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Carl D'Angio

TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentPediatrics
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 651
Rochester NY 14642
Other Positions
TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentMedical Humanities and Bioethics

 
 Awards And Honors
1990     The PHS Citation, US Public Health Service
1998     Bicentennial Unit Commendation, US Public Health Service
1999 - 2000Buswell Fellowship Award, University of Rochester
2004 - 2010Best Doctors in America
2007 - 2010Guide to America's Top Pediatricians
2008 - 2009Who's Who in America
2009 - 2010Who's Who in Medicine and Healthcare
2009     America's Top Doctors
2011 - 2012America's Top Doctors
 
 Overview
Dr. D'Angio's research focuses on immunizations and infections in the premature infant. He has recently led federally-funded multi-center studies investigating the responses of premature infants to the conjugate pneumococcal vaccine and influenza vaccine. He is the principal investigator of the Premature Infant Vaccine Collaborative, formed to evaluate vaccine immunogenicity in premature infants. He is principal investigator for a combined University of Rochester-University of Buffalo site in the NICHD Neonatal Research Network, an 18-center consortium performing research in newborns. He is a co-investigator on NIH grants investigating respiratory infections and outcomes in the premature infant. Dr. D'Angio is also involved in research into prevention of catheter-related infections, neonatal outcomes and clinical and research ethics.

 
 Selected Publications
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  1. DeMauro SB, D'Agostino JA, Bann C, Bernbaum J, Gerdes M, Bell EF, Carlo WA, D'Angio CT, Das A, Higgins R, Hintz SR, Laptook AR, Natarajan G, Nelin L, Poindexter BB, Sanchez PJ, Shankaran S, Stoll BJ, Truog W, Van Meurs KP, Vohr B, Walsh MC, Kirpalani H. Developmental outcomes of very preterm infants with tracheostomies. J Pediatr. 2014 Jun; 164(6):1303-1310.e2.
    View in: PubMed
  2. D'Angio CT, Murray TE, Li L, Heyne RJ, O'Shea TM, Schelonka RL, Shankaran S, Duara S, Goldberg RN, Stoll BJ, Stevenson DK, Vohr BR, Phelps DL, Carlo WA, Pichichero ME, Das A, Higgins RD. Immunogenicity of Haemophilus influenzae Type b Protein Conjugate Vaccines in Very Low Birth Weight Infants. Pediatr Infect Dis J. 2013 Dec; 32(12):1400-2.
    View in: PubMed
  3. Wynn JL, Li L, Cotten CM, Phelps DL, Shankaran S, Goldberg RN, Carlo WA, Van Meurs K, Das A, Vohr BR, Higgins RD, Stoll BJ, D'Angio CT. Blood stream infection is associated with altered heptavalent pneumococcal conjugate vaccine immune responses in very low birth weight infants. J Perinatol. 2013 Aug; 33(8):613-8.
    View in: PubMed
  4. Butler-O'Hara M, D'Angio CT, Hoey H, Stevens TP. An evidence-based catheter bundle alters central venous catheter strategy in newborn infants. J Pediatr. 2012 Jun; 160(6):972-7.e2.
    View in: PubMed
  5. D'Angio CT, Heyne RJ, Duara S, Holmes LC, O'Shea TM, Wang H, Wang D, Sánchez PJ, Welliver RC, Ryan RM, Schnabel KC, Hall CB. Immunogenicity of trivalent influenza vaccine in extremely low-birth-weight, premature versus term infants. Pediatr Infect Dis J. 2011 Jul; 30(7):570-4.
    View in: PubMed
  6. Ang JY, Lua JL, Asmar BI, Shankaran S, Heyne RJ, Schelonka RL, Das A, Li L, Jackson DM, Higgins RD, D'Angio CT. Nasopharyngeal carriage of Streptococcus pneumoniae in very low-birth-weight infants after administration of heptavalent pneumococcal conjugate vaccine. Arch Pediatr Adolesc Med. 2010 Dec; 164(12):1173-5.
