Jacob Finkelstein
| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Pediatrics |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester NY 14642
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| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Environmental Medicine |
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| 1974 |
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| Sigma Xi Graduate Research Symposium Award | | 1986 |
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| Elected member, Perinatal Research Society | | 2006 |
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| March of Dimes Health Leadership Award |
Dr. Finkelstein's laboratory research emphasizes the role of the alveolar epithelium in modulating the pulmonary injury response to physiological and toxicological stimuli. This includes studies of oxidant induced signaling in the pulmonary epithelium and macrophages and epithelial production of cytokines and chemokines in the regulation of the inflammatory functions of alveolar macrophages. His previous research effort focused on the pulmonary alveolar type II cell as the site of pulmonary surfactant synthesis and secretion, and studies on the basic cell and molecular biology of these processes are still an important facet of his work. In addition, the type II cell also plays an important role as the stem cell for renewal of the alveolar epithelium both in the normal lung development and during epithelial repair and renewal following lung injury. The most recent data suggest that type II cells may also be involved in regulating the inflammatory functions of alveolar macrophages, as well as the actions of interstitial fibroblasts during lung growth or pulmonary fibrosis.
The overall goal of the current research is to identify some of the key control mechanisms involved in epithelial cell and fibroblast proliferation, and in related extracellular matrix synthesis, processing and assembly. This work seeks to define such mechanisms not only during normal lung growth and normal development, but also during the repair of epithelial damage, and may have important implications for pediatric and adult lung disease, including bronchopulmonary dysplasia (BPD) in premature infants. This work is funded by grants from NIH, EPA and DoD.
The overall goal of some of their additional current research is to identify some of the key control mechanisms involved in epithelial cell and fibroblast proliferation, and in related extracellular matrix synthesis, processing and assembly. This work seeks to define such mechanisms not only during normal lung growth and normal development, but also during the repair of epithelial damage, and may have important implications for pediatric and adult lung disease, including bronchopulmonary dysplasia (BPD) in premature infants.
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O'Reilly MA, Yee M, Buczynski BW, Vitiello PF, Keng PC, Welle SL, Finkelstein JN, Dean DA, Lawrence BP. Neonatal oxygen increases sensitivity to influenza a virus infection in adult mice by suppressing epithelial expression of ear1. Am J Pathol. 2012 Aug; 181(2):441-51.
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Han X, Corson N, Wade-Mercer P, Gelein R, Jiang J, Sahu M, Biswas P, Finkelstein JN, Elder A, Oberdörster G. Assessing the relevance of in vitro studies in nanotoxicology by examining correlations between in vitro and in vivo data. Toxicology. 2012 Jul 16; 297(1-3):1-9.
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Han X, Gelein R, Corson N, Wade-Mercer P, Jiang J, Biswas P, Finkelstein JN, Elder A, Oberdörster G. Validation of an LDH assay for assessing nanoparticle toxicity. Toxicology. 2011 Sep 5; 287(1-3):99-104.
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Johnston CJ, Manning C, Hernady E, Reed C, Thurston SW, Finkelstein JN, Williams JP. Effect of total body irradiation on late lung effects: hidden dangers. Int J Radiat Biol. 2011 Aug; 87(8):902-13.
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Wilson KM, Finkelstein JN, Blumkin AK, Best D, Klein JD. Micronutrient levels in children exposed to secondhand tobacco smoke. Nicotine Tob Res. 2011 Sep; 13(9):800-8.
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Marples B, Downing L, Sawarynski KE, Finkelstein JN, Williams JP, Martinez AA, Wilson GD, Sims MD. Pulmonary injury after combined exposures to low-dose low-LET radiation and fungal spores. Radiat Res. 2011 Apr; 175(4):501-9.
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Williams JP, Johnston CJ, Finkelstein JN. Treatment for radiation-induced pulmonary late effects: spoiled for choice or looking in the wrong direction? Curr Drug Targets. 2010 Nov; 11(11):1386-94.
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Johnston CJ, Hernady E, Reed C, Thurston SW, Finkelstein JN, Williams JP. Early alterations in cytokine expression in adult compared to developing lung in mice after radiation exposure. Radiat Res. 2010 Apr; 173(4):522-35.
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Kim SC, Chen DR, Qi C, Gelein RM, Finkelstein JN, Elder A, Bentley K, Oberdörster G, Pui DY. A nanoparticle dispersion method for in vitro and in vivo nanotoxicity study. Nanotoxicology. 2010 Mar; 4(1):42-51.
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Rushton EK, Jiang J, Leonard SS, Eberly S, Castranova V, Biswas P, Elder A, Han X, Gelein R, Finkelstein J, Oberdörster G. Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics. J Toxicol Environ Health A. 2010; 73(5):445-61.
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Saperstein S, Huyck H, Kimball E, Johnston C, Finkelstein J, Pryhuber G. The effects of interleukin-1beta in tumor necrosis factor-alpha-induced acute pulmonary inflammation in mice. Mediators Inflamm. 2009; 2009:958658.
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Fazal F, Bijli KM, Minhajuddin M, Rein T, Finkelstein JN, Rahman A. Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cells. J Biol Chem. 2009 Jul 31; 284(31):21047-56.
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Saperstein S, Chen L, Oakes D, Pryhuber G, Finkelstein J. IL-1beta augments TNF-alpha-mediated inflammatory responses from lung epithelial cells. J Interferon Cytokine Res. 2009 May; 29(5):273-84.
