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Fonseca VA, Alvarado-Ruiz R, Raccah D, Boka G, Miossec P, Gerich JE. Efficacy and safety of the once-daily GLP-1 receptor agonist lixisenatide in monotherapy: a randomized, double-blind, placebo-controlled trial in patients with type 2 diabetes (GetGoal-Mono). Diabetes Care. 2012 Jun; 35(6):1225-31.
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Gerich JE, Bastien A. Development of the sodium-glucose co-transporter 2 inhibitor dapagliflozin for the treatment of patients with Type 2 diabetes mellitus. Expert Rev Clin Pharmacol. 2011 Nov; 4(6):669-83.
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Dimitriadis G, Hatziagelaki E, Mitrou P, Lambadiari V, Maratou E, Raptis AE, Gerich JE, Raptis SA. Effect of hyperthyroidism on clearance and secretion of glucagon in man. Exp Clin Endocrinol Diabetes. 2011 Apr; 119(4):214-7.
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Gerich J. DPP-4 inhibitors: what may be the clinical differentiators? Diabetes Res Clin Pract. 2010 Nov; 90(2):131-40.
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Aryangat AV, Gerich JE. Type 2 diabetes: postprandial hyperglycemia and increased cardiovascular risk. Vasc Health Risk Manag. 2010; 6:145-55.
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Gerich JE. Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications. Diabet Med. 2010 Feb; 27(2):136-42.
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Samsom M, Bharucha A, Gerich JE, Herrmann K, Limmer J, Linke R, Maggs D, Schirra J, Vella A, Wörle HJ, Göke B. Diabetes mellitus and gastric emptying: questions and issues in clinical practice. Diabetes Metab Res Rev. 2009 Sep; 25(6):502-14.
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King KB, Gerich JE, Guzick DS, King KU, McDermott MP. Is a history of gestational diabetes related to risk factors for coronary heart disease? Res Nurs Health. 2009 Jun; 32(3):298-306.
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Emerson P, Van Haeften TW, Pimenta W, Plummer E, Woerle HJ, Mitrakou A, Szoke E, Gerich J, Meyer C. Different pathophysiology of impaired glucose tolerance in first-degree relatives of individuals with type 2 diabetes mellitus. Metabolism. 2009 May; 58(5):602-7.
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Zinman B, Gerich J, Buse JB, Lewin A, Schwartz S, Raskin P, Hale PM, Zdravkovic M, Blonde L. Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD). Diabetes Care. 2009 Jul; 32(7):1224-30.
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Woerle HJ, Albrecht M, Linke R, Zschau S, Neumann C, Nicolaus M, Gerich JE, Göke B, Schirra J. Impaired hyperglycemia-induced delay in gastric emptying in patients with type 1 diabetes deficient for islet amyloid polypeptide. Diabetes Care. 2008 Dec; 31(12):2325-31.
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Ceriello A, Colagiuri S, Gerich J, Tuomilehto J. Guideline for management of postmeal glucose. Nutr Metab Cardiovasc Dis. 2008 May; 18(4):S17-33.
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Szoke E, Shrayyef MZ, Messing S, Woerle HJ, van Haeften TW, Meyer C, Mitrakou A, Pimenta W, Gerich JE. Effect of aging on glucose homeostasis: accelerated deterioration of beta-cell function in individuals with impaired glucose tolerance. Diabetes Care. 2008 Mar; 31(3):539-43.
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Gadegbeku CA, Dhandayuthapani A, Taylor TP, Shrayyef Z, Gerich J, Garvey WT, Egan BM. Insulin's actions on plasma free fatty acids are normal in patients with stage 2 to 3 chronic kidney disease. J Am Soc Hypertens. 2007 Nov-Dec; 1(6):414-22.
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Woerle HJ, Albrecht M, Linke R, Zschau S, Neumann C, Nicolaus M, Gerich J, Göke B, Schirra J. Importance of changes in gastric emptying for postprandial plasma glucose fluxes in healthy humans. Am J Physiol Endocrinol Metab. 2008 Jan; 294(1):E103-9.
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Schwarz SL, Gerich JE, Marcellari A, Jean-Louis L, Purkayastha D, Baron MA. Nateglinide, alone or in combination with metformin, is effective and well tolerated in treatment-naïve elderly patients with type 2 diabetes. Diabetes Obes Metab. 2008 Aug; 10(8):652-60.
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Gerich JE, Odawara M, Terauchi Y. The rationale for paired pre- and postprandial self-monitoring of blood glucose: the role of glycemic variability in micro- and macrovascular risk. Curr Med Res Opin. 2007 Aug; 23(8):1791-8.
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Mieszczanska H, Kaba NK, Francis CW, Gerich JE, Dodis R, Schwarz KQ, Phipps RP, Smith BH, Lee M, Messing S, Taubman MB. Effects of pioglitazone on fasting and postprandial levels of lipid and hemostatic variables in overweight non-diabetic patients with coronary artery disease. J Thromb Haemost. 2007 May; 5(5):942-9.
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Dunning BE, Gerich JE. The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications. Endocr Rev. 2007 May; 28(3):253-83.
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Woerle HJ, Neumann C, Zschau S, Tenner S, Irsigler A, Schirra J, Gerich JE, Göke B. Impact of fasting and postprandial glycemia on overall glycemic control in type 2 diabetes Importance of postprandial glycemia to achieve target HbA1c levels. Diabetes Res Clin Pract. 2007 Aug; 77(2):280-5.
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Gerich JE. Type 2 diabetes mellitus is associated with multiple cardiometabolic risk factors. Clin Cornerstone. 2007; 8(3):53-68.
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Meyer C, Pimenta W, Woerle HJ, Van Haeften T, Szoke E, Mitrakou A, Gerich J. Different mechanisms for impaired fasting glucose and impaired postprandial glucose tolerance in humans. Diabetes Care. 2006 Aug; 29(8):1909-14.
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Gerich JE. Clinicians can help their patients control postprandial hyperglycemia as a means of reducing cardiovascular risk. Diabetes Educ. 2006 Jul-Aug; 32(4):513-4, 520-2.
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Israelian Z, Szoke E, Woerle J, Bokhari S, Schorr M, Schwenke DC, Cryer PE, Gerich JE, Meyer C. Multiple defects in counterregulation of hypoglycemia in modestly advanced type 2 diabetes mellitus. Metabolism. 2006 May; 55(5):593-8.
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Gerich J, Becker RH, Zhu R, Bolli GB. Fluctuation of serum basal insulin levels following single and multiple dosing of insulin glargine. Diabetes Technol Ther. 2006 Apr; 8(2):237-43.
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Szoke E, Gosmanov NR, Sinkin JC, Nihalani A, Fender AB, Cryer PE, Meyer C, Gerich JE. Effects of glimepiride and glyburide on glucose counterregulation and recovery from hypoglycemia. Metabolism. 2006 Jan; 55(1):78-83.
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Gerich JE. Glycemic control in the metabolic syndrome and implications in preventing cardiovascular disease. Metab Syndr Relat Disord. 2006; 4(4):315-27.
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Gerich JE. Postprandial hyperglycemia and cardiovascular disease. Endocr Pract. 2006 Jan-Feb; 12 Suppl 1:47-51.
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Israelian Z, Gosmanov NR, Szoke E, Schorr M, Bokhari S, Cryer PE, Gerich JE, Meyer C. Increasing the decrement in insulin secretion improves glucagon responses to hypoglycemia in advanced type 2 diabetes. Diabetes Care. 2005 Nov; 28(11):2691-6.
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Meyer C, Saar P, Soydan N, Eckhard M, Bretzel RG, Gerich J, Linn T. A potential important role of skeletal muscle in human counterregulation of hypoglycemia. J Clin Endocrinol Metab. 2005 Nov; 90(11):6244-50.
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Gerich JE. The importance of tight glycemic control. Am J Med. 2005 Sep; 118(Suppl 9A):7S-11S.
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Gerich J, Raskin P, Jean-Louis L, Purkayastha D, Baron MA. PRESERVE-beta: two-year efficacy and safety of initial combination therapy with nateglinide or glyburide plus metformin. Diabetes Care. 2005 Sep; 28(9):2093-9.
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Woerle HJ, Szoke E, Meyer C, Dostou JM, Wittlin SD, Gosmanov NR, Welle SL, Gerich JE. Mechanisms for abnormal postprandial glucose metabolism in type 2 diabetes. Am J Physiol Endocrinol Metab. 2006 Jan; 290(1):E67-E77.
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Skyler JS, Weinstock RS, Raskin P, Yale JF, Barrett E, Gerich JE, Gerstein HC. Use of inhaled insulin in a basal/bolus insulin regimen in type 1 diabetic subjects: a 6-month, randomized, comparative trial. Diabetes Care. 2005 Jul; 28(7):1630-5.
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Gosmanov NR, Szoke E, Israelian Z, Smith T, Cryer PE, Gerich JE, Meyer C. Role of the decrement in intraislet insulin for the glucagon response to hypoglycemia in humans. Diabetes Care. 2005 May; 28(5):1124-31.
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Szoke E, Gerich JE. Role of impaired insulin secretion and insulin resistance in the pathogenesis of type 2 diabetes mellitus. Compr Ther. 2005; 31(2):106-12.
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Fonseca VA, Kelley DE, Cefalu W, Baron MA, Purkayastha D, Nestler JE, Hsia S, Gerich JE. Hypoglycemic potential of nateglinide versus glyburide in patients with type 2 diabetes mellitus. Metabolism. 2004 Oct; 53(10):1331-5.
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Meyer C, Woerle HJ, Gerich J. Paradoxical changes of muscle glutamine release during hyperinsulinemia euglycemia and hypoglycemia in humans: further evidence for the glucose-glutamine cycle. Metabolism. 2004 Sep; 53(9):1208-14.
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Gerich JE, Dailey G. Advances in diabetes for the millennium: understanding insulin resistance. MedGenMed. 2004; 6(3 Suppl):11.
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Meyer C, Woerle HJ, Dostou JM, Welle SL, Gerich JE. Abnormal renal, hepatic, and muscle glucose metabolism following glucose ingestion in type 2 diabetes. Am J Physiol Endocrinol Metab. 2004 Dec; 287(6):E1049-56.
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Woerle HJ, Pimenta WP, Meyer C, Gosmanov NR, Szoke E, Szombathy T, Mitrakou A, Gerich JE. Diagnostic and therapeutic implications of relationships between fasting, 2-hour postchallenge plasma glucose and hemoglobin a1c values. Arch Intern Med. 2004 Aug 9-23; 164(15):1627-32.
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Gerich JE. Insulin glargine: long-acting basal insulin analog for improved metabolic control. Curr Med Res Opin. 2004 Jan; 20(1):31-7.
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Riddle MC, Rosenstock J, Gerich J. The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients. Diabetes Care. 2003 Nov; 26(11):3080-6.
