Regis O'Keefe
| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Orthopaedics |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 665
Rochester NY 14642
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| Title | Chair |
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| Institution | School of Medicine and Dentistry |
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| Department | Orthopaedics |
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| Title | Associate Dean for Clinical Affairs |
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| Institution | School of Medicine and Dentistry |
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| Department | Dean's Office, SMD |
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| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Biochemistry and Biophysics |
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| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Environmental Medicine |
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| 1988 |
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| AOA Resident Traveling Research Award, "Differential expression of transforming growth factor-ß receptors and biological effects in maturationally distinct subpopulations of growth plate chondrocytes. | | 1995 |
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| Kappa Delta Award, Orthopaedic Research & Education Foundation. | | 1997 |
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| The Dane and Mary Louise Miller Endowed Research Grant, Orthopaedic Research and Educational Foundation, | | 1998 |
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| Dean's Endowed Chair, Associate Professor of Orthopaedics, University of Rochester
School of Medicine. | | 1999 |
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| American Orthopaedic Association ABC Traveling Fellowship, | | 2000 |
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| Dean's Endowed Chair, Professor of Orthopaedics and Oncology, University of Rochester School of Medicine. | | 2003 |
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| Fifth Annual Dr. Marvin J Hoffman Award in the Area of Faculty Mentoring to Medical Students, Awarded at the Annual Hoffman Awards Ceremony, | | 2009 |
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| Best Doctors in America for Cancerous Tumor Surgery |
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Farhat YM, Al-Maliki AA, Chen T, Juneja SC, Schwarz EM, O'Keefe RJ, Awad HA. Gene Expression Analysis of the Pleiotropic Effects of TGF-ß1 in an In Vitro Model of Flexor Tendon Healing. PLoS One. 2012; 7(12):e51411.
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Wang M, Tang D, Shu B, Wang B, Jin H, Hao S, Dresser KA, Shen J, Im HJ, Sampson ER, Rubery PT, Zuscik MJ, Schwarz EM, O'Keefe RJ, Wang Y, Chen D. Conditional activation of ß-catenin signaling in mice leads to severe defects in intervertebral disc tissue. Arthritis Rheum. 2012 Aug; 64(8):2611-23.
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Dao DY, Jonason JH, Zhang Y, Hsu W, Chen D, Hilton MJ, O'Keefe RJ. Cartilage-specific ß-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development. J Bone Miner Res. 2012 Aug; 27(8):1680-94.
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Loiselle AE, Frisch BJ, Wolenski M, Jacobson JA, Calvi LM, Schwarz EM, Awad HA, O'Keefe RJ. Bone marrow-derived matrix metalloproteinase-9 is associated with fibrous adhesion formation after murine flexor tendon injury. PLoS One. 2012; 7(7):e40602.
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Kim KO, Sampson ER, Maynard RD, O'Keefe RJ, Chen D, Drissi H, Rosier RN, Hilton MJ, Zuscik MJ. Ski inhibits TGF-ß/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes. J Cell Biochem. 2012 Jun; 113(6):2156-66.
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Zuch D, Giang AH, Shapovalov Y, Schwarz E, Rosier R, O'Keefe R, Eliseev RA. Targeting radioresistant osteosarcoma cells with parthenolide. J Cell Biochem. 2012 Apr; 113(4):1282-91.
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Kohn A, Dong Y, Mirando AJ, Jesse AM, Honjo T, Zuscik MJ, O'Keefe RJ, Hilton MJ. Cartilage-specific RBPj?-dependent and -independent Notch signals regulate cartilage and bone development. Development. 2012 Mar; 139(6):1198-212.
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Kung MH, Yukata K, O'Keefe RJ, Zuscik MJ. Aryl hydrocarbon receptor-mediated impairment of chondrogenesis and fracture healing by cigarette smoke and benzo(a)pyrene. J Cell Physiol. 2012 Mar; 227(3):1062-70.
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Takahata M, Schwarz EM, Chen T, O'Keefe RJ, Awad HA. Delayed short-course treatment with teriparatide (PTH(1-34) ) improves femoral allograft healing by enhancing intramembranous bone formation at the graft-host junction. J Bone Miner Res. 2012 Jan; 27(1):26-37.
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O'Keefe RJ, Mao J. Bone tissue engineering and regeneration: from discovery to the clinic-an overview. Tissue Eng Part B Rev. 2011 Dec; 17(6):389-92.
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Shu B, Zhang M, Xie R, Wang M, Jin H, Hou W, Tang D, Harris SE, Mishina Y, O'Keefe RJ, Hilton MJ, Wang Y, Chen D. BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. J Cell Sci. 2011 Oct 15; 124(Pt 20):3428-40.
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Sampson ER, Hilton MJ, Tian Y, Chen D, Schwarz EM, Mooney RA, Bukata SV, O'Keefe RJ, Awad H, Puzas JE, Rosier RN, Zuscik MJ. Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis. Sci Transl Med. 2011 Sep 21; 3(101):101ra93.
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Hu CT, Offley SC, Yaseen Z, O'Keefe RJ, Humphrey CA. Murine model of oligotrophic tibial nonunion. J Orthop Trauma. 2011 Aug; 25(8):500-5.
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Xie C, Schwarz EM, Sampson ER, Dhillon RS, Li D, O'Keefe RJ, Tyler W. Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf-a and decreased ang-1 expression. J Orthop Res. 2012 Feb; 30(2):325-33.
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Bukata SV, Kates SL, O'Keefe RJ. Short-term and long-term orthopaedic issues in patients with fragility fractures. Clin Orthop Relat Res. 2011 Aug; 469(8):2225-36.
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Katzel EB, Koltz PF, Tierney R, Williams JP, Awad HA, O'keefe RJ, Langstein HN. The impact of Smad3 loss of function on TGF-ß signaling and radiation-induced capsular contracture. Plast Reconstr Surg. 2011 Jun; 127(6):2263-9.
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Sampson ER, Martin BA, Morris AE, Xie C, Schwarz EM, O'Keefe RJ, Rosier RN. The orally bioavailable met inhibitor PF-2341066 inhibits osteosarcoma growth and osteolysis/matrix production in a xenograft model. J Bone Miner Res. 2011 Jun; 26(6):1283-94.
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Takahata M, Awad HA, O'Keefe RJ, Bukata SV, Schwarz EM. Endogenous tissue engineering: PTH therapy for skeletal repair. Cell Tissue Res. 2012 Mar; 347(3):545-52.
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Zhang M, Ho HC, Sheu TJ, Breyer MD, Flick LM, Jonason JH, Awad HA, Schwarz EM, O'Keefe RJ. EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair. J Bone Miner Res. 2011 Apr; 26(4):792-802.
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Sampson ER, Beck CA, Ketz J, Canary KL, Hilton MJ, Awad H, Schwarz EM, Chen D, O'Keefe RJ, Rosier RN, Zuscik MJ. Establishment of an index with increased sensitivity for assessing murine arthritis. J Orthop Res. 2011 Aug; 29(8):1145-51.
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Yazici C, Takahata M, Reynolds DG, Xie C, Samulski RJ, Samulski J, Beecham EJ, Gertzman AA, Spilker M, Zhang X, O'Keefe RJ, Awad HA, Schwarz EM. Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur. Mol Ther. 2011 Aug; 19(8):1416-25.
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Yanoso-Scholl L, Jacobson JA, Bradica G, Lerner AL, O'Keefe RJ, Schwarz EM, Zuscik MJ, Awad HA. Evaluation of dense polylactic acid/beta-tricalcium phosphate scaffolds for bone tissue engineering. J Biomed Mater Res A. 2010 Dec 1; 95(3):717-26.
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Shane E, Burr D, Ebeling PR, Abrahamsen B, Adler RA, Brown TD, Cheung AM, Cosman F, Curtis JR, Dell R, Dempster D, Einhorn TA, Genant HK, Geusens P, Klaushofer K, Koval K, Lane JM, McKiernan F, McKinney R, Ng A, Nieves J, O'Keefe R, Papapoulos S, Sen HT, van der Meulen MC, Weinstein RS, Whyte M. Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res. 2010 Nov; 25(11):2267-94.
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Katzel EB, Koltz PF, Tierney R, Williams JP, Awad HA, O'Keefe RJ, Langstein HN. A novel animal model for studying silicone gel-related capsular contracture. Plast Reconstr Surg. 2010 Nov; 126(5):1483-91.
