Yuhchyau Chen
| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Radiation Oncology |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 647
Rochester NY 14642
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| Title | Chair |
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| Institution | School of Medicine and Dentistry |
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| Department | Radiation Oncology |
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| 1982 |
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| 1983 | Research Assistantship in Surgery | University of Washington School of Medicine | | 1983 |
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| 1984 | Graduate School Research Assistantship | | 1986 |
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| 1990 | Course Honors | University of Washington School of Medicine | | 2001 |
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| Teacher of the Year | The Association of Residents in Radiation Oncology |
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Sun H, Tsai Y, Nowak I, Liesveld J, Chen Y. Eltrombopag, a thrombopoietin receptor agonist, enhances human umbilical cord blood hematopoietic stem/primitive progenitor cell expansion and promotes multi-lineage hematopoiesis. Stem Cell Res. 2012 Sep; 9(2):77-86.
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Reid R, Bennett JM, Becker M, Chen Y, Milner L, Phillips Ii GL, Liesveld J. Use of eltrombopag, a thrombopoietin receptor agonist, in post-transplantation thrombocytopenia. Am J Hematol. 2012 Jul; 87(7):743-5.
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Milano MT, Zhang H, Usuki KY, Singh DP, Chen Y. Definitive radiotherapy for stage I nonsmall cell lung cancer: A population-based study of survival. Cancer. 2012 Nov 15; 118(22):5572-9.
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Milano MT, Peterson CR, Zhang H, Singh DP, Chen Y. Second primary lung cancer after head and neck squamous cell cancer: Population-based study of risk factors. Head Neck. 2012 Dec; 34(12):1782-8.
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Schuette W, Krzakowski MJ, Massuti B, Otterson GA, Lizambri R, Wei H, Berger DP, Chen Y. Randomized Phase II Study of Palifermin for Reducing Dysphagia in Patients Receiving Concurrent Chemoradiotherapy for Locally Advanced Unresectable Non-small Cell Lung Cancer. J Thorac Oncol. 2012 Jan; 7(1):157-64.
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Zhang H, Travis LB, Chen R, Hyrien O, Milano MT, Newlands SD, Chen Y. Impact of radiotherapy on laryngeal cancer survival: A Population-Based Study of 13,808 US Patients. Cancer. 2012 Mar 1; 118(5):1276-87.
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Cheruvu P, Metcalfe SK, Metcalfe J, Chen Y, Okunieff P, Milano MT. Comparison of outcomes in patients with stage III versus limited stage IV non-small cell lung cancer. Radiat Oncol. 2011; 6:80.
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Le QT, Kim HE, Schneider CJ, Muraközy G, Skladowski K, Reinisch S, Chen Y, Hickey M, Mo M, Chen MG, Berger D, Lizambri R, Henke M. Palifermin reduces severe mucositis in definitive chemoradiotherapy of locally advanced head and neck cancer: a randomized, placebo-controlled study. J Clin Oncol. 2011 Jul 10; 29(20):2808-14.
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Peslak SA, Wenger J, Bemis JC, Kingsley PD, Frame JM, Koniski AD, Chen Y, Williams JP, McGrath KE, Dertinger SD, Palis J. Sublethal radiation injury uncovers a functional transition during erythroid maturation. Exp Hematol. 2011 Apr; 39(4):434-45.
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Sun H, Tsai Y, Nowak I, Dertinger SD, Wu JH, Chen Y. Response kinetics of radiation-induced micronucleated reticulocytes in human bone marrow culture. Mutat Res. 2011 Jan 10; 718(1-2):38-43.
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Chen Y, Pandya KJ, Hyrien O, Keng PC, Smudzin T, Anderson J, Qazi R, Smith B, Watson TJ, Feins RH, Johnstone DW. Preclinical and pilot clinical studies of docetaxel chemoradiation for Stage III non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2011 Aug 1; 80(5):1358-64.