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Ehrenberg MS, Friedman AE, Finkelstein JN, Oberdörster G, McGrath JL. The influence of protein adsorption on nanoparticle association with cultured endothelial cells. Biomaterials. 2009 Feb; 30(4):603-10.
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Pryhuber GS, Huyck HL, Bhagwat S, O'Reilly MA, Finkelstein JN, Gigliotti F, Wright TW. Parenchymal cell TNF receptors contribute to inflammatory cell recruitment and respiratory failure in Pneumocystis carinii-induced pneumonia. J Immunol. 2008 Jul 15; 181(2):1409-19.
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Carter JM, Corson N, Driscoll KE, Elder A, Finkelstein JN, Harkema JN, Gelein R, Wade-Mercer P, Nguyen K, Oberdorster G. A comparative dose-related response of several key pro- and antiinflammatory mediators in the lungs of rats, mice, and hamsters after subchronic inhalation of carbon black. J Occup Environ Med. 2006 Dec; 48(12):1265-78.
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Johnston CJ, Holm BA, Gelein R, Finkelstein JN. Postnatal lung development: immediate-early gene responses post ozone and LPS exposure. Inhal Toxicol. 2006 Oct; 18(11):875-83.
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Oberdörster G, Finkelstein JN. In vitro dosing of cells with poorly soluble particles. Toxicol Sci. 2006 Dec; 94(2):439; author reply 440.
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Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Ito Y, Finkelstein J, Oberdörster G. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ Health Perspect. 2006 Aug; 114(8):1172-8.
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Yee M, Vitiello PF, Roper JM, Staversky RJ, Wright TW, McGrath-Morrow SA, Maniscalco WM, Finkelstein JN, O'Reilly MA. Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung development. Am J Physiol Lung Cell Mol Physiol. 2006 Nov; 291(5):L1101-11.
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Vitiello PF, Staversky RJ, Gehen SC, Johnston CJ, Finkelstein JN, Wright TW, O'Reilly MA. p21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growth. Am J Pathol. 2006 Jun; 168(6):1838-47.
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Bruckner L, Gigliotti F, Wright T, Harmsen A, Notter RH, Chess P, Wang Z, Finkelstein J. Pneumocystis carinii infection sensitizes lung to radiation-induced injury after syngeneic marrow transplantation: role of CD4+ T cells. Am J Physiol Lung Cell Mol Physiol. 2006 Jun; 290(6):L1087-96.
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Elder A, Gelein R, Finkelstein JN, Driscoll KE, Harkema J, Oberdörster G. Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology. Toxicol Sci. 2005 Dec; 88(2):614-29.
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Singal M, Finkelstein JN. Use of indicator cell lines for determining inflammatory gene changes and screening the inflammatory potential of particulate and non-particulate stimuli. Inhal Toxicol. 2005 Aug; 17(9):415-25.
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Singal M, Finkelstein JN. Amorphous silica particles promote inflammatory gene expression through the redox sensitive transcription factor, AP-1, in alveolar epithelial cells. Exp Lung Res. 2005 Jul-Aug; 31(6):581-97.
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Elder A, Johnston C, Gelein R, Finkelstein J, Wang Z, Notter R, Oberdörster G. Lung inflammation induced by endotoxin is enhanced in rats depleted of alveolar macrophages with aerosolized clodronate. Exp Lung Res. 2005 Jul-Aug; 31(6):527-46.
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Chess PR, O'Reilly MA, Sachs F, Finkelstein JN. Reactive oxidant and p42/44 MAP kinase signaling is necessary for mechanical strain-induced proliferation in pulmonary epithelial cells. J Appl Physiol. 2005 Sep; 99(3):1226-32.
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Okunieff P, Cornelison T, Mester M, Liu W, Ding I, Chen Y, Zhang H, Williams JP, Finkelstein J. Mechanism and modification of gastrointestinal soft tissue response to radiation: role of growth factors. Int J Radiat Oncol Biol Phys. 2005 May 1; 62(1):273-8.
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Johnston CJ, Holm BA, Finkelstein JN. Sequential exposures to ozone and lipopolysaccharide in postnatal lung enhance or inhibit cytokine responses. Exp Lung Res. 2005 May; 31(4):431-47.
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Wang J, Gigliotti F, Maggirwar S, Johnston C, Finkelstein JN, Wright TW. Pneumocystis carinii activates the NF-kappaB signaling pathway in alveolar epithelial cells. Infect Immun. 2005 May; 73(5):2766-77.
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Johnston CJ, Williams JP, Elder A, Hernady E, Finkelstein JN. Inflammatory cell recruitment following thoracic irradiation. Exp Lung Res. 2004 Jul-Aug; 30(5):369-82.
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Elder AC, Gelein R, Azadniv M, Frampton M, Finkelstein J, Oberdörster G. Systemic effects of inhaled ultrafine particles in two compromised, aged rat strains. Inhal Toxicol. 2004 Jun; 16(6-7):461-71.
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Williams JP, Hernady E, Johnston CJ, Reed CM, Fenton B, Okunieff P, Finkelstein JN. Effect of administration of lovastatin on the development of late pulmonary effects after whole-lung irradiation in a murine model. Radiat Res. 2004 May; 161(5):560-7.
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Finkelstein JN, Johnston CJ. Enhanced sensitivity of the postnatal lung to environmental insults and oxidant stress. Pediatrics. 2004 Apr; 113(4 Suppl):1092-6.
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Elder AC, Gelein R, Oberdörster G, Finkelstein J, Notter R, Wang Z. Efficient depletion of alveolar macrophages using intratracheally inhaled aerosols of liposome-encapsulated clodronate. Exp Lung Res. 2004 Mar; 30(2):105-20.
