Mark Sowden
| Title | Research Associate Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Medicine in the Aab Cardiovascular Research Institute |
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| Address | Aab Cardiovascular Research Institute
211 Bailey Road
West Henrietta NY 14586
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Dr. Sowden received the University of Rochester Deans Institutional Award in 2002-04 to study the role of activation induced deaminase as an RNA editing enzyme in human B-cell function. Since then, he has received support from the UR Environmental Health Sciences Center and the Philip Morris External Research Program for related studies of smoking-associated carcinogenesis and teh APOBEC family of deaminases.
He is currently working with Dr. Peter Sims and Dr. Therese Wiedmer in studies of phospholipid scramblases.
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Chen CW, Sowden M, Zhao Q, Wiedmer T, Sims PJ. Nuclear phospholipid scramblase 1 prolongs the mitotic expansion of granulocyte precursors during G-CSF-induced granulopoiesis. J Leukoc Biol. 2011 Aug; 90(2):221-33.
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Lehmann DM, Galloway CA, MacElrevey C, Sowden MP, Wedekind JE, Smith HC. Functional characterization of APOBEC-1 complementation factor phosphorylation sites. Biochim Biophys Acta. 2007 Mar; 1773(3):408-18.
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Bennett RP, Diner E, Sowden MP, Lees JA, Wedekind JE, Smith HC. APOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot traffic. Biochem Biophys Res Commun. 2006 Nov 10; 350(1):214-9.
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Lehmann DM, Galloway CA, Sowden MP, Smith HC. Metabolic regulation of apoB mRNA editing is associated with phosphorylation of APOBEC-1 complementation factor. Nucleic Acids Res. 2006; 34(11):3299-308.
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Ichikawa HT, Sowden MP, Torelli AT, Bachl J, Huang P, Dance GS, Marr SH, Robert J, Wedekind JE, Smith HC, Bottaro A. Structural phylogenetic analysis of activation-induced deaminase function. J Immunol. 2006 Jul 1; 177(1):355-61.
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Sparks JD, Collins HL, Chirieac DV, Cianci J, Jokinen J, Sowden MP, Galloway CA, Sparks CE. Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase. Biochem J. 2006 Apr 15; 395(2):363-71.
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Smith HC, Bottaro A, Sowden MP, Wedekind JE. Activation induced deaminase: the importance of being specific. Trends Genet. 2004 Jun; 20(6):224-7.
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Xie K, Sowden MP, Dance GS, Torelli AT, Smith HC, Wedekind JE. The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1. Proc Natl Acad Sci U S A. 2004 May 25; 101(21):8114-9.
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Sowden MP, Lehmann DM, Lin X, Smith CO, Smith HC. Identification of novel alternative splice variants of APOBEC-1 complementation factor with different capacities to support apolipoprotein B mRNA editing. J Biol Chem. 2004 Jan 2; 279(1):197-206.
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Wedekind JE, Dance GS, Sowden MP, Smith HC. Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business. Trends Genet. 2003 Apr; 19(4):207-16.
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Galloway CA, Sowden MP, Smith HC. Increasing the yield of soluble recombinant protein expressed in E. coli by induction during late log phase. Biotechniques. 2003 Mar; 34(3):524-6, 528, 530.
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Sowden MP, Ballatori N, Jensen KL, Reed LH, Smith HC. The editosome for cytidine to uridine mRNA editing has a native complexity of 27S: identification of intracellular domains containing active and inactive editing factors. J Cell Sci. 2002 Mar 1; 115(Pt 5):1027-39.
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Dance GS, Sowden MP, Cartegni L, Cooper E, Krainer AR, Smith HC. Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing. J Biol Chem. 2002 Apr 12; 277(15):12703-9.
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Giangreco A, Sowden MP, Mikityansky I, Smith HC. Ethanol stimulates apolipoprotein B mRNA editing in the absence of de novo RNA or protein synthesis. Biochem Biophys Res Commun. 2001 Dec 21; 289(5):1162-7.
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Sowden MP, Smith HC. Commitment of apolipoprotein B RNA to the splicing pathway regulates cytidine-to-uridine editing-site utilization. Biochem J. 2001 Nov 1; 359(Pt 3):697-705.
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Yang Y, Sowden MP, Yang Y, Smith HC. Intracellular trafficking determinants in APOBEC-1, the catalytic subunit for cytidine to uridine editing of apolipoprotein B mRNA. Exp Cell Res. 2001 Jul 15; 267(2):153-64.
