PubMed
• Chang JW, Coleman PD, O'Banion MK. Prostaglandin G/H synthase-2 (cyclooxygenase-2) mRNA expression is decreased in Alzheimer's disease. Neurobiol Aging. 1996 Sep-Oct; 17(5):801-8.
  View in: PubMed
• O'Banion MK, Finch CE. Inflammatory mechanisms and anti-inflammatory therapy in Alzheimer's disease. Neurobiol Aging. 1996 Sep-Oct; 17(5):669-71.
  View in: PubMed
• O'Banion MK, Miller JC, Chang JW, Kaplan MD, Coleman PD. Interleukin-1 beta induces prostaglandin G/H synthase-2 (cyclooxygenase-2) in primary murine astrocyte cultures. J Neurochem. 1996 Jun; 66(6):2532-40.
  View in: PubMed
• Bohn MC, O'Banion MK, Young DA, Giuliano R, Hussain S, Dean DO, Cunningham LA. In vitro studies of glucocorticoid effects on neurons and astrocytes. Ann N Y Acad Sci. 1994 Nov 30; 746:243-58; discussion 258-9, 289-93.
  View in: PubMed
• Pritchard KA, O'Banion MK, Miano JM, Vlasic N, Bhatia UG, Young DA, Stemerman MB. Induction of cyclooxygenase-2 in rat vascular smooth muscle cells in vitro and in vivo. J Biol Chem. 1994 Mar 18; 269(11):8504-9.
  View in: PubMed
• O'Banion MK, Young DA, Bohn MC. Corticosterone-responsive mRNAs in primary rat astrocytes. Brain Res Mol Brain Res. 1994 Mar; 22(1-4):57-68.
  View in: PubMed
• O'Banion MK, Winn VD, Settleman J, Young DA. Genetic definition of a new bovine papillomavirus type 1 open reading frame, E5B, that encodes a hydrophobic protein involved in altering host-cell protein processing. J Virol. 1993 Jun; 67(6):3427-34.
  View in: PubMed
• Winn VD, O'Banion MK, Young DA. Anti-inflammatory glucocorticoid action: inhibition of griPGHS, a new cyclooxygenase. J Lipid Mediat. 1993 Mar-Apr; 6(1-3):101-11.
  View in: PubMed
• O'Banion MK, Levenson RM, Brinckmann UG, Young DA. Glucocorticoid modulation of transformed cell proliferation is oncogene specific and correlates with effects on c-myc levels. Mol Endocrinol. 1992 Sep; 6(9):1371-80.
  View in: PubMed
• O'Banion MK, Winn VD, Young DA. cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc Natl Acad Sci U S A. 1992 Jun 1; 89(11):4888-92.
  View in: PubMed
• O'Banion MK, Jacobson ER, Sundberg JP. Molecular cloning and partial characterization of a parrot papillomavirus. Intervirology. 1992; 33(2):91-6.
  View in: PubMed
• O'Banion MK, Sadowski HB, Winn V, Young DA. A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein. J Biol Chem. 1991 Dec 5; 266(34):23261-7.
  View in: PubMed
• O'Banion MK, Young DA. Bovine papillomavirus type 1 alters the processing of host glucose- and calcium-modulated endoplasmic reticulum proteins. J Virol. 1991 Jul; 65(7):3481-8.
  View in: PubMed
• Levenson RM, Brinckmann UG, O'Banion MK, Androphy EJ, Schiller JT, Tabatabai F, Turek LP, Neary K, Chin MT, Broker TR, et al. Papillomavirus-associated inductions of cellular proteins in mouse C127 cells: correlation with the presence of open reading frame E2. Virology. 1989 Sep; 172(1):170-9.
  View in: PubMed
• Sundberg JP, O'Banion MK, Shima A, Knupp C, Reichmann ME. Papillomas and carcinomas associated with a papillomavirus in European harvest mice (Micromys minutus). Vet Pathol. 1988 Sep; 25(5):356-61.
  View in: PubMed
• Ogilvie GK, Sundberg JP, O'Banion MK, Badertscher RR, Wheaton LG, Reichmann ME. Papillary squamous cell carcinoma in three young dogs. J Am Vet Med Assoc. 1988 Apr 1; 192(7):933-6.
  View in: PubMed
• Garden JM, O'Banion MK, Shelnitz LS, Pinski KS, Bakus AD, Reichmann ME, Sundberg JP. Papillomavirus in the vapor of carbon dioxide laser-treated verrucae. JAMA. 1988 Feb 26; 259(8):1199-202.
  View in: PubMed
• O'Banion MK, Reichmann ME, Sundberg JP. Cloning and characterization of a papillomavirus associated with papillomas and carcinomas in the European harvest mouse (Micromys minutus). J Virol. 1988 Jan; 62(1):226-33.
  View in: PubMed
• O'Banion MK, Cialkowski ME, Reichmann ME, Sundberg JP. Cloning and molecular characterization of an oral papillomavirus of domestic rabbits. Virology. 1988 Jan; 162(1):221-31.
  View in: PubMed
• O'Banion MK, Sundberg JP. Papillomavirus genomes in experimentally induced fibromas in white-tailed deer. Am J Vet Res. 1987 Oct; 48(10):1453-5.
  View in: PubMed
• O'Banion MK, Sundberg JP, Shima AL, Reichmann ME. Venereal papilloma and papillomavirus in a colobus monkey (Colobus guereza). Intervirology. 1987; 28(4):232-7.
  View in: PubMed
• O'Banion MK, Sundberg JP, Reszka AA, Reichmann ME. Cross-hybridization and relationships of various papillomavirus DNAs at different degrees of stringency. Intervirology. 1987; 28(2):114-21.
  View in: PubMed
• Munson L, Heuschele W, O'Banion MK, Sundberg JP, Oosterhuis JE. Polyp in the urogenital canal of an African elephant. J Am Vet Med Assoc. 1986 Nov 1; 189(9):1190-1.
  View in: PubMed
• Jacobson ER, Sundberg JP, Gaskin JM, Kollias GV, O'Banion MK. Cutaneous papillomas associated with a herpesvirus-like infection in a herd of captive African elephants. J Am Vet Med Assoc. 1986 Nov 1; 189(9):1075-8.
  View in: PubMed
• O'Banion MK, Reichmann ME, Sundberg JP. Cloning and characterization of an equine cutaneous papillomavirus. Virology. 1986 Jul 15; 152(1):100-9.
  View in: PubMed
• Sundberg JP, O'Banion MK, Schmidt-Didier E, Reichmann ME. Cloning and characterization of a canine oral papillomavirus. Am J Vet Res. 1986 May; 47(5):1142-4.
  View in: PubMed
• Sundberg JP, Junge RE, O'Banion MK, Basgall EJ, Harrison G, Herron AJ, Shivaprasad HL. Cloacal papillomas in psittacines. Am J Vet Res. 1986 Apr; 47(4):928-32.
  View in: PubMed
• Schnitzlein WM, O'Banion MK, Poirot MK, Reichmann ME. Effect of intracellular vesicular stomatitis virus mRNA concentration on the inhibition of host cell protein synthesis. J Virol. 1983 Jan; 45(1):206-14.
  View in: PubMed