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Elder A, Gelein R, Finkelstein J, Phipps R, Frampton M, Utell M, Kittelson DB, Watts WF, Hopke P, Jeong CH, Kim E, Liu W, Zhao W, Zhuo L, Vincent R, Kumarathasan P, Oberdörster G. On-road exposure to highway aerosols. 2. Exposures of aged, compromised rats. Inhal Toxicol. 2004; 16 Suppl 1:41-53.
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D'Angio CT, LoMonaco MB, Johnston CJ, Reed CK, Finkelstein JN. Differential roles for NF-kappa B in endotoxin and oxygen induction of interleukin-8 in the macrophage. Am J Physiol Lung Cell Mol Physiol. 2004 Jan; 286(1):L30-6.
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Liu W, Chen Y, Wang W, Keng P, Finkelstein J, Hu D, Liang L, Guo M, Fenton B, Okunieff P, Ding I. Combination of radiation and celebrex (celecoxib) reduce mammary and lung tumor growth. Am J Clin Oncol. 2003 Aug; 26(4):S103-9.
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Williams J, Chen Y, Rubin P, Finkelstein J, Okunieff P. The biological basis of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol. 2003 Jul; 13(3):182-8.
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Hjort MR, Brenyo AJ, Finkelstein JN, Frampton MW, LoMonaco MB, Stewart JC, Johnston CJ, D'Angio CT. Alveolar epithelial cell-macrophage interactions affect oxygen-stimulated interleukin-8 release. Inflammation. 2003 Jun; 27(3):137-45.
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Roper JM, Staversky RJ, Finkelstein JN, Keng PC, O'Reilly MA. Identification and isolation of mouse type II cells on the basis of intrinsic expression of enhanced green fluorescent protein. Am J Physiol Lung Cell Mol Physiol. 2003 Sep; 285(3):L691-700.
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Pryhuber GS, Huyck HL, Baggs R, Oberdörster G, Finkelstein JN. Induction of chemokines by low-dose intratracheal silica is reduced in TNFR I (p55) null mice. Toxicol Sci. 2003 Mar; 72(1):150-7.
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O'Reilly MA, Staversky RJ, Finkelstein JN, Keng PC. Activation of the G2 cell cycle checkpoint enhances survival of epithelial cells exposed to hyperoxia. Am J Physiol Lung Cell Mol Physiol. 2003 Feb; 284(2):L368-75.
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Johnston CJ, Oberdörster G, Gelein R, Finkelstein JN. Endotoxin potentiates ozone-induced pulmonary chemokine and inflammatory responses. Exp Lung Res. 2002 Sep; 28(6):419-33.
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Waheed S, D'Angio CT, Wagner CL, Madtes DK, Finkelstein JN, Paxhia A, Ryan RM. Transforming growth factor alpha (TGF(alpha)) is increased during hyperoxia and fibrosis. Exp Lung Res. 2002 Jul-Aug; 28(5):361-72.
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Johnston CJ, Williams JP, Okunieff P, Finkelstein JN. Radiation-induced pulmonary fibrosis: examination of chemokine and chemokine receptor families. Radiat Res. 2002 Mar; 157(3):256-65.
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Chen Y, Williams J, Ding I, Hernady E, Liu W, Smudzin T, Finkelstein JN, Rubin P, Okunieff P. Radiation pneumonitis and early circulatory cytokine markers. Semin Radiat Oncol. 2002 Jan; 12(1 Suppl 1):26-33.
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D'Angio CT, Basavegowda K, Avissar NE, Finkelstein JN, Sinkin RA. Comparison of tracheal aspirate and bronchoalveolar lavage specimens from premature infants. Biol Neonate. 2002; 82(3):145-9.
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Chow E, Wong R, Hruby G, Connolly R, Franssen E, Fung KW, Andersson L, Schueller T, Stefaniuk K, Szumacher E, Hayter C, Pope J, Holden L, Loblaw A, Finkelstein J, Danjoux C. Prospective patient-based assessment of effectiveness of palliative radiotherapy for bone metastases. Radiother Oncol. 2001 Oct; 61(1):77-82.
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Johnston CJ, Oberdörster G, Finkelstein JN. Recovery from oxidant-mediated lung injury: response of metallothionein, MIP-2, and MCP-1 to nitrogen dioxide, oxygen, and ozone exposures. Inhal Toxicol. 2001 Aug; 13(8):689-702.
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O'Reilly MA, Staversky RJ, Watkins RH, Reed CK, de Mesy Jensen KL, Finkelstein JN, Keng PC. The cyclin-dependent kinase inhibitor p21 protects the lung from oxidative stress. Am J Respir Cell Mol Biol. 2001 Jun; 24(6):703-10.
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Johnston CJ, Finkelstein JN, Mercer P, Corson N, Gelein R, Oberdörster G. Pulmonary effects induced by ultrafine PTFE particles. Toxicol Appl Pharmacol. 2000 Nov 1; 168(3):208-15.
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Avissar NE, Reed CK, Cox C, Frampton MW, Finkelstein JN. Ozone, but not nitrogen dioxide, exposure decreases glutathione peroxidases in epithelial lining fluid of human lung. Am J Respir Crit Care Med. 2000 Oct; 162(4 Pt 1):1342-7.
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D'Angio CT, Finkelstein JN. Oxygen regulation of gene expression: a study in opposites. Mol Genet Metab. 2000 Sep-Oct; 71(1-2):371-80.
