Paul Rubery
| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Orthopaedics |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 665
Rochester NY 14642
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| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Pediatrics |
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| 1984 |
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| Omicron Delta Kappa Leadership Honor Society, The Johns Hopkins University | | 1987 |
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| Alpha Omega Alpha, Cornell University Medical College | | 1988 |
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| T.Campbell Thompson Prize in Orthopaedics, Cornell University Medical College | | 1993 |
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| POCNY research prize for best resident paper at Pediatric Orthopaedic Club of New York annual research night | | 2009 |
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| Best Doctors in America for Spinal Surgery |
The use of gene transfer to improve cartilage repair, ligament healing, and restoration of various additional tissues, including tendon and meniscus shows great promise. Other applications include intervertebral disc degeneration, aseptic loosening, osteoporosis, genetic diseases, and orthopaedic tumors. Dr. Rubery's research focuses on finding gene delivery systems that can mediate site-specific transduction restricted to within the margins of the defect during routine arthroscopy. He serves as a consulting scientist for LAGeT Musculoskeletal, LLC in the development of a technology process, termed LAGT (Light Activated Gene Therapy) for articular and meniscal cartilage repair, ligament and tendon healing and enhanced spinal fusion.
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Offley SC, Coyne E, Horodyski M, Rubery PT, Zeidman SM, Rechtine GR. Randomized trial demonstrates that extended-release epidural morphine may provide safe pain control for lumbar surgery patients. Surg Neurol Int. 2013; 4(Suppl 2):S51-7.
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Rubery PT, Brown R, Prasarn M, Small J, Conrad B, Horodyski M, Rechtine G. Stabilization of 2-column thoracolumbar fractures with orthoses: a cadaver model. Spine (Phila Pa 1976). 2013 Mar 1; 38(5):E270-5.
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Wang M, Tang D, Shu B, Wang B, Jin H, Hao S, Dresser KA, Shen J, Im HJ, Sampson ER, Rubery PT, Zuscik MJ, Schwarz EM, O'Keefe RJ, Wang Y, Chen D. Conditional activation of ß-catenin signaling in mice leads to severe defects in intervertebral disc tissue. Arthritis Rheum. 2012 Aug; 64(8):2611-23.
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Prasarn ML, Horodyski M, Conrad B, Rubery PT, Dubose D, Small J, Rechtine GR. Comparison of external fixation versus the trauma pelvic orthotic device on unstable pelvic injuries: A cadaveric study of stability. J Trauma Acute Care Surg. 2012 Jun; 72(6):1671-5.
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Prasarn ML, Conrad B, Rubery PT, Wendling A, Aydog T, Horodyski M, Rechtine GR. Comparison of 4 airway devices on cervical spine alignment in a cadaver model with global ligamentous instability at c5-c6. Spine (Phila Pa 1976). 2012 Mar 15; 37(6):476-81.
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Papuga MO, Kwok E, You Z, Rubery PT, Dougherty PE, Pryhuber G, Beck CA, Hilton MJ, Awad HA, Schwarz EM. TNF is required for the induction but not the maintenance of compression-induced BME signals in murine tail vertebrae: limitations of anti-TNF therapy for degenerative disc disease. J Orthop Res. 2011 Sep; 29(9):1367-74.
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Papuga MO, Proulx ST, Kwok E, You Z, Rubery PT, Dougherty PE, Hilton MJ, Awad HA, Schwarz EM. Chronic axial compression of the mouse tail segment induces MRI bone marrow edema changes that correlate with increased marrow vasculature and cellularity. J Orthop Res. 2010 Sep; 28(9):1220-8.
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Rubery PT. Enhancing allograft bone healing through gene therapy. Spine (Phila Pa 1976). 2010 Aug 1; 35(17):1640-7.
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Rubery PT, Bukata SV. Teriparatide may accelerate healing in delayed unions of type III odontoid fractures: a report of 3 cases. J Spinal Disord Tech. 2010 Apr; 23(2):151-5.
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Brandenstein D, Molinari RW, Rubery PT, Rechtine GR. Unstable subaxial cervical spine injury with normal computed tomography and magnetic resonance initial imaging studies: a report of four cases and review of the literature. Spine (Phila Pa 1976). 2009 Sep 15; 34(20):E743-50.
