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Senior AE. Two ATPases. J Biol Chem. 2012 Aug 31; 287(36):30049-62.
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Senior AE. Reaction chemistry ABC-style. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15015-6.
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Li W, Brudecki LE, Senior AE, Ahmad Z. Role of {alpha}-subunit VISIT-DG sequence residues Ser-347 and Gly-351 in the catalytic sites of Escherichia coli ATP synthase. J Biol Chem. 2009 Apr 17; 284(16):10747-54.
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Lee JY, Urbatsch IL, Senior AE, Wilkens S. Nucleotide-induced structural changes in P-glycoprotein observed by electron microscopy. J Biol Chem. 2008 Feb 29; 283(9):5769-79.
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Senior AE. ATP synthase: motoring to the finish line. Cell. 2007 Jul 27; 130(2):220-1.
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Carrier I, Urbatsch IL, Senior AE, Gros P. Mutational analysis of conserved aromatic residues in the A-loop of the ABC transporter ABCB1A (mouse Mdr3). FEBS Lett. 2007 Jan 23; 581(2):301-8.
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Senior AE, Muharemagic A, Wilke-Mounts S. Assembly of the stator in Escherichia coli ATP synthase. Complexation of alpha subunit with other F1 subunits is prerequisite for delta subunit binding to the N-terminal region of alpha. Biochemistry. 2006 Dec 26; 45(51):15893-902.
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Ahmad Z, Senior AE. Inhibition of the ATPase activity of Escherichia coli ATP synthase by magnesium fluoride. FEBS Lett. 2006 Jan 23; 580(2):517-20.
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Ahmad Z, Senior AE. Identification of phosphate binding residues of Escherichia coli ATP synthase. J Bioenerg Biomembr. 2005 Dec; 37(6):437-40.
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Tombline G, Senior AE. The occluded nucleotide conformation of p-glycoprotein. J Bioenerg Biomembr. 2005 Dec; 37(6):497-500.
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Tombline G, Urbatsch IL, Virk N, Muharemagic A, White LB, Senior AE. Expression, purification, and characterization of cysteine-free mouse P-glycoprotein. Arch Biochem Biophys. 2006 Jan 1; 445(1):124-8.
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Delannoy S, Urbatsch IL, Tombline G, Senior AE, Vogel PD. Nucleotide binding to the multidrug resistance P-glycoprotein as studied by ESR spectroscopy. Biochemistry. 2005 Oct 25; 44(42):14010-9.
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Tombline G, Muharemagic A, White LB, Senior AE. Involvement of the "occluded nucleotide conformation" of P-glycoprotein in the catalytic pathway. Biochemistry. 2005 Sep 27; 44(38):12879-86.
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Wilkens S, Borchardt D, Weber J, Senior AE. Structural characterization of the interaction of the delta and alpha subunits of the Escherichia coli F1F0-ATP synthase by NMR spectroscopy. Biochemistry. 2005 Sep 6; 44(35):11786-94.
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Ahmad Z, Senior AE. Modulation of charge in the phosphate binding site of Escherichia coli ATP synthase. J Biol Chem. 2005 Jul 29; 280(30):27981-9.
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Ahmad Z, Senior AE. Involvement of ATP synthase residues alphaArg-376, betaArg-182, and betaLys-155 in Pi binding. FEBS Lett. 2005 Jan 17; 579(2):523-8.
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Tombline G, Bartholomew LA, Tyndall GA, Gimi K, Urbatsch IL, Senior AE. Properties of P-glycoprotein with mutations in the "catalytic carboxylate" glutamate residues. J Biol Chem. 2004 Nov 5; 279(45):46518-26.
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Ahmad Z, Senior AE. Role of betaAsn-243 in the phosphate-binding subdomain of catalytic sites of Escherichia coli F(1)-ATPase. J Biol Chem. 2004 Oct 29; 279(44):46057-64.
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Tombline G, Bartholomew LA, Urbatsch IL, Senior AE. Combined mutation of catalytic glutamate residues in the two nucleotide binding domains of P-glycoprotein generates a conformation that binds ATP and ADP tightly. J Biol Chem. 2004 Jul 23; 279(30):31212-20.
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Ahmad Z, Senior AE. Mutagenesis of residue betaArg-246 in the phosphate-binding subdomain of catalytic sites of Escherichia coli F1-ATPase. J Biol Chem. 2004 Jul 23; 279(30):31505-13.
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Weber J, Muharemagic A, Wilke-Mounts S, Senior AE. Analysis of sequence determinants of F1Fo-ATP synthase in the N-terminal region of alpha subunit for binding of delta subunit. J Biol Chem. 2004 Jun 11; 279(24):25673-9.
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Senior AE, Weber J. Happy motoring with ATP synthase. Nat Struct Mol Biol. 2004 Feb; 11(2):110-2.
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Weber J, Wilke-Mounts S, Nadanaciva S, Senior AE. Quantitative determination of direct binding of b subunit to F1 in Escherichia coli F1F0-ATP synthase. J Biol Chem. 2004 Mar 19; 279(12):11253-8.
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Weber J, Senior AE. Fluorescent probes applied to catalytic cooperativity in ATP synthase. Methods Enzymol. 2004; 380:132-52.
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Tombline G, Bartholomew L, Gimi K, Tyndall GA, Senior AE. Synergy between conserved ABC signature Ser residues in P-glycoprotein catalysis. J Biol Chem. 2004 Feb 13; 279(7):5363-73.