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Johnston CJ, Driscoll KE, Finkelstein JN, Baggs R, O'Reilly MA, Carter J, Gelein R, Oberdörster G. Pulmonary chemokine and mutagenic responses in rats after subchronic inhalation of amorphous and crystalline silica. Toxicol Sci. 2000 Aug; 56(2):405-13.
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Oberdörster G, Finkelstein JN, Johnston C, Gelein R, Cox C, Baggs R, Elder AC. Acute pulmonary effects of ultrafine particles in rats and mice. Res Rep Health Eff Inst. 2000 Aug; (96):5-74; disc. 75-86.
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Chess PR, Toia L, Finkelstein JN. Mechanical strain-induced proliferation and signaling in pulmonary epithelial H441 cells. Am J Physiol Lung Cell Mol Physiol. 2000 Jul; 279(1):L43-51.
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Elder AC, Finkelstein J, Johnston C, Gelein R, Oberdörster G. Induction of adaptation to inhaled lipopolysaccharide in young and old rats and mice. Inhal Toxicol. 2000 Mar; 12(3):225-43.
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Johnston CJ, Reed CK, Avissar NE, Gelein R, Finkelstein JN. Antioxidant and inflammatory response after acute nitrogen dioxide and ozone exposures in C57Bl/6 mice. Inhal Toxicol. 2000 Mar; 12(3):187-203.
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Johnston CJ, Oberdörster G, Gelein R, Finkelstein JN. Newborn mice differ from adult mice in chemokine and cytokine expression to ozone, but not to endotoxin. Inhal Toxicol. 2000 Mar; 12(3):205-24.
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Pryhuber GS, Huyck HL, Staversky RJ, Finkelstein JN, O'Reilly MA. Tumor necrosis factor-alpha-induced lung cell expression of antiapoptotic genes TRAF1 and cIAP2. Am J Respir Cell Mol Biol. 2000 Feb; 22(2):150-6.
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Elder AC, Gelein R, Finkelstein JN, Cox C, Oberdörster G. Pulmonary inflammatory response to inhaled ultrafine particles is modified by age, ozone exposure, and bacterial toxin. Inhal Toxicol. 2000; 12 Suppl 4:227-46.
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Barrett EG, Johnston C, Oberdörster G, Finkelstein JN. Silica binds serum proteins resulting in a shift of the dose-response for silica-induced chemokine expression in an alveolar type II cell line. Toxicol Appl Pharmacol. 1999 Dec 1; 161(2):111-22.
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Wright TW, Gigliotti F, Finkelstein JN, McBride JT, An CL, Harmsen AG. Immune-mediated inflammation directly impairs pulmonary function, contributing to the pathogenesis of Pneumocystis carinii pneumonia. J Clin Invest. 1999 Nov; 104(9):1307-17.
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Barrett EG, Johnston C, Oberdörster G, Finkelstein JN. Antioxidant treatment attenuates cytokine and chemokine levels in murine macrophages following silica exposure. Toxicol Appl Pharmacol. 1999 Aug 1; 158(3):211-20.
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Wright TW, Johnston CJ, Harmsen AG, Finkelstein JN. Chemokine gene expression during Pneumocystis carinii-driven pulmonary inflammation. Infect Immun. 1999 Jul; 67(7):3452-60.
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Barrett EG, Johnston C, Oberdörster G, Finkelstein JN. Silica-induced chemokine expression in alveolar type II cells is mediated by TNF-alpha-induced oxidant stress. Am J Physiol. 1999 Jun; 276(6 Pt 1):L979-88.
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Charafeddine L, D'Angio CT, Richards JL, Stripp BR, Finkelstein JN, Orlowski CC, LoMonaco MB, Paxhia A, Ryan RM. Hyperoxia increases keratinocyte growth factor mRNA expression in neonatal rabbit lung. Am J Physiol. 1999 Jan; 276(1 Pt 1):L105-13.
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Johnston CJ, Stripp BR, Reynolds SD, Avissar NE, Reed CK, Finkelstein JN. Inflammatory and antioxidant gene expression in C57BL/6J mice after lethal and sublethal ozone exposures. Exp Lung Res. 1999 Jan-Feb; 25(1):81-97.
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Johnston CJ, Finkelstein JN, Oberdörster G, Reynolds SD, Stripp BR. Clara cell secretory protein-deficient mice differ from wild-type mice in inflammatory chemokine expression to oxygen and ozone, but not to endotoxin. Exp Lung Res. 1999 Jan-Feb; 25(1):7-21.
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Adawi A, Zhang Y, Baggs R, Rubin P, Williams J, Finkelstein J, Phipps RP. Blockade of CD40-CD40 ligand interactions protects against radiation-induced pulmonary inflammation and fibrosis. Clin Immunol Immunopathol. 1998 Dec; 89(3):222-30.
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Johnston CJ, Finkelstein JN, Gelein R, Oberdörster G. Pulmonary cytokine and chemokine mRNA levels after inhalation of lipopolysaccharide in C57BL/6 mice. Toxicol Sci. 1998 Dec; 46(2):300-7.
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Barrett EG, Johnston C, Oberdörster G, Finkelstein JN. Silica-induced chemokine expression in alveolar type II cells is mediated by TNF-alpha. Am J Physiol. 1998 Dec; 275(6 Pt 1):L1110-9.
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Okunieff P, Wang X, Rubin P, Finkelstein JN, Constine LS, Ding I. Radiation-induced changes in bone perfusion and angiogenesis. Int J Radiat Oncol Biol Phys. 1998 Nov 1; 42(4):885-9.
