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Karen Kaplan

TitleProfessor Emeritus
InstitutionSchool of Medicine and Dentistry
DepartmentMedicine
Address200 East 78th Street, Apt. 18G
New York NY 10075
 
 Awards And Honors
      Phi Beta Kappa
      Sigma XI
      Alpha Omega Alpha
 
 Selected Publications
  • Komrokji RS, Uppal NP, Khorana AA, Lyman GH, Kaplan KL, Fisher RI, Francis CW. Venous thromboembolism in patients with diffuse large B-cell lymphoma. Leuk Lymphoma. 2006 Jun; 47(6):1029-33.
    View in: PubMed
  • Kaplan KL, Goldstein LB. What does cerebral platelet activation mean in the setting of carotid stenosis? Neurology. 2006 Mar 28; 66(6):792-3.
    View in: PubMed
  • O'Reilly KM, Boscia JA, Kaplan KL, Sime PJ. A case of steroid responsive pulmonary hyalinising granuloma: complicated by deep venous thrombosis. Eur Respir J. 2004 Jun; 23(6):954-6.
    View in: PubMed
  • Deitcher SR, Ngengwe R, Kaplan R, Liebman H, Kaplan K, Blinder M. Subcutaneous lepirudin for heparin-induced thrombocytopenia and when other anticoagulants fail: illustrative cases. Clin Adv Hematol Oncol. 2004 Jun; 2(6):382-4; discussion 384-6.
    View in: PubMed
  • Lustik SJ, Papadakos PJ, Jackman KV, Rubery PT, Kaplan KL, Chhibber AK. Nicardipine versus nitroprusside for deliberate hypotension during idiopathic scoliosis repair. J Clin Anesth. 2004 Feb; 16(1):25-33.
    View in: PubMed
  • Gomes MP, Kaplan KL, Deitcher SR. Patients with inferior vena caval filters should receive chronic thromboprophylaxis. Med Clin North Am. 2003 Nov; 87(6):1189-203.
    View in: PubMed
  • Kaplan KL. Direct thrombin inhibitors. Expert Opin Pharmacother. 2003 May; 4(5):653-66.
    View in: PubMed
  • Schwimmer J, Nadasdy TA, Spitalnik PF, Kaplan KL, Zand MS. De novo thrombotic microangiopathy in renal transplant recipients: a comparison of hemolytic uremic syndrome with localized renal thrombotic microangiopathy. Am J Kidney Dis. 2003 Feb; 41(2):471-9.
    View in: PubMed
  • Kaplan KL, Francis CW. Direct thrombin inhibitors. Semin Hematol. 2002 Jul; 39(3):187-96.
    View in: PubMed
  • Kaplan KL, Fitzpatrick P, Cox C, Shammas NW, Marder VJ. Use of thrombolytic therapy for acute myocardial infarction: effects of gender and age on treatment rates. J Thromb Thrombolysis. 2002 Feb; 13(1):21-6.
    View in: PubMed
  • Kaplan KL. Coagulation activation in sepsis. Crit Care Med. 2000 Feb; 28(2):585-6.
    View in: PubMed
  • Kaplan KL, Francis CW. Heparin-induced thrombocytopenia. Blood Rev. 1999 Mar; 13(1):1-7.
    View in: PubMed
  • Turhal N, Henehan MD, Kaplan KL. Multiple myeloma: a patient with unusual features including intracranial and meningeal involvement, testicular involvement, organomegaly, and plasma cell leukemia. Am J Hematol. 1998 Jan; 57(1):51-6.
    View in: PubMed
  • Zangari M, Kaplan KL, Glanville RW, Rand JH. Reduced thrombogenicity of type VI collagen as compared to type I collagen. Thromb Res. 1995 Sep 15; 79(5-6):429-36.
    View in: PubMed
  • Kaplan KL. Methods for assessing activation of coagulation by contrast materials or catheters. Semin Hematol. 1991 Oct; 28(4 Suppl 7):16-21; discussion 38-41.
    View in: PubMed
  • Carson CW, Hunder GG, Kaplan KL, Johnson CM. Inducible release of an endothelial cell-specific protein. Am J Pathol. 1991 Jul; 139(1):199-206.
    View in: PubMed
  • Ginsberg HN, Barr SL, Gilbert A, Karmally W, Deckelbaum R, Kaplan K, Ramakrishnan R, Holleran S, Dell RB. Reduction of plasma cholesterol levels in normal men on an American Heart Association Step 1 diet or a Step 1 diet with added monounsaturated fat. N Engl J Med. 1990 Mar 1; 322(9):574-9.
    View in: PubMed
  • Kaplan KL, Bini A, Fenoglio J, Kudryk B. Fibrin and the vessel wall. Adv Exp Med Biol. 1990; 281:313-8.
    View in: PubMed
  • Bini A, Mesa-Tejada R, Fenoglio JJ, Kudryk B, Kaplan KL. Immunohistochemical characterization of fibrin(ogen)-related antigens in human tissues using monoclonal antibodies. Lab Invest. 1989 Jun; 60(6):814-21.