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Jacobson JA, Yanoso-Scholl L, Reynolds DG, Dadali T, Bradica G, Bukata S, Puzas EJ, Zuscik MJ, Rosier R, O'Keefe RJ, Schwarz EM, Awad HA. Teriparatide therapy and beta-tricalcium phosphate enhance scaffold reconstruction of mouse femoral defects. Tissue Eng Part A. 2011 Feb; 17(3-4):389-98.
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Sampson ER, Amin V, Schwarz EM, O'Keefe RJ, Rosier RN. The histone deacetylase inhibitor vorinostat selectively sensitizes fibrosarcoma cells to chemotherapy. J Orthop Res. 2011 Apr; 29(4):623-32.
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Reynolds DG, Takahata M, Lerner AL, O'Keefe RJ, Schwarz EM, Awad HA. Teriparatide therapy enhances devitalized femoral allograft osseointegration and biomechanics in a murine model. Bone. 2011 Mar 1; 48(3):562-70.
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Dhakal S, Chen J, McCance S, Rosier R, O'Keefe R, Constine LS. Bone density changes after radiation for extremity sarcomas: exploring the etiology of pathologic fractures. Int J Radiat Oncol Biol Phys. 2011 Jul 15; 80(4):1158-63.
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Katzel EB, Wolenski M, Loiselle AE, Basile P, Flick LM, Langstein HN, Hilton MJ, Awad HA, Hammert WC, O'Keefe RJ. Impact of Smad3 loss of function on scarring and adhesion formation during tendon healing. J Orthop Res. 2011 May; 29(5):684-93.
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Gunnell LM, Jonason JH, Loiselle AE, Kohn A, Schwarz EM, Hilton MJ, O'Keefe RJ. TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways. J Bone Miner Res. 2010 Aug; 25(8):1784-97.
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Li TF, Gao L, Sheu TJ, Sampson ER, Flick LM, Konttinen YT, Chen D, Schwarz EM, Zuscik MJ, Jonason JH, O'Keefe RJ. Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis. Arthritis Rheum. 2010 Aug; 62(8):2359-69.
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Dong Y, Jesse AM, Kohn A, Gunnell LM, Honjo T, Zuscik MJ, O'Keefe RJ, Hilton MJ. RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development. Development. 2010 May; 137(9):1461-71.
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Li D, Gromov K, Proulx ST, Xie C, Li J, Crane DP, Søballe K, O'Keefe RJ, Awad HA, Xing L, Schwarz EM. Effects of antiresorptive agents on osteomyelitis: novel insights into the pathogenesis of osteonecrosis of the jaw. Ann N Y Acad Sci. 2010 Mar; 1192:84-94.
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Wu Q, Zhu M, Rosier RN, Zuscik MJ, O'Keefe RJ, Chen D. Beta-catenin, cartilage, and osteoarthritis. Ann N Y Acad Sci. 2010 Mar; 1192:344-50.
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Dao DY, Yang X, Flick LM, Chen D, Hilton MJ, O'Keefe RJ. Axin2 regulates chondrocyte maturation and axial skeletal development. J Orthop Res. 2010 Jan; 28(1):89-95.
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Tsutsumi R, Xie C, Wei X, Zhang M, Zhang X, Flick LM, Schwarz EM, O'Keefe RJ. PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis. J Bone Miner Res. 2009 Oct; 24(10):1753-62.
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Yan Y, Tang D, Chen M, Huang J, Xie R, Jonason JH, Tan X, Hou W, Reynolds D, Hsu W, Harris SE, Puzas JE, Awad H, O'Keefe RJ, Boyce BF, Chen D. Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult mice. J Cell Sci. 2009 Oct 1; 122(Pt 19):3566-78.
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Frisch BJ, Porter RL, Gigliotti BJ, Olm-Shipman AJ, Weber JM, O'Keefe RJ, Jordan CT, Calvi LM. In vivo prostaglandin E2 treatment alters the bone marrow microenvironment and preferentially expands short-term hematopoietic stem cells. Blood. 2009 Nov 5; 114(19):4054-63.
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Crane DP, Gromov K, Li D, Søballe K, Wahnes C, Büchner H, Hilton MJ, O'Keefe RJ, Murray CK, Schwarz EM. Efficacy of colistin-impregnated beads to prevent multidrug-resistant A. baumannii implant-associated osteomyelitis. J Orthop Res. 2009 Aug; 27(8):1008-15.
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Xie C, Liang B, Xue M, Lin AS, Loiselle A, Schwarz EM, Guldberg RE, O'Keefe RJ, Zhang X. Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4. Am J Pathol. 2009 Aug; 175(2):772-85.
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Darowish M, Rahman R, Li P, Bukata SV, Gelinas J, Huang W, Flick LM, Schwarz EM, O'Keefe RJ. Reduction of particle-induced osteolysis by interleukin-6 involves anti-inflammatory effect and inhibition of early osteoclast precursor differentiation. Bone. 2009 Oct; 45(4):661-8.
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Wei X, Zhang X, Flick LM, Drissi H, Schwarz EM, O'Keefe RJ. Titanium particles stimulate COX-2 expression in synovial fibroblasts through an oxidative stress-induced, calpain-dependent, NF-kappaB pathway. Am J Physiol Cell Physiol. 2009 Aug; 297(2):C310-20.
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Loiselle AE, Bragdon GA, Jacobson JA, Hasslund S, Cortes ZE, Schwarz EM, Mitten DJ, Awad HA, O'Keefe RJ. Remodeling of murine intrasynovial tendon adhesions following injury: MMP and neotendon gene expression. J Orthop Res. 2009 Jun; 27(6):833-40.
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Taylor DK, Meganck JA, Terkhorn S, Rajani R, Naik A, O'Keefe RJ, Goldstein SA, Hankenson KD. Thrombospondin-2 influences the proportion of cartilage and bone during fracture healing. J Bone Miner Res. 2009 Jun; 24(6):1043-54.
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Clark CA, Li TF, Kim KO, Drissi H, Zuscik MJ, Zhang X, O'Keefe RJ. Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation. J Orthop Res. 2009 Jun; 27(6):785-92.
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Wu Q, Huang JH, Sampson ER, Kim KO, Zuscik MJ, O'Keefe RJ, Chen D, Rosier RN. Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage. Exp Cell Res. 2009 Aug 15; 315(14):2386-98.
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Reynolds DG, Shaikh S, Papuga MO, Lerner AL, O'Keefe RJ, Schwarz EM, Awad HA. muCT-based measurement of cortical bone graft-to-host union. J Bone Miner Res. 2009 May; 24(5):899-907.
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Guise TA, O'Keefe R, Randall RL, Terek RM. Molecular biology and therapeutics in musculoskeletal oncology. J Bone Joint Surg Am. 2009 Mar 1; 91(3):724-32.
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Naik AA, Xie C, Zuscik MJ, Kingsley P, Schwarz EM, Awad H, Guldberg R, Drissi H, Puzas JE, Boyce B, Zhang X, O'Keefe RJ. Reduced COX-2 expression in aged mice is associated with impaired fracture healing. J Bone Miner Res. 2009 Feb; 24(2):251-64.
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Zhu M, Tang D, Wu Q, Hao S, Chen M, Xie C, Rosier RN, O'Keefe RJ, Zuscik M, Chen D. Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice. J Bone Miner Res. 2009 Jan; 24(1):12-21.
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Wu Q, Kim KO, Sampson ER, Chen D, Awad H, O'Brien T, Puzas JE, Drissi H, Schwarz EM, O'Keefe RJ, Zuscik MJ, Rosier RN. Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice. Arthritis Rheum. 2008 Oct; 58(10):3132-44.
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Tsutsumi R, Hock C, Bechtold CD, Proulx ST, Bukata SV, Ito H, Awad HA, Nakamura T, O'Keefe RJ, Schwarz EM. Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT. J Orthop Res. 2008 Oct; 26(10):1340-6.
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Kaback LA, Soung do Y, Naik A, Geneau G, Schwarz EM, Rosier RN, O'Keefe RJ, Drissi H. Teriparatide (1-34 human PTH) regulation of osterix during fracture repair. J Cell Biochem. 2008 Sep 1; 105(1):219-26.
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Xie C, Ming X, Wang Q, Schwarz EM, Guldberg RE, O'Keefe RJ, Zhang X. COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing. Bone. 2008 Dec; 43(6):1075-83.
