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Irene Richard

TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentNeurology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 673
Rochester NY 14642
Other Positions
TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentPsychiatry

 
 Awards And Honors
1985     Phi Kappa Phi Honor Society
1987     Cornell Presidential Scholar
1987     President, Cornell Honor Society
1987     First Place, Cornell Public Speaking Contest
1990     Rock Sleyster Scholar (Psychiatry)
2005     Elected member American Neurological Association
2011     Langston Award, Michael J. Fox Foundation
 
 Overview
Dr. Richard's clinical research is aimed at understanding the pathophysiology of and developing effective treatments (medical and surgical) through clinical trials for neurological and psychiatric aspects of movement disorders, with a particular emphasis on depression in Parkinson's disease.

 
 Selected Publications
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  1. A randomized clinical trial of high-dosage coenzyme q10 in early Parkinson disease: no evidence of benefit. JAMA Neurol. 2014 May 1; 71(5):543-52.
    View in: PubMed
  2. Moonen AJ, Wijers A, Leentjens AF, Christine CW, Factor SA, Juncos J, Lyness JM, Marsh L, Panisset M, Pfeiffer R, Rottenberg D, Serrano Ramos C, Shulman L, Singer C, Slevin J, McDonald W, Auinger P, Richard IH. Severity of depression and anxiety are predictors of response to antidepressant treatment in Parkinson's disease. Parkinsonism Relat Disord. 2014 Jun; 20(6):644-6.
    View in: PubMed
  3. Leentjens AF, Moonen AJ, Dujardin K, Marsh L, Martinez-Martin P, Richard IH, Starkstein SE, Köhler S. Modeling depression in Parkinson disease: Disease-specific and nonspecific risk factors. Neurology. 2013 Sep 17; 81(12):1036-43.
    View in: PubMed
  4. Forjaz MJ, Martinez-Martin P, Dujardin K, Marsh L, Richard IH, Starkstein SE, Leentjens AF. Rasch analysis of anxiety scales in Parkinson's disease. J Psychosom Res. 2013 May; 74(5):414-9.
    View in: PubMed
  5. Leentjens AF, Dujardin K, Marsh L, Martinez-Martin P, Richard IH, Starkstein SE. Anxiety and motor fluctuations in Parkinson's disease: A cross-sectional observational study. Parkinsonism Relat Disord. 2012 Dec; 18(10):1084-8.
    View in: PubMed
  6. Richard IH, McDermott MP, Kurlan R, Lyness JM, Como PG, Pearson N, Factor SA, Juncos J, Serrano Ramos C, Brodsky M, Manning C, Marsh L, Shulman L, Fernandez HH, Black KJ, Panisset M, Christine CW, Jiang W, Singer C, Horn S, Pfeiffer R, Rottenberg D, Slevin J, Elmer L, Press D, Hyson HC, McDonald W. A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease. Neurology. 2012 Apr 17; 78(16):1229-36.
    View in: PubMed
  7. LeWitt PA, Rezai AR, Leehey MA, Ojemann SG, Flaherty AW, Eskandar EN, Kostyk SK, Thomas K, Sarkar A, Siddiqui MS, Tatter SB, Schwalb JM, Poston KL, Henderson JM, Kurlan RM, Richard IH, Van Meter L, Sapan CV, During MJ, Kaplitt MG, Feigin A. AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial. Lancet Neurol. 2011 Apr; 10(4):309-19.
    View in: PubMed
  8. Leentjens AF, Dujardin K, Marsh L, Richard IH, Starkstein SE, Martinez-Martin P. Anxiety rating scales in Parkinson's disease: a validation study of the Hamilton anxiety rating scale, the Beck anxiety inventory, and the hospital anxiety and depression scale. Mov Disord. 2011 Feb 15; 26(3):407-15.
    View in: PubMed
  9. Leentjens AF, Dujardin K, Marsh L, Martinez-Martin P, Richard IH, Starkstein SE. Symptomatology and markers of anxiety disorders in Parkinson's disease: a cross-sectional study. Mov Disord. 2011 Feb 15; 26(3):484-92.
