Dr. Schwartz' research interests are:
1) Molecular physiology of acid-base disturbances
2) Kidney tubular acidosis
3) Disorders of sodium, potassium, and magnesium transport
4) Carbonic anhydrase deficiency diseases
5) Assessment of kidney function (glomerular filtration rate)

The long term goal is to determine how intercalated cells of the kidney cortical collecting duct (CCD) sense a change in extracellular pH and adapt by reversing their polarity of H+/HCO3 transporters. After exposure to a 3 h incubation at pH 6.8, rabbit CCDs, which normally secrete HCO3, reverse polarity, secrete H+ and endocytically remove apical Cl/HCO3 exchangers to stop HCO3 secretion. The novel protein hensin is expressed in the extracellular matrix (ECM) surrounding adapting HCO3-secreting intercalated cells (B-ICs) and plays a key role in this adaptation.

Aim 1 determines the mechanisms by which polymerized hensin is deposited in the ECM and how hensin signals the adaptation of B-ICs during metabolic acidosis. Other proteins interacting with hensin include integrins, galectin 3, and cyclophilin A (cyp A); these proteins may be regulated by acid-base disturbances and hensin polymerization. Cyclosporin (CsA) causes renal tubular acidosis and inhibits cyp A peptidyl prolyl isomerase activity. To assess CsA's effect, cultured intercalated cells are plated at high density in the presence of CsA and examined for hensin polymerization in the media and ECM. A cyp A "knockdown" model using siRNAs will be examined similarly; to determine if hensin fails to polymerize without this isomerase activity.

Aim 2 examines the adaptation of CCD ICs to metabolic alkalosis regarding proteins of the hensin pathway and investigates if in vitro alkalosis can reverse the adaptation occurring in response to in vivo metabolic acidosis.

Aim 3 addresses early events in response to metabolic acidosis. Our data suggest that low cell pH is the signal to initiate the adaptation; the role of the adjacent principal cell in this signaling will be determined. We will show whether low pH stimulates endothelin-1 and nitric oxide, and whether they mediate changes in HCO3 transport during acidosis. The early steps of tyrosine phosphorylation and c-Src activation in response to low pH will also be examined.

These studies will illustrate how ICs respond to acid-base perturbations and change functional polarity.

• Schwartz GJ, Schneider MF, Maier PS, Moxey-Mims M, Dharnidharka VR, Warady BA, Furth SL, Muñoz A. Improved equations estimating GFR in children with chronic kidney disease using an immunonephelometric determination of cystatin C. Kidney Int. 2012 Aug; 82(4):445-53.
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• Alvarez O, Miller ST, Wang WC, Luo Z, McCarville MB, Schwartz GJ, Thompson B, Howard T, Iyer RV, Rana SR, Rogers ZR, Sarnaik SA, Thornburg CD, Ware RE. Effect of hydroxyurea treatment on renal function parameters: results from the multi-center placebo-controlled BABY HUG clinical trial for infants with sickle cell anemia. Pediatr Blood Cancer. 2012 Oct; 59(4):668-74.
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• Dodson JL, Jerry-Fluker JV, Ng DK, Moxey-Mims M, Schwartz GJ, Dharnidharka VR, Warady BA, Furth SL. Urological disorders in chronic kidney disease in children cohort: clinical characteristics and estimation of glomerular filtration rate. J Urol. 2011 Oct; 186(4):1460-6.
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• Wang E, Meier DJ, Sandoval RM, Von Hendy-Willson VE, Pressler BM, Bunch RM, Alloosh M, Sturek MS, Schwartz GJ, Molitoris BA. A portable fiberoptic ratiometric fluorescence analyzer provides rapid point-of-care determination of glomerular filtration rate in large animals. Kidney Int. 2012 Jan; 81(1):112-7.
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• Furth SL, Abraham AG, Jerry-Fluker J, Schwartz GJ, Benfield M, Kaskel F, Wong C, Mak RH, Moxey-Mims M, Warady BA. Metabolic abnormalities, cardiovascular disease risk factors, and GFR decline in children with chronic kidney disease. Clin J Am Soc Nephrol. 2011 Sep; 6(9):2132-40.
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• Ng DK, Schwartz GJ, Jacobson LP, Palella FJ, Margolick JB, Warady BA, Furth SL, Muñoz A. Universal GFR determination based on two time points during plasma iohexol disappearance. Kidney Int. 2011 Aug; 80(4):423-30.