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Zhu M, Chen M, Zuscik M, Wu Q, Wang YJ, Rosier RN, O'Keefe RJ, Chen D. Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction. Arthritis Rheum. 2008 Jul; 58(7):2053-64.
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Hasslund S, Jacobson JA, Dadali T, Basile P, Ulrich-Vinther M, Søballe K, Schwarz EM, O'Keefe RJ, Mitten DJ, Awad HA. Adhesions in a murine flexor tendon graft model: autograft versus allograft reconstruction. J Orthop Res. 2008 Jun; 26(6):824-33.
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Zhang X, Awad HA, O'Keefe RJ, Guldberg RE, Schwarz EM. A perspective: engineering periosteum for structural bone graft healing. Clin Orthop Relat Res. 2008 Aug; 466(8):1777-87.
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Wu Q, Wang M, Zuscik MJ, Chen D, O'Keefe RJ, Rosier RN. Regulation of embryonic endochondral ossification by Smurf2. J Orthop Res. 2008 May; 26(5):704-12.
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Chen M, Zhu M, Awad H, Li TF, Sheu TJ, Boyce BF, Chen D, O'Keefe RJ. Inhibition of beta-catenin signaling causes defects in postnatal cartilage development. J Cell Sci. 2008 May 1; 121(Pt 9):1455-65.
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Wu Q, Chen D, Zuscik MJ, O'Keefe RJ, Rosier RN. Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin. J Bone Miner Res. 2008 Apr; 23(4):552-63.
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Usui M, Xing L, Drissi H, Zuscik M, O'Keefe R, Chen D, Boyce BF. Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2. J Bone Miner Res. 2008 Mar; 23(3):314-25.
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Zuscik MJ, Hilton MJ, Zhang X, Chen D, O'Keefe RJ. Regulation of chondrogenesis and chondrocyte differentiation by stress. J Clin Invest. 2008 Feb; 118(2):429-38.
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Xie C, Xue M, Wang Q, Schwarz EM, O'Keefe RJ, Zhang X. Tamoxifen-inducible CreER-mediated gene targeting in periosteum via bone-graft transplantation. J Bone Joint Surg Am. 2008 Feb; 90 Suppl 1:9-13.
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Eliseev RA, Dong YF, Sampson E, Zuscik MJ, Schwarz EM, O'Keefe RJ, Rosier RN, Drissi MH. Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis. Oncogene. 2008 Jun 5; 27(25):3605-14.
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Basile P, Dadali T, Jacobson J, Hasslund S, Ulrich-Vinther M, Søballe K, Nishio Y, Drissi MH, Langstein HN, Mitten DJ, O'Keefe RJ, Schwarz EM, Awad HA. Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery. Mol Ther. 2008 Mar; 16(3):466-73.
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Kaback LA, Soung do Y, Naik A, Smith N, Schwarz EM, O'Keefe RJ, Drissi H. Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossification. J Cell Physiol. 2008 Jan; 214(1):173-82.
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Li D, Gromov K, Søballe K, Puzas JE, O'Keefe RJ, Awad H, Drissi H, Schwarz EM. Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity. J Orthop Res. 2008 Jan; 26(1):96-105.
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Bostrom M, O'Keefe R. What experimental approaches (eg, in vivo, in vitro, tissue retrieval) are effective in investigating the biologic effects of particles? J Am Acad Orthop Surg. 2008; 16 Suppl 1:S63-7.
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McGrail JC, O'Keefe RT. The U1, U2 and U5 snRNAs crosslink to the 5' exon during yeast pre-mRNA splicing. Nucleic Acids Res. 2008 Feb; 36(3):814-25.
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Dao DY, Yang X, Chen D, Zuscik M, O'Keefe RJ. Axin1 and Axin2 are regulated by TGF- and mediate cross-talk between TGF- and Wnt signaling pathways. Ann N Y Acad Sci. 2007 Nov; 1116:82-99.
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Zhu M, Chen M, Lichtler AC, O'Keefe RJ, Chen D. Tamoxifen-inducible Cre-recombination in articular chondrocytes of adult Col2a1-CreER(T2) transgenic mice. Osteoarthritis Cartilage. 2008 Jan; 16(1):129-30.
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Zuscik MJ, Ma L, Buckley T, Puzas JE, Drissi H, Schwarz EM, O'Keefe RJ. Lead induces chondrogenesis and alters transforming growth factor-beta and bone morphogenetic protein signaling in mesenchymal cell populations. Environ Health Perspect. 2007 Sep; 115(9):1276-82.
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Frazer LN, O'Keefe RT. A new series of yeast shuttle vectors for the recovery and identification of multiple plasmids from Saccharomyces cerevisiae. Yeast. 2007 Sep; 24(9):777-89.
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Zhang X, Sun B. Organic crystal fibers aligned into oriented bundles with polarized emission. J Phys Chem B. 2007 Sep 20; 111(37):10881-5.
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Dong YF, Soung do Y, Chang Y, Enomoto-Iwamoto M, Paris M, O'Keefe RJ, Schwarz EM, Drissi H. Transforming growth factor-beta and Wnt signals regulate chondrocyte differentiation through Twist1 in a stage-specific manner. Mol Endocrinol. 2007 Nov; 21(11):2805-20.
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Awad HA, Zhang X, Reynolds DG, Guldberg RE, O'Keefe RJ, Schwarz EM. Recent advances in gene delivery for structural bone allografts. Tissue Eng. 2007 Aug; 13(8):1973-85.
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Soung do Y, Dong Y, Wang Y, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H. Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation. J Bone Miner Res. 2007 Aug; 22(8):1260-70.
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Bärnighausen T, Liu Y, Zhang X, Sauerborn R. Willingness to pay for social health insurance among informal sector workers in Wuhan, China: a contingent valuation study. BMC Health Serv Res. 2007; 7:114.
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Dobbyn HC, McEwan PA, Krause A, Novak-Frazer L, Bella J, O'Keefe RT. Analysis of pre-mRNA and pre-rRNA processing factor Snu13p structure and mutants. Biochem Biophys Res Commun. 2007 Sep 7; 360(4):857-62.
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Reynolds DG, Hock C, Shaikh S, Jacobson J, Zhang X, Rubery PT, Beck CA, O'keefe RJ, Lerner AL, Schwarz EM, Awad HA. Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts. J Biomech. 2007; 40(14):3178-86.
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Wang YJ, Zhou CJ, Shi Q, Smith N, Li TF. Aging delays the regeneration process following sciatic nerve injury in rats. J Neurotrauma. 2007 May; 24(5):885-94.
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Xie C, Reynolds D, Awad H, Rubery PT, Pelled G, Gazit D, Guldberg RE, Schwarz EM, O'Keefe RJ, Zhang X. Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering. Tissue Eng. 2007 Mar; 13(3):435-45.
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Wang Q, Wei X, Zhu T, Zhang M, Shen R, Xing L, O'Keefe RJ, Chen D. Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2. J Biol Chem. 2007 Apr 6; 282(14):10742-8.
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Chen M, Lichtler AC, Sheu TJ, Xie C, Zhang X, O'Keefe RJ, Chen D. Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase. Genesis. 2007 Jan; 45(1):44-50.
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Baumhauer JF, O'Keefe RJ, Schon LC, Pinzur MS. Cytokine-induced osteoclastic bone resorption in charcot arthropathy: an immunohistochemical study. Foot Ankle Int. 2006 Oct; 27(10):797-800.
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Dong YF, Soung do Y, Schwarz EM, O'Keefe RJ, Drissi H. Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor. J Cell Physiol. 2006 Jul; 208(1):77-86.
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Wang YJ, Shi Q, Lu WW, Cheung KC, Darowish M, Li TF, Dong YF, Zhou CJ, Zhou Q, Hu ZJ, Liu M, Bian Q, Li CG, Luk KD, Leong JC. Cervical intervertebral disc degeneration induced by unbalanced dynamic and static forces: a novel in vivo rat model. Spine (Phila Pa 1976). 2006 Jun 15; 31(14):1532-8.
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Robertson G, Xie C, Chen D, Awad H, Schwarz EM, O'Keefe RJ, Guldberg RE, Zhang X. Alteration of femoral bone morphology and density in COX-2-/- mice. Bone. 2006 Oct; 39(4):767-72.