    View in: PubMed
  7. D'Angio CT, Heyne RJ, O'Shea TM, Schelonka RL, Shankaran S, Duara S, Goldberg RN, Stoll BJ, Van Meurs KP, Vohr BR, Das A, Li L, Burton RL, Hastings B, Phelps DL, Sanchez PJ, Carlo WA, Stevenson DK, Higgins RD. Heptavalent pneumococcal conjugate vaccine immunogenicity in very-low-birth-weight, premature infants. Pediatr Infect Dis J. 2010 Jul; 29(7):600-6.
    View in: PubMed
  8. Ellsworth MA, Stevens TP, D'Angio CT. Infant race affects application of clinical guidelines when screening for drugs of abuse in newborns. Pediatrics. 2010 Jun; 125(6):e1379-85.
    View in: PubMed
  9. Weinberg GA, D'Angio CT. The search for new diagnostic tests for neonatal sepsis. J Pediatr. 2009 Nov; 155(5):763-4; author reply 764.
    View in: PubMed
  10. Panthagani ID, Santos MC, D'Angio CT. Use of computed tomography to categorize the type of tracheal agenesis. J Pediatr Surg. 2009 May; 44(5):1044-6.
    View in: PubMed
  11. Ambalavanan N, Carlo WA, D'Angio CT, McDonald SA, Das A, Schendel D, Thorsen P, Higgins RD. Cytokines associated with bronchopulmonary dysplasia or death in extremely low birth weight infants. Pediatrics. 2009 Apr; 123(4):1132-41.
    View in: PubMed
  12. Narang S, Roy J, Stevens TP, Butler-O'Hara M, Mullen CA, D'Angio CT. Risk factors for umbilical venous catheter-associated thrombosis in very low birth weight infants. Pediatr Blood Cancer. 2009 Jan; 52(1):75-9.
    View in: PubMed
  13. D'Angio CT, Boohene PA, Mowrer A, Audet S, Menegus MA, Schmid DS, Beeler JA. Measles-mumps-rubella and varicella vaccine responses in extremely preterm infants. Pediatrics. 2007 Mar; 119(3):e574-9.
    View in: PubMed
  14. D'Angio CT. Active immunization of premature and low birth-weight infants: a review of immunogenicity, efficacy, and tolerability. Paediatr Drugs. 2007; 9(1):17-32.
    View in: PubMed
  15. Chess PR, D'Angio CT, Pryhuber GS, Maniscalco WM. Pathogenesis of bronchopulmonary dysplasia. Semin Perinatol. 2006 Aug; 30(4):171-8.
    View in: PubMed
  16. Butler-O'Hara M, Buzzard CJ, Reubens L, McDermott MP, DiGrazio W, D'Angio CT. A randomized trial comparing long-term and short-term use of umbilical venous catheters in premature infants with birth weights of less than 1251 grams. Pediatrics. 2006 Jul; 118(1):e25-35.
    View in: PubMed
  17. Reininger A, Khalak R, Kendig JW, Ryan RM, Stevens TP, Reubens L, D'Angio CT. Surfactant administration by transient intubation in infants 29 to 35 weeks' gestation with respiratory distress syndrome decreases the likelihood of later mechanical ventilation: a randomized controlled trial. J Perinatol. 2005 Nov; 25(11):703-8.
    View in: PubMed
  18. Harris MC, D'Angio CT, Gallagher PR, Kaufman D, Evans J, Kilpatrick L. Cytokine elaboration in critically ill infants with bacterial sepsis, necrotizing entercolitis, or sepsis syndrome: correlation with clinical parameters of inflammation and mortality. J Pediatr. 2005 Oct; 147(4):462-8.
    View in: PubMed
  19. D'Angio CT, Chess PR, Kovacs SJ, Sinkin RA, Phelps DL, Kendig JW, Myers GJ, Reubens L, Ryan RM. Pressure-regulated volume control ventilation vs synchronized intermittent mandatory ventilation for very low-birth-weight infants: a randomized controlled trial. Arch Pediatr Adolesc Med. 2005 Sep; 159(9):868-75.