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Weber J, Senior AE. ATP synthesis driven by proton transport in F1F0-ATP synthase. FEBS Lett. 2003 Jun 12; 545(1):61-70.
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Urbatsch IL, Tyndall GA, Tombline G, Senior AE. P-glycoprotein catalytic mechanism: studies of the ADP-vanadate inhibited state. J Biol Chem. 2003 Jun 20; 278(25):23171-9.
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Weber J, Muharemagic A, Wilke-Mounts S, Senior AE. F1F0-ATP synthase. Binding of delta subunit to a 22-residue peptide mimicking the N-terminal region of alpha subunit. J Biol Chem. 2003 Apr 18; 278(16):13623-6.
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Weber J, Wilke-Mounts S, Senior AE. Identification of the F1-binding surface on the delta-subunit of ATP synthase. J Biol Chem. 2003 Apr 11; 278(15):13409-16.
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Lee JY, Urbatsch IL, Senior AE, Wilkens S. Projection structure of P-glycoprotein by electron microscopy. Evidence for a closed conformation of the nucleotide binding domains. J Biol Chem. 2002 Oct 18; 277(42):40125-31.
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Weber J, Wilke-Mounts S, Senior AE. Quantitative determination of binding affinity of delta-subunit in Escherichia coli F1-ATPase: effects of mutation, Mg2+, and pH on Kd. J Biol Chem. 2002 May 24; 277(21):18390-6.
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Senior AE, Nadanaciva S, Weber J. The molecular mechanism of ATP synthesis by F1F0-ATP synthase. Biochim Biophys Acta. 2002 Feb 15; 1553(3):188-211.
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Weber J, Bijol V, Wilke-Mounts S, Senior AE. Cysteine-reactive fluorescence probes of catalytic sites of ATP synthase. Arch Biochem Biophys. 2002 Jan 1; 397(1):1-10.
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Weber J, Senior AE. Bi-site catalysis in F1-ATPase: does it exist? J Biol Chem. 2001 Sep 21; 276(38):35422-8.
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Urbatsch IL, Gimi K, Wilke-Mounts S, Lerner-Marmarosh N, Rousseau ME, Gros P, Senior AE. Cysteines 431 and 1074 are responsible for inhibitory disulfide cross-linking between the two nucleotide-binding sites in human P-glycoprotein. J Biol Chem. 2001 Jul 20; 276(29):26980-7.
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Urbatsch IL, Wilke-Mounts S, Gimi K, Senior AE. Purification and characterization of N-glycosylation mutant mouse and human P-glycoproteins expressed in Pichia pastoris cells. Arch Biochem Biophys. 2001 Apr 1; 388(1):171-7.
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Weber J, Nadanaciva S, Senior AE. ATP-driven rotation of the gamma subunit in F(1)-ATPase. FEBS Lett. 2000 Oct 13; 483(1):1-5.
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Urbatsch IL, Gimi K, Wilke-Mounts S, Senior AE. Investigation of the role of glutamine-471 and glutamine-1114 in the two catalytic sites of P-glycoprotein. Biochemistry. 2000 Oct 3; 39(39):11921-7.
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Senior AE, Weber J, Nadanaciva S. The catalytic transition state in ATP synthase. J Bioenerg Biomembr. 2000 Oct; 32(5):523-9.
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Urbatsch IL, Gimi K, Wilke-Mounts S, Senior AE. Conserved walker A Ser residues in the catalytic sites of P-glycoprotein are critical for catalysis and involved primarily at the transition state step. J Biol Chem. 2000 Aug 11; 275(32):25031-8.
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Nadanaciva S, Weber J, Senior AE. New probes of the F1-ATPase catalytic transition state reveal that two of the three catalytic sites can assume a transition state conformation simultaneously. Biochemistry. 2000 Aug 8; 39(31):9583-90.
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Kwan T, Loughrey H, Brault M, Gruenheid S, Urbatsch IL, Senior AE, Gros P. Functional analysis of a tryptophan-less P-glycoprotein: a tool for tryptophan insertion and fluorescence spectroscopy. Mol Pharmacol. 2000 Jul; 58(1):37-47.
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Weber J, Senior AE. ATP synthase: what we know about ATP hydrolysis and what we do not know about ATP synthesis. Biochim Biophys Acta. 2000 May 31; 1458(2-3):300-9.
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Weber J, Senior AE. Features of F(1)-ATPase catalytic and noncatalytic sites revealed by fluorescence lifetimes and acrylamide quenching of specifically inserted tryptophan residues. Biochemistry. 2000 May 9; 39(18):5287-94.
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Senior AE, Nadanaciva S, Weber J. Rate acceleration of ATP hydrolysis by F(1)F(o)-ATP synthase. J Exp Biol. 2000 Jan; 203(Pt 1):35-40.
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Lerner-Marmarosh N, Gimi K, Urbatsch IL, Gros P, Senior AE. Large scale purification of detergent-soluble P-glycoprotein from Pichia pastoris cells and characterization of nucleotide binding properties of wild-type, Walker A, and Walker B mutant proteins. J Biol Chem. 1999 Dec 3; 274(49):34711-8.
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Nadanaciva S, Weber J, Wilke-Mounts S, Senior AE. Importance of F1-ATPase residue alpha-Arg-376 for catalytic transition state stabilization. Biochemistry. 1999 Nov 23; 38(47):15493-9.
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Weber J, Dunn SD, Senior AE. Effect of the epsilon-subunit on nucleotide binding to Escherichia coli F1-ATPase catalytic sites. J Biol Chem. 1999 Jul 2; 274(27):19124-8.