    View in: PubMed
  • Kaplan KL, Bini A. Thrombosis in atherogenesis. Crit Rev Oncol Hematol. 1989; 9(4):305-18.
    View in: PubMed
  • Kaplan KL, Mather T, DeMarco L, Solomon S. Effect of fibrin on endothelial cell production of prostacyclin and tissue plasminogen activator. Arteriosclerosis. 1989 Jan-Feb; 9(1):43-9.
    View in: PubMed
  • Bini A, Fenoglio JJ, Mesa-Tejada R, Kudryk B, Kaplan KL. Identification and distribution of fibrinogen, fibrin, and fibrin(ogen) degradation products in atherosclerosis. Use of monoclonal antibodies. Arteriosclerosis. 1989 Jan-Feb; 9(1):109-21.
    View in: PubMed
  • Bini A, Fenoglio J, Sobel J, Owen J, Fejgl M, Kaplan KL. Immunochemical characterization of fibrinogen, fibrin I, and fibrin II in human thrombi and atherosclerotic lesions. Blood. 1987 Apr; 69(4):1038-45.
    View in: PubMed
  • Kaplan K, Davison R, Parker M, Mayberry B, Feiereisel P, Salinger M. Role of heparin after intravenous thrombolytic therapy for acute myocardial infarction. Am J Cardiol. 1987 Feb 1; 59(4):241-4.
    View in: PubMed
  • Owen J, Kaplan KL. Blood tests for the detection of thrombosis. Effects of blood flow and location of the sampling site. Ann N Y Acad Sci. 1987; 516:621-30.
    View in: PubMed
  • Liu CY, Sobel JH, Weitz JI, Kaplan KL, Nossel HL. Immunologic identification of the cleavage products from the A alpha- and B beta-chains in the early stages of plasmin digestion of fibrinogen. Thromb Haemost. 1986 Aug 20; 56(1):100-6.
    View in: PubMed
  • Kaplan KL, Owen J. Plasma levels of platelet secretory proteins. Crit Rev Oncol Hematol. 1986; 5(3):235-55.
    View in: PubMed
  • DePinho RA, Kaplan KL. The Hermansky-Pudlak syndrome. Report of three cases and review of pathophysiology and management considerations. Medicine (Baltimore). 1985 May; 64(3):192-202.
    View in: PubMed
  • Kaplan KL, Niewiarowski S. Nomenclature of secreted platelet proteins--report of the Working Party on Secreted Platelet Proteins of the Subcommittee on Platelets. Thromb Haemost. 1985 Apr 22; 53(2):282-4.
    View in: PubMed
  • Nawroth PP, Stern DM, Kaplan KL, Nossel HL. Prostacyclin production by perturbed bovine aortic endothelial cells in culture. Blood. 1984 Oct; 64(4):801-6.
    View in: PubMed
  • Kaplan KL, Weber D, Cook P, Dalecki M, Rogozinski L, Sepe O, Knowles D, Butler VP. Monoclonal antibodies to E92, an endothelial cell surface antigen. Arteriosclerosis. 1983 Sep-Oct; 3(5):403-12.
    View in: PubMed
  • Pham TD, Kaplan KL, Butler VP. Immunoelectron microscopic localization of platelet factor 4 and fibrinogen in the granules of human platelets. J Histochem Cytochem. 1983 Jul; 31(7):905-10.
    View in: PubMed
  • Marcella JJ, Nichols AB, Johnson LL, Owen J, Reison DS, Kaplan KL, Cannon PJ. Exercise-induced myocardial ischemia in patients with coronary artery disease: lack of evidence for platelet activation or fibrin formation in peripheral venous blood. J Am Coll Cardiol. 1983 May; 1(5):1185-93.
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  • Owen J, Kvam D, Nossel HL, Kaplan KL, Kernoff PB. Thrombin and plasmin activity and platelet activation in the development of venous thrombosis. Blood. 1983 Mar; 61(3):476-82.
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  • Holmsen H, Kaplan KL, Dangelmaier CA. Differential energy requirements for platelet responses. A simultaneous study of aggregation, three secretory processes, arachidonate liberation, phosphatidylinositol breakdown and phosphatidate production. Biochem J. 1982 Oct 15; 208(1):9-18.
    View in: PubMed
  • Nichols AB, Owen J, Kaplan KL, Sciacca RR, Cannon PJ, Nossel HL. Fibrinopeptide A, platelet factor 4, and beta-thromboglobulin levels in coronary heart disease. Blood. 1982 Sep; 60(3):650-4.
    View in: PubMed
  • Kaplan KL, Owen J. Radioimmunoassay of platelet factor 4. Methods Enzymol. 1982; 84:83-92.
    View in: PubMed
  • Kaplan KL, Owen J. Radioimmunoassay of beta-thromboglobulin. Methods Enzymol. 1982; 84:93-102.
