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Janet Casey

TitleClinical Associate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentPediatrics
AddressLegacy Pediatrics
1815 South Clinton Avenue
Rochester NY 14618
 
 Selected Publications
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  1. Kaur R, Casey JR, Pichichero ME. Relationship with original pathogen in recurrence of acute otitis media after completion of amoxicillin/clavulanate: bacterial relapse or new pathogen. Pediatr Infect Dis J. 2013 Nov; 32(11):1159-62.
    View in: PubMed
  2. Pichichero ME, Casey JR, Almudevar A. Nonprotective responses to pediatric vaccines occur in children who are otitis prone. Pediatr Infect Dis J. 2013 Nov; 32(11):1163-8.
    View in: PubMed
  3. Casey JR, Kaur R, Friedel VC, Pichichero ME. Acute otitis media otopathogens during 2008 to 2010 in Rochester, new york. Pediatr Infect Dis J. 2013 Aug; 32(8):805-9.
    View in: PubMed
  4. Pichichero ME, Casey JR, Almudevar A. Reducing the frequency of acute otitis media by individualized care. Pediatr Infect Dis J. 2013 May; 32(5):473-8.
    View in: PubMed
  5. Xu Q, Almudervar A, Casey JR, Pichichero ME. Nasopharyngeal bacterial interactions in children. Emerg Infect Dis. 2012 Nov; 18(11):1738-45.
    View in: PubMed
  6. Casey JR, Block SL, Hedrick J, Almudevar A, Pichichero ME. Comparison of amoxicillin/clavulanic acid high dose with cefdinir in the treatment of acute otitis media. Drugs. 2012 Oct 22; 72(15):1991-7.
    View in: PubMed
  7. Kaur R, Kim T, Casey JR, Pichichero ME. Antibody in middle ear fluid of children originates predominantly from sera and nasopharyngeal secretions. Clin Vaccine Immunol. 2012 Oct; 19(10):1593-6.
    View in: PubMed
  8. Xu Q, Casey JR, Chang A, Pichichero ME. When co-colonizing the nasopharynx haemophilus influenzae predominates over Streptococcus pneumoniae except serotype 19A strains to cause acute otitis media. Pediatr Infect Dis J. 2012 Jun; 31(6):638-40.
    View in: PubMed
  9. Pichichero ME, Kaur R, Casey JR, Xu Q, Almudevar A, Ochs M. Antibody response to Streptococcus pneumoniae proteins PhtD, LytB, PcpA, PhtE and Ply after nasopharyngeal colonization and acute otitis media in children. Hum Vaccin Immunother. 2012 Jun; 8(6):799-805.
    View in: PubMed
  10. Sharma SK, Casey JR, Pichichero ME. Reduced serum IgG responses to pneumococcal antigens in otitis-prone children may be due to poor memory B-cell generation. J Infect Dis. 2012 Apr 15; 205(8):1225-9.
    View in: PubMed
  11. Sharma SK, Casey JR, Pichichero ME. Reduced memory CD4+ T-cell generation in the circulation of young children may contribute to the otitis-prone condition. J Infect Dis. 2011 Aug 15; 204(4):645-53.
    View in: PubMed
  12. Kaur R, Casey JR, Pichichero ME. Serum antibody response to five Streptococcus pneumoniae proteins during acute otitis media in otitis-prone and non-otitis-prone children. Pediatr Infect Dis J. 2011 Aug; 30(8):645-50.
    View in: PubMed
  13. Kaur R, Chang A, Xu Q, Casey JR, Pichichero ME. Phylogenetic relatedness and diversity of non-typable Haemophilus influenzae in the nasopharynx and middle ear fluid of children with acute otitis media. J Med Microbiol. 2011 Dec; 60(Pt 12):1841-8.
    View in: PubMed
  14. Casey JR, Block S, Puthoor P, Hedrick J, Almudevar A, Pichichero ME. A simple scoring system to improve clinical assessment of acute otitis media. Clin Pediatr (Phila). 2011 Jul; 50(7):623-9.
    View in: PubMed
  15. Benninger M, Brook I, Bernstein JM, Casey JR, Roos K, Marple B, Farrar JR. Bacterial interference in upper respiratory tract infections: a systematic review. Am J Rhinol Allergy. 2011 Mar-Apr; 25(2):82-8.
    View in: PubMed
  16. Xu Q, Kaur R, Casey JR, Sabharwal V, Pelton S, Pichichero ME. Nontypeable Streptococcus pneumoniae as an otopathogen. Diagn Microbiol Infect Dis. 2011 Feb; 69(2):200-4.