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Perlmutter DH, Campbell S, Rubery PT, Vates EG, Silberstein HJ. Aneurysmal bone cyst: surgical management in the pediatric cervical spine. Spine (Phila Pa 1976). 2009 Jan 1; 34(1):E50-3.
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Andersson GB, Bridwell KH, Danielsson A, Dolan LA, Everett CR, Fisher CG, Mercado E, Mulpuri K, Richards BS, Rubery PT, Sponseller PD, Weinstein JN. Evidence-based medicine summary statement. Spine (Phila Pa 1976). 2007 Sep 1; 32(19 Suppl):S64-5.
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Reynolds DG, Hock C, Shaikh S, Jacobson J, Zhang X, Rubery PT, Beck CA, O'keefe RJ, Lerner AL, Schwarz EM, Awad HA. Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts. J Biomech. 2007; 40(14):3178-86.
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Xie C, Reynolds D, Awad H, Rubery PT, Pelled G, Gazit D, Guldberg RE, Schwarz EM, O'Keefe RJ, Zhang X. Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering. Tissue Eng. 2007 Mar; 13(3):435-45.
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Maloney MD, Goater JJ, Parsons R, Ito H, O'Keefe RJ, Rubery PT, Drissi MH, Schwarz EM. Safety and efficacy of ultraviolet-a light-activated gene transduction for gene therapy of articular cartilage defects. J Bone Joint Surg Am. 2006 Apr; 88(4):753-61.
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Zhang X, Xie C, Lin AS, Ito H, Awad H, Lieberman JR, Rubery PT, Schwarz EM, O'Keefe RJ, Guldberg RE. Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering. J Bone Miner Res. 2005 Dec; 20(12):2124-37.
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Koefoed M, Ito H, Gromov K, Reynolds DG, Awad HA, Rubery PT, Ulrich-Vinther M, Soballe K, Guldberg RE, Lin AS, O'Keefe RJ, Zhang X, Schwarz EM. Biological effects of rAAV-caAlk2 coating on structural allograft healing. Mol Ther. 2005 Aug; 12(2):212-8.
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Ito H, Koefoed M, Tiyapatanaputi P, Gromov K, Goater JJ, Carmouche J, Zhang X, Rubery PT, Rabinowitz J, Samulski RJ, Nakamura T, Soballe K, O'Keefe RJ, Boyce BF, Schwarz EM. Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy. Nat Med. 2005 Mar; 11(3):291-7.
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Tiyapatanaputi P, Rubery PT, Carmouche J, Schwarz EM, O'keefe RJ, Zhang X. A novel murine segmental femoral graft model. J Orthop Res. 2004 Nov; 22(6):1254-60.
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Lustik SJ, Papadakos PJ, Jackman KV, Rubery PT, Kaplan KL, Chhibber AK. Nicardipine versus nitroprusside for deliberate hypotension during idiopathic scoliosis repair. J Clin Anesth. 2004 Feb; 16(1):25-33.
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Ito H, Goater JJ, Tiyapatanaputi P, Rubery PT, O'Keefe RJ, Schwarz EM. Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells. Gene Ther. 2004 Jan; 11(1):34-41.
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Patel RK, Rubery PT, Myers S, Everett CR. Pedicle lesion in the toddler: a radiologic review. Pain Physician. 2003 Apr; 6(2):213-6.
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Rubery PT, Bradford DS. Athletic activity after spine surgery in children and adolescents: results of a survey. Spine (Phila Pa 1976). 2002 Feb 15; 27(4):423-7.
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Rubery PT, Smith MD, Cammisa FP, Silane M. Mycotic aortic aneurysm in patients who have lumbar vertebral osteomyelitis. A report of two cases. J Bone Joint Surg Am. 1995 Nov; 77(11):1729-32.
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Rubery PT, Spielman JH, Hester P, Axelrod E, Burke SW, Levine DB. Scoliosis in familial dysautonomia. Operative treatment. J Bone Joint Surg Am. 1995 Sep; 77(9):1362-9.
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