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Meyer C, Stumvoll M, Welle S, Woerle HJ, Haymond M, Gerich J. Relative importance of liver, kidney, and substrates in epinephrine-induced increased gluconeogenesis in humans. Am J Physiol Endocrinol Metab. 2003 Oct; 285(4):E819-26.
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Gerich JE. Clinical significance, pathogenesis, and management of postprandial hyperglycemia. Arch Intern Med. 2003 Jun 9; 163(11):1306-16.
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Woerle HJ, Meyer C, Popa EM, Cryer PE, Gerich JE. Renal compensation for impaired hepatic glucose release during hypoglycemia in type 2 diabetes: further evidence for hepatorenal reciprocity. Diabetes. 2003 Jun; 52(6):1386-92.
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Woerle HJ, Mariuz PR, Meyer C, Reichman RC, Popa EM, Dostou JM, Welle SL, Gerich JE. Mechanisms for the deterioration in glucose tolerance associated with HIV protease inhibitor regimens. Diabetes. 2003 Apr; 52(4):918-25.
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Gerich JE. Contributions of insulin-resistance and insulin-secretory defects to the pathogenesis of type 2 diabetes mellitus. Mayo Clin Proc. 2003 Apr; 78(4):447-56.
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Pimenta WP, Santos ML, Cruz NS, Aragon FF, Padovani CR, Gerich JE. Insulin secretion, insulin sensitivity, and hepatic insulin extraction in first-degree relatives of type 2 diabetic patients. Braz J Med Biol Res. 2003 Mar; 36(3):301-8.
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Woerle HJ, Meyer C, Dostou JM, Gosmanov NR, Islam N, Popa E, Wittlin SD, Welle SL, Gerich JE. Pathways for glucose disposal after meal ingestion in humans. Am J Physiol Endocrinol Metab. 2003 Apr; 284(4):E716-25.
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Pimenta WP, Santos ML, Cruz NS, Aragon FF, Padovani CR, Gerich JE. Brazilian individuals with impaired glucose tolerance are characterized by impaired insulin secretion. Diabetes Metab. 2002 Dec; 28(6 Pt 1):468-76.
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Woerle HJ, Popa E, Dostou J, Welle S, Gerich J, Meyer C. Exogenous insulin replacement in type 2 diabetes reverses excessive hepatic glucose release, but not excessive renal glucose release and impaired free fatty acid clearance. Metabolism. 2002 Nov; 51(11):1494-500.
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Fritsche A, Tschritter O, Häring H, Gerich J, Stumvoll M. The role of beta-adrenergic sensitivity in the pathogenesis of hypoglycaemia unawareness. Diabetes Nutr Metab. 2002 Oct; 15(5):357-61; discussion 361-2.
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Gerich JE. Hepatorenal glucose reciprocity in physiologic and pathologic conditions. Diabetes Nutr Metab. 2002 Oct; 15(5):298-302; discussion 302-3.
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Toft I, Gerich JE, Jenssen T. Autoregulation of endogenous glucose production during hyperglucagonemia. Metabolism. 2002 Sep; 51(9):1128-34.
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Gerich JE. Novel insulins: expanding options in diabetes management. Am J Med. 2002 Sep; 113(4):308-16.
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Korytkowski M, Thomas A, Reid L, Tedesco MB, Gooding WE, Gerich J. Glimepiride improves both first and second phases of insulin secretion in type 2 diabetes. Diabetes Care. 2002 Sep; 25(9):1607-11.
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Gerich JE. Redefining the clinical management of type 2 diabetes: matching therapy to pathophysiology. Eur J Clin Invest. 2002 Jun; 32 Suppl 3:46-53.
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Meyer C, Gerich JE. Role of the kidney in hyperglycemia in type 2 diabetes. Curr Diab Rep. 2002 Jun; 2(3):237-41.
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van Haeften TW, Pimenta W, Mitrakou A, Korytkowski M, Jenssen T, Yki-Jarvinen H, Gerich JE. Disturbances in beta-cell function in impaired fasting glycemia. Diabetes. 2002 Feb; 51 Suppl 1:S265-70.
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Meyer C, Dostou JM, Welle SL, Gerich JE. Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis. Am J Physiol Endocrinol Metab. 2002 Feb; 282(2):E419-27.
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Meyer C, Stumvoll M, Dostou J, Welle S, Haymond M, Gerich J. Renal substrate exchange and gluconeogenesis in normal postabsorptive humans. Am J Physiol Endocrinol Metab. 2002 Feb; 282(2):E428-34.
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Gerich JE. Is reduced first-phase insulin release the earliest detectable abnormality in individuals destined to develop type 2 diabetes? Diabetes. 2002 Feb; 51 Suppl 1:S117-21.
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Fritsche A, Stefan N, Häring H, Gerich J, Stumvoll M. Avoidance of hypoglycemia restores hypoglycemia awareness by increasing beta-adrenergic sensitivity in type 1 diabetes. Ann Intern Med. 2001 May 1; 134(9 Pt 1):729-36.
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Gerich JE. Matching treatment to pathophysiology in type 2 diabetes. Clin Ther. 2001 May; 23(5):646-59; discussion 645.
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Gerich JE. Measurements of renal glucose release. Diabetes. 2001 Apr; 50(4):905.
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Stumvoll M, Van Haeften T, Fritsche A, Gerich J. Oral glucose tolerance test indexes for insulin sensitivity and secretion based on various availabilities of sampling times. Diabetes Care. 2001 Apr; 24(4):796-7.
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Stumvoll M, Gerich J. Clinical features of insulin resistance and beta cell dysfunction and the relationship to type 2 diabetes. Clin Lab Med. 2001 Mar; 21(1):31-51.
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Gerich JE, Meyer C, Woerle HJ, Stumvoll M. Renal gluconeogenesis: its importance in human glucose homeostasis. Diabetes Care. 2001 Feb; 24(2):382-91.
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Dostou J, Gerich J. Pathogenesis of type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes. 2001; 109 Suppl 2:S149-56.
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Gerich JE. Hypoglycaemia and counterregulation in type 2 diabetes. Lancet. 2000 Dec 9; 356(9246):1946-7.
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Gerich JE. Physiology of glucose homeostasis. Diabetes Obes Metab. 2000 Dec; 2(6):345-50.
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Gerich JE. Addressing the insulin secretion defect: a logical first-line approach. Metabolism. 2000 Oct; 49(10 Suppl 2):12-6.
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van Haeften TW, Pimenta W, Mitrakou A, Korytkowski M, Jenssen T, Yki-Jarvinen H, Gerich JE. Relative conributions of beta-cell function and tissue insulin sensitivity to fasting and postglucose-load glycemia. Metabolism. 2000 Oct; 49(10):1318-25.
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Stumvoll M, Mitrakou A, Pimenta W, Jenssen T, Yki-Järvinen H, Van Haeften T, Häring H, Fritsche A, Gerich J. Assessment of insulin secretion from the oral glucose tolerance test in white patients with type 2 diabetes. Diabetes Care. 2000 Sep; 23(9):1440-1.
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Gerich JE. Insulin resistance is not necessarily an essential component of type 2 diabetes. J Clin Endocrinol Metab. 2000 Jun; 85(6):2113-5.
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Gerich JE, Meyer C, Stumvoll MW. Hormonal control of renal and systemic glutamine metabolism. J Nutr. 2000 Apr; 130(4S Suppl):995S-1001S.
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Stumvoll M, Mitrakou A, Pimenta W, Jenssen T, Yki-Järvinen H, Van Haeften T, Renn W, Gerich J. Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care. 2000 Mar; 23(3):295-301.
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Fritsche A, Stumvoll M, Häring HU, Gerich JE. Reversal of hypoglycemia unawareness in a long-term type 1 diabetic patient by improvement of beta-adrenergic sensitivity after prevention of hypoglycemia. J Clin Endocrinol Metab. 2000 Feb; 85(2):523-5.
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Gerich JE. Is insulin resistance the principal cause of type 2 diabetes? Diabetes Obes Metab. 1999 Sep; 1(5):257-63.
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Stumvoll M, Meyer C, Mitrakou A, Gerich JE. Important role of the kidney in human carbohydrate metabolism. Med Hypotheses. 1999 May; 52(5):363-6.
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Meyer C, Dostou JM, Gerich JE. Role of the human kidney in glucose counterregulation. Diabetes. 1999 May; 48(5):943-8.
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Stumvoll M, Perriello G, Meyer C, Gerich J. Role of glutamine in human carbohydrate metabolism in kidney and other tissues. Kidney Int. 1999 Mar; 55(3):778-92.
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Meyer C, Dostou J, Nadkarni V, Gerich J. Effects of physiological hyperinsulinemia on systemic, renal, and hepatic substrate metabolism. Am J Physiol. 1998 Dec; 275(6 Pt 2):F915-21.
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Korytkowski MT, Mokan M, Veneman TF, Mitrakou A, Cryer PE, Gerich JE. Reduced beta-adrenergic sensitivity in patients with type 1 diabetes and hypoglycemia unawareness. Diabetes Care. 1998 Nov; 21(11):1939-43.
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Meyer C, Grossmann R, Mitrakou A, Mahler R, Veneman T, Gerich J, Bretzel RG. Effects of autonomic neuropathy on counterregulation and awareness of hypoglycemia in type 1 diabetic patients. Diabetes Care. 1998 Nov; 21(11):1960-6.
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Stumvoll M, Meyer C, Kreider M, Perriello G, Gerich J. Effects of glucagon on renal and hepatic glutamine gluconeogenesis in normal postabsorptive humans. Metabolism. 1998 Oct; 47(10):1227-32.
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Jones CE, Koshibu K, DeCambre M, Gerich JE, Bessey PQ, Krusch DA. The Kidney's role in glucose balance following partial hepatectomy. J Surg Res. 1998 Oct; 79(2):136-40.
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Fritsche A, Stumvoll M, Grüb M, Sieslack S, Renn W, Schmülling RM, Häring HU, Gerich JE. Effect of hypoglycemia on beta-adrenergic sensitivity in normal and type 1 diabetic subjects. Diabetes Care. 1998 Sep; 21(9):1505-10.
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Gerich JE. The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity. Endocr Rev. 1998 Aug; 19(4):491-503.
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Meyer C, Stumvoll M, Nadkarni V, Dostou J, Mitrakou A, Gerich J. Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus. J Clin Invest. 1998 Aug 1; 102(3):619-24.
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Meyer C, Hering BJ, Grossmann R, Brandhorst H, Brandhorst D, Gerich J, Federlin K, Bretzel RG. Improved glucose counterregulation and autonomic symptoms after intraportal islet transplants alone in patients with long-standing type I diabetes mellitus. Transplantation. 1998 Jul 27; 66(2):233-40.
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Stumvoll M, Meyer C, Perriello G, Kreider M, Welle S, Gerich J. Human kidney and liver gluconeogenesis: evidence for organ substrate selectivity. Am J Physiol. 1998 May; 274(5 Pt 1):E817-26.