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• Fadrowski JJ, Neu AM, Schwartz GJ, Furth SL. Pediatric GFR estimating equations applied to adolescents in the general population. Clin J Am Soc Nephrol. 2011 Jun; 6(6):1427-35.
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• Abraham AG, Muñoz A, Furth SL, Warady B, Schwartz GJ. Extracellular volume and glomerular filtration rate in children with chronic kidney disease. Clin J Am Soc Nephrol. 2011 Apr; 6(4):741-7.
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• Ross RA, Rossetti L, Lam TK, Schwartz GJ. Differential effects of hypothalamic long-chain fatty acid infusions on suppression of hepatic glucose production. Am J Physiol Endocrinol Metab. 2010 Oct; 299(4):E633-9.
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• Purkerson JM, Tsuruoka S, Suter DZ, Nakamori A, Schwartz GJ. Adaptation to metabolic acidosis and its recovery are associated with changes in anion exchanger distribution and expression in the cortical collecting duct. Kidney Int. 2010 Nov; 78(10):993-1005.
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• Lande MB, Adams H, Falkner B, Waldstein SR, Schwartz GJ, Szilagyi PG, Wang H, Palumbo D. Parental assessment of executive function and internalizing and externalizing behavior in primary hypertension after anti-hypertensive therapy. J Pediatr. 2010 Jul; 157(1):114-9.
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• Schwartz GJ, Abraham AG, Furth SL, Warady BA, Muñoz A. Optimizing iohexol plasma disappearance curves to measure the glomerular filtration rate in children with chronic kidney disease. Kidney Int. 2010 Jan; 77(1):65-71.
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• Schwartz GJ, Work DF. Measurement and estimation of GFR in children and adolescents. Clin J Am Soc Nephrol. 2009 Nov; 4(11):1832-43.
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• Abraham AG, Schwartz GJ, Furth S, Warady BA, Muñoz A. Longitudinal formulas to estimate GFR in children with CKD. Clin J Am Soc Nephrol. 2009 Nov; 4(11):1724-30.
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• Wong CS, Pierce CB, Cole SR, Warady BA, Mak RH, Benador NM, Kaskel F, Furth SL, Schwartz GJ. Association of proteinuria with race, cause of chronic kidney disease, and glomerular filtration rate in the chronic kidney disease in children study. Clin J Am Soc Nephrol. 2009 Apr; 4(4):812-9.
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• Schwartz GJ, Muñoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL. New equations to estimate GFR in children with CKD. J Am Soc Nephrol. 2009 Mar; 20(3):629-37.
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• Peng H, Vijayakumar S, Schiene-Fischer C, Li H, Purkerson JM, Malesevic M, Liebscher J, Al-Awqati Q, Schwartz GJ. Secreted cyclophilin A, a peptidylprolyl cis-trans isomerase, mediates matrix assembly of hensin, a protein implicated in epithelial differentiation. J Biol Chem. 2009 Mar 6; 284(10):6465-75.
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• Lande MB, Adams H, Falkner B, Waldstein SR, Schwartz GJ, Szilagyi PG, Wang H, Palumbo D. Parental assessments of internalizing and externalizing behavior and executive function in children with primary hypertension. J Pediatr. 2009 Feb; 154(2):207-12.
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• Groesbeck D, Köttgen A, Parekh R, Selvin E, Schwartz GJ, Coresh J, Furth S. Age, gender, and race effects on cystatin C levels in US adolescents. Clin J Am Soc Nephrol. 2008 Nov; 3(6):1777-85.
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• Romanenko VG, Nakamoto T, Catalán MA, Gonzalez-Begne M, Schwartz GJ, Jaramillo Y, Sepúlveda FV, Figueroa CD, Melvin JE. Clcn2 encodes the hyperpolarization-activated chloride channel in the ducts of mouse salivary glands. Am J Physiol Gastrointest Liver Physiol. 2008 Nov; 295(5):G1058-67.
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• Schwartz GJ, Kwong T, Erway B, Warady B, Sokoll L, Hellerstein S, Dharnidharka V, Furth S, Muñoz A. Validation of creatinine assays utilizing HPLC and IDMS traceable standards in sera of children. Pediatr Nephrol. 2009 Jan; 24(1):113-9.
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• Work DF, Schwartz GJ. Estimating and measuring glomerular filtration rate in children. Curr Opin Nephrol Hypertens. 2008 May; 17(3):320-5.