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  • Marcus AJ, Safier LB, Ullman HL, Wong KT, Broekman MJ, Weksler BB, Kaplan KL. Effects of acetyl glyceryl ether phosphorylcholine on human platelet function in vitro. Blood. 1981 Nov; 58(5):1027-31.
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  • Kaplan KL, Dauzier MJ, Rose S. ADP and epinephrine-induced release of platelet fibrinogen. Blood. 1981 Oct; 58(4):797-802.
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  • Kaplan KL, Drillings M, Lesznik G. Fibrinopeptide A cleavage and platelet release in whole blood in vitro. Effects of stimuli, inhibitors, and agitation. J Clin Invest. 1981 May; 67(5):1561-8.
    View in: PubMed
  • Kaplan KL, Owen J. Plasma levels of beta-thromboglobulin and platelet factor 4 as indices of platelet activation in vivo. Blood. 1981 Feb; 57(2):199-202.
    View in: PubMed
  • Weiss HJ, Rosove MH, Lages BA, Kaplan KL. Acquired storage pool deficiency with increased platelet-associated IgG. Report of five cases. Am J Med. 1980 Nov; 69(5):711-7.
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  • Liu CY, Kaplan KL, Markowitz AH, Nossel HL. Thermodynamic characterization of thrombin binding by cross-linked and non-cross-linked fibrin in the presence and absence of Ca2+. J Biol Chem. 1980 Aug 25; 255(16):7627-30.
    View in: PubMed
  • Kaplan KL. beta-Thromboglobulin. Prog Hemost Thromb. 1980; 5:153-78.
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  • Weiss HJ, Witte LD, Kaplan KL, Lages BA, Chernoff A, Nossel HL, Goodman DS, Baumgartner HR. Heterogeneity in storage pool deficiency: studies on granule-bound substances in 18 patients including variants deficient in alpha-granules, platelet factor 4, beta-thromboglobulin, and platelet-derived growth factor. Blood. 1979 Dec; 54(6):1296-319.
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  • Nossel HL, Wasser J, Kaplan KL, LaGamma KS, Yudelman I, Canfield RE. Sequence of fibrinogen proteolysis and platelet release after intrauterine infusion of hypertonic saline. J Clin Invest. 1979 Nov; 64(5):1371-8.
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  • Zucker MB, Broekman MJ, Kaplan KL. Factor VIII-related antigen in human blood platelets: localization and release by thrombin and collagen. J Lab Clin Med. 1979 Nov; 94(5):675-82.
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  • Liu CY, Nossel HL, Kaplan KL. The binding of thrombin by fibrin. J Biol Chem. 1979 Oct 25; 254(20):10421-5.
    View in: PubMed
  • Linder BL, Chernoff A, Kaplan KL, Goodman DS. Release of platelet-derived growth factor from human platelets by arachidonic acid. Proc Natl Acad Sci U S A. 1979 Aug; 76(8):4107-11.
    View in: PubMed
  • Zucker MB, Mosesson MW, Broekman MJ, Kaplan KL. Release of platelet fibronectin (cold-insoluble globulin) from alpha granules induced by thrombin or collagen; lack of requirement for plasma fibronectin in ADP-induced platelet aggregation. Blood. 1979 Jul; 54(1):8-12.
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  • Kaplan KL, Broekman MJ, Chernoff A, Lesznik GR, Drillings M. Platelet alpha-granule proteins: studies on release and subcellular localization. Blood. 1979 Apr; 53(4):604-18.
    View in: PubMed
  • Yudelman IM, Nossel HL, Kaplan KL, Hirsh J. Plasma fibrinopeptide A levels in symptomatic venous thromboembolism. Blood. 1978 Jun; 51(6):1189-95.
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  • Kaplan KL, Nossel HL, Drillings M, Lesznik G. Radioimmunoassay of platelet factor 4 and beta-thromboglobulin: development and application to studies of platelet release in relation to fibrinopeptide A generation. Br J Haematol. 1978 May; 39(1):129-46.
    View in: PubMed
  • Witte LD, Kaplan KL, Nossel HL, Lages BA, Weiss HJ, Goodman DS. Studies of the release from human platelets of the growth factor for cultured human arterial smooth muscle cells. Circ Res. 1978 Mar; 42(3):402-9.
    View in: PubMed
  • Kaplan KL. Proteins secreted by platelets: significance in detecting thrombosis. Adv Exp Med Biol. 1978; 102:105-19.
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  • Nossel HL, Ti M, Kaplan KL, Spanondis K, Soland T, Butler VP. The generation of fibrinopeptide A in clinical blood samples: evidence for thrombin activity. J Clin Invest. 1976 Nov; 58(5):1136-44.
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  • Kaplan KL, Nachman RL. The interaction of platelets and concanavalin A. Thromb Res. 1975 Dec; 7(6):847-59.
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  • Kaplan KL, Nachman RL. The effect of platelet membrane antibodies on aggregation and release. Br J Haematol. 1974 Dec; 28(4):551-60.
    View in: PubMed

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