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Robert Gelein

TitleAssociate (Part-Time)
InstitutionSchool of Medicine and Dentistry
DepartmentEnvironmental Medicine
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box EHSC
Rochester NY 14642
 
 Selected Publications
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  1. Singh I, Sagare AP, Coma M, Perlmutter D, Gelein R, Bell RD, Deane RJ, Zhong E, Parisi M, Ciszewski J, Kasper RT, Deane R. Low levels of copper disrupt brain amyloid-ß homeostasis by altering its production and clearance. Proc Natl Acad Sci U S A. 2013 Sep 3; 110(36):14771-6.
    View in: PubMed
  2. Mortensen LJ, Jatana S, Gelein R, De Benedetto A, De Mesy Bentley KL, Beck LA, Elder A, Delouise LA. Quantification of quantum dot murine skin penetration with UVR barrier impairment. Nanotoxicology. 2013 Dec; 7:1386-98.
    View in: PubMed
  3. Gunter TE, Gerstner B, Gunter KK, Malecki J, Gelein R, Valentine WM, Aschner M, Yule DI. Manganese transport via the transferrin mechanism. Neurotoxicology. 2013 Jan; 34:118-27.
    View in: PubMed
  4. Lee DL, Strathmann FG, Gelein R, Walton J, Mayer-Pröschel M. Iron deficiency disrupts axon maturation of the developing auditory nerve. J Neurosci. 2012 Apr 4; 32(14):5010-5.
    View in: PubMed
  5. Han X, Corson N, Wade-Mercer P, Gelein R, Jiang J, Sahu M, Biswas P, Finkelstein JN, Elder A, Oberdörster G. Assessing the relevance of in vitro studies in nanotoxicology by examining correlations between in vitro and in vivo data. Toxicology. 2012 Jul 16; 297(1-3):1-9.
    View in: PubMed
  6. Han X, Gelein R, Corson N, Wade-Mercer P, Jiang J, Biswas P, Finkelstein JN, Elder A, Oberdörster G. Validation of an LDH assay for assessing nanoparticle toxicity. Toxicology. 2011 Sep 5; 287(1-3):99-104.
    View in: PubMed
  7. Mihaila C, Schramm J, Strathmann FG, Lee DL, Gelein RM, Luebke AE, Mayer-Pröschel M. Identifying a window of vulnerability during fetal development in a maternal iron restriction model. PLoS One. 2011; 6(3):e17483.
    View in: PubMed
  8. Kim SC, Chen DR, Qi C, Gelein RM, Finkelstein JN, Elder A, Bentley K, Oberdörster G, Pui DY. A nanoparticle dispersion method for in vitro and in vivo nanotoxicity study. Nanotoxicology. 2010 Mar; 4(1):42-51.
    View in: PubMed
  9. Ishitobi H, Stern S, Thurston SW, Zareba G, Langdon M, Gelein R, Weiss B. Organic and inorganic mercury in neonatal rat brain after prenatal exposure to methylmercury and mercury vapor. Environ Health Perspect. 2010 Feb; 118(2):242-8.
    View in: PubMed
  10. Rushton EK, Jiang J, Leonard SS, Eberly S, Castranova V, Biswas P, Elder A, Han X, Gelein R, Finkelstein J, Oberdörster G. Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics. J Toxicol Environ Health A. 2010; 73(5):445-61.
    View in: PubMed
  11. Yee M, Chess PR, McGrath-Morrow SA, Wang Z, Gelein R, Zhou R, Dean DA, Notter RH, O'Reilly MA. Neonatal oxygen adversely affects lung function in adult mice without altering surfactant composition or activity. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L641-9.
    View in: PubMed
  12. Elder A, Couderc JP, Gelein R, Eberly S, Cox C, Xia X, Zareba W, Hopke P, Watts W, Kittelson D, Frampton M, Utell M, Oberdörster G. Effects of on-road highway aerosol exposures on autonomic responses in aged, spontaneously hypertensive rats. Inhal Toxicol. 2007 Jan; 19(1):1-12.
    View in: PubMed
  13. Carter JM, Corson N, Driscoll KE, Elder A, Finkelstein JN, Harkema JN, Gelein R, Wade-Mercer P, Nguyen K, Oberdorster G. A comparative dose-related response of several key pro- and antiinflammatory mediators in the lungs of rats, mice, and hamsters after subchronic inhalation of carbon black. J Occup Environ Med. 2006 Dec; 48(12):1265-78.
    View in: PubMed
  14. Johnston CJ, Holm BA, Gelein R, Finkelstein JN. Postnatal lung development: immediate-early gene responses post ozone and LPS exposure. Inhal Toxicol. 2006 Oct; 18(11):875-83.
    View in: PubMed
  15. Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Ito Y, Finkelstein J, Oberdörster G. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ Health Perspect. 2006 Aug; 114(8):1172-8.