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Gerich JE. Metabolic abnormalities in impaired glucose tolerance. Metabolism. 1997 Dec; 46(12 Suppl 1):40-3.
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Meyer C, Robson D, Rackovsky N, Nadkarni V, Gerich J. Role of the kidney in human leptin metabolism. Am J Physiol. 1997 Nov; 273(5 Pt 1):E903-7.
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Meyer C, Nadkarni V, Stumvoll M, Gerich J. Human kidney free fatty acid and glucose uptake: evidence for a renal glucose-fatty acid cycle. Am J Physiol. 1997 Sep; 273(3 Pt 1):E650-4.
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Stumvoll M, Meyer C, Mitrakou A, Nadkarni V, Gerich JE. Renal glucose production and utilization: new aspects in humans. Diabetologia. 1997 Jul; 40(7):749-57.
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Kreider ME, Stumvoll M, Meyer C, Overkamp D, Welle S, Gerich J. Steady-state and non-steady-state measurements of plasma glutamine turnover in humans. Am J Physiol. 1997 Apr; 272(4 Pt 1):E621-7.
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Perriello G, Nurjhan N, Stumvoll M, Bucci A, Welle S, Dailey G, Bier DM, Toft I, Jenssen TG, Gerich JE. Regulation of gluconeogenesis by glutamine in normal postabsorptive humans. Am J Physiol. 1997 Mar; 272(3 Pt 1):E437-45.
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Gerich JE. Pathogenesis and treatment of type 2 (noninsulin-dependent) diabetes mellitus (NIDDM). Horm Metab Res. 1996 Sep; 28(9):404-12.
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Pimenta W, Mitrakou A, Jensen T, Yki-Järvinen H, Daily G, Gerich J. Insulin secretion and insulin sensitivity in people with impaired glucose tolerance. Diabet Med. 1996 Sep; 13(9 Suppl 6):S33-6.
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Stumvoll M, Perriello G, Nurjhan N, Bucci A, Welle S, Jansson PA, Dailey G, Bier D, Jenssen T, Gerich J. Glutamine and alanine metabolism in NIDDM. Diabetes. 1996 Jul; 45(7):863-8.
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Stumvoll M, Chintalapudi U, Perriello G, Welle S, Gutierrez O, Gerich J. Uptake and release of glucose by the human kidney. Postabsorptive rates and responses to epinephrine. J Clin Invest. 1995 Nov; 96(5):2528-33.
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Perriello G, Jorde R, Nurjhan N, Stumvoll M, Dailey G, Jenssen T, Bier DM, Gerich JE. Estimation of glucose-alanine-lactate-glutamine cycles in postabsorptive humans: role of skeletal muscle. Am J Physiol. 1995 Sep; 269(3 Pt 1):E443-50.
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Stumvoll M, Nurjhan N, Perriello G, Dailey G, Gerich JE. Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. N Engl J Med. 1995 Aug 31; 333(9):550-4.
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Pimenta W, Korytkowski M, Mitrakou A, Jenssen T, Yki-Jarvinen H, Evron W, Dailey G, Gerich J. Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM. Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative. JAMA. 1995 Jun 21; 273(23):1855-61.
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Nurjhan N, Bucci A, Perriello G, Stumvoll M, Dailey G, Bier DM, Toft I, Jenssen TG, Gerich JE. Glutamine: a major gluconeogenic precursor and vehicle for interorgan carbon transport in man. J Clin Invest. 1995 Jan; 95(1):272-7.
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Mokan M, Mitrakou A, Veneman T, Ryan C, Korytkowski M, Cryer P, Gerich J. Hypoglycemia unawareness in IDDM. Diabetes Care. 1994 Dec; 17(12):1397-403.
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Veneman T, Mitrakou A, Mokan M, Cryer P, Gerich J. Effect of hyperketonemia and hyperlacticacidemia on symptoms, cognitive dysfunction, and counterregulatory hormone responses during hypoglycemia in normal humans. Diabetes. 1994 Nov; 43(11):1311-7.
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Pimenta W, Nurjhan N, Jansson PA, Stumvoll M, Gerich J, Korytkowski M. Glycogen: its mode of formation and contribution to hepatic glucose output in postabsorptive humans. Diabetologia. 1994 Jul; 37(7):697-702.
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Jansson PA, Veneman T, Nurjhan N, Gerich J. An improved method to calculate adipose tissue interstitial substrate recovery for microdialysis studies. Life Sci. 1994; 54(21):1621-4.
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Fanelli C, Calderone S, Epifano L, De Vincenzo A, Modarelli F, Pampanelli S, Perriello G, De Feo P, Brunetti P, Gerich JE, et al. Demonstration of a critical role for free fatty acids in mediating counterregulatory stimulation of gluconeogenesis and suppression of glucose utilization in humans. J Clin Invest. 1993 Oct; 92(4):1617-22.
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Consoli A, Gerich JE. Corrigendum for limitations in the use of [2-14C]acetate for measuring gluconeogenesis in vivo. Diabetes. 1993 Sep; 42(9):1381-2.
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Veneman T, Mitrakou A, Mokan M, Cryer P, Gerich J. Induction of hypoglycemia unawareness by asymptomatic nocturnal hypoglycemia. Diabetes. 1993 Sep; 42(9):1233-7.
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Jenssen T, Nurjhan N, Consoli A, Gerich JE. Dose-response effects of lactate infusions on gluconeogenesis from lactate in normal man. Eur J Clin Invest. 1993 Aug; 23(8):448-54.
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Gerich JE. Control of glycaemia. Baillieres Clin Endocrinol Metab. 1993 Jul; 7(3):551-86.
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Consoli A, Nurjhan N, Capani F, Pangburn T, Lapenna D, Gerich J. Limitations in the use of [2-14C]acetate for measuring gluconeogenesis in vivo. Diabetes. 1993 May; 42(5):732-7.
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Mitrakou A, Mokan M, Ryan C, Veneman T, Cryer P, Gerich J. Influence of plasma glucose rate of decrease on hierarchy of responses to hypoglycemia. J Clin Endocrinol Metab. 1993 Feb; 76(2):462-5.
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Consoli A, Gerich JE, Bier DM. Ketone and lactate metabolism: an exchange of conclusions. Metabolism. 1993 Feb; 42(2):262-6.
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Heiling VJ, Campbell PJ, Gottesman IS, Tsalikian E, Beaufrere B, Gerich JE, Haymond MW. Differential effects of hyperglycemia and hyperinsulinemia on leucine rate of appearance in normal humans. J Clin Endocrinol Metab. 1993 Jan; 76(1):203-6.
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Gerich JE, Nurjhan N. Gluconeogenesis in type 2 diabetes. Adv Exp Med Biol. 1993; 334:253-8.
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Dinneen S, Gerich J, Rizza R. Carbohydrate metabolism in non-insulin-dependent diabetes mellitus. N Engl J Med. 1992 Sep 3; 327(10):707-13.
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Gerich JE. Unawareness of hypoglycaemia and human insulin. BMJ. 1992 Aug 8; 305(6849):324-5.
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Mokan M, Gerich JE. A simple insulin infusion algorithm for establishing and maintaining overnight near-normoglycemia in type I and type II diabetes. J Clin Endocrinol Metab. 1992 Apr; 74(4):943-5.
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Consoli A, Nurjahan N, Gerich JE, Mandarino LJ. Skeletal muscle is a major site of lactate uptake and release during hyperinsulinemia. Metabolism. 1992 Feb; 41(2):176-9.
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Mitrakou A, Mokan M, Bolli G, Veneman T, Jenssen T, Cryer P, Gerich J. Evidence against the hypothesis that hyperinsulinemia increases sympathetic nervous system activity in man. Metabolism. 1992 Feb; 41(2):198-200.
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Mitrakou A, Kelley D, Mokan M, Veneman T, Pangburn T, Reilly J, Gerich J. Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N Engl J Med. 1992 Jan 2; 326(1):22-9.
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Gerich JE. Role of liver and muscle in type II diabetes. Horm Metab Res Suppl. 1992; 26:18-21.
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Nurjhan N, Consoli A, Gerich J. Increased lipolysis and its consequences on gluconeogenesis in non-insulin-dependent diabetes mellitus. J Clin Invest. 1992 Jan; 89(1):169-75.
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De Feo P, Perriello G, Torlone E, Fanelli C, Ventura MM, Santeusanio F, Brunetti P, Gerich JE, Bolli GB. Contribution of adrenergic mechanisms to glucose counterregulation in humans. Am J Physiol. 1991 Dec; 261(6 Pt 1):E725-36.
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Gerich JE, Mokan M, Veneman T, Korytkowski M, Mitrakou A. Hypoglycemia unawareness. Endocr Rev. 1991 Nov; 12(4):356-71.
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Durrant JD, Gerich JE, Mitrakou A, Jenssen T, Hyre RJ. Changes in BAEP under hypoglycemia: temperature-related? Electroencephalogr Clin Neurophysiol. 1991 Nov-Dec; 80(6):547-50.
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Gerich JE. Is muscle the major site of insulin resistance in type 2 (non-insulin-dependent) diabetes mellitus? Diabetologia. 1991 Aug; 34(8):607-10.
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van Haeften TW, Veneman TF, Gerich JE, van der Veen EA. Influence of gliclazide on glucose-stimulated insulin release in man. Metabolism. 1991 Jul; 40(7):751-5.
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Van Haeften TW, Van Maarschalkerweerd WW, Gerich JE, Van der Veen EA. Decreased insulin secretory capacity and normal pancreatic B-cell glucose sensitivity in non-obese patients with NIDDM. Eur J Clin Invest. 1991 Apr; 21(2):168-74.
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Mitrakou A, Jones R, Okuda Y, Pena J, Nurjhan N, Field JB, Gerich JE. Pathway and carbon sources for hepatic glycogen repletion in dogs. Am J Physiol. 1991 Feb; 260(2 Pt 1):E194-202.
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De Feo P, Perriello G, Torlone E, Fanelli C, Ventura MM, Santeusanio F, Brunetti P, Gerich JE, Bolli GB. Evidence against important catecholamine compensation for absent glucagon counterregulation. Am J Physiol. 1991 Feb; 260(2 Pt 1):E203-12.
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Mitrakou A, Ryan C, Veneman T, Mokan M, Jenssen T, Kiss I, Durrant J, Cryer P, Gerich J. Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction. Am J Physiol. 1991 Jan; 260(1 Pt 1):E67-74.
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Miles JM, Cattalini M, Sharbrough FW, Wold LE, Wharen RE, Gerich JE, Haymond MW. Metabolic and neurologic effects of an intravenous medium-chain triglyceride emulsion. JPEN J Parenter Enteral Nutr. 1991 Jan-Feb; 15(1):37-41.
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van Haeften TW, Boonstra E, Veneman TF, Gerich JE, van der Veen EA. Dose-response characteristics for glucose-stimulated insulin release in man and assessment of influence of glucose on arginine-stimulated insulin release. Metabolism. 1990 Dec; 39(12):1292-9.
