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Patricia Chess

TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentPediatrics
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 651
Rochester NY 14642
Other Positions
TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentBiomedical Engineering

 
 Awards And Honors
1979     Valedictorian, Cardinal Mooney High School (of 287 students)
1979 - 1983New York State Regents Scholar
1991     Outstanding Teaching of Medical Students, University of Rochester
1992 - 1995NIH National Research Service Award in Pulmonary Biology
1997 - 1999American Lung Association Research Award Grantee (National)
1999 - 2004NIH Mentored Clinical Scientist Investigator Award (K08)  | Institute of Medicine
2004     Best Doctors in America  | America's Best Doctors
2006     Marquis' Who's Who in America Award
2008     Strong Memorial Hospital Exceptional Service Award
2014     Ruth A. Lawrence Academic Faculty Service Award for Excellence in Training, Department of Pediatrics, University of Rochester, R
 
 Overview
Dr Chess' research focuses on lung injury and repair in the neonate and optimizing treatment of neonatal respiratory failure. Clinical trials include adaptation of the immune response in BPD, cardiac dysfunction in Congenital Diaphragmatic Hernias (CDH), inositol supplementation in ROP and BPD, and use of omegaven in HAL-induced cholestasis. A novel respiratory monitor to detect changes in chest motion for patients on high frequency ventilation has been developed in collaboration with BME and is being optimized for clinical use. This research compliments clinical areas of focus related to optimizing treatment of neonatal respiratory failure, especially in CDH, including optimal modes of ventilation, surfactant therapy, iNO, and ECMO. (funded by NIH and UofR)

