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Jacqueline Williams

TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentEnvironmental Medicine
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box EHSC
Rochester NY 14642
Other Positions
TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentRadiation Oncology

 
 Awards And Honors
1999     Casarett Award for Excellence in Translational Research  | Department of Radiation Oncology, University of Rochester
2004     Rubin-Mitchell Teaching Award  | Department of Radiation Oncology, University of Rochester
2009     Casarett Award for Excellence in Translational Research  | Department of Radiation Oncology
2010     Educator of the Year  | Association of Residents in Radiation Oncology (ARRO)
2011     Fellow  | American Society for Therapeutic Radiology and Oncology
 
 Selected Publications
List All   |   Timeline
  1. Cherry JD, Williams JP, O'Banion MK, Olschowka JA. Thermal injury lowers the threshold for radiation-induced neuroinflammation and cognitive dysfunction. Radiat Res. 2013 Oct; 180(4):398-406.
    View in: PubMed
  2. Ryan JL, Heckler CE, Ling M, Katz A, Williams JP, Pentland AP, Morrow GR. Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients. Radiat Res. 2013 Jul; 180(1):34-43.
    View in: PubMed
  3. Manning CM, Johnston CJ, Hernady E, Miller JN, Reed CK, Lawrence BP, Williams JP, Finkelstein JN. Exacerbation of lung radiation injury by viral infection: the role of clara cells and clara cell secretory protein. Radiat Res. 2013 Jun; 179(6):617-29.
    View in: PubMed
  4. Cherry JD, Liu B, Frost JL, Lemere CA, Williams JP, Olschowka JA, O'Banion MK. Galactic cosmic radiation leads to cognitive impairment and increased aß plaque accumulation in a mouse model of Alzheimer's disease. PLoS One. 2012; 7(12):e53275.
    View in: PubMed
  5. Manning CM, Johnston CJ, Reed CK, Lawrence BP, Williams JP, Finkelstein JN. Lung irradiation increases mortality after influenza a virus challenge occurring late after exposure. Int J Radiat Oncol Biol Phys. 2013 May 1; 86(1):128-35.
    View in: PubMed
  6. Johnson MD, O'Connell M, Iqbal MA, Williams JP. Radiation effects on human leptomeningeal cell response to cerebrospinal fluid and PDGF-BB. Int J Radiat Biol. 2012 Jul; 88(7):547-55.
    View in: PubMed
  7. DiCarlo AL, Jackson IL, Shah JR, Czarniecki CW, Maidment BW, Williams JP. Development and licensure of medical countermeasures to treat lung damage resulting from a radiological or nuclear incident. Radiat Res. 2012 May; 177(5):717-21.
    View in: PubMed
  8. Williams JP, Jackson IL, Shah JR, Czarniecki CW, Maidment BW, DiCarlo AL. Animal models and medical countermeasures development for radiation-induced lung damage: report from an NIAID Workshop. Radiat Res. 2012 May; 177(5):e0025-39.
    View in: PubMed
  9. Johnston CJ, Manning CM, Rangel-Moreno J, Randall TD, Hernady E, Finkelstein JN, Williams JP. Neonatal irradiation sensitizes mice to delayed pulmonary challenge. Radiat Res. 2013 Apr; 179(4):475-84.
    View in: PubMed
  10. Williams JP, Huser AK, Brenner DJ. Introduction. Int J Radiat Biol. 2011 Aug; 87(8):747.
    View in: PubMed
  11. Moravan MJ, Olschowka JA, Williams JP, O'Banion MK. Cranial irradiation leads to acute and persistent neuroinflammation with delayed increases in T-cell infiltration and CD11c expression in C57BL/6 mouse brain. Radiat Res. 2011 Oct; 176(4):459-73.
    View in: PubMed
  12. Katzel EB, Koltz PF, Tierney R, Williams JP, Awad HA, O'keefe RJ, Langstein HN. The impact of Smad3 loss of function on TGF-ß signaling and radiation-induced capsular contracture. Plast Reconstr Surg. 2011 Jun; 127(6):2263-9.
    View in: PubMed
  13. Johnston CJ, Manning C, Hernady E, Reed C, Thurston SW, Finkelstein JN, Williams JP. Effect of total body irradiation on late lung effects: hidden dangers. Int J Radiat Biol. 2011 Aug; 87(8):902-13.