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Li TF, Chen D, Wu Q, Chen M, Sheu TJ, Schwarz EM, Drissi H, Zuscik M, O'Keefe RJ. Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes. J Biol Chem. 2006 Jul 28; 281(30):21296-304.
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Shen R, Wang X, Drissi H, Liu F, O'Keefe RJ, Chen D. Cyclin D1-cdk4 induce runx2 ubiquitination and degradation. J Biol Chem. 2006 Jun 16; 281(24):16347-53.
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Schwarz EM, Looney RJ, Drissi MH, O'Keefe RJ, Boyce BF, Xing L, Ritchlin CT. Autoimmunity and bone. Ann N Y Acad Sci. 2006 Apr; 1068:275-83.
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Maloney MD, Goater JJ, Parsons R, Ito H, O'Keefe RJ, Rubery PT, Drissi MH, Schwarz EM. Safety and efficacy of ultraviolet-a light-activated gene transduction for gene therapy of articular cartilage defects. J Bone Joint Surg Am. 2006 Apr; 88(4):753-61.
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Zhang X, Sun B, Friend RH, Guo H, Nau D, Giessen H. Metallic photonic crystals based on solution-processible gold nanoparticles. Nano Lett. 2006 Apr; 6(4):651-5.
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O'Keefe RJ, Tiyapatanaputi P, Xie C, Li TF, Clark C, Zuscik MJ, Chen D, Drissi H, Schwarz E, Zhang X. COX-2 has a critical role during incorporation of structural bone allografts. Ann N Y Acad Sci. 2006 Apr; 1068:532-42.
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Nishio Y, Dong Y, Paris M, O'Keefe RJ, Schwarz EM, Drissi H. Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene. Gene. 2006 May 10; 372:62-70.
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Xing L, Thorndyke B, Schreibmann E, Yang Y, Li TF, Kim GY, Luxton G, Koong A. Overview of image-guided radiation therapy. Med Dosim. 2006; 31(2):91-112.
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Looney RJ, Schwarz EM, Boyd A, O'Keefe RJ. Periprosthetic osteolysis: an immunologist's update. Curr Opin Rheumatol. 2006 Jan; 18(1):80-7.
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Eliseev RA, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H, Rosier RN. Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase. J Cell Biochem. 2005 Dec 15; 96(6):1262-73.
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Mandelin J, Hukkanen M, Li TF, Korhonen M, Liljeström M, Sillat T, Hanemaaijer R, Salo J, Santavirta S, Konttinen YT. Human osteoblasts produce cathepsin K. Bone. 2006 Jun; 38(6):769-77.
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Andela VB, Schwarz EM, O'Keefe RJ, Puzas EJ, Rosenblatt JD, Rosier RN. A genome-wide expression profile and system-level integration of nuclear factor kappa B regulated genes reveals fundamental metabolic adaptations during cell growth and survival. FEBS Lett. 2005 Dec 19; 579(30):6814-20.
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Shen R, Chen M, Wang YJ, Kaneki H, Xing L, O'keefe RJ, Chen D. Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation. J Biol Chem. 2006 Feb 10; 281(6):3569-76.
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Eliseev RA, Schwarz EM, Zuscik MJ, O'Keefe RJ, Drissi H, Rosier RN. Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB. Exp Cell Res. 2006 Jan 1; 312(1):40-50.
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Zhang X, Naik A, Xie C, Reynolds D, Palmer J, Lin A, Awad H, Guldberg R, Schwarz E, O'Keefe R. Periosteal stem cells are essential for bone revitalization and repair. J Musculoskelet Neuronal Interact. 2005 Oct-Dec; 5(4):360-2.
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O'Keefe RJ. Summary--Cell therapies for orthopedic applications. J Musculoskelet Neuronal Interact. 2005 Oct-Dec; 5(4):367-8.
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Li TF, Darowish M, Zuscik MJ, Chen D, Schwarz EM, Rosier RN, Drissi H, O'Keefe RJ. Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation. J Bone Miner Res. 2006 Jan; 21(1):4-16.
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Voloshin I, Gelinas J, Maloney MD, O'Keefe RJ, Bigliani LU, Blaine TA. Proinflammatory cytokines and metalloproteases are expressed in the subacromial bursa in patients with rotator cuff disease. Arthroscopy. 2005 Sep; 21(9):1076.
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Boyce BF, Li P, Yao Z, Zhang Q, Badell IR, Schwarz EM, O'Keefe RJ, Xing L. TNF-alpha and pathologic bone resorption. Keio J Med. 2005 Sep; 54(3):127-31.
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Zhang X, Xie C, Lin AS, Ito H, Awad H, Lieberman JR, Rubery PT, Schwarz EM, O'Keefe RJ, Guldberg RE. Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering. J Bone Miner Res. 2005 Dec; 20(12):2124-37.
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Koefoed M, Ito H, Gromov K, Reynolds DG, Awad HA, Rubery PT, Ulrich-Vinther M, Soballe K, Guldberg RE, Lin AS, O'Keefe RJ, Zhang X, Schwarz EM. Biological effects of rAAV-caAlk2 coating on structural allograft healing. Mol Ther. 2005 Aug; 12(2):212-8.
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Dong Y, Drissi H, Chen M, Chen D, Zuscik MJ, Schwarz EM, O'Keefe RJ. Wnt-mediated regulation of chondrocyte maturation: modulation by TGF-beta. J Cell Biochem. 2005 Aug 1; 95(5):1057-68.
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Mandelin J, Liljeström M, Li TF, Ainola M, Hukkanen M, Salo J, Santavirta S, Konttinen YT. Pseudosynovial fluid from loosened total hip prosthesis induces osteoclast formation. J Biomed Mater Res B Appl Biomater. 2005 Jul; 74(1):582-8.
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Soloviev A, Schwarz EM, Darowish M, O'Keefe RJ. Sphingomyelinase mediates macrophage activation by titanium particles independent of phagocytosis: a role for free radicals, NFkappaB, and TNFalpha. J Orthop Res. 2005 Nov; 23(6):1258-65.
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Drissi H, Zuscik M, Rosier R, O'Keefe R. Transcriptional regulation of chondrocyte maturation: potential involvement of transcription factors in OA pathogenesis. Mol Aspects Med. 2005 Jun; 26(3):169-79.
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Carmouche JJ, Puzas JE, Zhang X, Tiyapatanaputi P, Cory-Slechta DA, Gelein R, Zuscik M, Rosier RN, Boyce BF, O'Keefe RJ, Schwarz EM. Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency. Environ Health Perspect. 2005 Jun; 113(6):749-55.
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Wang Y, Belflower RM, Dong YF, Schwarz EM, O'Keefe RJ, Drissi H. Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward chondrogenesis. J Bone Miner Res. 2005 Sep; 20(9):1624-36.
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Gordon AH, O'Keefe RJ, Schwarz EM, Rosier RN, Puzas JE. Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone. Cancer Res. 2005 Apr 15; 65(8):3209-17.
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Mandelin J, Li TF, Hukkanen M, Liljeström M, Salo J, Santavirta S, Konttinen YT. Interface tissue fibroblasts from loose total hip replacement prosthesis produce receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and cathepsin K. J Rheumatol. 2005 Apr; 32(4):713-20.
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Smith N, Dong Y, Lian JB, Pratap J, Kingsley PD, van Wijnen AJ, Stein JL, Schwarz EM, O'Keefe RJ, Stein GS, Drissi MH. Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development. J Cell Physiol. 2005 Apr; 203(1):133-43.
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Clark CA, Schwarz EM, Zhang X, Ziran NM, Drissi H, O'Keefe RJ, Zuscik MJ. Differential regulation of EP receptor isoforms during chondrogenesis and chondrocyte maturation. Biochem Biophys Res Commun. 2005 Mar 18; 328(3):764-76.
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Wei X, Zhang X, Zuscik MJ, Drissi MH, Schwarz EM, O'Keefe RJ. Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles. J Bone Miner Res. 2005 Jul; 20(7):1136-48.
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Ito H, Koefoed M, Tiyapatanaputi P, Gromov K, Goater JJ, Carmouche J, Zhang X, Rubery PT, Rabinowitz J, Samulski RJ, Nakamura T, Soballe K, O'Keefe RJ, Boyce BF, Schwarz EM. Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy. Nat Med. 2005 Mar; 11(3):291-7.
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Yu S, Zhang X, He Z, Liu Y. [Corrosiveness of Ti-Fe-Mo-Mn-Nb-Zr alloys in various pH lactic acids]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2005 Feb; 22(1):91-4.