    View in: PubMed
  20. Van Meurs KP, Wright LL, Ehrenkranz RA, Lemons JA, Ball MB, Poole WK, Perritt R, Higgins RD, Oh W, Hudak ML, Laptook AR, Shankaran S, Finer NN, Carlo WA, Kennedy KA, Fridriksson JH, Steinhorn RH, Sokol GM, Konduri GG, Aschner JL, Stoll BJ, D'Angio CT, Stevenson DK. Inhaled nitric oxide for premature infants with severe respiratory failure. N Engl J Med. 2005 Jul 7; 353(1):13-22.
    View in: PubMed
  21. D'Angio CT, Maniscalco WM. Bronchopulmonary dysplasia in preterm infants: pathophysiology and management strategies. Paediatr Drugs. 2004; 6(5):303-30.
    View in: PubMed
  22. Varughese R, Nayak JL, LoMonaco M, O'Reilly MA, Ryan RM, D'Angio CT. Effects of hyperoxia on tumor necrosis factor alpha and Grobeta expression in newborn rabbit lungs. Lung. 2003 Nov-Dec; 181(6):335-46.
    View in: PubMed
  23. D'Angio CT, LoMonaco MB, Johnston CJ, Reed CK, Finkelstein JN. Differential roles for NF-kappa B in endotoxin and oxygen induction of interleukin-8 in the macrophage. Am J Physiol Lung Cell Mol Physiol. 2004 Jan; 286(1):L30-6.
    View in: PubMed
  24. Hjort MR, Brenyo AJ, Finkelstein JN, Frampton MW, LoMonaco MB, Stewart JC, Johnston CJ, D'Angio CT. Alveolar epithelial cell-macrophage interactions affect oxygen-stimulated interleukin-8 release. Inflammation. 2003 Jun; 27(3):137-45.
    View in: PubMed
  25. D'Angio CT, Sinkin RA, Stevens TP, Landfish NK, Merzbach JL, Ryan RM, Phelps DL, Palumbo DR, Myers GJ. Longitudinal, 15-year follow-up of children born at less than 29 weeks' gestation after introduction of surfactant therapy into a region: neurologic, cognitive, and educational outcomes. Pediatrics. 2002 Dec; 110(6):1094-102.
    View in: PubMed
  26. Uy IP, D'Angio CT, Menegus M, Guillet R. Changes in early-onset group B beta hemolytic streptococcus disease with changing recommendations for prophylaxis. J Perinatol. 2002 Oct-Nov; 22(7):516-22.
    View in: PubMed
  27. Butler-O'Hara M, D'Angio CT. Risk of persistent renal insufficiency in premature infants following the prenatal use of indomethacin for suppression of preterm labor. J Perinatol. 2002 Oct-Nov; 22(7):541-6.
    View in: PubMed
  28. Staversky RJ, Watkins RH, Wright TW, Hernady E, LoMonaco MB, D'Angio CT, Williams JP, Maniscalco WM, O'Reilly MA. Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1). Am J Pathol. 2002 Oct; 161(4):1383-93.
    View in: PubMed
  29. D'Angio CT, Maniscalco WM. The role of vascular growth factors in hyperoxia-induced injury to the developing lung. Front Biosci. 2002 Jul 1; 7:d1609-23.
    View in: PubMed
  30. Waheed S, D'Angio CT, Wagner CL, Madtes DK, Finkelstein JN, Paxhia A, Ryan RM. Transforming growth factor alpha (TGF(alpha)) is increased during hyperoxia and fibrosis. Exp Lung Res. 2002 Jul-Aug; 28(5):361-72.
    View in: PubMed
  31. Hastings RH, Ryan RM, D'Angio CT, Holm BA, Patel A, Quintana R, Biederman E, Burton DW, Deftos LJ. Parathyroid hormone-related protein response to hyperoxic lung injury. Am J Physiol Lung Cell Mol Physiol. 2002 Jun; 282(6):L1198-208.
    View in: PubMed
  32. Kirmani KI, Lofthus G, Pichichero ME, Voloshen T, D'Angio CT. Seven-year follow-up of vaccine response in extremely premature infants. Pediatrics. 2002 Mar; 109(3):498-504.