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• Schwartz GJ. Diagnosis of distal renal tubular acidosis: use of furosemide plus fludrocortisone versus ammonium chloride. Nat Clin Pract Nephrol. 2007 Nov; 3(11):590-1.
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• Erkan E, Devarajan P, Schwartz GJ. Mitochondria are the major targets in albumin-induced apoptosis in proximal tubule cells. J Am Soc Nephrol. 2007 Apr; 18(4):1199-208.
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• Purkerson JM, Kittelberger AM, Schwartz GJ. Basolateral carbonic anhydrase IV in the proximal tubule is a glycosylphosphatidylinositol-anchored protein. Kidney Int. 2007 Mar; 71(5):407-16.
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• Schwartz GJ, Furth SL. Glomerular filtration rate measurement and estimation in chronic kidney disease. Pediatr Nephrol. 2007 Nov; 22(11):1839-48.
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• Purkerson JM, Schwartz GJ. The role of carbonic anhydrases in renal physiology. Kidney Int. 2007 Jan; 71(2):103-15.
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• Vijayakumar S, Takito J, Gao X, Schwartz GJ, Al-Awqati Q. Differentiation of columnar epithelia: the hensin pathway. J Cell Sci. 2006 Dec 1; 119(Pt 23):4797-801.
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• Schwartz GJ, Furth S, Cole SR, Warady B, Muñoz A. Glomerular filtration rate via plasma iohexol disappearance: pilot study for chronic kidney disease in children. Kidney Int. 2006 Jun; 69(11):2070-7.
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• Tsuruoka S, Watanabe S, Purkerson JM, Fujimura A, Schwartz GJ. Endothelin and nitric oxide mediate adaptation of the cortical collecting duct to metabolic acidosis. Am J Physiol Renal Physiol. 2006 Oct; 291(4):F866-73.
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• Schwartz GJ, Lerner NB. The kallikrein-kinin system in sickle cell nephropathy: does it play a role? J Pediatr Hematol Oncol. 2006 Mar; 28(3):111-4.
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• Schwaderer AL, Vijayakumar S, Al-Awqati Q, Schwartz GJ. Galectin-3 expression is induced in renal beta-intercalated cells during metabolic acidosis. Am J Physiol Renal Physiol. 2006 Jan; 290(1):F148-58.
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• Schwartz GJ, Al-Awqati Q. Role of hensin in mediating the adaptation of the cortical collecting duct to metabolic acidosis. Curr Opin Nephrol Hypertens. 2005 Jul; 14(4):383-8.
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• Tsuruoka S, Schwartz GJ, Ioka T, Yamamoto H, Ando H, Fujimura A. Citrate reverses cyclosporin A-induced metabolic acidosis and bone resorption in rats. Am J Nephrol. 2005 May-Jun; 25(3):233-9.
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• Purkerson JM, Schwartz GJ. Expression of membrane-associated carbonic anhydrase isoforms IV, IX, XII, and XIV in the rabbit: induction of CA IV and IX during maturation. Am J Physiol Regul Integr Comp Physiol. 2005 May; 288(5):R1256-63.
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• Erkan E, Devarajan P, Schwartz GJ. Apoptotic response to albumin overload: proximal vs. distal/collecting tubule cells. Am J Nephrol. 2005 Mar-Apr; 25(2):121-31.
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• Schwaderer AL, Schwartz GJ. Treating hypernatremic dehydration. Pediatr Rev. 2005 Apr; 26(4):148-50.
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• Lande MB, Varade W, Erkan E, Niederbracht Y, Schwartz GJ. Role of urinary supersaturation in the evaluation of children with urolithiasis. Pediatr Nephrol. 2005 Apr; 20(4):491-4.
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• Schwaderer AL, Schwartz GJ. Back to basics: acidosis and alkalosis. Pediatr Rev. 2004 Oct; 25(10):350-7.
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• Watanabe S, Tsuruoka S, Vijayakumar S, Fischer G, Zhang Y, Fujimura A, Al-Awqati Q, Schwartz GJ. Cyclosporin A produces distal renal tubular acidosis by blocking peptidyl prolyl cis-trans isomerase activity of cyclophilin. Am J Physiol Renal Physiol. 2005 Jan; 288(1):F40-7.
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• von Meyenburg C, Hrupka BH, Arsenijevic D, Schwartz GJ, Landmann R, Langhans W. Role for CD14, TLR2, and TLR4 in bacterial product-induced anorexia. Am J Physiol Regul Integr Comp Physiol. 2004 Aug; 287(2):R298-305.