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Gu X, Feng Y, Shi C, Li M, Fu Z, Zhang X. Antiapoptotic mechanism of insulin in reoxygenation-induced injury in cultured cardiomyocytes of neonatal rats. J Huazhong Univ Sci Technolog Med Sci. 2005; 25(6):632-5.
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Li TF, O'Keefe RJ, Chen D. TGF-beta signaling in chondrocytes. Front Biosci. 2005 Jan 1; 10:681-8.
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Blaine TA, Kim YS, Voloshin I, Chen D, Murakami K, Chang SS, Winchester R, Lee FY, O'keefe RJ, Bigliani LU. The molecular pathophysiology of subacromial bursitis in rotator cuff disease. J Shoulder Elbow Surg. 2005 Jan-Feb; 14(1 Suppl S):84S-89S.
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Schwarz EM, O'Keefe RJ, Looney RJ. Bone implant interface, osteolysis and potential therapies. J Musculoskelet Neuronal Interact. 2004 Dec; 4(4):390-2.
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Guldberg RE, Oest M, Lin AS, Ito H, Chao X, Gromov K, Goater JJ, Koefoed M, Schwarz EM, O'Keefe RJ, Zhang X. Functional integration of tissue-engineered bone constructs. J Musculoskelet Neuronal Interact. 2004 Dec; 4(4):399-400.
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Tiyapatanaputi P, Rubery PT, Carmouche J, Schwarz EM, O'keefe RJ, Zhang X. A novel murine segmental femoral graft model. J Orthop Res. 2004 Nov; 22(6):1254-60.
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Li TF, Zuscik MJ, Ionescu AM, Zhang X, Rosier RN, Schwarz EM, Drissi H, O'Keefe RJ. PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling. Exp Cell Res. 2004 Oct 15; 300(1):159-69.
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Li TF, Dong Y, Ionescu AM, Rosier RN, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H. Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway. Exp Cell Res. 2004 Sep 10; 299(1):128-36.
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Ritchlin CT, Schwarz EM, O'Keefe RJ, Looney RJ. RANK, RANKL and OPG in inflammatory arthritis and periprosthetic osteolysis. J Musculoskelet Neuronal Interact. 2004 Sep; 4(3):276-84.
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Ferguson CM, Schwarz EM, Puzas JE, Zuscik MJ, Drissi H, O'Keefe RJ. Transforming growth factor-beta1 induced alteration of skeletal morphogenesis in vivo. J Orthop Res. 2004 Jul; 22(4):687-96.
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Ulrich-Vinther M, Duch MR, Søballe K, O'Keefe RJ, Schwarz EM, Pedersen FS. In vivo gene delivery to articular chondrocytes mediated by an adeno-associated virus vector. J Orthop Res. 2004 Jul; 22(4):726-34.
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Zuscik MJ, Baden JF, Wu Q, Sheu TJ, Schwarz EM, Drissi H, O'Keefe RJ, Puzas JE, Rosier RN. 5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes. J Cell Biochem. 2004 May 15; 92(2):316-31.
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Zhang X, Ziran N, Goater JJ, Schwarz EM, Puzas JE, Rosier RN, Zuscik M, Drissi H, O'Keefe RJ. Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation. Bone. 2004 May; 34(5):809-17.
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Ionescu AM, Drissi H, Schwarz EM, Kato M, Puzas JE, McCance DJ, Rosier RN, Zuscik MJ, O'Keefe RJ. CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter. J Cell Physiol. 2004 Mar; 198(3):428-40.
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Li P, Schwarz EM, O'Keefe RJ, Ma L, Boyce BF, Xing L. RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis. J Bone Miner Res. 2004 Feb; 19(2):207-13.
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Yu S, Zhang X, He Z, Gao Z, Wang C. [The influence of Ce on microstructures and mechanics performances of Ti-Fe-Mo-Mn-Nb-Zr alloys]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2004 Feb; 21(1):102-6.
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Zhang X, Wang T. Quantitative analysis on economic contribution of community health service in China. J Huazhong Univ Sci Technolog Med Sci. 2004; 24(1):103-6.
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Bukata SV, Gelinas J, Wei X, Rosier RN, Puzas JE, Zhang X, Schwarz EM, Song XY, Griswold DE, O'Keefe RJ. PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway. J Orthop Res. 2004 Jan; 22(1):6-12.
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Li P, Schwarz EM, O'Keefe RJ, Ma L, Looney RJ, Ritchlin CT, Boyce BF, Xing L. Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice. Arthritis Rheum. 2004 Jan; 50(1):265-76.
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Ito H, Goater JJ, Tiyapatanaputi P, Rubery PT, O'Keefe RJ, Schwarz EM. Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells. Gene Ther. 2004 Jan; 11(1):34-41.
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Drissi MH, Li X, Sheu TJ, Zuscik MJ, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ. Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes. J Cell Biochem. 2003 Dec 15; 90(6):1287-98.
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Puzas JE, O'Keefe RJ, Schwarz EM, Zhang X. Pharmacologic modulators of fracture healing: the role of cyclooxygenase inhibition. J Musculoskelet Neuronal Interact. 2003 Dec; 3(4):308-12; discussion 320-1.
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Schwarz EM, Campbell D, Totterman S, Boyd A, O'Keefe RJ, Looney RJ. Use of volumetric computerized tomography as a primary outcome measure to evaluate drug efficacy in the prevention of peri-prosthetic osteolysis: a 1-year clinical pilot of etanercept vs. placebo. J Orthop Res. 2003 Nov; 21(6):1049-55.
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Ulrich-Vinther M, Maloney MD, Schwarz EM, Rosier R, O'Keefe RJ. Articular cartilage biology. J Am Acad Orthop Surg. 2003 Nov-Dec; 11(6):421-30.
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Huang W, Drissi MH, O'Keefe RJ, Schwarz EM. A rapid multiparameter approach to study factors that regulate osteoclastogenesis: demonstration of the combinatorial dominant effects of TNF-alpha and TGF-ss in RANKL-mediated osteoclastogenesis. Calcif Tissue Int. 2003 Dec; 73(6):584-93.
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O'Keefe RJ, Guise TA. Molecular mechanisms of bone metastasis and therapeutic implications. Clin Orthop Relat Res. 2003 Oct; (415 Suppl):S100-4.
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Andela VB, Pirri M, Schwarz EM, Puzas EJ, O'Keefe RJ, Rosenblatt JD, Rosier RN. The mevalonate synthesis pathway as a therapeutic target in cancer. Clin Orthop Relat Res. 2003 Oct; (415 Suppl):S59-66.
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Andela VB, Gordon AH, Zotalis G, Rosier RN, Goater JJ, Lewis GD, Schwarz EM, Puzas JE, O'Keefe RJ. NFkappaB: a pivotal transcription factor in prostate cancer metastasis to bone. Clin Orthop Relat Res. 2003 Oct; (415 Suppl):S75-85.
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Zhang D, Schwarz EM, Rosier RN, Zuscik MJ, Puzas JE, O'Keefe RJ. ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. J Bone Miner Res. 2003 Sep; 18(9):1593-604.
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Li X, Ionescu AM, Schwarz EM, Zhang X, Drissi H, Puzas JE, Rosier RN, Zuscik MJ, O'Keefe RJ. Smad6 is induced by BMP-2 and modulates chondrocyte differentiation. J Orthop Res. 2003 Sep; 21(5):908-13.
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Mandelin J, Li TF, Hukkanen MV, Liljeström M, Chen ZK, Santavirta S, Kitti U, Konttinen YT. Increased expression of a novel osteoclast-stimulating factor, ADAM8, in interface tissue around loosened hip prostheses. J Rheumatol. 2003 Sep; 30(9):2033-8.
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Ionescu AM, Schwarz EM, Zuscik MJ, Drissi H, Puzas JE, Rosier RN, O'Keefe RJ. ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation. Exp Cell Res. 2003 Aug 1; 288(1):198-207.
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Flick LM, Weaver JM, Ulrich-Vinther M, Abuzzahab F, Zhang X, Dougall WC, Anderson D, O'Keefe RJ, Schwarz EM. Effects of receptor activator of NFkappaB (RANK) signaling blockade on fracture healing. J Orthop Res. 2003 Jul; 21(4):676-84.