    View in: PubMed
  16. Lee DW, Gelein RM, Opanashuk LA. Heme-oxygenase-1 promotes polychlorinated biphenyl mixture aroclor 1254-induced oxidative stress and dopaminergic cell injury. Toxicol Sci. 2006 Mar; 90(1):159-67.
    View in: PubMed
  17. Elder A, Gelein R, Finkelstein JN, Driscoll KE, Harkema J, Oberdörster G. Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology. Toxicol Sci. 2005 Dec; 88(2):614-29.
    View in: PubMed
  18. Weiss B, Stern S, Cernichiari E, Gelein R. Methylmercury contamination of laboratory animal diets. Environ Health Perspect. 2005 Sep; 113(9):1120-2.
    View in: PubMed
  19. Elder A, Johnston C, Gelein R, Finkelstein J, Wang Z, Notter R, Oberdörster G. Lung inflammation induced by endotoxin is enhanced in rats depleted of alveolar macrophages with aerosolized clodronate. Exp Lung Res. 2005 Jul-Aug; 31(6):527-46.
    View in: PubMed
  20. Carmouche JJ, Puzas JE, Zhang X, Tiyapatanaputi P, Cory-Slechta DA, Gelein R, Zuscik M, Rosier RN, Boyce BF, O'Keefe RJ, Schwarz EM. Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency. Environ Health Perspect. 2005 Jun; 113(6):749-55.
    View in: PubMed
  21. Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, Cox C. Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol. 2004 Jun; 16(6-7):437-45.
    View in: PubMed
  22. Elder AC, Gelein R, Azadniv M, Frampton M, Finkelstein J, Oberdörster G. Systemic effects of inhaled ultrafine particles in two compromised, aged rat strains. Inhal Toxicol. 2004 Jun; 16(6-7):461-71.
    View in: PubMed
  23. Elder AC, Gelein R, Oberdörster G, Finkelstein J, Notter R, Wang Z. Efficient depletion of alveolar macrophages using intratracheally inhaled aerosols of liposome-encapsulated clodronate. Exp Lung Res. 2004 Mar; 30(2):105-20.
    View in: PubMed
  24. Elder A, Gelein R, Finkelstein J, Phipps R, Frampton M, Utell M, Kittelson DB, Watts WF, Hopke P, Jeong CH, Kim E, Liu W, Zhao W, Zhuo L, Vincent R, Kumarathasan P, Oberdörster G. On-road exposure to highway aerosols. 2. Exposures of aged, compromised rats. Inhal Toxicol. 2004; 16 Suppl 1:41-53.
    View in: PubMed
  25. Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Lunts A, Kreyling W, Cox C. Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J Toxicol Environ Health A. 2002 Oct 25; 65(20):1531-43.
    View in: PubMed
  26. Johnston CJ, Oberdörster G, Gelein R, Finkelstein JN. Endotoxin potentiates ozone-induced pulmonary chemokine and inflammatory responses. Exp Lung Res. 2002 Sep; 28(6):419-33.
    View in: PubMed
  27. Zareba G, Gelein R, Morrow PE, Utell MJ. Percutaneous absorption studies of octamethylcyclotetrasiloxane using the human skin/nude mouse model. Skin Pharmacol Appl Skin Physiol. 2002 May-Jun; 15(3):184-94.
    View in: PubMed
  28. Johnston CJ, Finkelstein JN, Mercer P, Corson N, Gelein R, Oberdörster G. Pulmonary effects induced by ultrafine PTFE particles. Toxicol Appl Pharmacol. 2000 Nov 1; 168(3):208-15.
    View in: PubMed
  29. Oberdörster G, Finkelstein JN, Johnston C, Gelein R, Cox C, Baggs R, Elder AC. Acute pulmonary effects of ultrafine particles in rats and mice. Res Rep Health Eff Inst. 2000 Aug; (96):5-74; disc. 75-86.
    View in: PubMed
  30. Johnston CJ, Driscoll KE, Finkelstein JN, Baggs R, O'Reilly MA, Carter J, Gelein R, Oberdörster G. Pulmonary chemokine and mutagenic responses in rats after subchronic inhalation of amorphous and crystalline silica. Toxicol Sci. 2000 Aug; 56(2):405-13.
    View in: PubMed
  31. Johnston CJ, Oberdörster G, Gelein R, Finkelstein JN. Newborn mice differ from adult mice in chemokine and cytokine expression to ozone, but not to endotoxin. Inhal Toxicol. 2000 Mar; 12(3):205-24.
    View in: PubMed
  32. Elder AC, Finkelstein J, Johnston C, Gelein R, Oberdörster G. Induction of adaptation to inhaled lipopolysaccharide in young and old rats and mice. Inhal Toxicol. 2000 Mar; 12(3):225-43.
    View in: PubMed
  33. Johnston CJ, Reed CK, Avissar NE, Gelein R, Finkelstein JN. Antioxidant and inflammatory response after acute nitrogen dioxide and ozone exposures in C57Bl/6 mice. Inhal Toxicol. 2000 Mar; 12(3):187-203.