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• Al-Awqati Q, Schwartz GJ. A fork in the road of cell differentiation in the kidney tubule. J Clin Invest. 2004 Jun; 113(11):1528-30.
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• Nicoletta JA, Schwartz GJ. Distal renal tubular acidosis. Curr Opin Pediatr. 2004 Apr; 16(2):194-8.
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• Lande MB, Kaczorowski JM, Auinger P, Schwartz GJ, Weitzman M. Elevated blood pressure and decreased cognitive function among school-age children and adolescents in the United States. J Pediatr. 2003 Dec; 143(6):720-4.
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• Alvarez BV, Loiselle FB, Supuran CT, Schwartz GJ, Casey JR. Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter. Biochemistry. 2003 Oct 28; 42(42):12321-9.
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• Hogg RJ, Furth S, Lemley KV, Portman R, Schwartz GJ, Coresh J, Balk E, Lau J, Levin A, Kausz AT, Eknoyan G, Levey AS. National Kidney Foundation's Kidney Disease Outcomes Quality Initiative clinical practice guidelines for chronic kidney disease in children and adolescents: evaluation, classification, and stratification. Pediatrics. 2003 Jun; 111(6 Pt 1):1416-21.
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• Tsuruoka S, Schwartz GJ, Wakaumi M, Nishiki K, Yamamoto H, Purkerson JM, Fujimura A. Nitric oxide production modulates cyclosporin A-induced distal renal tubular acidosis in the rat. J Pharmacol Exp Ther. 2003 Jun; 305(3):840-5.
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• Nishiki K, Tsuruoka S, Kawaguchi A, Sugimoto K, Schwartz GJ, Suzuki M, Imai M, Fujimura A. Inhibition of Rho-kinase reduces renal Na-H exchanger activity and causes natriuresis in rat. J Pharmacol Exp Ther. 2003 Feb; 304(2):723-8.
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• Yip KP, Tsuruoka S, Schwartz GJ, Kurtz I. Apical H(+)/base transporters mediating bicarbonate absorption and pH(i) regulation in the OMCD. Am J Physiol Renal Physiol. 2002 Nov; 283(5):F1098-104.
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• Tsuruoka S, Ishibashi K, Yamamoto H, Wakaumi M, Suzuki M, Schwartz GJ, Imai M, Fujimura A. Functional analysis of ABCA8, a new drug transporter. Biochem Biophys Res Commun. 2002 Oct 18; 298(1):41-5.
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• Schwartz GJ, Kittelberger AM, Watkins RH, O'Reilly MA. Carbonic anhydrase XII mRNA encodes a hydratase that is differentially expressed along the rabbit nephron. Am J Physiol Renal Physiol. 2003 Feb; 284(2):F399-410.
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• Lugarini F, Hrupka BJ, Schwartz GJ, Plata-Salaman CR, Langhans W. A role for cyclooxygenase-2 in lipopolysaccharide-induced anorexia in rats. Am J Physiol Regul Integr Comp Physiol. 2002 Oct; 283(4):R862-8.
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• Schwartz GJ. Physiology and molecular biology of renal carbonic anhydrase. J Nephrol. 2002 Mar-Apr; 15 Suppl 5:S61-74.
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• Schwartz GJ, Tsuruoka S, Vijayakumar S, Petrovic S, Mian A, Al-Awqati Q. Acid incubation reverses the polarity of intercalated cell transporters, an effect mediated by hensin. J Clin Invest. 2002 Jan; 109(1):89-99.
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• Aja S, Sahandy S, Ladenheim EE, Schwartz GJ, Moran TH. Intracerebroventricular CART peptide reduces food intake and alters motor behavior at a hindbrain site. Am J Physiol Regul Integr Comp Physiol. 2001 Dec; 281(6):R1862-7.
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• Bi S, Ladenheim EE, Schwartz GJ, Moran TH. A role for NPY overexpression in the dorsomedial hypothalamus in hyperphagia and obesity of OLETF rats. Am J Physiol Regul Integr Comp Physiol. 2001 Jul; 281(1):R254-60.
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• Simpson AM, Schwartz GJ. Distal renal tubular acidosis with severe hypokalaemia, probably caused by colonic H(+)-K(+)-ATPase deficiency. Arch Dis Child. 2001 Jun; 84(6):504-7.