    View in: PubMed
  14. Janelsins MC, Mustian KM, Palesh OG, Mohile SG, Peppone LJ, Sprod LK, Heckler CE, Roscoe JA, Katz AW, Williams JP, Morrow GR. Differential expression of cytokines in breast cancer patients receiving different chemotherapies: implications for cognitive impairment research. Support Care Cancer. 2012 Apr; 20(4):831-9.
    View in: PubMed
  15. Janelsins MC, Davis PG, Wideman L, Katula JA, Sprod LK, Peppone LJ, Palesh OG, Heckler CE, Williams JP, Morrow GR, Mustian KM. Effects of Tai Chi Chuan on insulin and cytokine levels in a randomized controlled pilot study on breast cancer survivors. Clin Breast Cancer. 2011 Jun; 11(3):161-70.
    View in: PubMed
  16. Williams JP, McBride WH. After the bomb drops: a new look at radiation-induced multiple organ dysfunction syndrome (MODS). Int J Radiat Biol. 2011 Aug; 87(8):851-68.
    View in: PubMed
  17. Peslak SA, Wenger J, Bemis JC, Kingsley PD, Frame JM, Koniski AD, Chen Y, Williams JP, McGrath KE, Dertinger SD, Palis J. Sublethal radiation injury uncovers a functional transition during erythroid maturation. Exp Hematol. 2011 Apr; 39(4):434-45.
    View in: PubMed
  18. Williams JP. Assessment of radiation-induced lung disease. Clin Adv Hematol Oncol. 2011 Feb; 9(2):160-2.
    View in: PubMed
  19. Marples B, Downing L, Sawarynski KE, Finkelstein JN, Williams JP, Martinez AA, Wilson GD, Sims MD. Pulmonary injury after combined exposures to low-dose low-LET radiation and fungal spores. Radiat Res. 2011 Apr; 175(4):501-9.
    View in: PubMed
  20. Williams JP, Johnston CJ, Finkelstein JN. Treatment for radiation-induced pulmonary late effects: spoiled for choice or looking in the wrong direction? Curr Drug Targets. 2010 Nov; 11(11):1386-94.
    View in: PubMed
  21. Katzel EB, Koltz PF, Tierney R, Williams JP, Awad HA, O'Keefe RJ, Langstein HN. A novel animal model for studying silicone gel-related capsular contracture. Plast Reconstr Surg. 2010 Nov; 126(5):1483-91.
    View in: PubMed
  22. Travis LB, Beard C, Allan JM, Dahl AA, Feldman DR, Oldenburg J, Daugaard G, Kelly JL, Dolan ME, Hannigan R, Constine LS, Oeffinger KC, Okunieff P, Armstrong G, Wiljer D, Miller RC, Gietema JA, van Leeuwen FE, Williams JP, Nichols CR, Einhorn LH, Fossa SD. Testicular cancer survivorship: research strategies and recommendations. J Natl Cancer Inst. 2010 Aug 4; 102(15):1114-30.
    View in: PubMed
  23. Demaria S, Williams JP. Introduction to the special BR-RIDGE issue. Radiat Res. 2010 Apr; 173(4):403-5.
    View in: PubMed
  24. Johnston CJ, Hernady E, Reed C, Thurston SW, Finkelstein JN, Williams JP. Early alterations in cytokine expression in adult compared to developing lung in mice after radiation exposure. Radiat Res. 2010 Apr; 173(4):522-35.
    View in: PubMed
  25. Williams JP, Brown SL, Georges GE, Hauer-Jensen M, Hill RP, Huser AK, Kirsch DG, Macvittie TJ, Mason KA, Medhora MM, Moulder JE, Okunieff P, Otterson MF, Robbins ME, Smathers JB, McBride WH. Animal models for medical countermeasures to radiation exposure. Radiat Res. 2010 Apr; 173(4):557-78.
    View in: PubMed
  26. Bentzen SM, Parliament M, Deasy JO, Dicker A, Curran WJ, Williams JP, Rosenstein BS. Biomarkers and surrogate endpoints for normal-tissue effects of radiation therapy: the importance of dose-volume effects. Int J Radiat Oncol Biol Phys. 2010 Mar 1; 76(3 Suppl):S145-50.