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Yang Y, Sowden MP, Smith HC. Induction of cytidine to uridine editing on cytoplasmic apolipoprotein B mRNA by overexpressing APOBEC-1. J Biol Chem. 2000 Jul 28; 275(30):22663-9.
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Dance GS, Sowden MP, Yang Y, Smith HC. APOBEC-1 dependent cytidine to uridine editing of apolipoprotein B RNA in yeast. Nucleic Acids Res. 2000 Jan 15; 28(2):424-9.
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Siddiqui JF, Van Mater D, Sowden MP, Smith HC. Disproportionate relationship between APOBEC-1 expression and apolipoprotein B mRNA editing activity. Exp Cell Res. 1999 Oct 10; 252(1):154-64.
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Sowden MP, Collins HL, Smith HC, Garrow TA, Sparks JD, Sparks CE. Apolipoprotein B mRNA and lipoprotein secretion are increased in McArdle RH-7777 cells by expression of betaine-homocysteine S-methyltransferase. Biochem J. 1999 Aug 1; 341 ( Pt 3):639-45.
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Van Mater D, Sowden MP, Cianci J, Sparks JD, Sparks CE, Ballatori N, Smith HC. Ethanol increases apolipoprotein B mRNA editing in rat primary hepatocytes and McArdle cells. Biochem Biophys Res Commun. 1998 Nov 18; 252(2):334-9.
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Sparks JD, Phung TL, Bolognino M, Cianci J, Khurana R, Peterson RG, Sowden MP, Corsetti JP, Sparks CE. Lipoprotein alterations in 10- and 20-week-old Zucker diabetic fatty rats: hyperinsulinemic versus insulinopenic hyperglycemia. Metabolism. 1998 Nov; 47(11):1315-24.
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Sowden MP, Eagleton MJ, Smith HC. Apolipoprotein B RNA sequence 3' of the mooring sequence and cellular sources of auxiliary factors determine the location and extent of promiscuous editing. Nucleic Acids Res. 1998 Apr 1; 26(7):1644-52.
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Stewart J, Kozlowski P, Sowden M, Messing E, Smith HC. A quantitative assay for assessing allelic proportions by iterative gap ligation. Nucleic Acids Res. 1998 Feb 15; 26(4):961-6.
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Sparks JD, Collins HL, Sabio I, Sowden MP, Smith HC, Cianci J, Sparks CE. Effects of fatty acids on apolipoprotein B secretion by McArdle RH-7777 rat hepatoma cells. Biochim Biophys Acta. 1997 Jul 12; 1347(1):51-61.
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Smith HC, Sowden MP. Base-modification mRNA editing through deamination--the good, the bad and the unregulated. Trends Genet. 1996 Oct; 12(10):418-24.
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Phung TL, Sowden MP, Sparks JD, Sparks CE, Smith HC. Regulation of hepatic apolipoprotein B RNA editing in the genetically obese Zucker rat. Metabolism. 1996 Sep; 45(9):1056-8.
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Marsh JB, Diffenderfer MR, Fisher EA, Sowden M, Dong M, Paterniti JR, Burkey BF. Effect of experimental nephrosis on hepatic lipoprotein secretion and urinary lipoprotein excretion in rats expressing the human apolipoprotein A-I gene. J Lipid Res. 1996 May; 37(5):1113-24.
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Sowden M, Hamm JK, Spinelli S, Smith HC. Determinants involved in regulating the proportion of edited apolipoprotein B RNAs. RNA. 1996 Mar; 2(3):274-88.
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Sowden M, Hamm JK, Smith HC. Overexpression of APOBEC-1 results in mooring sequence-dependent promiscuous RNA editing. J Biol Chem. 1996 Feb 9; 271(6):3011-7.
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Skuse GR, Cappione AJ, Sowden M, Metheny LJ, Smith HC. The neurofibromatosis type I messenger RNA undergoes base-modification RNA editing. Nucleic Acids Res. 1996 Feb 1; 24(3):478-85.
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Sowden M, Harrison S, Ashfield R, Kingsman AJ, Kingsman SM. Multiple cooperative interactions constrain BPV-1 E2 dependent activation of transcription. Nucleic Acids Res. 1989 Apr 25; 17(8):2959-72.
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Stanway CA, Sowden MP, Wilson LE, Kingsman AJ, Kingsman SM. Efficient activation of transcription in yeast by the BPV1 E2 protein. Nucleic Acids Res. 1989 Mar 25; 17(6):2187-96.
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