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Cai J, Yao N, Gibbs E, Finkelstein J, Phillips B, O'Donnell M, Hurwitz J. ATP hydrolysis catalyzed by human replication factor C requires participation of multiple subunits. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11607-12.
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D'Angio CT, Johnston CJ, Wright TW, Reed CK, Finkelstein JN. Chemokine mRNA alterations in newborn and adult mouse lung during acute hyperoxia. Exp Lung Res. 1998 Sep-Oct; 24(5):685-702.
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Mango GW, Johnston CJ, Reynolds SD, Finkelstein JN, Plopper CG, Stripp BR. Clara cell secretory protein deficiency increases oxidant stress response in conducting airways. Am J Physiol. 1998 Aug; 275(2 Pt 1):L348-56.
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Johnston CJ, Wright TW, Rubin P, Finkelstein JN. Alterations in the expression of chemokine mRNA levels in fibrosis-resistant and -sensitive mice after thoracic irradiation. Exp Lung Res. 1998 May-Jun; 24(3):321-37.
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Daly HE, Baecher-Allan CM, Paxhia AT, Ryan RM, Barth RK, Finkelstein JN. Cell-specific gene expression reveals changes in epithelial cell populations after bleomycin treatment. Lab Invest. 1998 Apr; 78(4):393-400.
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Adawi A, Zhang Y, Baggs R, Finkelstein J, Phipps RP. Disruption of the CD40-CD40 ligand system prevents an oxygen-induced respiratory distress syndrome. Am J Pathol. 1998 Mar; 152(3):651-7.
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Johnston CJ, Stripp BR, Piedbeouf B, Wright TW, Mango GW, Reed CK, Finkelstein JN. Inflammatory and epithelial responses in mouse strains that differ in sensitivity to hyperoxic injury. Exp Lung Res. 1998 Mar-Apr; 24(2):189-202.
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Chess PR, Ryan RM, Finkelstein JN. H441 pulmonary epithelial cell mitogenic effects and signaling pathways in response to HGF and TGF-alpha. Exp Lung Res. 1998 Jan-Feb; 24(1):27-39.
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O'Reilly MA, Staversky RJ, Stripp BR, Finkelstein JN. Exposure to hyperoxia induces p53 expression in mouse lung epithelium. Am J Respir Cell Mol Biol. 1998 Jan; 18(1):43-50.
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Johnston CJ, Wright TW, Reed CK, Finkelstein JN. Comparison of adult and newborn pulmonary cytokine mRNA expression after hyperoxia. Exp Lung Res. 1997 Nov-Dec; 23(6):537-52.
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Wright TW, Johnston CJ, Harmsen AG, Finkelstein JN. Analysis of cytokine mRNA profiles in the lungs of Pneumocystis carinii-infected mice. Am J Respir Cell Mol Biol. 1997 Oct; 17(4):491-500.
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Finkelstein JN, Johnston C, Barrett T, Oberdörster G. Particulate-cell interactions and pulmonary cytokine expression. Environ Health Perspect. 1997 Sep; 105 Suppl 5:1179-82.
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Johnston CJ, Mango GW, Finkelstein JN, Stripp BR. Altered pulmonary response to hyperoxia in Clara cell secretory protein deficient mice. Am J Respir Cell Mol Biol. 1997 Aug; 17(2):147-55.
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D'Angio CT, Finkelstein JN, Lomonaco MB, Paxhia A, Wright SA, Baggs RB, Notter RH, Ryan RM. Changes in surfactant protein gene expression in a neonatal rabbit model of hyperoxia-induced fibrosis. Am J Physiol. 1997 Apr; 272(4 Pt 1):L720-30.
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Daly HE, Baecher-Allan CM, Barth RK, D'Angio CT, Finkelstein JN. Bleomycin induces strain-dependent alterations in the pattern of epithelial cell-specific marker expression in mouse lung. Toxicol Appl Pharmacol. 1997 Feb; 142(2):303-10.
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O'Reilly MA, Staversky RJ, Flanders KC, Johnston CJ, Finkelstein JN. Temporal changes in expression of TGF-beta isoforms in mouse lung exposed to oxygen. Am J Physiol. 1997 Jan; 272(1 Pt 1):L60-7.
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Johnston CJ, Finkelstein JN, Gelein R, Baggs R, Oberdörster G. Characterization of the early pulmonary inflammatory response associated with PTFE fume exposure. Toxicol Appl Pharmacol. 1996 Sep; 140(1):154-63.
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Johnston CJ, Piedboeuf B, Rubin P, Williams JP, Baggs R, Finkelstein JN. Early and persistent alterations in the expression of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor alpha mRNA levels in fibrosis-resistant and sensitive mice after thoracic irradiation. Radiat Res. 1996 Jun; 145(6):762-7.
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Oberdörster G, Finkelstein J, Ferin J, Godleski J, Chang LY, Gelein R, Johnston C, Crapo JD. Ultrafine particles as a potential environmental health hazard. Studies with model particles. Chest. 1996 Mar; 109(3 Suppl):68S-69S.
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Avissar N, Finkelstein JN, Horowitz S, Willey JC, Coy E, Frampton MW, Watkins RH, Khullar P, Xu YL, Cohen HJ. Extracellular glutathione peroxidase in human lung epithelial lining fluid and in lung cells. Am J Physiol. 1996 Feb; 270(2 Pt 1):L173-82.