    View in: PubMed
  27. Rubin P, Williams JP, Devesa SS, Travis LB, Constine LS. Cancer genesis across the age spectrum: associations with tissue development, maintenance, and senescence. Semin Radiat Oncol. 2010 Jan; 20(1):3-11.
    View in: PubMed
  28. Paulino AC, Constine LS, Rubin P, Williams JP. Normal tissue development, homeostasis, senescence, and the sensitivity to radiation injury across the age spectrum. Semin Radiat Oncol. 2010 Jan; 20(1):12-20.
    View in: PubMed
  29. Rosenstein BS, Held KD, Rockwell S, Williams JP, Zeman EM. American Society for Radiation Oncology (ASTRO) survey of radiation biology educators in U.S. and Canadian radiation oncology residency programs. Int J Radiat Oncol Biol Phys. 2009 Nov 1; 75(3):896-905.
    View in: PubMed
  30. Veenema TG, Walden B, Feinstein N, Williams JP. Factors affecting hospital-based nurses' willingness to respond to a radiation emergency. Disaster Med Public Health Prep. 2008 Dec; 2(4):224-9.
    View in: PubMed
  31. Okunieff P, Swarts S, Keng P, Sun W, Wang W, Kim J, Yang S, Zhang H, Liu C, Williams JP, Huser AK, Zhang L. Antioxidants reduce consequences of radiation exposure. Adv Exp Med Biol. 2008; 614:165-78.
    View in: PubMed
  32. Lakatos HF, Burgess HA, Thatcher TH, Redonnet MR, Hernady E, Williams JP, Sime PJ. Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation. Exp Lung Res. 2006 May; 32(5):181-99.
    View in: PubMed
  33. Okunieff P, Cornelison T, Mester M, Liu W, Ding I, Chen Y, Zhang H, Williams JP, Finkelstein J. Mechanism and modification of gastrointestinal soft tissue response to radiation: role of growth factors. Int J Radiat Oncol Biol Phys. 2005 May 1; 62(1):273-8.
    View in: PubMed
  34. Chen Y, Hyrien O, Williams J, Okunieff P, Smudzin T, Rubin P. Interleukin (IL)-1A and IL-6: applications to the predictive diagnostic testing of radiation pneumonitis. Int J Radiat Oncol Biol Phys. 2005 May 1; 62(1):260-6.
    View in: PubMed
  35. Moore AH, Olschowka JA, Williams JP, Okunieff P, O'Banion MK. Regulation of prostaglandin E2 synthesis after brain irradiation. Int J Radiat Oncol Biol Phys. 2005 May 1; 62(1):267-72.
    View in: PubMed
  36. Johnston CJ, Williams JP, Elder A, Hernady E, Finkelstein JN. Inflammatory cell recruitment following thoracic irradiation. Exp Lung Res. 2004 Jul-Aug; 30(5):369-82.
    View in: PubMed
  37. Williams JP, Hernady E, Johnston CJ, Reed CM, Fenton B, Okunieff P, Finkelstein JN. Effect of administration of lovastatin on the development of late pulmonary effects after whole-lung irradiation in a murine model. Radiat Res. 2004 May; 161(5):560-7.
    View in: PubMed
  38. Moore AH, Olschowka JA, Williams JP, Paige SL, O'Banion MK. Radiation-induced edema is dependent on cyclooxygenase 2 activity in mouse brain. Radiat Res. 2004 Feb; 161(2):153-60.
    View in: PubMed
  39. Singh D, Yi WS, Brasacchio RA, Muhs AG, Smudzin T, Williams JP, Messing E, Okunieff P. Is there a favorable subset of patients with prostate cancer who develop oligometastases? Int J Radiat Oncol Biol Phys. 2004 Jan 1; 58(1):3-10.
    View in: PubMed
  40. Liang L, Hu D, Liu W, Williams JP, Okunieff P, Ding I. Celecoxib reduces skin damage after radiation: selective reduction of chemokine and receptor mRNA expression in irradiated skin but not in irradiated mammary tumor. Am J Clin Oncol. 2003 Aug; 26(4):S114-21.
    View in: PubMed
  41. Bentzen SM, Dörr W, Anscher MS, Denham JW, Hauer-Jensen M, Marks LB, Williams J. Normal tissue effects: reporting and analysis. Semin Radiat Oncol. 2003 Jul; 13(3):189-202.