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Nadanaciva S, Weber J, Senior AE. The role of beta-Arg-182, an essential catalytic site residue in Escherichia coli F1-ATPase. Biochemistry. 1999 Jun 15; 38(24):7670-7.
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Nadanaciva S, Weber J, Senior AE. Binding of the transition state analog MgADP-fluoroaluminate to F1-ATPase. J Biol Chem. 1999 Mar 12; 274(11):7052-8.
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Weber J, Senior AE. Effects of the inhibitors azide, dicyclohexylcarbodiimide, and aurovertin on nucleotide binding to the three F1-ATPase catalytic sites measured using specific tryptophan probes. J Biol Chem. 1998 Dec 11; 273(50):33210-5.
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Weber J, Wilke-Mounts S, Hammond ST, Senior AE. Tryptophan substitutions surrounding the nucleotide in catalytic sites of F1-ATPase. Biochemistry. 1998 Sep 1; 37(35):12042-50.
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Senior AE, Gros P, Urbatsch IL. Residues in P-glycoprotein catalytic sites that react with the inhibitor 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole. Arch Biochem Biophys. 1998 Sep 1; 357(1):121-5.
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Senior AE. Catalytic mechanism of P-glycoprotein. Acta Physiol Scand Suppl. 1998 Aug; 643:213-8.
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Löbau S, Weber J, Senior AE. Catalytic site nucleotide binding and hydrolysis in F1F0-ATP synthase. Biochemistry. 1998 Jul 28; 37(30):10846-53.
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Rebbeor JF, Senior AE. Effects of cardiovascular drugs on ATPase activity of P-glycoprotein in plasma membranes and in purified reconstituted form. Biochim Biophys Acta. 1998 Feb 2; 1369(1):85-93.
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Senior AE, Bhagat S. P-glycoprotein shows strong catalytic cooperativity between the two nucleotide sites. Biochemistry. 1998 Jan 20; 37(3):831-6.
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Weber J, Hammond ST, Wilke-Mounts S, Senior AE. Mg2+ coordination in catalytic sites of F1-ATPase. Biochemistry. 1998 Jan 13; 37(2):608-14.
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Senior AE, al-Shawi MK, Urbatsch IL. ATPase activity of Chinese hamster P-glycoprotein. Methods Enzymol. 1998; 292:514-23.
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Sankaran B, Bhagat S, Senior AE. Photoaffinity labelling of P-glycoprotein catalytic sites. FEBS Lett. 1997 Nov 3; 417(1):119-22.
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Weber J, Senior AE. Binding of TNP-ATP and TNP-ADP to the non-catalytic sites of Escherichia coli F1-ATPase. FEBS Lett. 1997 Jul 21; 412(1):169-72.
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Sankaran B, Bhagat S, Senior AE. Inhibition of P-glycoprotein ATPase activity by beryllium fluoride. Biochemistry. 1997 Jun 3; 36(22):6847-53.
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Senior AE, Gadsby DC. ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR. Semin Cancer Biol. 1997 Jun; 8(3):143-50.
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Sankaran B, Bhagat S, Senior AE. Inhibition of P-glycoprotein ATPase activity by procedures involving trapping of nucleotide in catalytic sites. Arch Biochem Biophys. 1997 May 1; 341(1):160-9.
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Weber J, Senior AE. Catalytic mechanism of F1-ATPase. Biochim Biophys Acta. 1997 Mar 28; 1319(1):19-58.
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Löbau S, Weber J, Senior AE. Nucleotide occupancy of F1-ATPase catalytic sites under crystallization conditions. FEBS Lett. 1997 Mar 3; 404(1):15-8.
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Löbau S, Weber J, Wilke-Mounts S, Senior AE. F1-ATPase, roles of three catalytic site residues. J Biol Chem. 1997 Feb 7; 272(6):3648-56.
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Weber J, Bowman C, Senior AE. Specific tryptophan substitution in catalytic sites of Escherichia coli F1-ATPase allows differentiation between bound substrate ATP and product ADP in steady-state catalysis. J Biol Chem. 1996 Aug 2; 271(31):18711-8.
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Weber J, Senior AE. F1F0-ATP synthase: development of direct optical probes of the catalytic mechanism. Biochim Biophys Acta. 1996 Jul 18; 1275(1-2):101-4.
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Weber J, Senior AE. Binding and hydrolysis of TNP-ATP by Escherichia coli F1-ATPase. J Biol Chem. 1996 Feb 16; 271(7):3474-7.
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Senior AE, al-Shawi MK, Urbatsch IL. The catalytic cycle of P-glycoprotein. FEBS Lett. 1995 Dec 27; 377(3):285-9.
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Wilke-Mounts S, Pagan J, Senior AE. Mutagenesis and reversion analysis of residue Met-209 of the beta-subunit of Escherichia coli ATP synthase. Arch Biochem Biophys. 1995 Dec 1; 324(1):153-8.
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Urbatsch IL, Sankaran B, Bhagat S, Senior AE. Both P-glycoprotein nucleotide-binding sites are catalytically active. J Biol Chem. 1995 Nov 10; 270(45):26956-61.
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Senior AE, Weber J, al-Shawi MK. Catalytic mechanism of Escherichia coli F1-ATPase. Biochem Soc Trans. 1995 Nov; 23(4):747-52.