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• Aja S, Schwartz GJ, Kuhar MJ, Moran TH. Intracerebroventricular CART peptide reduces rat ingestive behavior and alters licking microstructure. Am J Physiol Regul Integr Comp Physiol. 2001 Jun; 280(6):R1613-9.
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• Emond M, Schwartz GJ, Moran TH. Meal-related stimuli differentially induce c-Fos activation in the nucleus of the solitary tract. Am J Physiol Regul Integr Comp Physiol. 2001 May; 280(5):R1315-21.
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• Winkler CA, Kittelberger AM, Watkins RH, Maniscalco WM, Schwartz GJ. Maturation of carbonic anhydrase IV expression in rabbit kidney. Am J Physiol Renal Physiol. 2001 May; 280(5):F895-903.
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• Schwartz GJ. Plasticity of intercalated cell polarity: effect of metabolic acidosis. Nephron. 2001 Apr; 87(4):304-13.
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• Tsuruoka S, Swenson ER, Petrovic S, Fujimura A, Schwartz GJ. Role of basolateral carbonic anhydrase in proximal tubular fluid and bicarbonate absorption. Am J Physiol Renal Physiol. 2001 Jan; 280(1):F146-54.
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• Schwartz GJ, Kittelberger AM, Barnhart DA, Vijayakumar S. Carbonic anhydrase IV is expressed in H(+)-secreting cells of rabbit kidney. Am J Physiol Renal Physiol. 2000 Jun; 278(6):F894-904.
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• Schwartz GJ, Kittelberger AM, Segel GB. Cloning of rabbit Cct6 and the distribution of the Cct complex in mammalian tissues. Exp Nephrol. 2000 May-Jun; 8(3):152-60.
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• Pushkin A, Yip KP, Clark I, Abuladze N, Kwon TH, Tsuruoka S, Schwartz GJ, Nielsen S, Kurtz I. NBC3 expression in rabbit collecting duct: colocalization with vacuolar H+-ATPase. Am J Physiol. 1999 Dec; 277(6 Pt 2):F974-81.
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• Tsuruoka S, Schwartz GJ. Mechanisms of HCO(-)(3) secretion in the rabbit connecting segment. Am J Physiol. 1999 Oct; 277(4 Pt 2):F567-74.
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• Schwartz GJ, Olson J, Kittelberger AM, Matsumoto T, Waheed A, Sly WS. Postnatal development of carbonic anhydrase IV expression in rabbit kidney. Am J Physiol. 1999 Apr; 276(4 Pt 2):F510-20.
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• Tsuruoka S, Schwartz GJ. Adaptation of the outer medullary collecting duct to metabolic acidosis in vitro. Am J Physiol. 1998 Dec; 275(6 Pt 2):F982-90.
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• Gregory MJ, Schwartz GJ. Diagnosis and treatment of renal tubular disorders. Semin Nephrol. 1998 May; 18(3):317-29.
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• Tsuruoka S, Kittelberger AM, Schwartz GJ. Carbonic anhydrase II and IV mRNA in rabbit nephron segments: stimulation during metabolic acidosis. Am J Physiol. 1998 Feb; 274(2 Pt 2):F259-67.
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• Mathis C, Moran TH, Schwartz GJ. Load-sensitive rat gastric vagal afferents encode volume but not gastric nutrients. Am J Physiol. 1998 Feb; 274(2 Pt 2):R280-6.
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• Tsuruoka S, Schwartz GJ. HCO3- absorption in rabbit outer medullary collecting duct: role of luminal carbonic anhydrase. Am J Physiol. 1998 Jan; 274(1 Pt 2):F139-47.
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• Miller SG, Schwartz GJ. Hyperammonaemia with distal renal tubular acidosis. Arch Dis Child. 1997 Nov; 77(5):441-4.
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• Tsuruoka S, Bushinsky DA, Schwartz GJ. Defective renal calcium reabsorption in genetic hypercalciuric rats. Kidney Int. 1997 May; 51(5):1540-7.
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• Winkler CA, Kittelberger AM, Schwartz GJ. Expression of carbonic anhydrase IV mRNA in rabbit kidney: stimulation by metabolic acidosis. Am J Physiol. 1997 Apr; 272(4 Pt 2):F551-60.
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• Tsuruoka S, Schwartz GJ. Metabolic acidosis stimulates H+ secretion in the rabbit outer medullary collecting duct (inner stripe) of the kidney. J Clin Invest. 1997 Mar 15; 99(6):1420-31.