    View in: PubMed
  33. D'Angio CT, Basavegowda K, Avissar NE, Finkelstein JN, Sinkin RA. Comparison of tracheal aspirate and bronchoalveolar lavage specimens from premature infants. Biol Neonate. 2002; 82(3):145-9.
    View in: PubMed
  34. D'Angio CT, Ambati J, Phelps DL. Do urinary levels of vascular endothelial growth factor predict proliferative retinopathy? Curr Eye Res. 2001 Feb; 22(2):90-4.
    View in: PubMed
  35. O'Reilly MA, Staversky RJ, Huyck HL, Watkins RH, LoMonaco MB, D'Angio CT, Baggs RB, Maniscalco WM, Pryhuber GS. Bcl-2 family gene expression during severe hyperoxia induced lung injury. Lab Invest. 2000 Dec; 80(12):1845-54.
    View in: PubMed
  36. D'Angio CT, Finkelstein JN. Oxygen regulation of gene expression: a study in opposites. Mol Genet Metab. 2000 Sep-Oct; 71(1-2):371-80.
    View in: PubMed
  37. D'Angio CT. High altitude as an explanation for bronchiolitis-associated hospitalizations. Pediatr Infect Dis J. 2000 May; 19(5):492.
    View in: PubMed
  38. Dangio CT, Hall CB. Timing of vaccinations in premature infants. BioDrugs. 2000 May; 13(5):335-46.
    View in: PubMed
  39. Sinkin RA, Dweck HS, Horgan MJ, Gallaher KJ, Cox C, Maniscalco WM, Chess PR, D'Angio CT, Guillet R, Kendig JW, Ryan RM, Phelps DL. Early dexamethasone-attempting to prevent chronic lung disease. Pediatrics. 2000 Mar; 105(3 Pt 1):542-8.
    View in: PubMed
  40. D'Angio CT, Maniscalco WM, Ryan RM, Avissar NE, Basavegowda K, Sinkin RA. Vascular endothelial growth factor in pulmonary lavage fluid from premature infants: effects of age and postnatal dexamethasone. Biol Neonate. 1999 Nov; 76(5):266-73.
    View in: PubMed
  41. D'Angio CT. Immunization of the premature infant. Pediatr Infect Dis J. 1999 Sep; 18(9):824-5.
    View in: PubMed
  42. D'Angio CT, LoMonaco MB, Chaudhry SA, Paxhia A, Ryan RM. Discordant pulmonary proinflammatory cytokine expression during acute hyperoxia in the newborn rabbit. Exp Lung Res. 1999 Jul-Aug; 25(5):443-65.
    View in: PubMed
  43. Watkins RH, D'Angio CT, Ryan RM, Patel A, Maniscalco WM. Differential expression of VEGF mRNA splice variants in newborn and adult hyperoxic lung injury. Am J Physiol. 1999 May; 276(5 Pt 1):L858-67.
    View in: PubMed
  44. Charafeddine L, D'Angio CT, Phelps DL. Atypical chronic lung disease patterns in neonates. Pediatrics. 1999 Apr; 103(4 Pt 1):759-65.
    View in: PubMed
  45. Charafeddine L, D'Angio CT, Richards JL, Stripp BR, Finkelstein JN, Orlowski CC, LoMonaco MB, Paxhia A, Ryan RM. Hyperoxia increases keratinocyte growth factor mRNA expression in neonatal rabbit lung. Am J Physiol. 1999 Jan; 276(1 Pt 1):L105-13.
    View in: PubMed
  46. D'Angio CT, Johnston CJ, Wright TW, Reed CK, Finkelstein JN. Chemokine mRNA alterations in newborn and adult mouse lung during acute hyperoxia. Exp Lung Res. 1998 Sep-Oct; 24(5):685-702.
    View in: PubMed
  47. D'Angio CT. Neonatology radiology casebook. Tracheal agenesis. J Perinatol. 1998 Jul-Aug; 18(4):320-1.
    View in: PubMed
  48. Khalak R, Pichichero ME, D'Angio CT. Three-year follow-up of vaccine response in extremely preterm infants. Pediatrics. 1998 Apr; 101(4 Pt 1):597-603.