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Li X, Schwarz EM, Zuscik MJ, Rosier RN, Ionescu AM, Puzas JE, Drissi H, Sheu TJ, O'Keefe RJ. Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5. Endocrinology. 2003 Jun; 144(6):2514-23.
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Andela VB, Gingold BI, Souza MD, O'Keefe RJ, Puzas EJ, Schwarz EM, Rosier RN. Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB. Cancer Lett. 2003 May 8; 194(1):37-43.
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Ballock RT, O'Keefe RJ. Physiology and pathophysiology of the growth plate. Birth Defects Res C Embryo Today. 2003 May; 69(2):123-43.
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Ballock RT, O'Keefe RJ. The biology of the growth plate. J Bone Joint Surg Am. 2003 Apr; 85-A(4):715-26.
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Huang W, O'Keefe RJ, Schwarz EM. Exposure to receptor-activator of NFkappaB ligand renders pre-osteoclasts resistant to IFN-gamma by inducing terminal differentiation. Arthritis Res Ther. 2003; 5(1):R49-59.
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Sheu TJ, Schwarz EM, Martinez DA, O'Keefe RJ, Rosier RN, Zuscik MJ, Puzas JE. A phage display technique identifies a novel regulator of cell differentiation. J Biol Chem. 2003 Jan 3; 278(1):438-43.
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Pateder DB, Gish MW, O'Keefe RJ, Hicks DG, Teot LA, Rosier RN. Parathyroid hormone-related Peptide expression in cartilaginous tumors. Clin Orthop Relat Res. 2002 Oct; (403):198-204.
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Andela VB, Sheu TJ, Puzas EJ, Schwarz EM, O'Keefe RJ, Rosier RN. Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB. Biochem Biophys Res Commun. 2002 Sep 20; 297(2):237-41.
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Zuscik MJ, O'Keefe RJ, Gunter TE, Puzas JE, Schwarz EM, Rosier RN. Parathyroid hormone-related peptide regulation of chick tibial growth plate chondrocyte maturation requires protein kinase A. J Orthop Res. 2002 Sep; 20(5):1079-90.
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Ulrich-Vinther M, Carmody EE, Goater JJ, S balle K, O'Keefe RJ, Schwarz EM. Recombinant adeno-associated virus-mediated osteoprotegerin gene therapy inhibits wear debris-induced osteolysis. J Bone Joint Surg Am. 2002 Aug; 84-A(8):1405-12.
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Ulrich-Vinther M, Maloney MD, Goater JJ, Søballe K, Goldring MB, O'Keefe RJ, Schwarz EM. Light-activated gene transduction enhances adeno-associated virus vector-mediated gene expression in human articular chondrocytes. Arthritis Rheum. 2002 Aug; 46(8):2095-104.
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Zuscik MJ, Pateder DB, Puzas JE, Schwarz EM, Rosier RN, O'Keefe RJ. Lead alters parathyroid hormone-related peptide and transforming growth factor-beta1 effects and AP-1 and NF-kappaB signaling in chondrocytes. J Orthop Res. 2002 Jul; 20(4):811-8.
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Soloviev A, Schwarz EM, Kuprash DV, Nedospasov SA, Puzas JE, Rosier RN, O'Keefe RJ. The role of p105 protein in NFkappaB activation in ANA-1 murine macrophages following stimulation with titanium particles. J Orthop Res. 2002 Jul; 20(4):714-22.
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Zuscik MJ, D'Souza M, Ionescu AM, Gunter KK, Gunter TE, O'Keefe RJ, Schwarz EM, Puzas JE, Rosier RN. Growth plate chondrocyte maturation is regulated by basal intracellular calcium. Exp Cell Res. 2002 Jun 10; 276(2):310-9.
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Zhang X, Schwarz EM, Young DA, Puzas JE, Rosier RN, O'Keefe RJ. Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J Clin Invest. 2002 Jun; 109(11):1405-15.
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O'Keefe RJ. Determination of responsiveness in biological systems is dependent on highly sensitive quantitative measures. Ann N Y Acad Sci. 2002 Jun; 961:206.
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Guilak F, Kapur R, Sefton MV, Vandenburgh HH, Koretsky AP, Kriete A, O'Keefe RJ. Functional assessment of engineered tissues and elements of tissue design: breakout session summary. Ann N Y Acad Sci. 2002 Jun; 961:207-9.
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Sheu TJ, Schwarz EM, O'Keefe RJ, Rosier RN, Puzas JE. Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae. J Bone Miner Res. 2002 May; 17(5):915-22.
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Carmody EE, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ. Viral interleukin-10 gene inhibition of inflammation, osteoclastogenesis, and bone resorption in response to titanium particles. Arthritis Rheum. 2002 May; 46(5):1298-308.
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Andela VB, Rosenblatt JD, Schwarz EM, Puzas EJ, O'Keefe RJ, Rosier RN. Synergism of aminobisphosphonates and farnesyl transferase inhibitors on tumor metastasis. Clin Orthop Relat Res. 2002 Apr; (397):228-39.
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Konttinen YT, Mandelin J, Li TF, Salo J, Lassus J, Liljeström M, Hukkanen M, Takagi M, Virtanen I, Santavirta S. Acidic cysteine endoproteinase cathepsin K in the degeneration of the superficial articular hyaline cartilage in osteoarthritis. Arthritis Rheum. 2002 Apr; 46(4):953-60.
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Good CR, O'Keefe RJ, Puzas JE, Schwarz EM, Rosier RN. Immunohistochemical study of receptor activator of nuclear factor kappa-B ligand (RANK-L) in human osteolytic bone tumors. J Surg Oncol. 2002 Mar; 79(3):174-9.
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Goater JJ, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM. Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis. J Orthop Res. 2002 Mar; 20(2):169-73.
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Childs LM, Paschalis EP, Xing L, Dougall WC, Anderson D, Boskey AL, Puzas JE, Rosier RN, O'Keefe RJ, Boyce BF, Schwarz EM. In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis. J Bone Miner Res. 2002 Feb; 17(2):192-9.
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Zhang D, Ferguson CM, O'Keefe RJ, Puzas JE, Rosier RN, Reynolds PR. A role for the BMP antagonist chordin in endochondral ossification. J Bone Miner Res. 2002 Feb; 17(2):293-300.
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Paavonen K, Mandelin J, Partanen T, Jussila L, Li TF, Ristimaki A, Alitalo K, Konttinen YT. Vascular endothelial growth factors C and D and their VEGFR-2 and 3 receptors in blood and lymphatic vessels in healthy and arthritic synovium. J Rheumatol. 2002 Jan; 29(1):39-45.
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Mungo DV, Zhang X, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM. COX-1 and COX-2 expression in osteoid osteomas. J Orthop Res. 2002 Jan; 20(1):159-62.
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Pateder DB, Sheu TJ, O'Keefe RJ, Puzas JE, Schwarz EM, Constine LS, Okunieff P, Rosier RN. Role of pentoxifylline in preventing radiation damage to epiphyseal growth plate chondrocytes. Radiat Res. 2002 Jan; 157(1):62-8.
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Puzas JE, O'Keefe RJ, Lieberman JR. The orthopaedic genome: what does the future hold and are we ready? J Bone Joint Surg Am. 2002 Jan; 84-A(1):133-41.
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Childs LM, Goater JJ, O'Keefe RJ, Schwarz EM. Effect of anti-tumor necrosis factor-alpha gene therapy on wear debris-induced osteolysis. J Bone Joint Surg Am. 2001 Dec; 83-A(12):1789-97.
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Looney RJ, Boyd A, Totterman S, Seo GS, Tamez-Pena J, Campbell D, Novotny L, Olcott C, Martell J, Hayes FA, O'Keefe RJ, Schwarz EM. Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear. Arthritis Res. 2002; 4(1):59-63.
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Pateder DB, Ferguson CM, Ionescu AM, Schwarz EM, Rosier RN, Puzas JE, O'Keefe RJ. PTHrP expression in chick sternal chondrocytes is regulated by TGF-beta through Smad-mediated signaling. J Cell Physiol. 2001 Sep; 188(3):343-51.
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Pollice PF, Rosier RN, Looney RJ, Puzas JE, Schwarz EM, O'Keefe RJ. Oral pentoxifylline inhibits release of tumor necrosis factor-alpha from human peripheral blood monocytes : a potential treatment for aseptic loosening of total joint components. J Bone Joint Surg Am. 2001 Jul; 83-A(7):1057-61.
