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Guan Wu

TitleAssociate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentUrology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 656
Rochester NY 14642
Other Positions
TitleAssociate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentPathology and Laboratory Medicine

TitleAssociate Professor
InstitutionUniversity of Rochester Medical Center
DepartmentCancer Center

 
 Awards And Honors
1982     Outstanding Medical Student Award
1985     Outstanding Graduate Student Award  | Beijing Medical University
1995     Smithkline-Beecham Travel Award  | Society for Basic Urologic Research
1996     The Pfizer Scholars in Urology Award
2004     Praecis Pharmaceuticals/AUA Gerald P. Murphy Scholar
2007     The AUA Northeastern Section Young Investigator Award
2008     Honored Visiting Professor of the Second Medical School and Tianjin Institute of Urology  | Tianjin Medical University
2011     The Robert S. Davis, M.D. Faculty Teaching Award  | University of Rochester Medical Center / Department of Urology
2011     Honorary Director of the Department of Urology  | Nanjing Drum Tower Hospital, Nanjing University Medical School
2011     America's Top Doctor  | U.S. News & World Report and Castle Connolly America
 
 Overview
The long-term goal of Dr. Wu's research is to refine our knowledge of the biology of kidney cancer. Currently, Dr. Wu's laboratory is studying genetic defects in kidney cancer cells and how these defects cause the disease.

Dr. Wu's laboratory has been working on the proteins produced by cancer critical genes. He and his associates are learning how the cellular and biochemical functions of these proteins cause kidney cancer to develop and progress. Dr. Wu's laboratory has identified several such complexes by purifying them from kidney cancer cell lines and by using yeast as a human protein carrier. This research is not only extending our understanding of kidney cancer, but also has broader implications for normal cell physiology.

Dr. Wu's laboratory is also analyzing the genetics of human kidney cancer specimens to look into DNA mutations. This research will be combined with the studies done with kidney cancer cell lines. Together, they will help us discover and validade new "tumor markers" (substances produced by the body that can indicate the presence of a specific cancer). This, in turn, will help us develop new ways to diagnose and treat kidney cancer.

 
 Selected Publications
List All   |   Timeline
  1. Kuo RI, Wu GK. The generation of direction selectivity in the auditory system. Neuron. 2012 Mar 8; 73(5):1016-27.
    View in: PubMed
  2. Wu GK, Tao HW, Zhang LI. From elementary synaptic circuits to information processing in primary auditory cortex. Neurosci Biobehav Rev. 2011 Nov; 35(10):2094-104.
    View in: PubMed
  3. Sun YJ, Wu GK, Liu BH, Li P, Zhou M, Xiao Z, Tao HW, Zhang LI. Fine-tuning of pre-balanced excitation and inhibition during auditory cortical development. Nature. 2010 Jun 17; 465(7300):927-31.
    View in: PubMed
  4. Zhou Y, Liu BH, Wu GK, Kim YJ, Xiao Z, Tao HW, Zhang LI. Preceding inhibition silences layer 6 neurons in auditory cortex. Neuron. 2010 Mar 11; 65(5):706-17.
    View in: PubMed
  5. Wu GK, Arbuckle R, Liu BH, Tao HW, Zhang LI. Lateral sharpening of cortical frequency tuning by approximately balanced inhibition. Neuron. 2008 Apr 10; 58(1):132-43.
    View in: PubMed
  6. Liu BH, Wu GK, Arbuckle R, Tao HW, Zhang LI. Defining cortical frequency tuning with recurrent excitatory circuitry. Nat Neurosci. 2007 Dec; 10(12):1594-600.
    View in: PubMed
  7. Wu GK, Li P, Tao HW, Zhang LI. Nonmonotonic synaptic excitation and imbalanced inhibition underlying cortical intensity tuning. Neuron. 2006 Nov 22; 52(4):705-15.
    View in: PubMed

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