    View in: PubMed
  10. Dinomais M, Gambart G, Bruneau A, Bontoux L, Deries X, Tessiot C, Richard I. Social functioning and self-esteem in young people with disabilities participating in adapted competitive sport. Neuropediatrics. 2010 Aug; 41(2):49-54.
    View in: PubMed
  11. Saoût V, Ombredane MP, Mouillie JM, Marteau C, Mathé JF, Richard I. Patients in a permanent vegetative state or minimally conscious state in the Maine-et-Loire county of France: A cross-sectional, descriptive study. Ann Phys Rehabil Med. 2010 Mar; 53(2):96-104.
    View in: PubMed
  12. Leentjens AF, Dujardin K, Marsh L, Martinez-Martin P, Richard IH, Starkstein SE, Weintraub D, Sampaio C, Poewe W, Rascol O, Stebbins GT, Goetz CG. Anxiety rating scales in Parkinson's disease: critique and recommendations. Mov Disord. 2008 Oct 30; 23(14):2015-25.
    View in: PubMed
  13. Leentjens AF, Dujardin K, Marsh L, Martinez-Martin P, Richard IH, Starkstein SE, Weintraub D, Sampaio C, Poewe W, Rascol O, Stebbins GT, Goetz CG. Apathy and anhedonia rating scales in Parkinson's disease: critique and recommendations. Mov Disord. 2008 Oct 30; 23(14):2004-14.
    View in: PubMed
  14. Palumbo DR, Sallee FR, Pelham WE, Bukstein OG, Daviss WB, McDermott MP. Clonidine for attention-deficit/hyperactivity disorder: I. Efficacy and tolerability outcomes. J Am Acad Child Adolesc Psychiatry. 2008 Feb; 47(2):180-8.
    View in: PubMed
  15. Daviss WB, Patel NC, Robb AS, McDermott MP, Bukstein OG, Pelham WE, Palumbo D, Harris P, Sallee FR. Clonidine for attention-deficit/hyperactivity disorder: II. ECG changes and adverse events analysis. J Am Acad Child Adolesc Psychiatry. 2008 Feb; 47(2):189-98.
    View in: PubMed
  16. Richard IH, LaDonna KA, Hartman R, Podgorski C, Kurlan R. The patients' perspective: Results of a survey assessing knowledge about and attitudes toward depression in PD. Neuropsychiatr Dis Treat. 2007 Dec; 3(6):903-6.
    View in: PubMed
  17. Constantinescu R, Richard I, Kurlan R. Levodopa responsiveness in disorders with parkinsonism: a review of the literature. Mov Disord. 2007 Nov 15; 22(15):2141-8; quiz 2295.
    View in: PubMed
  18. Biglan KM, Holloway RG, McDermott MP, Richard IH. Risk factors for somnolence, edema, and hallucinations in early Parkinson disease. Neurology. 2007 Jul 10; 69(2):187-95.
    View in: PubMed
  19. Richard IH. Depression and apathy in Parkinson's disease. Curr Neurol Neurosci Rep. 2007 Jul; 7(4):295-301.
    View in: PubMed
  20. Kurlan R, Cummings J, Raman R, Thal L. Quetiapine for agitation or psychosis in patients with dementia and parkinsonism. Neurology. 2007 Apr 24; 68(17):1356-63.
    View in: PubMed
  21. Griggs R, Vihola A, Hackman P, Talvinen K, Haravuori H, Faulkner G, Eymard B, Richard I, Selcen D, Engel A, Carpen O, Udd B. Zaspopathy in a large classic late-onset distal myopathy family. Brain. 2007 Jun; 130(Pt 6):1477-84.
    View in: PubMed
  22. Kurlan R, Richard IH, Deeley C. Medication tolerance and augmentation in restless legs syndrome: the need for drug class rotation. J Gen Intern Med. 2006 Dec; 21(12):C1-4.
    View in: PubMed
  23. Richard IH, Kurlan R. The under-recognition of depression in Parkinson's disease. Neuropsychiatr Dis Treat. 2006 Sep; 2(3):349-53.