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Pateder DB, Eliseev RA, O'Keefe RJ, Schwarz EM, Okunieff P, Constine LS, Puzas JE, Rosier RN. The role of autocrine growth factors in radiation damage to the epiphyseal growth plate. Radiat Res. 2001 Jun; 155(6):847-57.
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Zhang X, Morham SG, Langenbach R, Young DA, Xing L, Boyce BF, Puzas EJ, Rosier RN, O'Keefe RJ, Schwarz EM. Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis. J Bone Miner Res. 2001 Apr; 16(4):660-70.
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Childs LM, Goater JJ, O'Keefe RJ, Schwarz EM. Efficacy of etanercept for wear debris-induced osteolysis. J Bone Miner Res. 2001 Feb; 16(2):338-47.
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Ionescu AM, Schwarz EM, Vinson C, Puzas JE, Rosier R, Reynolds PR, O'Keefe RJ. PTHrP modulates chondrocyte differentiation through AP-1 and CREB signaling. J Biol Chem. 2001 Apr 13; 276(15):11639-47.
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Grimsrud CD, Romano PR, D'Souza M, Puzas JE, Schwarz EM, Reynolds PR, Roiser RN, O'Keefe RJ. BMP signaling stimulates chondrocyte maturation and the expression of Indian hedgehog. J Orthop Res. 2001 Jan; 19(1):18-25.
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Andela VB, Schwarz EM, Puzas JE, O'Keefe RJ, Rosier RN. Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappaB. Cancer Res. 2000 Dec 1; 60(23):6557-62.
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Ferguson CM, Schwarz EM, Reynolds PR, Puzas JE, Rosier RN, O'Keefe RJ. Smad2 and 3 mediate transforming growth factor-beta1-induced inhibition of chondrocyte maturation. Endocrinology. 2000 Dec; 141(12):4728-35.
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Chi H, Yang X, Kingsley PD, O'Keefe RJ, Puzas JE, Rosier RN, Shears SB, Reynolds PR. Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo. Mol Cell Biol. 2000 Sep; 20(17):6496-507.
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Li P, Sanz I, O'Keefe RJ, Schwarz EM. NF-kappa B regulates VCAM-1 expression on fibroblast-like synoviocytes. J Immunol. 2000 Jun 1; 164(11):5990-7.
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Reynolds SD, Zhang D, Puzas JE, O'Keefe RJ, Rosier RN, Reynolds PR. Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal tissues. Gene. 2000 May 2; 248(1-2):233-43.
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Pateder DB, Rosier RN, Schwarz EM, Reynolds PR, Puzas JE, D'Souza M, O'Keefe RJ. PTHrP expression in chondrocytes, regulation by TGF-beta, and interactions between epiphyseal and growth plate chondrocytes. Exp Cell Res. 2000 May 1; 256(2):555-62.
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Schwarz EM, Lu AP, Goater JJ, Benz EB, Kollias G, Rosier RN, Puzas JE, O'Keefe RJ. Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis. J Orthop Res. 2000 May; 18(3):472-80.
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Goater J, Müller R, Kollias G, Firestein GS, Sanz I, O'Keefe RJ, Schwarz EM. Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis. J Rheumatol. 2000 Apr; 27(4):983-9.
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Temple HT, Scully SP, O'Keefe RJ, Katapurum S, Mankin HJ. Clinical outcome of 38 patients with juxtacortical osteosarcoma. Clin Orthop Relat Res. 2000 Apr; (373):208-17.
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Schwarz EM, Looney RJ, O'Keefe RJ. Anti-TNF-alpha therapy as a clinical intervention for periprosthetic osteolysis. Arthritis Res. 2000; 2(3):165-8.
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Rosier RN, O'Keefe RJ. Hyaluronic acid therapy. Instr Course Lect. 2000; 49:495-502.
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Vena VE, Hsu J, Rosier RN, O'Keefe RJ. Pelvic reconstruction for severe periacetabular metastatic disease. Clin Orthop Relat Res. 1999 May; (362):171-80.
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Grimsrud CD, Romano PR, D'Souza M, Puzas JE, Reynolds PR, Rosier RN, O'Keefe RJ. BMP-6 is an autocrine stimulator of chondrocyte differentiation. J Bone Miner Res. 1999 Apr; 14(4):475-82.
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Chi H, Tiller GE, Dasouki MJ, Romano PR, Wang J, O'keefe RJ, Puzas JE, Rosier RN, Reynolds PR. Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19. Genomics. 1999 Mar 15; 56(3):324-36.
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Pollice PF, Hsu J, Hicks DG, Bukata S, Rosier RN, Reynolds PR, Puzas JE, O'Keefe RJ. Interleukin-10 inhibits cytokine synthesis in monocytes stimulated by titanium particles: evidence of an anti-inflammatory regulatory pathway. J Orthop Res. 1998 Nov; 16(6):697-704.
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Serletti JM, Carras AJ, O'Keefe RJ, Rosier RN. Functional outcome after soft-tissue reconstruction for limb salvage after sarcoma surgery. Plast Reconstr Surg. 1998 Oct; 102(5):1576-83; discussion 1584-5.
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Rosier RN, O'Keefe RJ, Hicks DG. The potential role of transforming growth factor beta in fracture healing. Clin Orthop Relat Res. 1998 Oct; (355 Suppl):S294-300.
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Guerra CE, Betts RF, O'Keefe RJ, Shilling JW. Mycobacterium bovis osteomyelitis involving a hip arthroplasty after intravesicular bacille Calmette-Guérin for bladder cancer. Clin Infect Dis. 1998 Sep; 27(3):639-40.
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Rapoport AP, Constine LS, Packman CH, Rosier RN, O'Keefe R, Hicks DG, Rubin SJ, Rowe JM. Treatment of multifocal lymphoma of bone with intensified ProMACE-CytaBOM chemotherapy and involved field radiotherapy. Am J Hematol. 1998 May; 58(1):1-7.
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Grimsrud CD, Rosier RN, Puzas JE, Reynolds PR, Reynolds SD, Hicks DG, O'Keefe RJ. Bone morphogenetic protein-7 in growth-plate chondrocytes: regulation by retinoic acid is dependent on the stage of chondrocyte maturation. J Orthop Res. 1998 Mar; 16(2):247-55.
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Romano PR, Wang J, O'Keefe RJ, Puzas JE, Rosier RN, Reynolds PR. HiPER1, a phosphatase of the endoplasmic reticulum with a role in chondrocyte maturation. J Cell Sci. 1998 Mar; 111 ( Pt 6):803-13.
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Rosier RN, O'Keefe RJ. Autocrine regulation of articular cartilage. Instr Course Lect. 1998; 47:469-75.
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O'Keefe RJ, Rosier RN, Teot LA, Stewart JM, Hicks DG. Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction. Iowa Orthop J. 1998; 18:26-34.
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Blaine TA, Pollice PF, Rosier RN, Reynolds PR, Puzas JE, O'Keefe RJ. Modulation of the production of cytokines in titanium-stimulated human peripheral blood monocytes by pharmacological agents. The role of cAMP-mediated signaling mechanisms. J Bone Joint Surg Am. 1997 Oct; 79(10):1519-28.
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Rosier RN, O'Keefe RJ, Teot LA, Fox EJ, Nester TA, Puzas JE, Reynolds PR, Hicks DG. P-glycoprotein expression in cartilaginous tumors. J Surg Oncol. 1997 Jun; 65(2):95-105.
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O'Keefe RJ, Teot LA, Singh D, Puzas JE, Rosier RN, Hicks DG. Osteoclasts constitutively express regulators of bone resorption: an immunohistochemical and in situ hybridization study. Lab Invest. 1997 Apr; 76(4):457-65.
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O'Keefe RJ, Loveys LS, Hicks DG, Reynolds PR, Crabb ID, Puzas JE, Rosier RN. Differential regulation of type-II and type-X collagen synthesis by parathyroid hormone-related protein in chick growth-plate chondrocytes. J Orthop Res. 1997 Mar; 15(2):162-74.
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Hicks DG, O'Keefe RJ, Reynolds KJ, Cory-Slechta DA, Puzas JE, Judkins A, Rosier RN. Effects of lead on growth plate chondrocyte phenotype. Toxicol Appl Pharmacol. 1996 Sep; 140(1):164-72.