    View in: PubMed
  42. Williams J, Chen Y, Rubin P, Finkelstein J, Okunieff P. The biological basis of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol. 2003 Jul; 13(3):182-8.
    View in: PubMed
  43. Ferland RJ, Williams JP, Gross RA, Applegate CD. The effects of brain-irradiation-induced decreases in hippocampal mitotic activity on flurothyl-induced epileptogenesis in adult C57BL/6J mice. Exp Neurol. 2003 Jan; 179(1):71-82.
    View in: PubMed
  44. Soni AB, Illig KA, Sternbach Y, Anthony P, Jacob P, Reddy G, Storey J, Gerety R, Williams JP, Schell M, Waldman D, Rubin P, Green R, Okunieff P. Benefits of external beam irradiation for peripheral arterial bypass: preliminary report on a phase I study. Int J Radiat Oncol Biol Phys. 2002 Nov 15; 54(4):1174-9.
    View in: PubMed
  45. Staversky RJ, Watkins RH, Wright TW, Hernady E, LoMonaco MB, D'Angio CT, Williams JP, Maniscalco WM, O'Reilly MA. Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1). Am J Pathol. 2002 Oct; 161(4):1383-93.
    View in: PubMed
  46. Kyrkanides S, Moore AH, Olschowka JA, Daeschner JC, Williams JP, Hansen JT, Kerry O'Banion M. Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury. Brain Res Mol Brain Res. 2002 Aug 15; 104(2):159-69.
    View in: PubMed
  47. Johnston CJ, Williams JP, Okunieff P, Finkelstein JN. Radiation-induced pulmonary fibrosis: examination of chemokine and chemokine receptor families. Radiat Res. 2002 Mar; 157(3):256-65.
    View in: PubMed
  48. Chen Y, Williams J, Ding I, Hernady E, Liu W, Smudzin T, Finkelstein JN, Rubin P, Okunieff P. Radiation pneumonitis and early circulatory cytokine markers. Semin Radiat Oncol. 2002 Jan; 12(1 Suppl 1):26-33.
    View in: PubMed
  49. Illig KA, Williams JP, Lyden SP, Hernady E, Soni A, Davies MG, Schell M, Okunieff P, Rubin P, Green RM. External beam irradiation for inhibition of intimal hyperplasia following prosthetic bypass: preliminary results. Ann Vasc Surg. 2001 Sep; 15(5):533-8.
    View in: PubMed
  50. Chen Y, Rubin P, Williams J, Hernady E, Smudzin T, Okunieff P. Circulating IL-6 as a predictor of radiation pneumonitis. Int J Radiat Oncol Biol Phys. 2001 Mar 1; 49(3):641-8.
    View in: PubMed
  51. Illig KA, Soni AB, Williams J, Shortell CK, Okunieff P, Schell M, Rubin P, Green RM. Irradiation for intimal hyperplasia: implications for peripheral arterial bypass. J Am Coll Surg. 2000 Mar; 190(3):364-70.
    View in: PubMed
  52. Williams JP, Eagleton M, Hernady E, Schell M, Illig K, Green R, Rubin P. Effectiveness of fractionated external beam radiation in the inhibition of vascular restenosis. Cardiovasc Radiat Med. 1999 Jul-Sep; 1(3):257-64.
    View in: PubMed
  53. Okunieff P, Barrett AJ, Phang SE, Li A, Constine LS, Williams JP, Rubin P, Wang X, Wu T, Chen Y, Ding I. Circulating basic fibroblast growth factor declines during Cy/TBI bone marrow transplantation. Bone Marrow Transplant. 1999 Jun; 23(11):1117-21.
    View in: PubMed
  54. Tallman MP, Williams JP, Eagleton MJ, Hernady E, Rubin P, Pomerantz RM. Tolerance of normal rabbit femoral arteries to single high dose external beam irradiation. Cardiovasc Radiat Med. 1999 Apr-Jun; 1(2):131-7.
    View in: PubMed
  55. Rubin P, Soni A, Williams JP. The molecular and cellular biologic basis for the radiation treatment of benign proliferative diseases. Semin Radiat Oncol. 1999 Apr; 9(2):203-14.