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Consoli A, Nurjhan N, Reilly JJ, Bier DM, Gerich JE. Mechanism of increased gluconeogenesis in noninsulin-dependent diabetes mellitus. Role of alterations in systemic, hepatic, and muscle lactate and alanine metabolism. J Clin Invest. 1990 Dec; 86(6):2038-45.
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Mitrakou A, Kelley D, Veneman T, Jenssen T, Pangburn T, Reilly J, Gerich J. Contribution of abnormal muscle and liver glucose metabolism to postprandial hyperglycemia in NIDDM. Diabetes. 1990 Nov; 39(11):1381-90.
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Consoli A, Nurjhan N, Reilly JJ, Bier DM, Gerich JE. Contribution of liver and skeletal muscle to alanine and lactate metabolism in humans. Am J Physiol. 1990 Nov; 259(5 Pt 1):E677-84.
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Gerich JE. Role of somatostatin and its analogues in the pathogenesis and treatment of diabetes mellitus. Metabolism. 1990 Sep; 39(9 Suppl 2):52-4.
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Virkamäki A, Puhakainen I, Nurjhan N, Gerich JE, Yki-Järvinen H. Measurement of lactate formation from glucose using [6-3H]- and [6-14C]glucose in humans. Am J Physiol. 1990 Sep; 259(3 Pt 1):E397-404.
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Jenssen T, Nurjhan N, Consoli A, Gerich JE. Failure of substrate-induced gluconeogenesis to increase overall glucose appearance in normal humans. Demonstration of hepatic autoregulation without a change in plasma glucose concentration. J Clin Invest. 1990 Aug; 86(2):489-97.
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Campbell PJ, Gerich JE. Impact of obesity on insulin action in volunteers with normal glucose tolerance: demonstration of a threshold for the adverse effect of obesity. J Clin Endocrinol Metab. 1990 Apr; 70(4):1114-8.
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Lecavalier L, Bolli G, Gerich J. Glucagon-cortisol interactions on glucose turnover and lactate gluconeogenesis in normal humans. Am J Physiol. 1990 Apr; 258(4 Pt 1):E569-75.
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Gerich JE, Mitrakou A, Kelley D, Mandarino L, Nurjhan N, Reilly J, Jenssen T, Veneman T, Consoli A. Contribution of impaired muscle glucose clearance to reduced postabsorptive systemic glucose clearance in NIDDM. Diabetes. 1990 Feb; 39(2):211-6.
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Gerich JE. Role of liver in the pathogenesis of type II diabetes. Adv Second Messenger Phosphoprotein Res. 1990; 24:507-10.
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Stanko RT, Mitrakou A, Greenawalt K, Gerich J. Effect of dihydroxyacetone and pyruvate on plasma glucose concentration and turnover in noninsulin-dependent diabetes mellitus. Clin Physiol Biochem. 1990; 8(6):283-8.
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Gerich JE. Oral hypoglycemic agents. N Engl J Med. 1989 Nov 2; 321(18):1231-45.
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Beaufrere B, Horber FF, Schwenk WF, Marsh HM, Matthews D, Gerich JE, Haymond MW. Glucocorticosteroids increase leucine oxidation and impair leucine balance in humans. Am J Physiol. 1989 Nov; 257(5 Pt 1):E712-21.
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van Haeften TW, Voetberg GA, Gerich JE, van der Veen EA. Dose-response characteristics for arginine-stimulated insulin secretion in man and influence of hyperglycemia. J Clin Endocrinol Metab. 1989 Nov; 69(5):1059-64.
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Heinemann L, Sonnenberg GE, Hohmann A, Ritzenhoff A, Berger M, Benn J, Sönksen P, Kelley D, Gerich J, Aoki T, et al. Pulsatile insulin infusion and glucose-homeostasis in well-controlled type 1 (insulin-dependent) diabetic patients. J Intern Med. 1989 Nov; 226(5):325-30.
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Benn JJ, Bozzard SJ, Kelley D, Mitrakou A, Aoki T, Sorensen J, Gerich J, Sonksen PH. Persistent abnormalities of the metabolism of an oral glucose load in insulin-treated type I diabetics. Metabolism. 1989 Nov; 38(11):1047-55.
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Nurjhan N, Consoli A, Gerich J. Isotopic estimation of plasma glucose conversion to plasma lactate using [6-3H]glucose and [6-14C]glucose. Proc Soc Exp Biol Med. 1989 Oct; 192(1):43-6.
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Cryer PE, Binder C, Bolli GB, Cherrington AD, Gale EA, Gerich JE, Sherwin RS. Hypoglycemia in IDDM. Diabetes. 1989 Sep; 38(9):1193-9.
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De Feo P, Perriello G, Torlone E, Ventura MM, Fanelli C, Santeusanio F, Brunetti P, Gerich JE, Bolli GB. Contribution of cortisol to glucose counterregulation in humans. Am J Physiol. 1989 Jul; 257(1 Pt 1):E35-42.
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Yki-Järvinen H, Consoli A, Nurjhan N, Young AA, Gerich JE. Mechanism for underestimation of isotopically determined glucose disposal. Diabetes. 1989 Jun; 38(6):744-51.
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Lecavalier L, Bolli G, Cryer P, Gerich J. Contributions of gluconeogenesis and glycogenolysis during glucose counterregulation in normal humans. Am J Physiol. 1989 Jun; 256(6 Pt 1):E844-51.
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De Feo P, Perriello G, Torlone E, Ventura MM, Santeusanio F, Brunetti P, Gerich JE, Bolli GB. Demonstration of a role for growth hormone in glucose counterregulation. Am J Physiol. 1989 Jun; 256(6 Pt 1):E835-43.
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Consoli A, Nurjhan N, Capani F, Gerich J. Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM. Diabetes. 1989 May; 38(5):550-7.
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Mitrakou A, Milde J, Michenfelder J, Gerich J. Rates of lactate appearance and disappearance and brain lactate balance after oral glucose in the dog. Horm Metab Res. 1989 May; 21(5):236-9.
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Consoli A, Nurjhan N, Gerich J. Rates of appearance and disappearance of plasma lactate after oral glucose: implications for indirect-pathway hepatic glycogen repletion in man. Clin Physiol Biochem. 1989; 7(2):70-8.
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Gerich JE. Lilly lecture 1988. Glucose counterregulation and its impact on diabetes mellitus. Diabetes. 1988 Dec; 37(12):1608-17.
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Perriello G, De Feo P, Torlone E, Calcinaro F, Ventura MM, Basta G, Santeusanio F, Brunetti P, Gerich JE, Bolli GB. The effect of asymptomatic nocturnal hypoglycemia on glycemic control in diabetes mellitus. N Engl J Med. 1988 Nov 10; 319(19):1233-9.
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Jensen MD, Miles JM, Gerich JE, Cryer PE, Haymond MW. Preservation of insulin effects on glucose production and proteolysis during fasting. Am J Physiol. 1988 Jun; 254(6 Pt 1):E700-7.
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Tessari P, Pehling G, Nissen SL, Gerich JE, Service FJ, Rizza RA, Haymond MW. Regulation of whole-body leucine metabolism with insulin during mixed-meal absorption in normal and diabetic humans. Diabetes. 1988 May; 37(5):512-9.
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Gerich JE. Role of insulin resistance in the pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus. Baillieres Clin Endocrinol Metab. 1988 May; 2(2):307-26.
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Kennedy FP, Gerich JE. Alpha-glucosidase inhibition and timing of preprandial insulin in patients with insulin-dependent diabetes mellitus (IDDM). Diabetes Res Clin Pract. 1988 Apr 6; 4(4):309-12.
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Nurjhan N, Kennedy F, Consoli A, Martin C, Miles J, Gerich J. Quantification of the glycolytic origin of plasma glycerol: implications for the use of the rate of appearance of plasma glycerol as an index of lipolysis in vivo. Metabolism. 1988 Apr; 37(4):386-9.
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Gerich JE, Campbell PJ. Overview of counterregulation and its abnormalities in diabetes mellitus and other conditions. Diabetes Metab Rev. 1988 Mar; 4(2):93-111.
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McMahon M, Gerich J, Rizza R. Effects of glucocorticoids on carbohydrate metabolism. Diabetes Metab Rev. 1988 Feb; 4(1):17-30.
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Clutter WE, Rizza RA, Gerich JE, Cryer PE. Regulation of glucose metabolism by sympathochromaffin catecholamines. Diabetes Metab Rev. 1988 Feb; 4(1):1-15.
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Bolli GB, Gottesman IS, Gerich JE. Preliminary experience on treatment of insulin-dependent diabetes mellitus with a long-acting somatostatin analogue (L363,586). Horm Res. 1988; 29(2-3):95-8.
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Gerich JE, Campbell PJ, Kennedy FP. Non-beta-cell islet abnormalities in noninsulin-dependent diabetes mellitus. Prog Clin Biol Res. 1988; 265:133-50.
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Campbell PJ, Mandarino LJ, Gerich JE. Quantification of the relative impairment in actions of insulin on hepatic glucose production and peripheral glucose uptake in non-insulin-dependent diabetes mellitus. Metabolism. 1988 Jan; 37(1):15-21.
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Campbell PJ, Gerich JE. Mechanisms for prevention, development, and reversal of hypoglycemia. Adv Intern Med. 1988; 33:205-30.
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Opara E, Kutlu M, van Haeften T, Kennedy FP, Gerich JE. Effect of internalization and degradation of insulin on rat adipocyte insulin receptor binding kinetics. Clin Physiol Biochem. 1988; 6(1):1-11.
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Kennedy FP, Go VL, Cryer PE, Bolli GB, Gerich JE. Subnormal pancreatic polypeptide and epinephrine responses to insulin-induced hypoglycemia identify patients with insulin-dependent diabetes mellitus predisposed to develop overt autonomic neuropathy. Ann Intern Med. 1988 Jan; 108(1):54-8.
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Campbell PJ, Bolli GB, Gerich JE. Prevention of the Dawn phenomenon (early morning hyperglycemia) in insulin-dependent diabetes mellitus by bedtime intranasal administration of a long-acting somatostatin analog. Metabolism. 1988 Jan; 37(1):34-7.
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Consoli A, Kennedy F, Miles J, Gerich J. Determination of Krebs cycle metabolic carbon exchange in vivo and its use to estimate the individual contributions of gluconeogenesis and glycogenolysis to overall glucose output in man. J Clin Invest. 1987 Nov; 80(5):1303-10.
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Kennedy FP, Gerich JE. A new alpha-glucosidase inhibitor (Bay-m-1099) reduces insulin requirements with meals in insulin-dependent diabetes mellitus. Clin Pharmacol Ther. 1987 Oct; 42(4):455-8.
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Kennedy FP, Miles JM, Heiling V, Gerich JE. The effect of two new alpha-glucosidase inhibitors on metabolic responses to a mixed meal in normal volunteers. Clin Exp Pharmacol Physiol. 1987 Aug; 14(8):633-40.