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Blaine TA, Rosier RN, Puzas JE, Looney RJ, Reynolds PR, Reynolds SD, O'Keefe RJ. Increased levels of tumor necrosis factor-alpha and interleukin-6 protein and messenger RNA in human peripheral blood monocytes due to titanium particles. J Bone Joint Surg Am. 1996 Aug; 78(8):1181-92.
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Reynolds SD, Johnston C, Leboy PS, O'Keefe RJ, Puzas JE, Rosier RN, Reynolds PR. Identification and characterization of a unique chondrocyte gene involved in transition to hypertrophy. Exp Cell Res. 1996 Jul 10; 226(1):197-207.
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Teot LA, O'Keefe RJ, Rosier RN, O'Connell JX, Fox EJ, Hicks DG. Extraosseous primary and recurrent giant cell tumors: transforming growth factor-beta1 and -beta2 expression may explain metaplastic bone formation. Hum Pathol. 1996 Jul; 27(7):625-32.
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Reynolds PR, Reynolds SD, O'Keefe RJ, Puzas JE, Rosier RN. Alternative splicing of a chondrocyte-specific gene. Ann N Y Acad Sci. 1996 Jun 8; 785:321-4.
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Hicks DG, Judkins AR, Sickel JZ, Rosier RN, Puzas JE, O'Keefe RJ. Granular histiocytosis of pelvic lymph nodes following total hip arthroplasty. The presence of wear debris, cytokine production, and immunologically activated macrophages. J Bone Joint Surg Am. 1996 Apr; 78(4):482-96.
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Scully SP, Temple HT, O'Keefe RJ, Mankin HJ, Gebhardt M. The surgical treatment of patients with osteosarcoma who sustain a pathologic fracture. Clin Orthop Relat Res. 1996 Mar; (324):227-32.
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Delsignore JL, Dvoretsky PM, Hicks DG, O'Keefe RJ, Rosier RN. Mastocytosis presenting as a skeletal disorder. Iowa Orthop J. 1996; 16:126-34.
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O'Keefe RJ, Scurry JP, Dennerstein G, Sfameni S, Brenan J. Audit of 114 non-neoplastic vulvar biopsies. Br J Obstet Gynaecol. 1995 Oct; 102(10):780-6.
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O'Keefe RJ, O'Donnell RJ, Temple HT, Scully SP, Mankin HJ. Giant cell tumor of bone in the foot and ankle. Foot Ankle Int. 1995 Oct; 16(10):617-23.
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O'Keefe RJ, O'Connell JX, Temple HT, Scully SP, Kattapuram SV, Springfield DS, Rosenberg AE, Mankin HJ. Calcific myonecrosis. A late sequela to compartment syndrome of the leg. Clin Orthop Relat Res. 1995 Sep; (318):205-13.
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Scully SP, Temple HT, O'Keefe RJ, Scarborough MT, Mankin HJ, Gebhardt MC. Role of surgical resection in pelvic Ewing's sarcoma. J Clin Oncol. 1995 Sep; 13(9):2336-41.
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Hughes SS, Hicks DG, O'Keefe RJ, Hurwitz SR, Crabb ID, Krasinskas AM, Loveys L, Puzas JE, Rosier RN. Shared phenotypic expression of osteoblasts and chondrocytes in fracture callus. J Bone Miner Res. 1995 Apr; 10(4):533-44.
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Hicks DG, Gokan T, O'Keefe RJ, Totterman SM, Fultz PJ, Judkins AR, Meyers SP, Rubens DJ, Sickel JZ, Rosier RN. Primary lymphoma of bone. Correlation of magnetic resonance imaging features with cytokine production by tumor cells. Cancer. 1995 Feb 15; 75(4):973-80.
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Rosier RN, Teot LA, Hicks DG, Schwartz C, O'Keefe RJ, Puzas JE. Multiple drug resistance in osteosarcoma. Iowa Orthop J. 1995; 15:66-73.
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Dennerstein GJ, Scurry JP, Garland SM, Brenan JA, Fortune DW, Sfameni SF, O'Keefe RJ, Tabrizi SN. Human papillomavirus vulvitis: a new disease or an unfortunate mistake? Br J Obstet Gynaecol. 1994 Nov; 101(11):992-8.
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O'Keefe RJ, Puzas JE, Loveys L, Hicks DG, Rosier RN. Analysis of type II and type X collagen synthesis in cultured growth plate chondrocytes by in situ hybridization: rapid induction of type X collagen in culture. J Bone Miner Res. 1994 Nov; 9(11):1713-22.
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Fraser SH, O'Keefe RJ, Scurry JP, Watkins AM, Drew JH, Chow CW. Hydrocephalus ex vacuo and clasp thumb deformity due to congenital cytomegalovirus infection. J Paediatr Child Health. 1994 Oct; 30(5):450-2.
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Scully SP, Mott MP, Temple HT, O'Keefe RJ, O'Donnell RJ, Mankin HJ. Late recurrence of giant-cell tumor of bone. A report of four cases. J Bone Joint Surg Am. 1994 Aug; 76(8):1231-3.
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O'Keefe RJ, Crabb ID, Puzas JE, Rosier RN. Effects of transforming growth factor-beta 1 and fibroblast growth factor on DNA synthesis in growth plate chondrocytes are enhanced by insulin-like growth factor-I. J Orthop Res. 1994 May; 12(3):299-310.
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Temple HT, Scully SP, O'Keefe RJ, Rosenthal DI, Mankin HJ. Clinical presentation of alveolar soft-part sarcoma. Clin Orthop Relat Res. 1994 Mar; (300):213-8.
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Scully SP, Temple HT, O'Keefe RJ, Gebhardt MC. Case report 830: Aneurysmal bone cyst. Skeletal Radiol. 1994 Feb; 23(2):157-60.
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Puzas JE, Hicks DG, Reynolds SD, O'Keefe RJ. Regulation of osteoclastic activity in infection. Methods Enzymol. 1994; 236:47-58.
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O'Keefe RJ, Jones JA, Hurwitz SR. Bilateral sacroiliac joint fracture-dislocation requiring late coccygectomy: a case report. J Trauma. 1992 Nov; 33(5):793-4.
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O'Keefe RJ, Crabb ID, Puzas JE, Rosier RN. Influence of prostaglandins on DNA and matrix synthesis in growth plate chondrocytes. J Bone Miner Res. 1992 Apr; 7(4):397-404.
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Crabb ID, O'Keefe RJ, Puzas JE, Rosier RN. Differential effects of parathyroid hormone on chick growth plate and articular chondrocytes. Calcif Tissue Int. 1992 Jan; 50(1):61-6.
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Crabb ID, O'Keefe RJ, Puzas JE, Rosier RN. Synergistic effect of transforming growth factor beta and fibroblast growth factor on DNA synthesis in chick growth plate chondrocytes. J Bone Miner Res. 1990 Nov; 5(11):1105-12.
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O'Keefe RJ, Rosier RN, Puzas JE. Differential expression of biological effects in maturationally distinct subpopulations of growth plate chondrocytes. Connect Tissue Res. 1990; 24(1):53-66.
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O'Keefe RJ, Crabb ID, Puzas JE, Rosier RN. Countercurrent centrifugal elutriation. High-resolution method for the separation of growth-plate chondrocytes. J Bone Joint Surg Am. 1989 Apr; 71(4):607-20.
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Rosier RN, O'Keefe RJ, Crabb ID, Puzas JE. Transforming growth factor beta: an autocrine regulator of chondrocytes. Connect Tissue Res. 1989; 20(1-4):295-301.
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O'Keefe RJ, Puzas JE, Brand JS, Rosier RN. Effect of transforming growth factor-beta on DNA synthesis by growth plate chondrocytes: modulation by factors present in serum. Calcif Tissue Int. 1988 Dec; 43(6):352-8.
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O'Keefe RJ, Puzas JE, Brand JS, Rosier RN. Effects of transforming growth factor-beta on matrix synthesis by chick growth plate chondrocytes. Endocrinology. 1988 Jun; 122(6):2953-61.
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O'Keefe RJ, Domalik-Wawrzynski L, Guerrero JL, Rosow CE, Lowenstein E, Powell WJ. Local and neurally mediated effects of sufentanil on canine skeletal muscle vascular resistance. J Pharmacol Exp Ther. 1987 Aug; 242(2):699-706.
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Vanore J, O'Keefe R, Pikscher I. Complications of silicone implants in foot surgery. Clin Podiatry. 1984 Apr; 1(1):175-98.
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