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Weber J, Bowman C, Wilke-Mounts S, Senior AE. alpha-Aspartate 261 is a key residue in noncatalytic sites of Escherichia coli F1-ATPase. J Biol Chem. 1995 Sep 8; 270(36):21045-9.
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Urbatsch IL, Sankaran B, Weber J, Senior AE. P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site. J Biol Chem. 1995 Aug 18; 270(33):19383-90.
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Schmidt G, Senior AE. ATP-dependent inactivation of the beta-Ser339Cys mutant F1-ATPase from Escherichia coli by N-ethylmaleimide. Biochemistry. 1995 Aug 1; 34(30):9694-9.
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Weber J, Senior AE. Location and properties of pyrophosphate-binding sites in Escherichia coli F1-ATPase. J Biol Chem. 1995 May 26; 270(21):12653-8.
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Gibson SL, al-Shawi MK, Senior AE, Hile R. Inhibition of the ATPase activity of P-glycoprotein by porphyrin photosensitization of multidrug-resistant cells in vitro. Photochem Photobiol. 1995 Apr; 61(4):390-6.
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Senior AE, al-Shawi MK, Urbatsch IL. ATP hydrolysis by multidrug-resistance protein from Chinese hamster ovary cells. J Bioenerg Biomembr. 1995 Feb; 27(1):31-6.
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Urbatsch IL, Senior AE. Effects of lipids on ATPase activity of purified Chinese hamster P-glycoprotein. Arch Biochem Biophys. 1995 Jan 10; 316(1):135-40.
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Weber J, Wilke-Mounts S, Senior AE. Cooperativity and stoichiometry of substrate binding to the catalytic sites of Escherichia coli F1-ATPase. Effects of magnesium, inhibitors, and mutation. J Biol Chem. 1994 Aug 12; 269(32):20462-7.
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Urbatsch IL, al-Shawi MK, Senior AE. Characterization of the ATPase activity of purified Chinese hamster P-glycoprotein. Biochemistry. 1994 Jun 14; 33(23):7069-76.
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Weber J, Wilke-Mounts S, Grell E, Senior AE. Tryptophan fluorescence provides a direct probe of nucleotide binding in the noncatalytic sites of Escherichia coli F1-ATPase. J Biol Chem. 1994 Apr 15; 269(15):11261-8.
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al-Shawi MK, Urbatsch IL, Senior AE. Covalent inhibitors of P-glycoprotein ATPase activity. J Biol Chem. 1994 Mar 25; 269(12):8986-92.
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Wilke-Mounts S, Weber J, Grell E, Senior AE. Tryptophan-free Escherichia coli F1-ATPase. Arch Biochem Biophys. 1994 Mar; 309(2):363-8.
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Hazard AL, Senior AE. Mutagenesis of subunit delta from Escherichia coli F1F0-ATP synthase. J Biol Chem. 1994 Jan 7; 269(1):418-26.
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Hazard AL, Senior AE. Defective energy coupling in delta-subunit mutants of Escherichia coli F1F0-ATP synthase. J Biol Chem. 1994 Jan 7; 269(1):427-32.
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Weber J, Wilke-Mounts S, Lee RS, Grell E, Senior AE. Specific placement of tryptophan in the catalytic sites of Escherichia coli F1-ATPase provides a direct probe of nucleotide binding: maximal ATP hydrolysis occurs with three sites occupied. J Biol Chem. 1993 Sep 25; 268(27):20126-33.
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Turina P, Aggeler R, Lee RS, Senior AE, Capaldi RA. The cysteine introduced into the alpha subunit of the Escherichia coli F1-ATPase by the mutation alpha R376C is near the alpha-beta subunit interface and close to a noncatalytic nucleotide binding site. J Biol Chem. 1993 Apr 5; 268(10):6978-84.
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Senior AE, Wilke-Mounts S, al-Shawi MK. Lysine 155 in beta-subunit is a catalytic residue of Escherichia coli F1 ATPase. J Biol Chem. 1993 Apr 5; 268(10):6989-94.
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Weber J, Lee RS, Wilke-Mounts S, Grell E, Senior AE. Combined application of site-directed mutagenesis, 2-azido-ATP labeling, and lin-benzo-ATP binding to study the noncatalytic sites of Escherichia coli F1-ATPase. J Biol Chem. 1993 Mar 25; 268(9):6241-7.
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al-Shawi MK, Senior AE. Characterization of the adenosine triphosphatase activity of Chinese hamster P-glycoprotein. J Biol Chem. 1993 Feb 25; 268(6):4197-206.
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Senior AE, al-Shawi MK. Further examination of seventeen mutations in Escherichia coli F1-ATPase beta-subunit. J Biol Chem. 1992 Oct 25; 267(30):21471-8.
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Senior AE. Catalytic sites of Escherichia coli F1-ATPase. J Bioenerg Biomembr. 1992 Oct; 24(5):479-84.
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Lee RS, Wilke-Mounts S, Senior AE. F1-ATPase with cysteine instead of serine at residue 373 of the alpha subunit. Arch Biochem Biophys. 1992 Sep; 297(2):334-9.
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Senior AE, Lee RS, al-Shawi MK, Weber J. Catalytic properties of Escherichia coli F1-ATPase depleted of endogenous nucleotides. Arch Biochem Biophys. 1992 Sep; 297(2):340-4.
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Weber J, Lee RS, Grell E, Senior AE. Investigation of the aurovertin binding site of Escherichia coli F1-ATPase by fluorescence spectroscopy and site-directed mutagenesis. Biochemistry. 1992 Jun 9; 31(22):5112-6.