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• Tsuruoka S, Schwartz GJ. Adaptation of rabbit cortical collecting duct HCO3- transport to metabolic acidosis in vitro. J Clin Invest. 1996 Feb 15; 97(4):1076-84.
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• Matsumoto T, Fejes-Toth G, Schwartz GJ. Postnatal differentiation of rabbit collecting duct intercalated cells. Pediatr Res. 1996 Jan; 39(1):1-12.
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• Satlin LM, Yasoshima K, Schwartz GJ. H+ secretion in rabbit mesonephric collecting tubule. Am J Physiol. 1994 Dec; 267(6 Pt 2):F979-86.
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• Matsumoto T, Winkler CA, Brion LP, Schwartz GJ. Expression of acid-base-related proteins in mesonephric kidney of the rabbit. Am J Physiol. 1994 Dec; 267(6 Pt 2):F987-97.
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• Fejes-Tóth G, Náray-Fejes-Tóth A, Satlin LM, Mehrgut FM, Schwartz GJ. Inhibition of bicarbonate transport in peanut lectin-positive intercalated cells by a monoclonal antibody. Am J Physiol. 1994 Jun; 266(6 Pt 2):F901-10.
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• Schwartz GJ, Brown D, Mankus R, Alexander EA, Schwartz JH. Low pH enhances expression of carbonic anhydrase II by cultured rat inner medullary collecting duct cells. Am J Physiol. 1994 Feb; 266(2 Pt 1):C508-14.
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• Brion LP, Zavilowitz BJ, Suarez C, Schwartz GJ. Metabolic acidosis stimulates carbonic anhydrase activity in rabbit proximal tubule and medullary collecting duct. Am J Physiol. 1994 Feb; 266(2 Pt 2):F185-95.
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• Matsumoto T, Fejes-Toth G, Schweartz GJ. Developmental expression of acid-base-related proteins in the rabbit kidney. Pediatr Nephrol. 1993 Dec; 7(6):792-7.
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• Schwartz GJ, Winkler CA, Zavilowitz BJ, Bargiello T. Carbonic anhydrase II mRNA is induced in rabbit kidney cortex during chronic metabolic acidosis. Am J Physiol. 1993 Dec; 265(6 Pt 2):F764-72.
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• Schwartz GJ. Does kL/PCr estimate GFR, or does GFR determine k? Pediatr Nephrol. 1992 Nov; 6(6):512-5.
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• Schwartz GJ, Zavilowitz BJ, Radice AD, Garcia-Perez A, Sands JM. Maturation of aldose reductase expression in the neonatal rat inner medulla. J Clin Invest. 1992 Oct; 90(4):1275-83.
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• Yasoshima K, Satlin LM, Schwartz GJ. Adaptation of rabbit cortical collecting duct to in vitro acid incubation. Am J Physiol. 1992 Oct; 263(4 Pt 2):F749-56.
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• Matsumoto T, Schwartz GJ. Novel method for performing carbonic anhydrase histochemistry and immunocytochemistry on cryosections. J Histochem Cytochem. 1992 Aug; 40(8):1223-7.
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• Satlin LM, Matsumoto T, Schwartz GJ. Postnatal maturation of rabbit renal collecting duct. III. Peanut lectin-binding intercalated cells. Am J Physiol. 1992 Feb; 262(2 Pt 2):F199-208.
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• Brion LP, Fleischman AR, Schwartz GJ. Gentamicin interval in newborn infants as determined by renal function and postconceptional age. Pediatr Nephrol. 1991 Nov; 5(6):675-9.
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• Brion LP, Zavilowitz BJ, Rosen O, Schwartz GJ. Changes in soluble carbonic anhydrase activity in response to maturation and NH4Cl loading in the rabbit. Am J Physiol. 1991 Nov; 261(5 Pt 2):R1204-13.
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• Evan AP, Satlin LM, Gattone VH, Connors B, Schwartz GJ. Postnatal maturation of rabbit renal collecting duct. II. Morphological observations. Am J Physiol. 1991 Jul; 261(1 Pt 2):F91-107.
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• Schwartz GJ, Brion LP, Corey HE, Dorfman HD. Case report 668. Carbonic anhydrase II deficiency syndrome (osteopetrosis associated with renal tubular acidosis and cerebral calcification). Skeletal Radiol. 1991; 20(6):447-52.
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• Mehrgut FM, Satlin LM, Schwartz GJ. Maturation of HCO3- transport in rabbit collecting duct. Am J Physiol. 1990 Nov; 259(5 Pt 2):F801-8.