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Metcalfe SK, Milano MT, Bylund K, Smudzin T, Rubin P, Chen Y. Split-course palliative radiotherapy for advanced non-small cell lung cancer. J Thorac Oncol. 2010 Feb; 5(2):185-90.
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Chen Y, Tsai Y, Nowak I, Wang N, Hyrien O, Wilkins R, Ferrarotto C, Sun H, Dertinger SD. Validating high-throughput micronucleus analysis of peripheral reticulocytes for radiation biodosimetry: benchmark against dicentric and CBMN assays in a mouse model. Health Phys. 2010 Feb; 98(2):218-27.
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Tucker SL, Jin H, Wei X, Wang S, Martel MK, Komaki R, Liu HH, Mohan R, Chen Y, Cox JD, Liao Z. Impact of toxicity grade and scoring system on the relationship between mean lung dose and risk of radiation pneumonitis in a large cohort of patients with non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2010 Jul 1; 77(3):691-8.
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Sun H, Dertinger SD, Hyrien O, Wu JH, Chen Y. Gamma-radiation induces micronucleated reticulocytes in 3D bone marrow bioreactors in vitro. Mutat Res. 2009 Nov-Dec; 680(1-2):49-55.
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Albain KS, Swann RS, Rusch VW, Turrisi AT, Shepherd FA, Smith C, Chen Y, Livingston RB, Feins RH, Gandara DR, Fry WA, Darling G, Johnson DH, Green MR, Miller RC, Ley J, Sause WT, Cox JD. Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial. Lancet. 2009 Aug 1; 374(9687):379-86.
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Woodward WA, Bristow RG, Clarke MF, Coppes RP, Cristofanilli M, Duda DG, Fike JR, Hambardzumyan D, Hill RP, Jordan CT, Milas L, Pajonk F, Curran WJ, Dicker AP, Chen Y. Radiation Therapy Oncology Group translational research program stem cell symposium: incorporating stem cell hypotheses into clinical trials. Int J Radiat Oncol Biol Phys. 2009 Aug 1; 74(5):1580-91.
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Milano MT, Chen Y, Katz AW, Philip A, Schell MC, Okunieff P. Central thoracic lesions treated with hypofractionated stereotactic body radiotherapy. Radiother Oncol. 2009 Jun; 91(3):301-6.
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Roscoe JA, Bushunow P, Jean-Pierre P, Heckler CE, Purnell JQ, Peppone LJ, Chen Y, Ling MN, Morrow GR. Acupressure bands are effective in reducing radiation therapy-related nausea. J Pain Symptom Manage. 2009 Sep; 38(3):381-9.
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Chawla S, Chen Y, Katz AW, Muhs AG, Philip A, Okunieff P, Milano MT. Stereotactic body radiotherapy for treatment of adrenal metastases. Int J Radiat Oncol Biol Phys. 2009 Sep 1; 75(1):71-5.
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Dertinger SD, Bemis JC, Phonethepswath S, Tsai Y, Nowak I, Hyrien O, Palis J, Chen Y. Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: effect of age. Mutat Res. 2009 Apr 30; 675(1-2):77-80.
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Jin H, Tucker SL, Liu HH, Wei X, Yom SS, Wang S, Komaki R, Chen Y, Martel MK, Mohan R, Cox JD, Liao Z. Dose-volume thresholds and smoking status for the risk of treatment-related pneumonitis in inoperable non-small cell lung cancer treated with definitive radiotherapy. Radiother Oncol. 2009 Jun; 91(3):427-32.
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Okunieff P, Chen Y, Maguire DJ, Huser AK. Molecular markers of radiation-related normal tissue toxicity. Cancer Metastasis Rev. 2008 Sep; 27(3):363-74.
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Zhang H, Hyrien O, Pandya KJ, Keng PC, Chen Y. Tumor response kinetics after schedule-dependent paclitaxel chemoradiation treatment for inoperable non-small cell lung cancer: a model for low-dose chemotherapy radiosensitization. J Thorac Oncol. 2008 Jun; 3(6):563-8.