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Opanashuk LA, Finkelstein JN. Relationship of lead-induced proteins to stress response proteins in astroglial cells. J Neurosci Res. 1995 Dec; 42(5):623-32.
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Maniscalco WM, Watkins RH, Finkelstein JN, Campbell MH. Vascular endothelial growth factor mRNA increases in alveolar epithelial cells during recovery from oxygen injury. Am J Respir Cell Mol Biol. 1995 Oct; 13(4):377-86.
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Rubin P, Johnston CJ, Williams JP, McDonald S, Finkelstein JN. A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis. Int J Radiat Oncol Biol Phys. 1995 Aug 30; 33(1):99-109.
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Wagner CL, Ryan RM, Forsythe DE, Keenan A, Finkelstein JN. Secretion of transforming growth factor-alpha (TGF alpha) by postnatal rabbit alveolar macrophages. Pediatr Res. 1995 Jul; 38(1):49-54.
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Johnston CJ, Piedboeuf B, Baggs R, Rubin P, Finkelstein JN. Differences in correlation of mRNA gene expression in mice sensitive and resistant to radiation-induced pulmonary fibrosis. Radiat Res. 1995 May; 142(2):197-203.
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D'Angio CT, Sinkin RA, LoMonaco MB, Finkelstein JN. Interleukin-8 and monocyte chemoattractant protein-1 mRNAs in oxygen-injured rabbit lung. Am J Physiol. 1995 May; 268(5 Pt 1):L826-31.
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Opanashuk LA, Finkelstein JN. Induction of newly synthesized proteins in astroglial cells exposed to lead. Toxicol Appl Pharmacol. 1995 Mar; 131(1):21-30.
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Sinkin RA, Sanders RS, Horowitz S, Finkelstein JN, Lomonaco MB. Cell-specific expression of fibronectin in adult and developing rabbit lung. Pediatr Res. 1995 Feb; 37(2):189-95.
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Chess PR, Ryan RM, Finkelstein JN. Tyrosine kinase activity is necessary for growth factor-stimulated rabbit type II pneumocyte proliferation. Pediatr Res. 1994 Oct; 36(4):481-6.
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Finkelstein JN, Johnston CJ, Baggs R, Rubin P. Early alterations in extracellular matrix and transforming growth factor beta gene expression in mouse lung indicative of late radiation fibrosis. Int J Radiat Oncol Biol Phys. 1994 Feb 1; 28(3):621-31.
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Ryan RM, Mineo-Kuhn MM, Kramer CM, Finkelstein JN. Growth factors alter neonatal type II alveolar epithelial cell proliferation. Am J Physiol. 1994 Jan; 266(1 Pt 1):L17-22.
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Widzowski DV, Finkelstein JN, Pokora MJ, Cory-Slechta DA. Time course of postnatal lead-induced changes in dopamine receptors and their relationship to changes in dopamine sensitivity. Neurotoxicology. 1994; 15(4):853-65.
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McDonald S, Rubin P, Chang AY, Penney DP, Finkelstein JN, Grossberg S, Feins R, Gregory PK. Pulmonary changes induced by combined mouse beta-interferon (rMuIFN-beta) and irradiation in normal mice--toxic versus protective effects. Radiother Oncol. 1993 Mar; 26(3):212-8.
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McBride JT, Kirchner KK, Russ G, Finkelstein J. Role of pulmonary blood flow in postpneumonectomy lung growth. J Appl Physiol. 1992 Dec; 73(6):2448-51.
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Sinkin RA, LoMonaco MB, Finkelstein JN, Watkins RH, Cox C, Horowitz S. Increased fibronectin mRNA in alveolar macrophages following in vivo hyperoxia. Am J Respir Cell Mol Biol. 1992 Nov; 7(5):548-55.
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Finkelstein JN, Horowitz S, Sinkin RA, Ryan RM. Cellular and molecular responses to lung injury in relation to induction of tissue repair and fibrosis. Clin Perinatol. 1992 Sep; 19(3):603-20.
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Oberdörster G, Ferin J, Gelein R, Soderholm SC, Finkelstein J. Role of the alveolar macrophage in lung injury: studies with ultrafine particles. Environ Health Perspect. 1992 Jul; 97:193-9.
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Oberdörster G, Ferin J, Finkelstein J, Soderholm S. Thermal degradation events as health hazards: particle vs gas phase effects, mechanistic studies with particles. Acta Astronaut. 1992; 27:251-6.
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Rubin P, Finkelstein J, Shapiro D. Molecular biology mechanisms in the radiation induction of pulmonary injury syndromes: interrelationship between the alveolar macrophage and the septal fibroblast. Int J Radiat Oncol Biol Phys. 1992; 24(1):93-101.
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Lehnert BE, Dethloff LA, Finkelstein JN, van der Kogel AJ. Temporal sequence of early alterations in rat lung following thoracic X-irradiation. Int J Radiat Biol. 1991 Oct; 60(4):657-75.
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Utell MJ, Frampton MW, Roberts NJ, Finkelstein JN, Cox C, Morrow PE. Mechanisms of nitrogen dioxide toxicity in humans. Res Rep Health Eff Inst. 1991 Aug; (43):1-33.
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Brandes ME, Finkelstein JN. The production of alveolar macrophage-derived growth-regulating proteins in response to lung injury. Toxicol Lett. 1990 Nov; 54(1):3-22; discussion 1-2.
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Horowitz S, Shapiro DL, Finkelstein JN, Notter RH, Johnston CJ, Quible DJ. Changes in gene expression in hyperoxia-induced neonatal lung injury. Am J Physiol. 1990 Feb; 258(2 Pt 1):L107-11.