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al-Shawi MK, Senior AE. Catalytic sites of Escherichia coli F1-ATPase. Characterization of unisite catalysis at varied pH. Biochemistry. 1992 Jan 28; 31(3):878-85.
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al-Shawi MK, Senior AE. Effects of dimethyl sulfoxide on catalysis in Escherichia coli F1-ATPase. Biochemistry. 1992 Jan 28; 31(3):886-91.
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Weber J, Lee RS, Grell E, Wise JG, Senior AE. On the location and function of tyrosine beta 331 in the catalytic site of Escherichia coli F1-ATPase. J Biol Chem. 1992 Jan 25; 267(3):1712-8.
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Lee RS, Pagan J, Wilke-Mounts S, Senior AE. Characterization of Escherichia coli ATP synthase beta-subunit mutations using a chromosomal deletion strain. Biochemistry. 1991 Jul 16; 30(28):6842-7.
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Pagan J, Senior AE. Tight ATP and ADP binding in the noncatalytic sites of Escherichia coli F1-ATPase is not affected by mutation of bulky residues in the 'glycine-rich loop'. FEBS Lett. 1990 Oct 29; 273(1-2):147-9.
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Greber UF, Senior A, Gerace L. A major glycoprotein of the nuclear pore complex is a membrane-spanning polypeptide with a large lumenal domain and a small cytoplasmic tail. EMBO J. 1990 May; 9(5):1495-502.
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al-Shawi MK, Parsonage D, Senior AE. Adenosine triphosphatase and nucleotide binding activity of isolated beta-subunit preparations from Escherichia coli F1F0-ATP synthase. J Biol Chem. 1990 Apr 5; 265(10):5595-601.
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al-Shawi MK, Parsonage D, Senior AE. Thermodynamic analyses of the catalytic pathway of F1-ATPase from Escherichia coli. Implications regarding the nature of energy coupling by F1-ATPases. J Biol Chem. 1990 Mar 15; 265(8):4402-10.
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Pagan J, Senior AE. Mutations in alpha-subunit of Escherichia coli F1-ATPase obtained by hydroxylamine-mutagenesis of plasmids carrying the uncA gene. Arch Biochem Biophys. 1990 Mar; 277(2):283-9.
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Senior AE. The proton-translocating ATPase of Escherichia coli. Annu Rev Biophys Biophys Chem. 1990; 19:7-41.
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al-Shawi MK, Parsonage D, Senior AE. Kinetic characterization of the unisite catalytic pathway of seven beta-subunit mutant F1-ATPases from Escherichia coli. J Biol Chem. 1989 Sep 15; 264(26):15376-83.
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Lee RS, Pagan J, Satre M, Vignais PV, Senior AE. Identification of a mutation in Escherichia coli F1-ATPase beta-subunit conferring resistance to aurovertin. FEBS Lett. 1989 Aug 14; 253(1-2):269-72.
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Grubmeyer C, Skiadopoulos M, Senior AE. L-histidinol dehydrogenase, a Zn2+-metalloenzyme. Arch Biochem Biophys. 1989 Aug 1; 272(2):311-7.
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Kironde FA, Parsonage D, Senior AE. Random mutagenesis of the gene for the beta-subunit of F1-ATPase from Escherichia coli. Biochem J. 1989 Apr 15; 259(2):421-6.
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Al-Shawi MK, Parsonage D, Senior AE. Directed mutagenesis of the strongly conserved aspartate 242 in the beta-subunit of Escherichia coli proton-ATPase. J Biol Chem. 1988 Dec 25; 263(36):19633-9.
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Al-Shawi MK, Senior AE. Complete kinetic and thermodynamic characterization of the unisite catalytic pathway of Escherichia coli F1-ATPase. Comparison with mitochondrial F1-ATPase and application to the study of mutant enzymes. J Biol Chem. 1988 Dec 25; 263(36):19640-8.
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Rao R, Pagan J, Senior AE. Directed mutagenesis of the strongly conserved lysine 175 in the proposed nucleotide-binding domain of alpha-subunit from Escherichia coli F1-ATPase. J Biol Chem. 1988 Nov 5; 263(31):15957-63.
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Parsonage D, Wilke-Mounts S, Senior AE. E. coli F1-ATPase: site-directed mutagenesis of the beta-subunit. FEBS Lett. 1988 May 9; 232(1):111-4.
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Rao R, Al-Shawi MK, Senior AE. Trinitrophenyl-ATP and -ADP bind to a single nucleotide site on isolated beta-subunit of Escherichia coli F1-ATPase. In vitro assembly of F1-subunits requires occupancy of the nucleotide-binding site on beta-subunit by nucleoside triphosphate. J Biol Chem. 1988 Apr 25; 263(12):5569-73.
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Rao R, Cunningham D, Cross RL, Senior AE. Pyridoxal 5'-diphospho-5'-adenosine binds at a single site on isolated alpha-subunit from Escherichia coli F1-ATPase and specifically reacts with lysine 201. J Biol Chem. 1988 Apr 25; 263(12):5640-5.
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Maggio MB, Parsonage D, Senior AE. A mutation in the alpha-subunit of F1-ATPase from Escherichia coli affects the binding of F1 to the membrane. J Biol Chem. 1988 Apr 5; 263(10):4619-23.
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Parsonage D, Al-Shawi MK, Senior AE. Directed mutations of the strongly conserved lysine 155 in the catalytic nucleotide-binding domain of beta-subunit of F1-ATPase from Escherichia coli. J Biol Chem. 1988 Apr 5; 263(10):4740-4.