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Chen Y, Pandya KJ, Feins R, Johnstone DW, Watson T, Smudzin T, Keng PC. Toxicity profile and pharmacokinetic study of a phase I low-dose schedule-dependent radiosensitizing paclitaxel chemoradiation regimen for inoperable non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2008 Jun 1; 71(2):407-13.
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Chambers MS, Jones CU, Biel MA, Weber RS, Hodge KM, Chen Y, Holland JM, Ship JA, Vitti R, Armstrong I, Garden AS, Haddad R. Open-label, long-term safety study of cevimeline in the treatment of postirradiation xerostomia. Int J Radiat Oncol Biol Phys. 2007 Dec 1; 69(5):1369-76.
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Dertinger SD, Tsai Y, Nowak I, Hyrien O, Sun H, Bemis JC, Torous DK, Keng P, Palis J, Chen Y. Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: dose-response and time-course profiles measured by flow cytometry. Mutat Res. 2007 Dec 1; 634(1-2):119-25.
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Dertinger SD, Miller RK, Brewer K, Smudzin T, Torous DK, Roberts DJ, Avlasevich SL, Bryce SM, Sugunan S, Chen Y. Automated human blood micronucleated reticulocyte measurements for rapid assessment of chromosomal damage. Mutat Res. 2007 Jan 10; 626(1-2):111-9.
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Chen Y, Trotti A, Coleman CN, Machtay M, Mirimanoff RO, Hay J, O'brien PC, El-Gueddari B, Salvajoli JV, Jeremic B. Adverse event reporting and developments in radiation biology after normal tissue injury: International Atomic Energy Agency consultation. Int J Radiat Oncol Biol Phys. 2006 Apr 1; 64(5):1442-51.
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Okunieff P, Cornelison T, Mester M, Liu W, Ding I, Chen Y, Zhang H, Williams JP, Finkelstein J. Mechanism and modification of gastrointestinal soft tissue response to radiation: role of growth factors. Int J Radiat Oncol Biol Phys. 2005 May 1; 62(1):273-8.
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Chen Y, Hyrien O, Williams J, Okunieff P, Smudzin T, Rubin P. Interleukin (IL)-1A and IL-6: applications to the predictive diagnostic testing of radiation pneumonitis. Int J Radiat Oncol Biol Phys. 2005 May 1; 62(1):260-6.
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Okunieff P, Fenton B, Chen Y. Past, present, and future of oxygen in cancer research. Adv Exp Med Biol. 2005; 566:213-22.
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Chen Y, Okunieff P. Radiation and third-generation chemotherapy. Hematol Oncol Clin North Am. 2004 Feb; 18(1):55-80.
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Dertinger SD, Camphausen K, Macgregor JT, Bishop ME, Torous DK, Avlasevich S, Cairns S, Tometsko CR, Menard C, Muanza T, Chen Y, Miller RK, Cederbrant K, Sandelin K, Pontén I, Bolcsfoldi G. Three-color labeling method for flow cytometric measurement of cytogenetic damage in rodent and human blood. Environ Mol Mutagen. 2004; 44(5):427-35.
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Dertinger SD, Chen Y, Miller RK, Brewer KJ, Smudzin T, Torous DK, Hall NE, Olvany KA, Murante FG, Tometsko CR. Micronucleated CD71-positive reticulocytes: a blood-based endpoint of cytogenetic damage in humans. Mutat Res. 2003 Dec 9; 542(1-2):77-87.
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Liu W, Chen Y, Wang W, Keng P, Finkelstein J, Hu D, Liang L, Guo M, Fenton B, Okunieff P, Ding I. Combination of radiation and celebrex (celecoxib) reduce mammary and lung tumor growth. Am J Clin Oncol. 2003 Aug; 26(4):S103-9.
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Williams J, Chen Y, Rubin P, Finkelstein J, Okunieff P. The biological basis of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol. 2003 Jul; 13(3):182-8.