    View in: PubMed
  49. Chess PR, D'Angio CT. Clonic movements following lorazepam administration in full-term infants. Arch Pediatr Adolesc Med. 1998 Jan; 152(1):98-9.
    View in: PubMed
  50. Ambati J, Chalam KV, Chawla DK, D'Angio CT, Guillet EG, Rose SJ, Vanderlinde RE, Ambati BK. Elevated gamma-aminobutyric acid, glutamate, and vascular endothelial growth factor levels in the vitreous of patients with proliferative diabetic retinopathy. Arch Ophthalmol. 1997 Sep; 115(9):1161-6.
    View in: PubMed
  51. Maniscalco WM, Watkins RH, D'Angio CT, Ryan RM. Hyperoxic injury decreases alveolar epithelial cell expression of vascular endothelial growth factor (VEGF) in neonatal rabbit lung. Am J Respir Cell Mol Biol. 1997 May; 16(5):557-67.
    View in: PubMed
  52. D'Angio CT, Finkelstein JN, Lomonaco MB, Paxhia A, Wright SA, Baggs RB, Notter RH, Ryan RM. Changes in surfactant protein gene expression in a neonatal rabbit model of hyperoxia-induced fibrosis. Am J Physiol. 1997 Apr; 272(4 Pt 1):L720-30.
    View in: PubMed
  53. Daly HE, Baecher-Allan CM, Barth RK, D'Angio CT, Finkelstein JN. Bleomycin induces strain-dependent alterations in the pattern of epithelial cell-specific marker expression in mouse lung. Toxicol Appl Pharmacol. 1997 Feb; 142(2):303-10.
    View in: PubMed
  54. D'Angio CT, Froehlke RG, Plank GA, Meehan DJ, Aguilar CM, Lande MB, Hugar L. Long-term outcome of Haemophilus influenzae meningitis in Navajo Indian children. Arch Pediatr Adolesc Med. 1995 Sep; 149(9):1001-8.
    View in: PubMed
  55. D'Angio CT, Maniscalco WM, Pichichero ME. Immunologic response of extremely premature infants to tetanus, Haemophilus influenzae, and polio immunizations. Pediatrics. 1995 Jul; 96(1 Pt 1):18-22.
    View in: PubMed
  56. D'Angio CT, Sinkin RA, LoMonaco MB, Finkelstein JN. Interleukin-8 and monocyte chemoattractant protein-1 mRNAs in oxygen-injured rabbit lung. Am J Physiol. 1995 May; 268(5 Pt 1):L826-31.
    View in: PubMed
  57. Sherer DM, Abramowicz JS, D'Angio C, Harshbarger R, Metlay LA, Woods JR. Hepatic interlobar fissure sonographically mimicking the diaphragm in a fetus with right congenital diaphragmatic hernia. Am J Perinatol. 1993 Jul; 10(4):319-22.
    View in: PubMed
  58. Mahone PR, Sherer DM, D'Angio C, Woods JR. Prenatal ultrasonographic findings associated with wide clefting of the upper two thirds of the fetal sternum. Am J Obstet Gynecol. 1992 Apr; 166(4):1219-21.
    View in: PubMed
  59. D'Angio CT, Dillon MJ, Leonard JV. Renal tubular dysfunction in methylmalonic acidaemia. Eur J Pediatr. 1991 Feb; 150(4):259-63.
    View in: PubMed
  60. St Geme JW, Bell LM, Baumgart S, D'Angio CT, Harris MC. Distinguishing sepsis from blood culture contamination in young infants with blood cultures growing coagulase-negative staphylococci. Pediatrics. 1990 Aug; 86(2):157-62.
    View in: PubMed
  61. D'Angio CT, McGowan KL, Baumgart S, St Geme J, Harris MC. Surface colonization with coagulase-negative staphylococci in premature neonates. J Pediatr. 1989 Jun; 114(6):1029-34.
    View in: PubMed
  62. D'Angio CT, Lloyd JK. Nephrocalcinosis in Shwachman's syndrome. Arch Dis Child. 1989 Apr; 64(4):614-5.
    View in: PubMed

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