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Parsonage D, Wilke-Mounts S, Senior AE. Directed mutagenesis of the dicyclohexylcarbodiimide-reactive carboxyl residues in beta-subunit of F1-ATPase of Escherichia coli. Arch Biochem Biophys. 1988 Feb 15; 261(1):222-5.
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Senior AE. ATP synthesis by oxidative phosphorylation. Physiol Rev. 1988 Jan; 68(1):177-231.
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Rao R, Senior AE. The properties of hybrid F1-ATPase enzymes suggest that a cyclical catalytic mechanism involving three catalytic sites occurs. J Biol Chem. 1987 Dec 25; 262(36):17450-4.
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Maggio MB, Pagan J, Parsonage D, Hatch L, Senior AE. The defective proton-ATPase of uncA mutants of Escherichia coli. Identification by DNA sequencing of residues in the alpha-subunit which are essential for catalysis or normal assembly. J Biol Chem. 1987 Jul 5; 262(19):8981-4.
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Parsonage D, Wilke-Mounts S, Senior AE. Directed mutagenesis of the beta-subunit of F1-ATPase from Escherichia coli. J Biol Chem. 1987 Jun 15; 262(17):8022-6.
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Rao R, Perlin DS, Senior AE. The defective proton-ATPase of uncA mutants of Escherichia coli: ATP-binding and ATP-induced conformational change in mutant alpha-subunits. Arch Biochem Biophys. 1987 Jun; 255(2):309-15.
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Parsonage D, Duncan TM, Wilke-Mounts S, Kironde FA, Hatch L, Senior AE. The defective proton-ATPase of uncD mutants of Escherichia coli. Identification by DNA sequencing of residues in the beta-subunit which are essential for catalysis or normal assembly. J Biol Chem. 1987 May 5; 262(13):6301-7.
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Wood JM, Wise JG, Senior AE, Futai M, Boyer PD. Catalytic properties of the F1-adenosine triphosphatase from Escherichia coli K-12 and its genetic variants as revealed by 18O exchanges. J Biol Chem. 1987 Feb 15; 262(5):2180-6.
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Cox GB, Hatch L, Webb D, Fimmel AL, Lin ZH, Senior AE, Gibson F. Amino acid substitutions in the epsilon-subunit of the F1F0-ATPase of Escherichia coli. Biochim Biophys Acta. 1987 Feb 11; 890(2):195-204.
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Duncan TM, Parsonage D, Senior AE. Structure of the nucleotide-binding domain in the beta-subunit of Escherichia coli F1-ATPase. FEBS Lett. 1986 Nov 10; 208(1):1-6.
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Wise JG, Senior AE. Catalytic properties of the Escherichia coli proton adenosinetriphosphatase: evidence that nucleotide bound at noncatalytic sites is not involved in regulation of oxidative phosphorylation. Biochemistry. 1985 Nov 19; 24(24):6949-54.
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Smith RA, Latchney LR, Senior AE. Tight divalent metal binding to Escherichia coli F1-adenosinetriphosphatase. Complete substitution of intrinsic magnesium by manganese or cobalt and studies of metal binding sites. Biochemistry. 1985 Jul 30; 24(16):4490-4.
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Perlin DS, Latchney LR, Senior AE. Inhibition of Escherichia coli H+-ATPase by venturicidin, oligomycin and ossamycin. Biochim Biophys Acta. 1985 May 31; 807(3):238-44.
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Duncan TM, Senior AE. The defective proton-ATPase of uncD mutants of Escherichia coli. Two mutations which affect the catalytic mechanism. J Biol Chem. 1985 Apr 25; 260(8):4901-7.
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Perlin DS, Senior AE. Functional effects and cross-reactivity of antibody to purified subunit b (uncF protein) of Escherichia coli proton-ATPase. Arch Biochem Biophys. 1985 Feb 1; 236(2):603-11.
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Perlin DS, Latchney LR, Wise JG, Senior AE. Specificity of the proton adenosinetriphosphatase of Escherichia coli for adenine, guanine, and inosine nucleotides in catalysis and binding. Biochemistry. 1984 Oct 9; 23(21):4998-5003.
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Senior AE. Disposition of polar and nonpolar residues on outer surfaces of transmembrane helical segments of proteins involved in proton translocation. Arch Biochem Biophys. 1984 Oct; 234(1):138-43.
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Wise JG, Latchney LR, Ferguson AM, Senior AE. Defective proton ATPase of uncA mutants of Escherichia coli. 5'-Adenylyl imidodiphosphate binding and ATP hydrolysis. Biochemistry. 1984 Mar 27; 23(7):1426-32.
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Senior AE, Latchney LR, Ferguson AM, Wise JG. Purification of F1-ATPase with impaired catalytic activity from partial revertants of Escherichia coli uncA mutant strains. Arch Biochem Biophys. 1984 Jan; 228(1):49-53.
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Wise JG, Duncan TM, Latchney LR, Cox DN, Senior AE. Properties of F1-ATPase from the uncD412 mutant of Escherichia coli. Biochem J. 1983 Nov 1; 215(2):343-50.
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Cox GB, Jans DA, Gibson F, Langman L, Senior AE, Fimmel AL. Oxidative phosphorylation by mutant Escherichia coli membranes with impaired proton permeability. Biochem J. 1983 Oct 15; 216(1):143-50.