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Finkelstein JN. Physiologic and toxicologic responses of alveolar type II cells. Toxicology. 1990 Jan-Feb; 60(1-2):41-52.
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Frampton MW, Finkelstein JN, Roberts NJ, Smeglin AM, Morrow PE, Utell MJ. Effects of nitrogen dioxide exposure on bronchoalveolar lavage proteins in humans. Am J Respir Cell Mol Biol. 1989 Dec; 1(6):499-505.
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Shapiro DL, Finkelstein JN, Van Diver T. Isolation of alveolar epithelial cells from lung tissue obtained at autopsy. In Vitro Cell Dev Biol. 1989 Nov; 25(11):1051-4.
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Rubin P, McDonald S, Maasilta P, Finkelstein JN, Shapiro DL, Penney D, Gregory PK. Serum markers for prediction of pulmonary radiation syndromes. Part I: Surfactant apoprotein. Int J Radiat Oncol Biol Phys. 1989 Sep; 17(3):553-8.
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Brandes ME, Finkelstein JN. Stimulated rabbit alveolar macrophages secrete a growth factor for type II pneumocytes. Am J Respir Cell Mol Biol. 1989 Aug; 1(2):101-9.
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Maniscalco WM, Finkelstein JN, Parkhurst AB. Effects of exogenous fatty acids and inhibition of de novo fatty acid synthesis on disaturated phosphatidylcholine production by fetal lung cells and adult type II cells. Exp Lung Res. 1989 May; 15(3):473-89.
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Frampton MW, Smeglin AM, Roberts NJ, Finkelstein JN, Morrow PE, Utell MJ. Nitrogen dioxide exposure in vivo and human alveolar macrophage inactivation of influenza virus in vitro. Environ Res. 1989 Apr; 48(2):179-92.
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Brandes ME, Finkelstein JN. Induction of the stress response by isolation of rabbit type II pneumocytes. Exp Lung Res. 1989; 15(1):93-111.
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Hendricks-Muñoz KD, Finkelstein JN, Shapiro DL. Membrane phospholipid methylation is associated with surfactant secretion in rabbit type II alveolar epithelial cells. Exp Lung Res. 1989; 15(1):63-76.
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Holm BA, Matalon S, Finkelstein JN, Notter RH. Type II pneumocyte changes during hyperoxic lung injury and recovery. J Appl Physiol. 1988 Dec; 65(6):2672-8.
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Aschner M, Rodier PM, Finkelstein JN. Increased axonal transport in the rat optic system after systemic exposure to methylmercury: differential effects in local vs systemic exposure conditions. Brain Res. 1987 Jan 13; 401(1):132-41.
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Jacobs AJ, Maniscalco WM, Finkelstein JN. Effects of methylmercuric chloride, cycloheximide, and colchicine on the reaggregation of dissociated mouse cerebellar cells. Toxicol Appl Pharmacol. 1986 Dec; 86(3):362-71.
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Aschner M, Rodier PM, Finkelstein JN. Reduction of axonal transport in the rat optic system after direct application of methylmercury. Brain Res. 1986 Sep 3; 381(2):244-50.
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Leary JF, Finkelstein JN, Notter RH, Shapiro DL. A quantitative study of the development of type II pneumocytes in fetal lung. Cytometry. 1986 Sep; 7(5):431-8.
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Rubin P, Finkelstein JN, Siemann DW, Shapiro DL, Van Houtte P, Penney DP. Predictive biochemical assays for late radiation effects. Int J Radiat Oncol Biol Phys. 1986 Apr; 12(4):469-76.
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Sichak SP, Mavis RD, Finkelstein JN, Clarkson TW. An examination of the oxidation of mercury vapor by rat brain homogenate. J Biochem Toxicol. 1986 Mar; 1(1):53-68.
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Shapiro DL, Livingston JN, Maniscalco WM, Finkelstein JN. Insulin receptors and insulin effects on type II alveolar epithelial cells. Biochim Biophys Acta. 1986 Feb 21; 885(2):216-20.
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Notter RH, Penney DP, Finkelstein JN, Shapiro DL. Adsorption of natural lung surfactant and phospholipid extracts related to tubular myelin formation. Pediatr Res. 1986 Jan; 20(1):97-101.
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Jacobs AJ, Maniscalco WM, Parkhurst AB, Finkelstein JN. In vivo and in vitro demonstration of reduced myelin synthesis following early postnatal exposure to ionizing radiation in the rat. Radiat Res. 1986 Jan; 105(1):97-104.
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Maniscalco WM, Finkelstein JN, Parkhurst AB. Dexamethasone increases de novo fatty acid synthesis in fetal rabbit lung explants. Pediatr Res. 1985 Dec; 19(12):1272-7.
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Holm BA, Notter RH, Finkelstein JN. Surface property changes from interactions of albumin with natural lung surfactant and extracted lung lipids. Chem Phys Lipids. 1985 Sep; 38(3):287-98.
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Finkelstein JN, Ghosh S. The effect of lateral mobility on the binding and reaction rate at membrane sites. Physiol Chem Phys Med NMR. 1985; 17(1):77-9.
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Notter RH, Finkelstein JN. Pulmonary surfactant: an interdisciplinary approach. J Appl Physiol. 1984 Dec; 57(6):1613-24.
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Gallo RL, Wersto RP, Notter RH, Finkelstein JN. Lysophosphatidylcholine cell depolarization: increased membrane permeability for use in the determination of cell membrane potentials. Arch Biochem Biophys. 1984 Dec; 235(2):544-54.