    View in: PubMed
  56. Kyrkanides S, Olschowka JA, Williams JP, Hansen JT, O'Banion MK. TNF alpha and IL-1beta mediate intercellular adhesion molecule-1 induction via microglia-astrocyte interaction in CNS radiation injury. J Neuroimmunol. 1999 Mar 1; 95(1-2):95-106.
    View in: PubMed
  57. Williams JP, Rubin P, Soni A, Hernady E, Schell M, Green R, Illig K, Pomerantz R, Okunieff P. Comparability of the external vs internal location of radiation in inhibiting neointimal hyperplasia. Cardiovasc Radiat Med. 1999 Jan-Mar; 1(1):55-63.
    View in: PubMed
  58. Rubin P, Williams JP, Schell MC, Okunieff P. Radiation inhibition of arterial restenosis -- a new frontier. Acta Oncol. 1999; 38(4):407-24.
    View in: PubMed
  59. Adawi A, Zhang Y, Baggs R, Rubin P, Williams J, Finkelstein J, Phipps RP. Blockade of CD40-CD40 ligand interactions protects against radiation-induced pulmonary inflammation and fibrosis. Clin Immunol Immunopathol. 1998 Dec; 89(3):222-30.
    View in: PubMed
  60. Rubin P, Williams JP, Riggs PN, Bartos S, Sarac T, Pomerantz R, Castano J, Schell M, Green RM. Cellular and molecular mechanisms of radiation inhibition of restenosis. Part I: role of the macrophage and platelet-derived growth factor. Int J Radiat Oncol Biol Phys. 1998 Mar 1; 40(4):929-41.
    View in: PubMed
  61. Okunieff P, Wang X, Li M, Sabet H, Huang K, Grieg JR, Williams J, Rubin P, Ding I. Chronic radiation bone toxicity is associated with decreased perfusion without elevation of circulating or soft tissue TGF beta or TNF alpha. Adv Exp Med Biol. 1998; 454:325-33.
    View in: PubMed
  62. Olschowka JA, Kyrkanides S, Harvey BK, O'Banion MK, Williams JP, Rubin P, Hansen JT. ICAM-1 induction in the mouse CNS following irradiation. Brain Behav Immun. 1997 Dec; 11(4):273-85.
    View in: PubMed
  63. Johnston CJ, Piedboeuf B, Rubin P, Williams JP, Baggs R, Finkelstein JN. Early and persistent alterations in the expression of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor alpha mRNA levels in fibrosis-resistant and sensitive mice after thoracic irradiation. Radiat Res. 1996 Jun; 145(6):762-7.
    View in: PubMed
  64. Rubin P, Johnston CJ, Williams JP, McDonald S, Finkelstein JN. A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis. Int J Radiat Oncol Biol Phys. 1995 Aug 30; 33(1):99-109.
    View in: PubMed
  65. Sarac TP, Riggs PN, Williams JP, Feins RH, Baggs R, Rubin P, Green RM. The effects of low-dose radiation on neointimal hyperplasia. J Vasc Surg. 1995 Jul; 22(1):17-24.
    View in: PubMed
  66. Rubin P, Gash DM, Hansen JT, Nelson DF, Williams JP. Disruption of the blood-brain barrier as the primary effect of CNS irradiation. Radiother Oncol. 1994 Apr; 31(1):51-60.
    View in: PubMed
  67. Coggle JE, Williams JP. Experimental studies of radiation carcinogenesis in the skin: a review. Int J Radiat Biol. 1990 Apr; 57(4):797-808.
    View in: PubMed
  68. Charles MW, Williams JP, Coggle JE. Skin carcinogenesis following uniform and nonuniform beta irradiation. Health Phys. 1988 Aug; 55(2):399-406.
    View in: PubMed
  69. Hopewell JW, Coggle JE, Wells J, Hamlet R, Williams JP, Charles MW. The acute effects of different energy beta-emitters on pig and mouse skin. Br J Radiol Suppl. 1986; 19:47-51.
    View in: PubMed
  70. Williams JP, Coggle JE, Charles MW, Wells J. Skin carcinogenesis in the mouse following uniform and non-uniform beta irradiation. Br J Radiol Suppl. 1986; 19:61-4.
    View in: PubMed

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