    View in: PubMed
  17. Chang A, Kaur R, Michel LV, Casey JR, Pichichero M. Haemophilus influenzae vaccine candidate outer membrane protein P6 is not conserved in all strains. Hum Vaccin. 2011 Jan 1; 7(1):102-5.
    View in: PubMed
  18. Xu Q, Kaur R, Casey JR, Adlowitz DG, Pichichero ME, Zeng M. Identification of Streptococcus pneumoniae and Haemophilus influenzae in culture-negative middle ear fluids from children with acute otitis media by combination of multiplex PCR and multi-locus sequencing typing. Int J Pediatr Otorhinolaryngol. 2011 Feb; 75(2):239-44.
    View in: PubMed
  19. Kaur R, Casey JR, Pichichero ME. Serum antibody response to three non-typeable Haemophilus influenzae outer membrane proteins during acute otitis media and nasopharyngeal colonization in otitis prone and non-otitis prone children. Vaccine. 2011 Jan 29; 29(5):1023-8.
    View in: PubMed
  20. Liu K, Casey J, Pichichero M. Serum intercellular adhesion molecule 1 variations in young children with acute otitis media. Clin Vaccine Immunol. 2010 Dec; 17(12):1909-16.
    View in: PubMed
  21. Pichichero ME, Kaur R, Casey JR, Sabirov A, Khan MN, Almudevar A. Antibody response to Haemophilus influenzae outer membrane protein D, P6, and OMP26 after nasopharyngeal colonization and acute otitis media in children. Vaccine. 2010 Oct 18; 28(44):7184-92.
    View in: PubMed
  22. Kaur R, Adlowitz DG, Casey JR, Zeng M, Pichichero ME. Simultaneous assay for four bacterial species including Alloiococcus otitidis using multiplex-PCR in children with culture negative acute otitis media. Pediatr Infect Dis J. 2010 Aug; 29(8):741-5.
    View in: PubMed
  23. Casey JR, Adlowitz DG, Pichichero ME. New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine. Pediatr Infect Dis J. 2010 Apr; 29(4):304-9.
    View in: PubMed
  24. Sabirov A, Casey JR, Murphy TF, Pichichero ME. Breast-feeding is associated with a reduced frequency of acute otitis media and high serum antibody levels against NTHi and outer membrane protein vaccine antigen candidate P6. Pediatr Res. 2009 Nov; 66(5):565-70.
    View in: PubMed
  25. Shaikh N, Martin JM, Casey JR, Pichichero ME, Wald ER, Colborn DK, Gerber MA, Kearney DH, Balentine TL, Haralam MA, Hoberman A. Development of a patient-reported outcome measure for children with streptococcal pharyngitis. Pediatrics. 2009 Oct; 124(4):e557-63.
    View in: PubMed
  26. Xu Q, Pichichero ME, Casey JR, Zeng M. Novel type of Streptococcus pneumoniae causing multidrug-resistant acute otitis media in children. Emerg Infect Dis. 2009 Apr; 15(4):547-51.
    View in: PubMed
  27. Casey JR, Pichichero ME. A comparison of 2 white blood cell count devices to aid judicious antibiotic prescribing. Clin Pediatr (Phila). 2009 Apr; 48(3):291-4.
    View in: PubMed
  28. Pichichero ME, Casey JR. Diagnostic inaccuracy and subject exclusions render placebo and observational studies of acute otitis media inconclusive. Pediatr Infect Dis J. 2008 Nov; 27(11):958-62.
    View in: PubMed
  29. Pichichero ME, Casey JR, Hoberman A, Schwartz R. Pathogens causing recurrent and difficult-to-treat acute otitis media, 2003-2006. Clin Pediatr (Phila). 2008 Nov; 47(9):901-6.
    View in: PubMed
  30. Casey JR, Kahn R, Gmoser D, Atlas E, Urbani K, Luber S, Pellman H, Pichichero ME. Frequency of symptomatic relapses of group A beta-hemolytic streptococcal tonsillopharyngitis in children from 4 pediatric practices following penicillin, amoxicillin, and cephalosporin antibiotic treatment. Clin Pediatr (Phila). 2008 Jul; 47(6):549-54.
    View in: PubMed
  31. Pichichero ME, Casey JR. Comparison of study designs for acute otitis media trials. Int J Pediatr Otorhinolaryngol. 2008 Jun; 72(6):737-50.