 
 Selected Publications
List All   |   Timeline
  1. Hoffmire CA, Chess PR, Ben Saad T, Glantz JC. Elective delivery before 39 weeks: the risk of infant admission to the neonatal intensive care unit. Matern Child Health J. 2012 Jul; 16(5):1053-62.
    View in: PubMed
  2. Chess PR, Benson RP, Maniscalco WM, Wright TW, O'Reilly MA, Johnston CJ. Murine mechanical ventilation stimulates alveolar epithelial cell proliferation. Exp Lung Res. 2010 Aug; 36(6):331-41.
    View in: PubMed
  3. Yee M, Chess PR, McGrath-Morrow SA, Wang Z, Gelein R, Zhou R, Dean DA, Notter RH, O'Reilly MA. Neonatal oxygen adversely affects lung function in adult mice without altering surfactant composition or activity. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L641-9.
    View in: PubMed
  4. Schwab U, Rohde KH, Wang Z, Chess PR, Notter RH, Russell DG. Transcriptional responses of Mycobacterium tuberculosis to lung surfactant. Microb Pathog. 2009 Apr; 46(4):185-93.
    View in: PubMed
  5. Raghavendran K, Davidson BA, Knight PR, Wang Z, Helinski J, Chess PR, Notter RH. Surfactant dysfunction in lung contusion with and without superimposed gastric aspiration in a rat model. Shock. 2008 Nov; 30(5):508-17.
    View in: PubMed
  6. Willson DF, Chess PR, Notter RH. Surfactant for pediatric acute lung injury. Pediatr Clin North Am. 2008 Jun; 55(3):545-75, ix.
    View in: PubMed
  7. Raghavendran K, Pryhuber GS, Chess PR, Davidson BA, Knight PR, Notter RH. Pharmacotherapy of acute lung injury and acute respiratory distress syndrome. Curr Med Chem. 2008; 15(19):1911-24.
    View in: PubMed
  8. Wang Z, Schwab U, Rhoades E, Chess PR, Russell DG, Notter RH. Peripheral cell wall lipids of Mycobacterium tuberculosis are inhibitory to surfactant function. Tuberculosis (Edinb). 2008 May; 88(3):178-86.
    View in: PubMed
  9. Russo TA, Wang Z, Davidson BA, Genagon SA, Beanan JM, Olson R, Holm BA, Knight PR, Chess PR, Notter RH. Surfactant dysfunction and lung injury due to the E. coli virulence factor hemolysin in a rat pneumonia model. Am J Physiol Lung Cell Mol Physiol. 2007 Mar; 292(3):L632-43.
    View in: PubMed
  10. Hickman-Davis JM, Wang Z, Fierro-Perez GA, Chess PR, Page GP, Matalon S, Notter RH. Surfactant dysfunction in SP-A-/- and iNOS-/- mice with mycoplasma infection. Am J Respir Cell Mol Biol. 2007 Jan; 36(1):103-13.
    View in: PubMed
  11. Chess PR, D'Angio CT, Pryhuber GS, Maniscalco WM. Pathogenesis of bronchopulmonary dysplasia. Semin Perinatol. 2006 Aug; 30(4):171-8.
    View in: PubMed
  12. Bruckner L, Gigliotti F, Wright T, Harmsen A, Notter RH, Chess P, Wang Z, Finkelstein J. Pneumocystis carinii infection sensitizes lung to radiation-induced injury after syngeneic marrow transplantation: role of CD4+ T cells. Am J Physiol Lung Cell Mol Physiol. 2006 Jun; 290(6):L1087-96.
    View in: PubMed
  13. Hutson AD, Davidson BA, Raghavendran K, Chess PR, Tait AR, Holm BA, Notter RH, Knight PR. Statistical prediction of the type of gastric aspiration lung injury based on early cytokine/chemokine profiles. Anesthesiology. 2006 Jan; 104(1):73-9.
    View in: PubMed
  14. D'Angio CT, Chess PR, Kovacs SJ, Sinkin RA, Phelps DL, Kendig JW, Myers GJ, Reubens L, Ryan RM. Pressure-regulated volume control ventilation vs synchronized intermittent mandatory ventilation for very low-birth-weight infants: a randomized controlled trial. Arch Pediatr Adolesc Med. 2005 Sep; 159(9):868-75.
    View in: PubMed
  15. Wang Z, Foye A, Chang Y, Chess PR, Wright TW, Bhagwat S, Gigliotti F, Notter RH. Inhibition of surfactant activity by Pneumocystis carinii organisms and components in vitro. Am J Physiol Lung Cell Mol Physiol. 2005 Jun; 288(6):L1124-31.
    View in: PubMed
  16. Chess PR, O'Reilly MA, Sachs F, Finkelstein JN. Reactive oxidant and p42/44 MAP kinase signaling is necessary for mechanical strain-induced proliferation in pulmonary epithelial cells. J Appl Physiol. 2005 Sep; 99(3):1226-32.
    View in: PubMed
  17. Davidson BA, Stewart CC, Russo TA, Chess PR, Knight PR. Discrimination of resident and infiltrated alveolar macrophages by flow cytometry in influenza A virus-infected mice. Exp Lung Res. 2005 Apr; 31(3):323-39.
    View in: PubMed
  18. Davidson BA, Knight PR, Wang Z, Chess PR, Holm BA, Russo TA, Hutson A, Notter RH. Surfactant alterations in acute inflammatory lung injury from aspiration of acid and gastric particulates. Am J Physiol Lung Cell Mol Physiol. 2005 Apr; 288(4):L699-708.
    View in: PubMed
  19. Kumar VH, Lakshminrusimha S, El Abiad MT, Chess PR, Ryan RM. Growth factors in lung development. Adv Clin Chem. 2005; 40:261-316.
    View in: PubMed