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De Feo P, Perriello G, Ventura MM, Brunetti P, Santeusanio F, Gerich JE, Bolli GB. The pancreatic-adrenocortical-pituitary clamp technique for study of counterregulation in humans. Am J Physiol. 1987 Apr; 252(4 Pt 1):E565-70.
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Van Haeften TW, Krom BA, Gerich JE. Prolonged fasting hypoglycemia due to insulin antibodies in patient with non-insulin-dependent diabetes mellitus: effect of insulin withdrawal on insulin-antibody-binding kinetics. Diabetes Care. 1987 Mar-Apr; 10(2):160-3.
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Kennedy FP, Bolli GB, Go VL, Cryer PE, Gerich JE. The significance of impaired pancreatic polypeptide and epinephrine responses to hypoglycemia in patients with insulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1987 Mar; 64(3):602-8.
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Van Haeften TW, Heiling VJ, Gerich JE. Adverse effects of insulin antibodies on postprandial plasma glucose and insulin profiles in diabetic patients without immune insulin resistance. Implications for intensive insulin regimens. Diabetes. 1987 Mar; 36(3):305-9.
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Gerich JE, Campbell PJ, Nurjhan N, Consoli A. [Hepatic and peripheral resistance to the action of insulin in non-insulin-dependent diabetes]. Journ Annu Diabetol Hotel Dieu. 1987; 267-79.
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Jensen MD, Haymond MW, Gerich JE, Cryer PE, Miles JM. Lipolysis during fasting. Decreased suppression by insulin and increased stimulation by epinephrine. J Clin Invest. 1987 Jan; 79(1):207-13.
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Campbell P, Triebwasser K, Gerich J. A comparison of regular insulin and vesicle encapsulated insulin on glucose metabolism in diabetic subjects. Int J Clin Pharmacol Ther Toxicol. 1986 Dec; 24(12):658-60.
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Nurjhan N, Campbell PJ, Kennedy FP, Miles JM, Gerich JE. Insulin dose-response characteristics for suppression of glycerol release and conversion to glucose in humans. Diabetes. 1986 Dec; 35(12):1326-31.
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Gerich JE. Insulin-dependent diabetes mellitus: pathophysiology. Mayo Clin Proc. 1986 Oct; 61(10):787-91.
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Campbell PJ, Gerich JE. Occurrence of dawn phenomenon without change in insulin clearance in patients with insulin-dependent diabetes mellitus. Diabetes. 1986 Jul; 35(7):749-52.
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Van Haeften TW, Bolli GB, Dimitriadis GD, Gottesman IS, Horwitz DL, Gerich JE. Effect of insulin antibodies and their kinetic characteristics on plasma free insulin dynamics in patients with diabetes mellitus. Metabolism. 1986 Jul; 35(7):649-56.
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Gottesman I, Tobert J, Vandlen R, Gerich J. Efficacy, pharmacokinetics and tolerability of a somatostatin analogue (L-363,586) in insulin-dependent diabetes mellitus. Life Sci. 1986 Jun 16; 38(24):2211-9.
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De Feo P, Perriello G, De Cosmo S, Ventura MM, Campbell PJ, Brunetti P, Gerich JE, Bolli GB. Comparison of glucose counterregulation during short-term and prolonged hypoglycemia in normal humans. Diabetes. 1986 May; 35(5):563-9.
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Hansen I, Tsalikian E, Beaufrere B, Gerich J, Haymond M, Rizza R. Insulin resistance in acromegaly: defects in both hepatic and extrahepatic insulin action. Am J Physiol. 1986 Mar; 250(3 Pt 1):E269-73.
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Gerich JE. Rationale for inhibition of growth hormone secretion in the management of the diabetic patient. Scand J Gastroenterol Suppl. 1986; 119:154-7.
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Schwenk WF, Rizza RA, Mandarino LJ, Gerich JE, Hayles AB, Haymond MW. Familial insulin resistance and acanthosis nigricans. Presence of a postbinding defect. Diabetes. 1986 Jan; 35(1):33-7.
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Campbell PJ, Bolli GB, Cryer PE, Gerich JE. Sequence of events during development of the dawn phenomenon in insulin-dependent diabetes mellitus. Metabolism. 1985 Dec; 34(12):1100-4.
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Dimitriadis G, Gerich J. Effect of twice daily subcutaneous administration of a long-acting somatostatin analog on 24-hour plasma glucose profiles in patients with insulin-dependent diabetes mellitus. Horm Metab Res. 1985 Oct; 17(10):510-1.
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Gerich JE. Selection of patients for intensive insulin therapy. Arch Intern Med. 1985 Aug; 145(8):1383-4.
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Cryer PE, Gerich JE. Glucose counterregulation, hypoglycemia, and intensive insulin therapy in diabetes mellitus. N Engl J Med. 1985 Jul 25; 313(4):232-41.
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Gerich JE. Sulfonylureas in the treatment of diabetes mellitus--1985. Mayo Clin Proc. 1985 Jul; 60(7):439-43.
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Campbell PJ, Bolli GB, Cryer PE, Gerich JE. Pathogenesis of the dawn phenomenon in patients with insulin-dependent diabetes mellitus. Accelerated glucose production and impaired glucose utilization due to nocturnal surges in growth hormone secretion. N Engl J Med. 1985 Jun 6; 312(23):1473-9.
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Dimitriadis GD, Pehling GB, Gerich JE. Abnormal glucose modulation of islet A- and B-cell responses to arginine in non-insulin-dependent diabetes mellitus. Diabetes. 1985 Jun; 34(6):541-7.
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Bolli G, De Feo P, Perriello G, De Cosmo S, Ventura M, Campbell P, Brunetti P, Gerich JE. Role of hepatic autoregulation in defense against hypoglycemia in humans. J Clin Invest. 1985 May; 75(5):1623-31.
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Dimitriadis G, Baker B, Marsh H, Mandarino L, Rizza R, Bergman R, Haymond M, Gerich J. Effect of thyroid hormone excess on action, secretion, and metabolism of insulin in humans. Am J Physiol. 1985 May; 248(5 Pt 1):E593-601.
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Dimitriadis GD, Tessari P, Go VL, Gerich JE. alpha-Glucosidase inhibition improves postprandial hyperglycemia and decreases insulin requirements in insulin-dependent diabetes mellitus. Metabolism. 1985 Mar; 34(3):261-5.
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Rizza RA, Mandarino LJ, Genest J, Baker BA, Gerich JE. Production of insulin resistance by hyperinsulinaemia in man. Diabetologia. 1985 Feb; 28(2):70-5.
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Dimitriadis G, Cryer P, Gerich J. Prolonged hyperglycaemia during infusion of glucose and somatostatin impairs pancreatic A- and B-cell responses to decrements in plasma glucose in normal man: evidence for induction of altered sensitivity to glucose. Diabetologia. 1985 Feb; 28(2):63-9.
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Gottesman IS, Gerich JE. Comparison of extraction procedures for radioimmunoassay of human plasma somatostatin. Clin Physiol Biochem. 1985; 3(1):23-8.
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Martin C, Wallum B, Krom B, Hall L, Gerich J. Effect of a zinc phosphate suspension of a long-acting somatostatin analog on postprandial plasma glucose, triglyceride and glucagon concentrations in alloxan diabetic dogs. Life Sci. 1984 Dec 24; 35(26):2627-33.
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Bolli GB, De Feo P, De Cosmo S, Perriello G, Ventura MM, Calcinaro F, Lolli C, Campbell P, Brunetti P, Gerich JE. Demonstration of a dawn phenomenon in normal human volunteers. Diabetes. 1984 Dec; 33(12):1150-3.
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Bolli GB, Gottesman IS, Campbell PJ, Haymond MW, Cryer PE, Gerich JE. Glucose counterregulation and waning of insulin in the Somogyi phenomenon (posthypoglycemic hyperglycemia). N Engl J Med. 1984 Nov 8; 311(19):1214-9.
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Mandarino LJ, Campbell PJ, Gottesman IS, Gerich JE. Abnormal coupling of insulin receptor binding in noninsulin-dependent diabetes. Am J Physiol. 1984 Nov; 247(5 Pt 1):E688-92.
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Pehling GB, Gerich JE. Comparison of plasma insulin profiles after subcutaneous administration of insulin by jet spray and conventional needle injection in patients with insulin-dependent diabetes mellitus. Mayo Clin Proc. 1984 Nov; 59(11):751-4.
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Tsalikian E, Simmons P, Gerich JE, Howard C, Haymond MW. Glucose production and utilization in children with glycogen storage disease type I. Am J Physiol. 1984 Oct; 247(4 Pt 1):E513-9.
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Mandarino L, Baker B, Rizza R, Genest J, Gerich J. Infusion of insulin impairs human adipocyte glucose metabolism in vitro without decreasing adipocyte insulin receptor binding. Diabetologia. 1984 Sep; 27(3):358-63.
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Tsalikian E, Howard C, Gerich JE, Haymond MW. Increased leucine flux in short-term fasted human subjects: evidence for increased proteolysis. Am J Physiol. 1984 Sep; 247(3 Pt 1):E323-7.
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Pehling G, Tessari P, Gerich JE, Haymond MW, Service FJ, Rizza RA. Abnormal meal carbohydrate disposition in insulin-dependent diabetes. Relative contributions of endogenous glucose production and initial splanchnic uptake and effect of intensive insulin therapy. J Clin Invest. 1984 Sep; 74(3):985-91.
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Bolli GB, Gottesman IS, Cryer PE, Gerich JE. Glucose counterregulation during prolonged hypoglycemia in normal humans. Am J Physiol. 1984 Aug; 247(2 Pt 1):E206-14.
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Miles JM, Nissen SL, Gerich JE, Haymond MW. Effects of epinephrine infusion on leucine and alanine kinetics in humans. Am J Physiol. 1984 Aug; 247(2 Pt 1):E166-72.
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Bolli GB, De Feo P, De Cosmo S, Perriello G, Ventura MM, Benedetti MM, Santeusanio F, Gerich JE, Brunetti P. A reliable and reproducible test for adequate glucose counterregulation in type I diabetes mellitus. Diabetes. 1984 Aug; 33(8):732-7.
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Bolli GB, Dimitriadis GD, Pehling GB, Baker BA, Haymond MW, Cryer PE, Gerich JE. Abnormal glucose counterregulation after subcutaneous insulin in insulin-dependent diabetes mellitus. N Engl J Med. 1984 Jun 28; 310(26):1706-11.
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Bolli GB, Tsalikian E, Haymond MW, Cryer PE, Gerich JE. Defective glucose counterregulation after subcutaneous insulin in noninsulin-dependent diabetes mellitus. Paradoxical suppression of glucose utilization and lack of compensatory increase in glucose production, roles of insulin resistance, abnormal neuroendocrine responses, and islet paracrine interactions. J Clin Invest. 1984 Jun; 73(6):1532-41.