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• Brion LP, Schwartz JH, Zavilowitz BJ, Schwartz GJ. Differentiation of proton-pumping activity in cultured renal inner medullary collecting duct cells. Pediatr Nephrol. 1990 Jul; 4(4):408-14.
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• Brion LP, Satlin LM, Schwartz GJ. Video fluorescence microscopy as a tool for the study of cellular heterogeneity in epithelia. Biotechniques. 1990 Mar; 8(3):282-9.
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• Schwartz GJ, al-Awqati Q. Identification and study of specific cell types in isolated nephron segments using fluorescent dyes. Methods Enzymol. 1990; 191:253-65.
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• Brion LP, Schwartz JH, Lachman HM, Zavilowitz BJ, Schwartz GJ. Development of H+ secretion by cultured renal inner medullary collecting duct cells. Am J Physiol. 1989 Sep; 257(3 Pt 2):F486-501.
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• Satlin LM, Schwartz GJ. Cellular remodeling of HCO3(-)-secreting cells in rabbit renal collecting duct in response to an acidic environment. J Cell Biol. 1989 Sep; 109(3):1279-88.
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• Schwartz GJ, Satlin LM. Fluorescent characterization of intercalated cells in the rabbit renal cortical collecting duct. Semin Nephrol. 1989 Mar; 9(1):79-82.
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• Brion LP, Schwartz GJ, Campbell D, Fleischman AR. Early hyperkalaemia in very low birthweight infants in the absence of oliguria. Arch Dis Child. 1989 Feb; 64(2):270-2.
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• Brion LP, Boeck MA, Gauthier B, Nussbaum MP, Schwartz GJ. Estimation of glomerular filtration rate in anorectic adolescents. Pediatr Nephrol. 1989 Jan; 3(1):16-21.
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• Brion LP, Schwartz JH, Zavilowitz BJ, Schwartz GJ. Micro-method for the measurement of carbonic anhydrase activity in cellular homogenates. Anal Biochem. 1988 Nov 15; 175(1):289-97.
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• Schwartz GJ, Satlin LM, Bergmann JE. Fluorescent characterization of collecting duct cells: a second H+-secreting type. Am J Physiol. 1988 Nov; 255(5 Pt 2):F1003-14.
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• Satlin LM, Evan AP, Gattone VH, Schwartz GJ. Postnatal maturation of the rabbit cortical collecting duct. Pediatr Nephrol. 1988 Jan; 2(1):135-45.
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• Satlin LM, Schwartz GJ. Postnatal maturation of rabbit renal collecting duct: intercalated cell function. Am J Physiol. 1987 Oct; 253(4 Pt 2):F622-35.
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• Schwartz GJ, Brion LP, Spitzer A. The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents. Pediatr Clin North Am. 1987 Jun; 34(3):571-90.
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• Clermont MJ, Brion LP, Schwartz GJ. Reliability of plasma creatinine measurement in infants and children. Clin Pediatr (Phila). 1986 Nov; 25(11):569-72.
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• Brion LP, Fleischman AR, McCarton C, Schwartz GJ. A simple estimate of glomerular filtration rate in low birth weight infants during the first year of life: noninvasive assessment of body composition and growth. J Pediatr. 1986 Oct; 109(4):698-707.
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• Schwartz GJ, Al-Awqati Q. Regulation of transepithelial H+ transport by exocytosis and endocytosis. Annu Rev Physiol. 1986; 48:153-61.
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• Brion L, Fleischman AR, Schwartz GJ. Evaluation of four length-weight formulas for estimating body surface area in newborn infants. J Pediatr. 1985 Nov; 107(5):801-3.
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• Schwartz GJ, Barasch J, Al-Awqati Q. Plasticity of functional epithelial polarity. Nature. 1985 Nov 28-Dec 4; 318(6044):368-71.
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• Goldsmith DI, Martinez AB, Schwartz GJ. Identification of osmotically active solutes in urine. Crit Care Med. 1985 Jun; 13(6):468-71.
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• Schwartz GJ, Al-Awqati Q. Carbon dioxide causes exocytosis of vesicles containing H+ pumps in isolated perfused proximal and collecting tubules. J Clin Invest. 1985 May; 75(5):1638-44.
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• Schwartz GJ, Gauthier B. A simple estimate of glomerular filtration rate in adolescent boys. J Pediatr. 1985 Mar; 106(3):522-6.