  20. Chess PR, O'Reilly MA, Toia L. Macroarray analysis reveals a strain-induced oxidant response in pulmonary epithelial cells. Exp Lung Res. 2004 Dec; 30(8):739-53.
    View in: PubMed
  21. Chess PR. The effect of gentle ventilation on survival in congenital diaphragmatic hernia. Pediatrics. 2004 Apr; 113(4):917.
    View in: PubMed
  22. Wright TW, Pryhuber GS, Chess PR, Wang Z, Notter RH, Gigliotti F. TNF receptor signaling contributes to chemokine secretion, inflammation, and respiratory deficits during Pneumocystis pneumonia. J Immunol. 2004 Feb 15; 172(4):2511-21.
    View in: PubMed
  23. Rancourt RC, Hayes DD, Chess PR, Keng PC, O'Reilly MA. Growth arrest in G1 protects against oxygen-induced DNA damage and cell death. J Cell Physiol. 2002 Oct; 193(1):26-36.
    View in: PubMed
  24. Stevens TP, Chess PR, McConnochie KM, Sinkin RA, Guillet R, Maniscalco WM, Fisher SG. Survival in early- and late-term infants with congenital diaphragmatic hernia treated with extracorporeal membrane oxygenation. Pediatrics. 2002 Sep; 110(3):590-6.
    View in: PubMed
  25. El Hassan NO, Chess PR, Huysman MW, Merkus PJ, de Jongste JC. Rescue use of DNase in critical lung atelectasis and mucus retention in premature neonates. Pediatrics. 2001 Aug; 108(2):468-70.
    View in: PubMed
  26. Miller CE, Donlon KJ, Toia L, Wong CL, Chess PR. Cyclic strain induces proliferation of cultured embryonic heart cells. In Vitro Cell Dev Biol Anim. 2000 Nov-Dec; 36(10):633-9.
    View in: PubMed
  27. Uy IP, Pryhuber GS, Chess PR, Notter RH. Combined-modality therapy with inhaled nitric oxide and exogenous surfactant in term infants with acute respiratory failure. Pediatr Crit Care Med. 2000 Oct; 1(2):107-10.
    View in: PubMed
  28. Chess PR, Toia L, Finkelstein JN. Mechanical strain-induced proliferation and signaling in pulmonary epithelial H441 cells. Am J Physiol Lung Cell Mol Physiol. 2000 Jul; 279(1):L43-51.
    View in: PubMed
  29. Bhatt AJ, Amin SB, Chess PR, Watkins RH, Maniscalco WM. Expression of vascular endothelial growth factor and Flk-1 in developing and glucocorticoid-treated mouse lung. Pediatr Res. 2000 May; 47(5):606-13.
    View in: PubMed
  30. Sinkin RA, Dweck HS, Horgan MJ, Gallaher KJ, Cox C, Maniscalco WM, Chess PR, D'Angio CT, Guillet R, Kendig JW, Ryan RM, Phelps DL. Early dexamethasone-attempting to prevent chronic lung disease. Pediatrics. 2000 Mar; 105(3 Pt 1):542-8.
    View in: PubMed
  31. Khalak R, Chess PR. Fulminant necrotizing enterocolitis in a premature neonate treated for supraventricular tachycardia. J Perinatol. 1998 Jul-Aug; 18(4):306-7.
    View in: PubMed
  32. Shrier DA, Wang AR, Patel U, Monajati A, Chess P, Numaguchi Y. Benign fibrous histiocytoma of the nasal cavity in a newborn: MR and CT findings. AJNR Am J Neuroradiol. 1998 Jun-Jul; 19(6):1166-8.
    View in: PubMed
  33. Maniscalco WM, Watkins RH, Chess PR, Sinkin RA, Horowitz S, Toia L. Cell-specific expression of fibronectin and EIIIA and EIIIB splice variants after oxygen injury. Am J Physiol. 1998 Apr; 274(4 Pt 1):L599-609.
    View in: PubMed
  34. Chess PR, Ryan RM, Finkelstein JN. H441 pulmonary epithelial cell mitogenic effects and signaling pathways in response to HGF and TGF-alpha. Exp Lung Res. 1998 Jan-Feb; 24(1):27-39.
    View in: PubMed
  35. Chess PR, D'Angio CT. Clonic movements following lorazepam administration in full-term infants. Arch Pediatr Adolesc Med. 1998 Jan; 152(1):98-9.
    View in: PubMed
  36. Sempowski GD, Chess PR, Phipps RP. CD40 is a functional activation antigen and B7-independent T cell costimulatory molecule on normal human lung fibroblasts. J Immunol. 1997 May 15; 158(10):4670-7.
    View in: PubMed
  37. Chess PR, Chess MA, Manuli MA, Guillet R. Screening head ultrasound to detect intraventricular hemorrhage in premature infants. Pediatr Radiol. 1997 Apr; 27(4):305-8.
    View in: PubMed
  38. Sempowski GD, Chess PR, Moretti AJ, Padilla J, Phipps RP, Blieden TM. CD40 mediated activation of gingival and periodontal ligament fibroblasts. J Periodontol. 1997 Mar; 68(3):284-92.
    View in: PubMed
  39. Gaspari AA, Sempowski GD, Chess P, Gish J, Phipps RP. Human epidermal keratinocytes are induced to secrete interleukin-6 and co-stimulate T lymphocyte proliferation by a CD40-dependent mechanism. Eur J Immunol. 1996 Jun; 26(6):1371-7.
    View in: PubMed
  40. Chess PR, Ryan RM, Finkelstein JN. Tyrosine kinase activity is necessary for growth factor-stimulated rabbit type II pneumocyte proliferation. Pediatr Res. 1994 Oct; 36(4):481-6.
    View in: PubMed

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