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Service FJ, Rizza RA, Westland RE, Hall LD, Gerich JE, Go VL. Gastric inhibitory polypeptide in obesity and diabetes mellitus. J Clin Endocrinol Metab. 1984 Jun; 58(6):1133-40.
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Briones ER, Palumbo PJ, Mao SJ, Gerich JE, Kottke BA. Acute effects of a glucose load on plasma apolipoproteins A-I, A-II, C-II, and C-III in normal and non-insulin-dependent diabetic men. Mayo Clin Proc. 1984 Jun; 59(6):399-403.
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Mandarino LJ, Gerich JE. Prolonged sulfonylurea administration decreases insulin resistance and increases insulin secretion in non-insulin-dependent diabetes mellitus: evidence for improved insulin action at a postreceptor site in hepatic as well as extrahepatic tissues. Diabetes Care. 1984 May-Jun; 7 Suppl 1:89-99.
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Bolli G, De Feo P, Perriello G, De Cosmo S, Compagnucci P, Ventura MM, Santeusanio F, Gerich JE, Brunetti P. [Prospective evaluation of the insulin infusion test to establish the adequacy of glucose counterregulation during hypoglycemia in type 1 diabetics undergoing intensive insulin therapy]. Minerva Endocrinol. 1984 Apr-Jun; 9(2):101-5.
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Gerich JE. Assessment of insulin resistance and its role in non-insulin-dependent diabetes mellitus. J Lab Clin Med. 1984 Apr; 103(4):497-505.
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Bolli G, De Feo P, De Cosmo S, Perriello G, Angeletti G, Ventura MR, Santeusanio F, Brunetti P, Gerich JE. Effects of long-term optimization and short-term deterioration of glycemic control on glucose counterregulation in type I diabetes mellitus. Diabetes. 1984 Apr; 33(4):394-400.
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Gerich JE. Role of growth hormone in diabetes mellitus. N Engl J Med. 1984 Mar 29; 310(13):848-50.
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Bolli GB, Gerich JE. The "dawn phenomenon"--a common occurrence in both non-insulin-dependent and insulin-dependent diabetes mellitus. N Engl J Med. 1984 Mar 22; 310(12):746-50.
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Gottesman I, Mandarino L, Gerich J. Use of glucose uptake and glucose clearance for the evaluation of insulin action in vivo. Diabetes. 1984 Feb; 33(2):184-91.
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Simmons PS, Miles JM, Gerich JE, Haymond MW. Increased proteolysis. An effect of increases in plasma cortisol within the physiologic range. J Clin Invest. 1984 Feb; 73(2):412-20.
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Staten M, Worcester B, Szekeres A, Waldeck N, Ascher M, Walsh KM, Rizza R, Gerich J, Charles MA. Comparison of porcine and semisynthetic human insulins using euglycemic clamp-derived glucose-insulin dose-response curves in insulin-dependent diabetes. Metabolism. 1984 Feb; 33(2):132-5.
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Baker B, Mandarino L, Brick B, Rizza R, Gerich J. Influence of changes in insulin receptor binding during insulin infusions on the shape of the insulin dose-response curve for glucose disposal in man. J Clin Endocrinol Metab. 1984 Feb; 58(2):392-6.
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Service FJ, Rizza RA, Hall LD, Westland RE, O'Brien PC, Clemens AH, Haymond MW, Gerich JE. Prandial insulin requirements in insulin-dependent diabetics: effects of size, time of day, and sequence of meals. J Clin Endocrinol Metab. 1983 Nov; 57(5):931-6.
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De Feo P, Bolli G, Perriello G, De Cosmo S, Compagnucci P, Angeletti G, Santeusanio F, Gerich JE, Motolese M, Brunetti P. The adrenergic contribution to glucose counterregulation in type I diabetes mellitus. Dependency on A-cell function and mediation through beta 2-adrenergic receptors. Diabetes. 1983 Oct; 32(10):887-93.
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Dimitriadis G, Tessari P, Gerich J. Effects of a long-acting somatostatin analogue on postprandial hyperglycemia in insulin-dependent diabetes mellitus. Metabolism. 1983 Oct; 32(10):987-92.
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Hogan MJ, Service FJ, Sharbrough FW, Gerich JE. Oral glucose tolerance test compared with a mixed meal in the diagnosis of reactive hypoglycemia. A caveat on stimulation. Mayo Clin Proc. 1983 Aug; 58(8):491-6.
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Dimitriadis GD, Gerich JE. Importance of timing of preprandial subcutaneous insulin administration in the management of diabetes mellitus. Diabetes Care. 1983 Jul-Aug; 6(4):374-7.
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Miles JM, Gerich JE. Glucose and ketone body kinetics in diabetic ketoacidosis. Clin Endocrinol Metab. 1983 Jul; 12(2):303-19.
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Miles JM, Haymond MW, Nissen SL, Gerich JE. Effects of free fatty acid availability, glucagon excess, and insulin deficiency on ketone body production in postabsorptive man. J Clin Invest. 1983 Jun; 71(6):1554-61.
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Gottesman I, Mandarino L, Gerich J. Estimation and kinetic analysis of insulin-independent glucose uptake in human subjects. Am J Physiol. 1983 Jun; 244(6):E632-5.
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Miles JM, Nissen SL, Rizza RA, Gerich JE, Haymond MW. Failure of infused beta-hydroxybutyrate to decrease proteolysis in man. Diabetes. 1983 Mar; 32(3):197-205.
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Bolli G, de Feo P, Compagnucci P, Cartechini MG, Angeletti G, Santeusanio F, Brunetti P, Gerich JE. Abnormal glucose counterregulation in insulin-dependent diabetes mellitus. Interaction of anti-insulin antibodies and impaired glucagon and epinephrine secretion. Diabetes. 1983 Feb; 32(2):134-41.
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Cryer PE, Gerich JE. Relevance of glucose counterregulatory systems to patients with diabetes: critical roles of glucagon and epinephrine. Diabetes Care. 1983 Jan-Feb; 6(1):95-9.
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Miles J, Glasscock R, Aikens J, Gerich J, Haymond M. A microfluorometric method for the determination of free fatty acids in plasma. J Lipid Res. 1983 Jan; 24(1):96-9.
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Rizza R, Go V, Cryer P, Verdonk C, Gerich J. Stimulation of human pancreatic polypeptide secretion by hypoglycemia is independent of adrenergic mechanisms. J Clin Endocrinol Metab. 1982 Dec; 55(6):1234-6.
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Gottesman I, Mandarino L, Verdonk C, Rizza R, Gerich J. Insulin increases the maximum velocity for glucose uptake without altering the Michaelis constant in man. Evidence that insulin increases glucose uptake merely by providing additional transport sites. J Clin Invest. 1982 Dec; 70(6):1310-4.
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Itoh M, Furman BL, Gerich JE. Dopaminergic suppression of pancreatic somatostatin secretion. Acta Endocrinol (Copenh). 1982 Sep; 101(1):56-61.
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Dimitriadis G, Tessari P, Go V, Gerich J. Effects of the disaccharidase inhibitor acarbose on meal and intravenous glucose tolerance in normal man. Metabolism. 1982 Aug; 31(8):841-3.
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Rizza RA, Mandarino LJ, Gerich JE. Effects of growth hormone on insulin action in man. Mechanisms of insulin resistance, impaired suppression of glucose production, and impaired stimulation of glucose utilization. Diabetes. 1982 Aug; 31(8 Pt 1):663-9.
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Rizza RA, Westland RE, Hall LD, Patton G, Haymond MW, Clemens AH, Gerich JE, Service FJ. Subcutaneous versus intraperitoneal administration of insulin on post-prandial hyperglycaemia and glucose turnover in alloxan diabetic dogs. Diabetologia. 1982 Jul; 23(1):61-4.
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Fischer U, Rizza RA, Hall LD, Westland RE, Haymond MW, Clemens AH, Gerich JE, Service FJ. Comparison of peripheral and portal venous insulin administration on postprandial metabolic responses in alloxan-diabetic dogs. Effects of identical preprogrammed complex insulin infusion waveforms. Diabetes. 1982 Jul; 31(7):579-84.
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Ternand C, Go VL, Gerich JE, Haymond MW. Endocrine pancreatic response of children with onset of insulin-requiring diabetes before age 3 and after age 5. J Pediatr. 1982 Jul; 101(1):36-9.
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Itoh M, Gerich JE. Adrenergic modulation of pancreatic somatostatin, insulin, and glucagon secretion: evidence for differential sensitivity of islet A, B, and D cells. Metabolism. 1982 Jul; 31(7):715-20.
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Service FJ, Rizza RA, Gerich JE. Implantation of insulin infusion devices. JAMA. 1982 Apr 2; 247(13):1866.
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Rizza RA, Service FJ, Gerich JE. New methods of treatment for diabetes mellitus. Compr Ther. 1982 Apr; 8(4):62-70.
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Rizza RA, Haymond MW, Gerich JE. Theophylline potentiates glucagon-induced hepatic glucose production in man but does not prevent hepatic downregulation to glucagon. Metabolism. 1982 Mar; 31(3):205-8.
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Rizza RA, Mandarino LJ, Gerich JE. Cortisol-induced insulin resistance in man: impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor detect of insulin action. J Clin Endocrinol Metab. 1982 Jan; 54(1):131-8.
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Gottesman IS, Mandarino LJ, Gerich JE. Somatostatin: its role in health and disease. Spec Top Endocrinol Metab. 1982; 4:177-243.
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Reach G, Poussier P, Gerich JE, Assan R. [Kinetic approach to the bio-artificial pancreas]. Journ Annu Diabetol Hotel Dieu. 1982; 147-59.
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Nissen SL, Miles JM, Gerich JE, Haymond MW. Regulation of alpha-ketoisocaproate binding to albumin in vivo by free fatty acids. Am J Physiol. 1982 Jan; 242(1):E67-71.
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Miles JM, Haymond MW, Gerich JE. Effects of free fatty acids, insulin, glucagon and adrenaline on ketone body production in humans. Ciba Found Symp. 1982; 87:192-213.
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Rizza RA, Mandarino LJ, Gerich JE. Mechanism and significance of insulin resistance in non-insulin-dependent diabetes mellitus. Diabetes. 1981 Dec; 30(12):990-5.
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Mackes K, Rizza R, Gerich J. Effect of intermittent physiologic hyperglucagonemia on postprandial plasma glucose levels in normal man. Metabolism. 1981 Nov; 30(11):1041-4.
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MacGorman LR, Rizza RA, Gerich JE. Physiological concentrations of growth hormone exert insulin-like and insulin antagonistic effects on both hepatic and extrahepatic tissues in man. J Clin Endocrinol Metab. 1981 Sep; 53(3):556-9.
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Mackes K, Itoh M, Greene K, Gerich J. Radioimmunoassay of human plasma somatostatin. Diabetes. 1981 Sep; 30(9):728-34.