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Perlin DS, Cox DN, Senior AE. Integration of F1 and the membrane sector of the proton-ATPase of Escherichia coli. Role of subunit "b" (uncF protein). J Biol Chem. 1983 Aug 25; 258(16):9793-800.
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Fimmel AL, Jans DA, Langman L, James LB, Ash GR, Downie JA, Senior AE, Gibson F, Cox GB. The F1F0-ATPase of Escherichia coli. Substitution of proline by leucine at position 64 in the c-subunit causes loss of oxidative phosphorylation. Biochem J. 1983 Aug 1; 213(2):451-8.
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Hamlyn JM, Senior AE. Evidence that Mg2+- or Ca2+-activated adenosine triphosphatase in rat pancreas is a plasma-membrane ecto-enzyme. Biochem J. 1983 Jul 15; 214(1):59-68.
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Senior AE. Secondary and tertiary structure of membrane proteins involved in proton translocation. Biochim Biophys Acta. 1983 Jul 15; 726(2):81-95.
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Jans DA, Fimmel AL, Langman L, James LB, Downie JA, Senior AE, Ash GR, Gibson F, Cox GB. Mutations in the uncE gene affecting assembly of the c-subunit of the adenosine triphosphatase of Escherichia coli. Biochem J. 1983 Jun 1; 211(3):717-26.
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Senior AE, Langman L, Cox GB, Gibson F. Oxidative phosphorylation in Escherichia coli. Characterization of mutant strains in which F1-ATPase contains abnormal beta-subunits. Biochem J. 1983 Feb 15; 210(2):395-403.
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Senior AE, Wise JG. The proton-ATPase of bacteria and mitochondria. J Membr Biol. 1983; 73(2):105-24.
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Skerrett KJ, Wise JG, Latchney LR, Senior AE. Trypsin cleavage of the alpha-subunit of beef heart F1-ATPase abolishes ATP synthesis and ATP-driven energy-transduction capabilities. Biochim Biophys Acta. 1981 Nov 12; 638(1):120-4.
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Wise JG, Latchney LR, Senior AE. The defective proton-ATPase of uncA mutants of Escherichia coli. Studies of nucleotide binding sites, bound aurovertin fluorescence, and labeling of essential residues of the purified F1-ATPase. J Biol Chem. 1981 Oct 25; 256(20):10383-9.
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Cox GB, Downie JA, Langman L, Senior AE, Ash G, Fayle DR, Gibson F. Assembly of the adenosine triphosphatase complex in Escherichia coli: assembly of F0 is dependent on the formation of specific F1 subunits. J Bacteriol. 1981 Oct; 148(1):30-42.
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Senior AE. Divalent metals in beef heart mitochondrial adenosine triphosphatase. Demonstration of the metals in membrane-bound enzyme and studies of the interconversion of the "1-Mg" and "2-Mg" forms of the enzyme. J Biol Chem. 1981 May 25; 256(10):4763-7.
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Martin SS, Senior AE. Membrane adenosine triphosphatase activities in rat pancreas. Biochim Biophys Acta. 1980 Nov 4; 602(2):401-18.
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Senior AE, Richardson LV, Baker K, Wise JG. Tight divalent cation-binding sites of soluble adenosine triphosphatase (F1) from beef heart mitochondria and Escherichia coli. J Biol Chem. 1980 Aug 10; 255(15):7211-7.
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Senior AE. Tightly bound magnesium in mitochondrial adenosine triphosphatase from beef heart. J Biol Chem. 1979 Nov 25; 254(22):11319-22.
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Senior AE, Fayle DR, Downie JA, Gibson F, Cox GB. Properties of membranes from mutant strains of Escherichia coli in which the beta-subunit of the adenosine triphosphatase is abnormal. Biochem J. 1979 Apr 15; 180(1):111-8.
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Senior AE, Downie JA, Cox GB, Gibson F, Langman L, Fayle DR. The uncA gene codes for the alpha-subunit of the adenosine triphosphatase of Escherichia coli. Electrophoretic analysis of uncA mutant strains. Biochem J. 1979 Apr 15; 180(1):103-9.
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Downie JA, Senior AE, Cox GB, Gibson F. Solubilization of adenosine triphosphatase from membranes of Escherichia coli: effect of p-aminobenzamidine. J Bacteriol. 1979 Apr; 138(1):87-91.
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Downie JA, Senior AE, Gibson F, Cox GB. A fifth gene (uncE) in the operon concerned with oxidative phosphorylation in Escherichia coli. J Bacteriol. 1979 Feb; 137(2):711-8.
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Smith RD, Hilf R, Senior AE. Prolactin binding to dissociated cells from rat mammary tumors and mammary gland. Cancer Biochem Biophys. 1979; 3(3):117-21.
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Senior AE. Oligomycin-sensitivity-conferring protein. Methods Enzymol. 1979; 55:391-7.
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Smith RD, Hilf R, Senior AE. The effect of altered thyroid state on prolactin binding to liver and 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats. Proc Soc Exp Biol Med. 1978 Sep; 158(4):517-20.
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Leimgruber RM, Senior AE. Tightly-bound ATP and ADP in reconstituted submitochondrial particles. Biochem Biophys Res Commun. 1978 Aug 14; 83(3):837-42.
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Smith RD, Hilf R, Senior AE. Prolactin binding to 7,12-dimethylbenz(a)anthracene-induced mammary tumors and liver in diabetic rats. Cancer Res. 1977 Nov; 37(11):4070-4.