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• Schlondorff D, Satriano JA, Schwartz GJ. Synthesis of prostaglandin E2 in different segments of isolated collecting tubules from adult and neonatal rabbits. Am J Physiol. 1985 Jan; 248(1 Pt 2):F134-44.
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• Schwartz GJ, Evan AP. Development of solute transport in rabbit proximal tubule. III. Na-K-ATPase activity. Am J Physiol. 1984 Jun; 246(6 Pt 2):F845-52.
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• Schwartz GJ, Feld LG, Langford DJ. A simple estimate of glomerular filtration rate in full-term infants during the first year of life. J Pediatr. 1984 Jun; 104(6):849-54.
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• Feld LG, Langford DJ, Schwartz GJ. The effect of neonatal hyperbilirubinemia on the measurement of plasma creatinine. Clin Pediatr (Phila). 1984 Mar; 23(3):154-6.
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• Schwartz GJ. Absence of Cl- -OH- or Cl- -HCO3- exchange in the rabbit renal proximal tubule. Am J Physiol. 1983 Oct; 245(4):F462-9.
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• Schwartz GJ, Evan AP. Development of solute transport in rabbit proximal tubule. I. HCO-3 and glucose absorption. Am J Physiol. 1983 Sep; 245(3):F382-90.
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• Evan AP, Gattone VH, Schwartz GJ. Development of solute transport in rabbit proximal tubule. II. Morphologic segmentation. Am J Physiol. 1983 Sep; 245(3):F391-407.
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• Schwartz GJ, Lin JT, Kinne R. A kinetic assay for Na-K-ATPase activity in isolated renal proximal tubules. Anal Biochem. 1983 Feb 15; 129(1):210-5.
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• Schlondorff D, Satriano JA, Schwartz GJ. Effect of antidiuretic hormone on prostaglandin E2 synthesis by isolated cortical and medullary collecting tubules. Adv Prostaglandin Thromboxane Leukot Res. 1983; 11:525-7.
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• Schwartz GJ. Na+-dependent H+ efflux from proximal tubule: evidence for reversible Na+-H+ exchange. Am J Physiol. 1981 Oct; 241(4):F380-5.
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• Schwartz GJ, Weinstein AM, Steele RE, Stephenson JL, Burg MB. Carbon dioxide permeability of rabbit proximal convoluted tubules. Am J Physiol. 1981 Mar; 240(3):F231-44.
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• Schwartz GJ, Haycock GB, Edelmann CM, Spitzer A. Late metabolic acidosis: a reassessment of the definition. J Pediatr. 1979 Jul; 95(1):102-7.
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• Schwartz GJ, Burg MB. Mineralocorticoid effects on cation transport by cortical collecting tubules in vitro. Am J Physiol. 1978 Dec; 235(6):F576-85.
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• Haycock GB, Schwartz GJ, Wisotsky DH. Geometric method for measuring body surface area: a height-weight formula validated in infants, children, and adults. J Pediatr. 1978 Jul; 93(1):62-6.
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• Schwartz GJ, Goldsmith DI, Fine LG. p-aminohippurate transport in the proximal straight tubule: development and substrate stimulation. Pediatr Res. 1978 Jul; 12(7):793-6.
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• Schwartz GJ, Hegyi T, Spitzer A. Subtherapeutic dicloxacillin levels in a neonate: possible mechanisms. J Pediatr. 1976 Aug; 89(2):310-2.
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• Schwartz GJ, Haycock GB, Edelmann CM, Spitzer A. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics. 1976 Aug; 58(2):259-63.
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• Laird WP, Friedman S, Koop CE, Schwartz GJ. Hepatic hemangiomatosis. Successful management by hepatic artery ligation. Am J Dis Child. 1976 Jun; 130(6):657-9.
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• Schwartz GJ, Haycock GB, Spitzer A. Plasma creatinine and urea concentration in children: normal values for age and sex. J Pediatr. 1976 May; 88(5):828-30.
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• Schwartz GJ, Cornfeld D. Bartter's syndrome: clinical study of its treatment with salt loading and propranolol. Clin Nephrol. 1975 Aug; 4(2):45-51.
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• Schwartz MW, Schwartz GJ, Cornfeld D. A 16-year follow-up study of 163 children with nephrotic syndrome. Pediatrics. 1974 Nov; 54(5):547-52.
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• Schwartz GJ, Cornfeld D. Letter: Propranolol in Bartter's syndrome. N Engl J Med. 1974 Apr 25; 290(17):966.
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