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Fraser CM, Venter JC, Finkelstein JN, Shapiro DL. Monoclonal antibodies to surface antigens of rabbit type II pneumocytes. Am Rev Respir Dis. 1984 Sep; 130(3):505-7.
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Gallo RL, Finkelstein JN, Notter RH. Characterization of the plasma and mitochondrial membrane potentials of alveolar type II cells by the use of ionic probes. Biochim Biophys Acta. 1984 Apr 11; 771(2):217-27.
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Brasch SP, Finkelstein JN, Makhani G, Ghosh S. Arterial influx, efflux and tissue content of albumin in rabbits in vivo. Cardiovasc Res. 1984 Apr; 18(4):244-8.
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Shapiro DL, Finkelstein JN, Rubin P, Penney DP, Siemann DW. Radiation induced secretion of surfactant from cell cultures of type II pneumocytes: an in vitro model of radiation toxicity. Int J Radiat Oncol Biol Phys. 1984 Mar; 10(3):375-8.
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Rubin P, Siemann DW, Shapiro DL, Finkelstein JN, Penney DP. Surfactant release as an early measure of radiation pneumonitis. Int J Radiat Oncol Biol Phys. 1983 Nov; 9(11):1669-73.
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Notter RH, Finkelstein JN, Taubold RD. Comparative adsorption of natural lung surfactant, extracted phospholipids, and artificial phospholipid mixtures to the air-water interface. Chem Phys Lipids. 1983 Jul; 33(1):67-80.
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Finkelstein JN, Maniscalco WM, Shapiro DL. Properties of freshly isolated type II alveolar epithelial cells. Biochim Biophys Acta. 1983 Jun 2; 762(3):398-404.
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Maniscalco WM, Finkelstein JN, Parkhurst AB. De novo fatty acid synthesis by freshly isolated alveolar type II epithelial cells. Biochim Biophys Acta. 1983 May 16; 751(3):462-9.
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Wright ES, Vang MJ, Finkelstein JN, Mavis RD. Changes in phospholipid biosynthetic enzymes in type II cells and alveolar macrophages isolated from rat lungs after NO2 exposure. Toxicol Appl Pharmacol. 1982 Nov; 66(2):305-11.
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Notter RH, Smith S, Taubold RD, Finkelstein JN. Path dependence of adsorption behavior of mixtures containing dipalmitoyl phosphatidylcholine. Pediatr Res. 1982 Jul; 16(7):515-9.
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Shapiro DL, Finkelstein JN, Penney DP, Siemann DW, Rubin P. Sequential effects of irradiation on the pulmonary surfactant system. Int J Radiat Oncol Biol Phys. 1982 May; 8(5):879-82.
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Maniscalco WM, Finkelstein JN, Parkhurst AB. De novo fatty acid synthesis in developing rat lung. Biochim Biophys Acta. 1982 Apr 15; 711(1):49-58.
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Leary JF, Finkelstein JN, Notter RH, Shapiro DL. Isolation of type II pneumocytes by laser flow cytometry. Am Rev Respir Dis. 1982 Mar; 125(3):326-30.
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Finkelstein JN, Shapiro DL. Isolation of type II alveolar epithelial cells using low protease concentrations. Lung. 1982; 160(2):85-98.
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Penney DP, Siemann DW, Rubin P, Shapiro DL, Finkelstein J, Cooper RA. Morphologic changes reflecting early and late effects of irradiation of the distal lung of the mouse: a review. Scan Electron Microsc. 1982; (Pt 1):413-25.
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Merritt TA, Stuard ID, Puccia J, Wood B, Edwards DK, Finkelstein J, Shapiro DL. Newborn tracheal aspirate cytology: classification during respiratory distress syndrome and bronchopulmonary dysplasia. J Pediatr. 1981 Jun; 98(6):949-56.
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Penney DP, Shapiro DL, Rubin P, Finkelstein J, Siemann DW. Effects of radiation on the mouse lung and potential induction of radiation pneumonitis. Virchows Arch B Cell Pathol Incl Mol Pathol. 1981; 37(3):327-36.
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Rubin P, Shapiro DL, Finklestein JN, Penney DP. The early release of surfactant following lung irradiation of alveolar type II cells. Int J Radiat Oncol Biol Phys. 1980 Jan; 6(1):75-7.
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Finkelstein JN, Mavis RD. Biochemical evidence for internal proteolytic damage during isolation of type II alveolar epithelial cells. Lung. 1979; 156(4):243-54.
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Mavis RD, Finkelstein JN, Hall BP. Pulmonary surfactant synthesis. A highly active microsomal phosphatidate phosphohydrolase in the lung. J Lipid Res. 1978 May; 19(4):467-77.
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Finkelstein JN, Carlin AS. Treatment of an unusual adolescent bed-wetting behavior by covert sensitization. A case study. J Am Acad Child Psychiatry. 1977; 16(1):159-64.
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Ghosh S, Finkelstein JN, Moss DB, Schweppe JS. Evaluation of the permeability parameters (influx, efflux and volume of distribution) of arterial wall for LDL and other proteins. Adv Exp Med Biol. 1976; 67(00):191-204.
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Basu MK, Finkelstein JN, Ghosh S, Schweppe JS. Studies on the binding of 1-anilino-8-naphthalene sulfonate to very low density and high density himan serum lipoproteins. Biochim Biophys Acta. 1975 Sep 19; 398(3):385-93.
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