    View in: PubMed
  34. Elder AC, Gelein R, Finkelstein JN, Cox C, Oberdörster G. Pulmonary inflammatory response to inhaled ultrafine particles is modified by age, ozone exposure, and bacterial toxin. Inhal Toxicol. 2000; 12 Suppl 4:227-46.
    View in: PubMed
  35. Reynolds SD, Mango GW, Gelein R, Bøe IM, Lund J, Stripp BR. Normal function and lack of fibronectin accumulation in kidneys of Clara cell secretory protein/uteroglobin deficient mice. Am J Kidney Dis. 1999 Mar; 33(3):541-51.
    View in: PubMed
  36. Johnston CJ, Finkelstein JN, Gelein R, Oberdörster G. Pulmonary cytokine and chemokine mRNA levels after inhalation of lipopolysaccharide in C57BL/6 mice. Toxicol Sci. 1998 Dec; 46(2):300-7.
    View in: PubMed
  37. Utell MJ, Gelein R, Yu CP, Kenaga C, Geigel E, Torres A, Chalupa D, Gibb FR, Speers DM, Mast RW, Morrow PE. Quantitative exposure of humans to an octamethylcyclotetrasiloxane (D4) vapor. Toxicol Sci. 1998 Aug; 44(2):206-13.
    View in: PubMed
  38. Oberdörster G, Cox C, Gelein R. Intratracheal instillation versus intratracheal-inhalation of tracer particles for measuring lung clearance function. Exp Lung Res. 1997 Jan-Feb; 23(1):17-34.
    View in: PubMed
  39. Stern S, Reuhl K, Soderholm S, Cox C, Sharma A, Balys M, Gelein R, Yin C, Weiss B. Perinatal methanol exposure in the rat. I. Blood methanol concentration and neural cell adhesion molecules. Fundam Appl Toxicol. 1996 Nov; 34(1):36-46.
    View in: PubMed
  40. Johnston CJ, Finkelstein JN, Gelein R, Baggs R, Oberdörster G. Characterization of the early pulmonary inflammatory response associated with PTFE fume exposure. Toxicol Appl Pharmacol. 1996 Sep; 140(1):154-63.
    View in: PubMed
  41. Rahill AA, Weiss B, Morrow PE, Frampton MW, Cox C, Gibb R, Gelein R, Speers D, Utell MJ. Human performance during exposure to toluene. Aviat Space Environ Med. 1996 Jul; 67(7):640-7.
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  42. Weiss B, Stern S, Soderholm SC, Cox C, Sharma A, Inglis GB, Preston R, Balys M, Reuhl KR, Gelein R. Developmental neurotoxicity of methanol exposure by inhalation in rats. Res Rep Health Eff Inst. 1996 Apr; (73):1-64; discussion 65-70.
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  43. Oberdörster G, Finkelstein J, Ferin J, Godleski J, Chang LY, Gelein R, Johnston C, Crapo JD. Ultrafine particles as a potential environmental health hazard. Studies with model particles. Chest. 1996 Mar; 109(3 Suppl):68S-69S.
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  44. Oberdorster G, Gelein RM, Ferin J, Weiss B. Association of particulate air pollution and acute mortality: involvement of ultrafine particles? Inhal Toxicol. 1995 Jan-Feb; 7(1):111-24.
    View in: PubMed
  45. Oberdörster G, Ferin J, Gelein R, Soderholm SC, Finkelstein J. Role of the alveolar macrophage in lung injury: studies with ultrafine particles. Environ Health Perspect. 1992 Jul; 97:193-9.
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  46. Diamond GL, Morrow PE, Panner BJ, Gelein RM, Baggs RB. Reversible uranyl fluoride nephrotoxicity in the Long Evans rat. Fundam Appl Toxicol. 1989 Jul; 13(1):65-78.
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  47. Zalups RK, Gelein RM, Morrow PE, Diamond GL. Nephrotoxicity of uranyl fluoride in uninephrectomized and sham-operated rats. Toxicol Appl Pharmacol. 1988 Jun 15; 94(1):11-22.
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  48. Currie WD, Gelein RM, Sanders AP. Comparison of protective agents against hyperbaric oxygen in large animals. Aerosp Med. 1973 Sep; 44(9):996-8.
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  49. Currie WD, Gelein RM, Sanders AP. Effects of hyperbaric oxygenation on metabolism. VI. Efficacy of protective agents at 5,7,9, and 11 atmospheres of 100 percent oxygen. Proc Soc Exp Biol Med. 1970 Jan; 133(1):103-5.
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  50. Currie WD, Gelein RM, Sanders AP. Effects of hyperbaric oxygenation on metabolism. V. Comparison on protective agents at 5 atmospheres 100 per cent oxygen. Proc Soc Exp Biol Med. 1969 Nov; 132(2):660-2.
    View in: PubMed

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