    View in: PubMed
  32. Pichichero ME, Casey JR, Block SL, Guttendorf R, Flanner H, Markowitz D, Clausen S. Pharmacodynamic analysis and clinical trial of amoxicillin sprinkle administered once daily for 7 days compared to penicillin V potassium administered four times daily for 10 days in the treatment of tonsillopharyngitis due to Streptococcus pyogenes in children. Antimicrob Agents Chemother. 2008 Jul; 52(7):2512-20.
    View in: PubMed
  33. Pichichero ME, Casey JR. Systematic review of factors contributing to penicillin treatment failure in Streptococcus pyogenes pharyngitis. Otolaryngol Head Neck Surg. 2007 Dec; 137(6):851-857.
    View in: PubMed
  34. Pichichero ME, Casey JR. Emergence of a multiresistant serotype 19A pneumococcal strain not included in the 7-valent conjugate vaccine as an otopathogen in children. JAMA. 2007 Oct 17; 298(15):1772-8.
    View in: PubMed
  35. Pichichero ME, Casey JR. Evolving microbiology and molecular epidemiology of acute otitis media in the pneumococcal conjugate vaccine era. Pediatr Infect Dis J. 2007 Oct; 26(10 Suppl):S12-6.
    View in: PubMed
  36. Pichichero ME, Casey JR. Bacterial eradication rates with shortened courses of 2nd- and 3rd-generation cephalosporins versus 10 days of penicillin for treatment of group A streptococcal tonsillopharyngitis in adults. Diagn Microbiol Infect Dis. 2007 Oct; 59(2):127-30.
    View in: PubMed
  37. Kranz C, Sun L, Eklund EA, Krasnewich D, Casey JR, Freeze HH. CDG-Id in two siblings with partially different phenotypes. Am J Med Genet A. 2007 Jul 1; 143A(13):1414-20.
    View in: PubMed
  38. Casey JR, Pichichero ME. Symptomatic relapse of group A beta-hemolytic streptococcal tonsillopharyngitis in children. Clin Pediatr (Phila). 2007 May; 46(4):307-10.
    View in: PubMed
  39. Pichichero ME, Casey JR. Safe use of selected cephalosporins in penicillin-allergic patients: a meta-analysis. Otolaryngol Head Neck Surg. 2007 Mar; 136(3):340-7.
    View in: PubMed
  40. Casey JR, Pichichero ME. The evidence base for cephalosporin superiority over penicillin in streptococcal pharyngitis. Diagn Microbiol Infect Dis. 2007 Mar; 57(3 Suppl):39S-45S.
    View in: PubMed
  41. Pichichero M, Papa T, Blatter M, Mitchell D, Kratz R, Sneed J, Bassily E, Casey J, Gilmet G. Immune memory in children previously vaccinated with an experimental quadrivalent meningococcal polysaccharide diphtheria toxoid conjugate vaccine. Pediatr Infect Dis J. 2006 Nov; 25(11):995-1000.
    View in: PubMed
  42. Pichichero ME, Casey JR, Francis AB, Marsocci SM, Murphy M, Hoeger W, Cleary C. Acellular pertussis vaccine boosters combined with diphtheria and tetanus toxoid boosters for adolescents: safety and immunogenicity assessment when preceded by different 5-dose DTaP/DTwP schedules. Clin Pediatr (Phila). 2006 Sep; 45(7):613-20.
    View in: PubMed
  43. Pichichero M, Casey J. Comparison of European and U.S. results for cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis. Eur J Clin Microbiol Infect Dis. 2006 Jun; 25(6):354-64.
    View in: PubMed
  44. Casey JR. Treating acute otitis media post-PCV-7: judicious antibiotic therapy. Postgrad Med. 2005 Dec; 118(6 Suppl Emerging):32-3, 24-31.
    View in: PubMed
  45. Casey JR, Pichichero ME. Metaanalysis of short course antibiotic treatment for group a streptococcal tonsillopharyngitis. Pediatr Infect Dis J. 2005 Oct; 24(10):909-17.
    View in: PubMed
  46. Pichichero ME, Casey JR. Acellular pertussis vaccines for adolescents. Pediatr Infect Dis J. 2005 Jun; 24(6 Suppl):S117-26.
    View in: PubMed
  47. Casey JR, Pichichero ME. Higher dosages of azithromycin are more effective in treatment of group A streptococcal tonsillopharyngitis. Clin Infect Dis. 2005 Jun 15; 40(12):1748-55.
    View in: PubMed
  48. Pichichero ME, Casey JR. Acute otitis media: making sense of recent guidelines on antimicrobial treatment. J Fam Pract. 2005 Apr; 54(4):313-22.