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Rizza RA, Westland RE, Hall LD, Patton GS, Haymond MW, Clemens AH, Gerich JE, Service FJ. Effect of peripheral versus portal venous administration of insulin on postprandial hyperglycemia and glucose turnover in alloxan-diabetic dogs. Mayo Clin Proc. 1981 Jul; 56(7):434-8.
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Rizza RA, Mandarino LJ, Gerich JE. Dose-response characteristics for effects of insulin on production and utilization of glucose in man. Am J Physiol. 1981 Jun; 240(6):E630-9.
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Verdonk CA, Rizza RA, Gerich JE. Effects of plasma glucose concentration on glucose utilization and glucose clearance in normal man. Diabetes. 1981 Jun; 30(6):535-7.
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Mandarino L, Stenner D, Blanchard W, Nissen S, Gerich J, Ling N, Brazeau P, Bohlen P, Esch F, Guillemin R. Selective effects of somatostatin-14, -25 and -28 on in vitro insulin and glucagon secretion. Nature. 1981 May 7; 291(5810):76-7.
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Rizza RA, Haymond MW, Verdonk CA, Mandarino LJ, Miles JM, Service FJ, Gerich JE. Pathogenesis of hypoglycemia in insulinoma patients: suppression of hepatic glucose production by insulin. Diabetes. 1981 May; 30(5):377-81.
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Reach G, Poussier P, Sausse A, Assan R, Itoh M, Gerich JE. Functional evaluation of a bioartificial pancreas using isolated islets perifused with blood ultrafiltrate. Diabetes. 1981 Apr; 30(4):296-301.
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Gerich JE. Somatostatin and diabetes. Am J Med. 1981 Mar; 70(3):619-26.
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Gerich JE. An appraisal of the role of biosynthetic human insulin in the future treatment of diabetes mellitus. Diabetes Care. 1981 Mar-Apr; 4(2):262-4.
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Rizza RA, Mandarino LJ, Gerich JE. Mechanisms of insulin resistance in man. Assessment using the insulin dose-response curve in conjunction with insulin-receptor binding. Am J Med. 1981 Jan; 70(1):169-76.
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Gerich JE. Physiology of glucagon. Int Rev Physiol. 1981; 24:243-75.
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Miles JM, Haymond MW, Gerich JE. Suppression of glucose production and stimulation of insulin secretion by physiological concentrations of ketone bodies in man. J Clin Endocrinol Metab. 1981 Jan; 52(1):34-7.
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Rizza RA, Gerich JE, Haymond MW, Westland RE, Hall LD, Clemens AH, Service FJ. Control of blood sugar in insulin-dependent diabetes: comparison of an artificial endocrine pancreas, continuous subcutaneous insulin infusion, and intensified conventional insulin therapy. N Engl J Med. 1980 Dec 4; 303(23):1313-8.
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Cryer PE, Rizza RA, Haymond MW, Gerich JE. Epinephrine and norepinephrine are cleared through beta-adrenergic, but not alpha-adrenergic, mechanisms in man. Metabolism. 1980 Nov; 29(11 Suppl 1):1114-8.
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Rizza RA, Cryer PE, Haymond MW, Gerich JE. Adrenergic mechanisms of catecholamine action on glucose homeostasis in man. Metabolism. 1980 Nov; 29(11 Suppl 1):1155-63.
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Gerich J, Cryer P, Rizza R. Hormonal mechanisms in acute glucose counterregulation: the relative roles of glucagon, epinephrine, norepinephrine, growth hormone, and cortisol. Metabolism. 1980 Nov; 29(11 Suppl 1):1164-75.
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Miles JM, Rizza RA, Haymond MW, Gerich JE. Effects of acute insulin deficiency on glucose and ketone body turnover in man: evidence for the primacy of overproduction of glucose and ketone bodies in the genesis of diabetic ketoacidosis. Diabetes. 1980 Nov; 29(11):926-30.
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Howard CP, Go VL, Infante AJ, Perrault J, Gerich JE, Haymond MW. Long-term survival in a case of functional pancreatic agenesis. J Pediatr. 1980 Nov; 97(5):786-9.
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Haymond MW, Howard CP, Miles JM, Gerich JE. Determination of leucine flux in vivo by gas chromatography-mass spectrometry utilizing stable isotopes for trace and internal standard. J Chromatogr. 1980 Oct 10; 183(4):403-9.
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Itoh M, Mandarino L, Gerich JE. Antisomatostatin gamma globulin augments secretion of both insulin and glucagon in vitro: evidence for a physiologic role for endogenous somatostatin in the regulation of pancreatic A- and B-cell function. Diabetes. 1980 Sep; 29(9):693-6.
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Tan MH, Havel RJ, Gerich JE, Soeldner JS, Kane JP. Pancreatic alpha and beta cell function in familial dysbetalipoproteinemia. Horm Metab Res. 1980 Sep; 12(9):421-5.
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Miles JM, Haymond MW, Rizza RA, Gerich JE. Determination of 14C radioactivity in ketone bodies: a new, simplified method and its validation. J Lipid Res. 1980 Jul; 21(5):646-50.
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Verdonk CA, Rizza RA, Nelson RL, Go VL, Gerich JE, Service FJ. Interaction of fat-stimulated gastric inhibitory polypeptide on pancreatic alpha and beta cell function. J Clin Invest. 1980 May; 65(5):1119-25.
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Rizza RA, Haymond MW, Miles JM, Verdonk CA, Cryer PE, Gerich JE. Effect of alpha-adrenergic stimulation and its blockade on glucose turnover in man. Am J Physiol. 1980 May; 238(5):E467-72.
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Verdonk CA, Rizza RA, Westland RE, Nelson RL, Gerich JE, Service FJ. Glucose clamping using the Biostator GCIIS. Horm Metab Res. 1980 Apr; 12(4):133-5.
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Rizza RA, Cryer PE, Haymond MW, Gerich JE. Adrenergic mechanisms for the effects of epinephrine on glucose production and clearance in man. J Clin Invest. 1980 Mar; 65(3):682-9.
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Service FJ, Rizza RA, Westland RE, Hall LD, Nelson RL, Haymond MW, Clemens AH, Gerich JE. Considerations for the programming of an open-loop insulin infusion device from the biostator glucose controller. Diabetes Care. 1980 Mar-Apr; 3(2):278-84.
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Mandarino L, Itoh M, Blanchard W, Patton G, Gerich J. Stimulation of insulin release in the absence of extracellular calcium by isobutylmethylxanthine and its inhibition by somatostatin. Endocrinology. 1980 Feb; 106(2):430-3.
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Rizza R, Verdonk C, Miles J, Service FJ, Haymond M, Gerich J. Somatostatin does not cause sustained fasting hyperglycemia in man. Horm Metab Res. 1979 Nov; 11(11):643-4.
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Rizza R, Haymond M, Cryer P, Gerich J. Differential effects of epinephrine on glucose production and disposal in man. Am J Physiol. 1979 Oct; 237(4):E356-62.
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Hara M, Patton GS, Gerich JE. Studies on the mechanism of action of somatostatin on the endocrine pancreas. I. Interaction with alpha-adrenergic receptors. Endocrinology. 1979 Sep; 105(3):801-5.
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Service FJ, Rizza RA, Gerich JE. Infusion-pump treatment of diabetes mellitus. N Engl J Med. 1979 Aug 2; 301(5):267-8.
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Rizza RA, Cryer PE, Gerich JE. Role of glucagon, catecholamines, and growth hormone in human glucose counterregulation. Effects of somatostatin and combined alpha- and beta-adrenergic blockade on plasma glucose recovery and glucose flux rates after insulin-induced hypoglycemia. J Clin Invest. 1979 Jul; 64(1):62-71.
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Gerich J, Greene K, Hara M, Rizza R, Patton G. Radioimmunoassay of somatostatin and its application in the study of pancreatic somatostatin secretion in vitro. J Lab Clin Med. 1979 Jun; 93(6):1009-17.
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Rizza R, Verdonk C, Miles J, Service FJ, Gerich J. Effect of intermittent endogenous hyperglucagonemia on glucose homeostasis in normal and diabetic man. J Clin Invest. 1979 Jun; 63(6):1119-23.
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Schmitt JK, Lorenzi M, Gerich JE, Bohannon NV, Karam JH, Forsham PH. Phentolamine and the action of somatostatin in man. J Clin Endocrinol Metab. 1979 May; 48(5):880-2.
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Gerich J, Davis J, Lorenzi M, Rizza R, Bohannon N, Karam J, Lewis S, Kaplan R, Schultz T, Cryer P. Hormonal mechanisms of recovery from insulin-induced hypoglycemia in man. Am J Physiol. 1979 Apr; 236(4):E380-5.
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Hara M, Patton G, Gerich J. Increased somatostatin release from pancreases of alloxan diabetic rats perfused in vitro. Life Sci. 1979 Feb 12; 24(7):625-8.
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Lorenzi M, Karam JH, Tsalikian E, Bohannon NV, Gerich JE, Forsham PH. Dopamine during alpha- or beta-adrenergic blockade in man. Hormonal, metabolic, and cardiovascular effects. J Clin Invest. 1979 Feb; 63(2):310-7.
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Rizza RA, Gerich JE. Persistent effect of sustained hyperglucagonemia on glucose production in man. J Clin Endocrinol Metab. 1979 Feb; 48(2):352-5.
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Gerich JE. Somatostatin--another pancreatic islet hormone. Adv Exp Med Biol. 1979; 124:63-84.
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Gerich JE. Somatostatin modulation of glucagon secretion and its importance in human glucose homeostasis. Metabolism. 1978 Sep; 27(9 Suppl 1):1283-90.
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Rizza RA, Gerich JE. Somatostatin and diabetes. Med Clin North Am. 1978 Jul; 62(4):735-46.
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Gerich JE, Patton GS. Somatostatin. Physiology and clinical applications. Med Clin North Am. 1978 Mar; 62(2):375-92.
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Lorenzi M, Tsalikian E, Bohannon NV, Gerich JE, Karam JH, Forsham PH. Differential effects of L-dopa and apomorphine on glucagon secretion in man: evidence against central dopaminergic stimulation of glucagon. J Clin Endocrinol Metab. 1977 Dec; 45(6):1154-8.
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Schultz TA, Lewis SB, Westbie DK, Wallin JD, Gerich JE. Glucose delivery: a modulator of glucose uptake in contracting skeletal muscle. Am J Physiol. 1977 Dec; 233(6):E514-8.
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Davis JL, Lewis SB, Gerich JE, Kaplan RA, Schultz TA, Wallin JD. Peripheral diabetic neuropathy treated with amitriptyline and fluphenazine. JAMA. 1977 Nov 21; 238(21):2291-2.
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Bohannon NV, Karam JH, Lorenzi M, Gerich JE, Matin SB, Forsham PH. Plasma glucagon suppression by phenformin in man. Diabetologia. 1977 Sep; 13(5):503-8.
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Gerich JE, Schultz TA, Lewis SB, Karam JH. Clinical evaluation of somatostatin as a potential ajunct to insulin in the management of diabetes mellitus. Diabetologia. 1977 Sep; 13(5):537-44.