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Smith RD, Hilf R, Senior AE. Prolactin binding to R3230AC mammary carcinoma and liver in hormone-treated and diabetic rats. Cancer Res. 1977 Feb; 37(2):595-8.
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Leimgruber RM, Senior AE. Removal of "tightly bound" nucleotides from soluble mitochondrial adenosine triphosphatase (F1). J Biol Chem. 1976 Nov 25; 251(22):7103-9.
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Leimgruber RM, Senior AE. Removal of "tightly bound" nucleotides from phosphorylating submitochondrial particles. J Biol Chem. 1976 Nov 25; 251(22):7110-3.
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Marinetti GV, Senior AE, Love R, Broadhurst CI. Reaction of amino-phospholipids of the inner mitochondrial membrane with fluorodinitrobenzene and trinitrobenzenesulfonate. Chem Phys Lipids. 1976 Oct; 17(2-3 SPEC NO):353-62.
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Smith RD, Hilf R, Senior AE. Prolactin binding to mammary gland, 7,12-dimethylbenz(a)-anthracene-induced mammary tumors, and liver in rats. Cancer Res. 1976 Oct; 36(10):3726-31.
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Senior AE, McGowan SE, Hilf R. A comparative study of inner membrane enzymes and transport systems in mitochondria from R3230AC mammary tumor and normal rat mammary gland. Cancer Res. 1975 Aug; 35(8):2061-7.
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Senior AE. Mitochondrial adenosine triphosphatase. Location of sulfhydryl groups and disulfide bonds in soluble enzyme from beef heart. Biochemistry. 1975 Feb 25; 14(4):660-4.
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Senior AE. The structure of mitochondrial ATPase. Biochim Biophys Acta. 1973 Dec 31; 301(3):249-77.
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Senior AE. Relationship of cysteine and tyrosine residues to adenosine triphosphate hydrolysis by mitochondrial adenine triphosphatase. Biochemistry. 1973 Sep 11; 12(19):3622-7.
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Holland PC, Senior AE, Sherratt HS. Biochemical effects of the hypoglycaemic compound pent-4-enoic acid and related non-hypoglycaemic fatty acids. Effects of their coenzyme A esters on enzymes of fatty acid oxidation. Biochem J. 1973 Sep; 136(1):173-84.
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Brooks JC, Senior AE. Methods for purification of each subunit of the mitochondrial oligomycin-insensitive adenosine triphosphatase. Biochemistry. 1972 Dec 5; 11(25):4675-8.
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Wakabayashi T, Senior AE, Hatase O, Hayashi H, Green DE. Conformational changes in membranous preparations of cytochrome oxidase. J Bioenerg. 1972 Aug; 3(5):339-44.
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Vanderkooi G, Senior AE, Capaldi RA, Hayashi H. Biological membrane structure. 3. The lattice structure of membranous cytochrome oxidase. Biochim Biophys Acta. 1972 Jul 3; 274(1):38-48.
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Holland PC, Senior AE, Sherratt HS. Mechanism of inhibition of fatty acid oxidation by pent-4-enoic acid: 3-oxoacyl-coenzyme A thiolase as the possible site of inhibition. Biochem J. 1972 Apr; 127(3):79P-80P.
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Brooks JC, Senior AE. Studies on the mitochondrial oligomycin-insensitive ATPase. II. The relationship of the specific protein inhibitor to the ATPase. Arch Biochem Biophys. 1971 Dec; 147(2):467-70.
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Senior AE. On the relationship between the oligomycin-sensitivity conferring protein and other mitochondrial coupling factors. J Bioenerg. 1971 Aug; 2(3):141-50.
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Blondin GA, DeCastro AF, Senior AE. The isolation and properties of a peptide ionophore from beef heart mitochondria. Biochem Biophys Res Commun. 1971 Apr 2; 43(1):28-35.
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Senior AE, MacLennan DH. Mitochondrial "structural protein." A reassessment. J Biol Chem. 1970 Oct 10; 245(19):5086-95.
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Senior AE, Brooks JC. Studies on the mitochondrial oligomycin-insensitivt ATPase. I. An improved method of purification and the behavior of the enzyme in solutions of various depolymerizing agents. Arch Biochem Biophys. 1970 Sep; 140(1):257-66.
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Senior AE, Sherratt HS. A comparison of the effects on blood glucose and ketone-body levels, and of the toxicities, of pent-4-enoic acid and four simple fatty acids. J Pharm Pharmacol. 1969 Feb; 21(2):85-92.
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Senior AE, Sherratt HS. Biochemical effects of the hypoglycaemic compound pent-4-enoic acid and related non-hypoglycaemic fatty acids. Oxidative phosphorylation and mitochondrial oxidation of pyruvate, 3-hydroxybutyrate and tricarboxylic acid-cycle intermediates. Biochem J. 1968 Dec; 110(3):499-509.
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Senior AE, Robson B, Sherratt HS. Biochemical effects of the hypoglycaemic compound pent--4-enoic acid and related non-hypoglycaemic fatty acids. Biochem J. 1968 Dec; 110(3):511-9.
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Senior AE, Sherratt HS. Biochemical effects of the hypoglycaemic compound pent-4-enoic acid and related non-hypoglycaemic fatty acids. Carbohydrate metabolism. Biochem J. 1968 Dec; 110(3):521-7.
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Senior AE, Sherratt HS. The effect of pent-4-enoic acid and some simple related compounds on the oxidation of fatty acids by rat-liver mitochondria. Biochem J. 1967 Sep; 104(3):56P.