    View in: PubMed
  49. Casey JR, Pichichero ME. Acellular pertussis vaccine safety and efficacy in children, adolescents and adults. Drugs. 2005; 65(10):1367-89.
    View in: PubMed
  50. Pichichero M, Casey J, Blatter M, Rothstein E, Ryall R, Bybel M, Gilmet G, Papa T. Comparative trial of the safety and immunogenicity of quadrivalent (A, C, Y, W-135) meningococcal polysaccharide-diphtheria conjugate vaccine versus quadrivalent polysaccharide vaccine in two- to ten-year-old children. Pediatr Infect Dis J. 2005 Jan; 24(1):57-62.
    View in: PubMed
  51. Perrin EM, Murphy ML, Casey JR, Pichichero ME, Runyan DK, Miller WC, Snider LA, Swedo SE. Does group A beta-hemolytic streptococcal infection increase risk for behavioral and neuropsychiatric symptoms in children? Arch Pediatr Adolesc Med. 2004 Sep; 158(9):848-56.
    View in: PubMed
  52. Casey JR, Pichichero ME. Changes in frequency and pathogens causing acute otitis media in 1995-2003. Pediatr Infect Dis J. 2004 Sep; 23(9):824-8.
    View in: PubMed
  53. Casey JR, Pichichero ME. Meta-analysis of cephalosporins versus penicillin for treatment of group A streptococcal tonsillopharyngitis in adults. Clin Infect Dis. 2004 Jun 1; 38(11):1526-34.
    View in: PubMed
  54. Casey JR, Pichichero ME. Meta-analysis of cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis in children. Pediatrics. 2004 Apr; 113(4):866-82.
    View in: PubMed
  55. Pichichero ME, Casey JR. Acute otitis media disease management. Minerva Pediatr. 2003 Oct; 55(5):415-38.
    View in: PubMed
  56. Pichichero ME, Hoeger WJ, Casey JR. Azithromycin for the treatment of pertussis. Pediatr Infect Dis J. 2003 Sep; 22(9):847-9.
    View in: PubMed
  57. Curtin CD, Casey JR, Murray PC, Cleary CT, Hoeger WJ, Marsocci SM, Murphy ML, Francis AB, Pichichero ME. Efficacy of cephalexin two vs. three times daily vs. cefadroxil once daily for streptococcal tonsillopharyngitis. Clin Pediatr (Phila). 2003 Jul-Aug; 42(6):519-26.
    View in: PubMed
  58. Curtin-Wirt C, Casey JR, Murray PC, Cleary CT, Hoeger WJ, Marsocci SM, Murphy ML, Francis AB, Pichichero ME. Efficacy of penicillin vs. amoxicillin in children with group A beta hemolytic streptococcal tonsillopharyngitis. Clin Pediatr (Phila). 2003 Apr; 42(3):219-25.
    View in: PubMed
  59. Casey JR, Marsocci SM, Murphy ML, Francis AB, Pichichero ME. White blood cell count can aid judicious antibiotic prescribing in acute upper respiratory infections in children. Clin Pediatr (Phila). 2003 Mar; 42(2):113-9.
    View in: PubMed
  60. Pichichero ME, Casey JR. Otitis media. Expert Opin Pharmacother. 2002 Aug; 3(8):1073-90.
    View in: PubMed
  61. Pichichero ME, Casey JR, Mayes T, Francis AB, Marsocci SM, Murphy AM, Hoeger W. Penicillin failure in streptococcal tonsillopharyngitis: causes and remedies. Pediatr Infect Dis J. 2000 Sep; 19(9):917-23.
    View in: PubMed
  62. Graham ML, Herndon JE, Casey JR, Chaffee S, Ciocci GH, Krischer JP, Kurtzberg J, Laughlin MJ, Longee DC, Olson JF, Paleologus N, Pennington CN, Friedman HS. High-dose chemotherapy with autologous stem-cell rescue in patients with recurrent and high-risk pediatric brain tumors. J Clin Oncol. 1997 May; 15(5):1814-23.
    View in: PubMed
  63. Trant CA, Casey JR, Hansell D, Cheifetz I, Meliones JN, Ungerleider RM, Browning I, Greeley WJ. Successful use of extracorporeal membrane oxygenation in the treatment of acute chest syndrome in a child with severe sickle cell anemia. ASAIO J. 1996 May-Jun; 42(3):236-9.
    View in: PubMed
  64. Casey JR, Petranka JG, Kottra J, Fleenor DE, Rosse WF. The structure of the urokinase-type plasminogen activator receptor gene. Blood. 1994 Aug 15; 84(4):1151-6.
    View in: PubMed

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