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Gerich JE. Diabetic control and the late complications of diabetes. Am Fam Physician. 1977 Aug; 16(2):85-91.
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Gerich JE. Somatostatin. Its possible role in carbohydrate homeostasis and the treatment of diabetes mellitus. Arch Intern Med. 1977 May; 137(5):659-66.
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Lewis SB, Schultz TA, Westbie DK, Gerich JE, Wallin JD. Insulin-glucose dynamics during flow-through perfusion of the isolated rat hindlimb. Horm Metab Res. 1977 May; 9(3):190-5.
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Tsalikian E, Dunphy TW, Bohannon NV, Lorenzi M, Gerich JE, Forsham PH, Kane JP, Karam JH. The effect of chronic oral antidiabetic therapy on insulin and glucagon responses to a meal. Diabetes. 1977 Apr; 26(4):314-21.
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Schultz TA, Lewis SB, Westbie DK, Gerich JE, Rushakoff RJ, Wallin JD. Glucose delivery--a clarification of its role in regulating glucose uptake in rat skeletal muscle. Life Sci. 1977 Feb 15; 20(4):733-5.
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Lewis SB, Wallin JD, Kane JP, Gerich JE. Effect of diet composition on metabolic adaptations to hypocaloric nutrition: comparison of high carbohydrate and high fat isocaloric diets. Am J Clin Nutr. 1977 Feb; 30(2):160-70.
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Gerich JE. Somatostatin: diabetes and acromegaly. Adv Intern Med. 1977; 22:251-72.
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Gerich JE. Use of somatostatin in the study of carbohydrate homeostasis in man: physiologic, pathologic, and therapeutic considerations. Adv Exp Med Biol. 1977; 87:299-318.
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Gerich JE. Metabolic effects of long-term somatostatin infusion in man. Metabolism. 1976 Nov; 25(11 Suppl 1):1505-7.
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Gerich JE. Control of pancreatic IRG secretion in vivo. Metabolism. 1976 Nov; 25(11 Suppl 1):1437-41.
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Gerich JE. Alpha cell function in diabetes mellitus. Metabolism. 1976 Nov; 25(11 Suppl 1):1513-6.
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Gerich JE, Lorenzi M, Tsalikian E, Bohannon NV, Schneider V, Karam JH, Forsham PH. Effects of acute insulin withdrawal and administration on plasma glucagon responses to intravenous arginine in insulin-dependent diabetic subjects. Diabetes. 1976 Oct; 25(10):955-60.
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Gerich JE, Langlois M, Noacco C, Lorenzi M, Karam JH, Korsham PH. Comparison of the suppressive effects of elevated plasma glucose and free fatty acid levels on glucagon secretion in normal and insulin-dependent diabetic subjects. Evidence for selective alpha-cell insensitivity to glucose in diabetes mellitus. J Clin Invest. 1976 Aug; 58(2):320-5.
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Deftos LJ, Lorenzi M, Bohanon N, Tsalakian E, Schneider V, Gerich JE. Somatostatin does not suppress plasma parathyroid hormone. J Clin Endocrinol Metab. 1976 Jul; 43(1):205-7.
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Gerich JE, Lorenzi M, Bier DM, Tsalikian E, Schneider V, Karam JH, Forsham PH. Effects of physiologic levels of glucagon and growth hormone on human carbohydrate and lipid metabolism. Studies involving administration of exogenous hormone during suppression of endogenous hormone secretion with somatostatin. J Clin Invest. 1976 Apr; 57(4):875-84.
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Gerich JE, Schneider VS, Lorenzi M, Tsalikian E, Karam JH, Bier DM, Forsham PH. Role of glucagon in human diabetic ketoacidosis: studies using somatostatin. Clin Endocrinol (Oxf). 1976; 5 Suppl:299S-305S.
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Gerich JE, Lorenzi M, Tsalikian E, Karam JH. Studies on the mechanism of epinephrine-induced hyperglycemia in man. Evidence for participation of pancreatic glucagon secretion. Diabetes. 1976 Jan; 25(1):65-71.
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Gerich JE, Charles MA, Grodsky GM. Regulation of pancreatic insulin and glucagon secretion. Annu Rev Physiol. 1976; 38:353-88.
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Gerich JE. Somatostatin and the endocrine pancreas. Curr Top Mol Endocrinol. 1976; 3:127-43.
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Guillemin R, Gerich JE. Somatostatin: physiological and clinical significance. Annu Rev Med. 1976; 27:379-88.
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Karam JH, Rosenthal M, O'Donnell JJ, Tsalikian E, Lorenzi M, Gerich JE, Siperstein MD, Forsham PH. Discordance of diabetic microangiopathy in identical twins. Diabetes. 1976 Jan; 25(1):24-8.
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Gerich JE, Tsalikian E, Lorenzi M, Schneider V, Bohannon NV, Gustafson G, Karam JH. Normalization of fasting hyperglucagonemia and excessive glucagon responses to intravenous arginine in human diabetes mellitus by prolonged infusion of insulin. J Clin Endocrinol Metab. 1975 Dec; 41(06):1178-80.
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Gerich JE, Lorenzi M, Karam JH, Schneider V, Forsham PH. Abnormal pancreatic glucagon secretion and postprandial hyperglycemia in diabetes mellitus. JAMA. 1975 Oct 13; 234(2):159-5.
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Mielke CH, Gerich JE, Lorenzi M, Tsalikian E, Rodvien R, Forsham PH. The effect of somatostatin on coagulation and platelet function in man. N Engl J Med. 1975 Sep 4; 293(10):480-3.
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Lorenzi M, Gerich JE, Karam JH, Forsham PH. Failure of somatostatin to inhibit tolbutamide-induced insulin secretion in patients with insulinomas: a possible diagnostic tool. J Clin Endocrinol Metab. 1975 Jun; 40(6):1121-4.
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Tyrrell JB, Lorenzi M, Gerich JE, Forsham PH. Inhibition by somatostatin of ACTH secretion in Nelson's syndrome. J Clin Endocrinol Metab. 1975 Jun; 40(6):1125-7.
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Gerich JE, Lorenzi M, Bier DM, Schneider V, Tsalikian E, Karam JH, Forsham PH. Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon. N Engl J Med. 1975 May 8; 292(19):985-9.
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Gerich JE, Tsalikian E, Lorenzi M, Karam JH, Bier DM. Plasma glucagon and alanine responses to acute insulin deficiency in man. J Clin Endocrinol Metab. 1975 Mar; 40(3):526-9.
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Frankel BJ, Gerich JE, Fanska RE, Gerritsen GC, Grodsky GM. Responses to arginine of the perfused pancreas of the genetically diabetic Chinese hamster. Diabetes. 1975 Mar; 24(3):273-9.
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Gerich JE, Lovinger R, Grodsky GM. Inhibition by somatostatin of glucagon and insulin release from the perfused rat pancreas in response to arginine, isoproterenol and theophylline: evidence for a preferential effect on glucagon secretion. Endocrinology. 1975 Mar; 96(3):749-54.
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Gerich JE, Lorenzi M, Hane S, Gustafson G, Guillemin R, Forsham PH. Evidence for a physiologic role of pancreatic glucagon in human glucose homeostasis: studies with somatostatin. Metabolism. 1975 Feb; 24(2):175-82.
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Gerich JE, Lorenzi M, Schneider V, Forsham PH. Effect of somatostatin on plasma glucose and insulin responses to glucagon and tolbutamide in man. J Clin Endocrinol Metab. 1974 Dec; 39(6):1057-60.
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Gerich JE, Lorenzi M, Schneider V, Kwan CW, Karam JH, Guillemin R, Forsham PH. Inhibition of pancreatic glucagon responses to arginine by somatostatin in normal man and in insulin-dependent diabetics. Diabetes. 1974 Nov; 23(11):876-80.
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Gerich JE, Charles MA, Grodsky GM. Characterization of the effects of arginine and glucose on glucagon and insulin release from the perfused rat pancreas. J Clin Invest. 1974 Oct; 54(4):833-41.
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Gerich JE, Lorenzi M, Schneider V, Karam JH, Rivier J, Guillemin R, Forsham PH. Effects of somatostatin on plasma glucose and glucagon levels in human diabetes mellitus. Pathophysiologic and therapeutic implications. N Engl J Med. 1974 Sep 12; 291(11):544-7.
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Frankel BJ, Gerich JE, Hagura R, Fanska RE, Gerritsen GC, Grodsky GM. Abnormal secretion of insulin and glucagon by the in vitro perfused pancreas of the genetically diabetic Chinese hamster. J Clin Invest. 1974 Jun; 53(6):1637-46.
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Gerich JE, Frankel BJ, Fanska R, West L, Forsham PH, Grodsky GM. Calcium dependency of glucagon secretion from the in vitro perfused rat pancreas. Endocrinology. 1974 May; 94(5):1381-5.
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Gerich JE, Langlois M, Schneider V, Karam JH, Noacco C. Effects of alternations of plasma free fatty acid levels on pancreatic glucagon secretion in man. J Clin Invest. 1974 May; 53(5):1284-9.
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Gerich JE, Langlois M, Noacco C, Schneider V, Forsham PH. Adrenergic modulation of pancreatic glucagon secretion in man. J Clin Invest. 1974 May; 53(5):1441-6.
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Gerich JE, Schneider V, Dippe SE, Langlois M, Noacco C, Karam JH, Forsham PH. Characterization of the glucagon response to hypoglycemia in man. J Clin Endocrinol Metab. 1974 Jan; 38(1):77-82.
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Grodsky GM, Sando H, Levin S, Gerich J, Karam J. Synthesis and secretion of insulin in dynamic perfusion systems. Adv Metab Disord. 1974; 7(0):155-70.
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Gerich JE, Langlois M, Noacco C, Karam JH, Forsham PH. Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha cell defect. Science. 1973 Oct 12; 182(108):171-3.
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Gerich JE, Karam JH, Forsham PH. Stimulation of glucagon secretion by epinephrine in man. J Clin Endocrinol Metab. 1973 Sep; 37(3):479-81.
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Gerich J, Penhos JC, Gutman RA, Recant L. Effect of dehydration and hyperosmolarity on glucose, free fatty acid and ketone body metabolism in the rat. Diabetes. 1973 Apr; 22(4):264-71.
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Gerich JE, Charles MA, Levin SR, Forsham PH, Grodsky GM. In vitro inhibition of pancreatic glucagon secretion by diphenylhydantoin. J Clin Endocrinol Metab. 1972 Dec; 35(6):823-4.
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Gerich JE, Martin MM, Recant L. Clinical and metabolic characteristics of hyperosmolar nonketotic coma. Diabetes. 1971 Apr; 20(4):228-38.
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Gerich JE. Hunter's syndrome: beta-galactosidase deficiency in skin. N Engl J Med. 1969 Apr 10; 280(15):799-802.