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Chen Y, Pandya K, Keng PC, Johnstone D, Li J, Lee YJ, Smudzin T, Okunieff P. Phase I/II clinical study of pulsed paclitaxel radiosensitization for thoracic malignancy: a therapeutic approach on the basis of preclinical research of human cancer cell lines. Clin Cancer Res. 2003 Mar; 9(3):969-75.
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Chen Y, Okunieff P, Ahrendt SA. Translational research in lung cancer. Semin Surg Oncol. 2003; 21(3):205-19.
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Chen Y, Williams J, Ding I, Hernady E, Liu W, Smudzin T, Finkelstein JN, Rubin P, Okunieff P. Radiation pneumonitis and early circulatory cytokine markers. Semin Radiat Oncol. 2002 Jan; 12(1 Suppl 1):26-33.
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Chen Y, Taghian AG, Rosenberg AE, O'Connell J, Okunieff P, Suit HD. Predictive value of histologic tumor necrosis after radiation. Int J Cancer. 2001 Dec 20; 96(6):334-40.
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Chen Y, Pandya K, Keng PP, Feins R, Raubertas R, Smudzin T, Rosenblatt J, Okunieff P. Schedule-dependent pulsed paclitaxel radiosensitization for thoracic malignancy. Am J Clin Oncol. 2001 Oct; 24(5):432-7.
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Chen Y, Rubin P, Williams J, Hernady E, Smudzin T, Okunieff P. Circulating IL-6 as a predictor of radiation pneumonitis. Int J Radiat Oncol Biol Phys. 2001 Mar 1; 49(3):641-8.
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Okunieff P, Barrett AJ, Phang SE, Li A, Constine LS, Williams JP, Rubin P, Wang X, Wu T, Chen Y, Ding I. Circulating basic fibroblast growth factor declines during Cy/TBI bone marrow transplantation. Bone Marrow Transplant. 1999 Jun; 23(11):1117-21.
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Poot M, Hoehn H, Kubbies M, Grossmann A, Chen Y, Rabinovitch PS. Cell-cycle analysis using continuous bromodeoxyuridine labeling and Hoechst 33358-ethidium bromide bivariate flow cytometry. Methods Cell Biol. 1994; 41:327-40.
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Chen Y, Richards TL, Izenberg S, Golden RN, Williams DL, Nelson JA, Steen RG. In vivo phosphorus NMR spectroscopy of skin using a crossover surface coil. Magn Reson Med. 1992 Jan; 23(1):46-54.
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Chen YY, Rabinovitch PS. Mitogen response and cell cycle kinetics of Swiss 3T3 cells in defined medium: differences from human fibroblasts and effects of cell density. Exp Cell Res. 1990 Oct; 190(2):145-50.
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Chen YY, Rabinovitch PS. Altered cell cycle responses to insulin-like growth factor I, but not platelet-derived growth factor and epidermal growth factor, in senescing human fibroblasts. J Cell Physiol. 1990 Jul; 144(1):18-25.
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Poot M, Hoehn H, Kubbies M, Grossmann A, Chen YC, Rabinovitch PS. Cell cycle analysis using continuous bromodeoxyuridine labeling and Hoechst 33258-ethidium bromide bivariate flow cytometry. Methods Cell Biol. 1990; 33:185-98.
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Chen Y, Rabinovitch PS. Platelet-derived growth factor, epidermal growth factor, and insulin-like growth factor I regulate specific cell-cycle parameters of human diploid fibroblasts in serum-free culture. J Cell Physiol. 1989 Jul; 140(1):59-67.
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Raghu G, Chen YY, Rusch V, Rabinovitch PS. Differential proliferation of fibroblasts cultured from normal and fibrotic human lungs. Am Rev Respir Dis. 1988 Sep; 138(3):703-8.
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Rabinovitch PS, Kubbies M, Chen YC, Schindler D, Hoehn H. BrdU-Hoechst flow cytometry: a unique tool for quantitative cell cycle analysis. Exp Cell Res. 1988 Feb; 174(2):309-18.
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