    View in: PubMed
  24. Richard IH. Apathy does not equal depression in Parkinson disease: why we should care. Neurology. 2006 Jul 11; 67(1):10-1.
    View in: PubMed
  25. Marsh L, McDonald WM, Cummings J, Ravina B. Provisional diagnostic criteria for depression in Parkinson's disease: report of an NINDS/NIMH Work Group. Mov Disord. 2006 Feb; 21(2):148-58.
    View in: PubMed
  26. Richard IH, Frank S, LaDonna KA, Wang H, McDermott MP, Kurlan R. Mood fluctuations in Parkinson's disease: a pilot study comparing the effects of intravenous and oral levodopa administration. Neuropsychiatr Dis Treat. 2005 Sep; 1(3):261-8.
    View in: PubMed
  27. Udd B, Vihola A, Sarparanta J, Richard I, Hackman P. Titinopathies and extension of the M-line mutation phenotype beyond distal myopathy and LGMD2J. Neurology. 2005 Feb 22; 64(4):636-42.
    View in: PubMed
  28. Richard IH. Anxiety disorders in Parkinson's disease. Adv Neurol. 2005; 96:42-55.
    View in: PubMed
  29. Fahn S, Oakes D, Shoulson I, Kieburtz K, Rudolph A, Lang A, Olanow CW, Tanner C, Marek K. Levodopa and the progression of Parkinson's disease. N Engl J Med. 2004 Dec 9; 351(24):2498-508.
    View in: PubMed
  30. Richard IH, Frank S, McDermott MP, Wang H, Justus AW, LaDonna KA, Kurlan R. The ups and downs of Parkinson disease: a prospective study of mood and anxiety fluctuations. Cogn Behav Neurol. 2004 Dec; 17(4):201-7.
    View in: PubMed
  31. Bontoux L, Roquelaure Y, Billabert C, Dubus V, Sancho PO, Colin D, Brami L, Moisan S, Fanello S, Penneau-Fontbonne D, Richard I. [Prospective study of the outcome at one year of patients with chronic low back pain in a program of intensive functional restoration and ergonomic intervention. Factors predicting their return to work]. Ann Readapt Med Phys. 2004 Oct; 47(8):563-72.
    View in: PubMed
  32. Richard IH, McDonald WM. Can "blue" genes affect mood and movement? Neurology. 2004 Aug 24; 63(4):610-1.
    View in: PubMed
  33. Ismail MS, Richard IH. A reality test: How well do we understand psychosis in Parkinson's disease? J Neuropsychiatry Clin Neurosci. 2004; 16(1):8-18.
    View in: PubMed
  34. McDonald WM, Richard IH, DeLong MR. Prevalence, etiology, and treatment of depression in Parkinson's disease. Biol Psychiatry. 2003 Aug 1; 54(3):363-75.
    View in: PubMed
  35. Factor SA, Feustel PJ, Friedman JH, Comella CL, Goetz CG, Kurlan R, Parsa M, Pfeiffer R. Longitudinal outcome of Parkinson's disease patients with psychosis. Neurology. 2003 Jun 10; 60(11):1756-61.
    View in: PubMed
  36. Richard I, Perrouin-Verbe B, Rome J, Bernat C, Mathé JF. [Pharmacological treatment of post-traumatic behavioural disorders]. Ann Readapt Med Phys. 2003 Feb; 46(1):49-57.
    View in: PubMed
  37. Richard IH, Papka M, Rubio A, Kurlan R. Parkinson's disease and dementia with Lewy bodies: one disease or two? Mov Disord. 2002 Nov; 17(6):1161-5.
    View in: PubMed
  38. Richard IH, Justus AW, Greig NH, Marshall F, Kurlan R. Worsening of motor function and mood in a patient with Parkinson's disease after pharmacologic challenge with oral rivastigmine. Clin Neuropharmacol. 2002 Nov-Dec; 25(6):296-9.
    View in: PubMed
  39. Treatment of ADHD in children with tics: a randomized controlled trial. Neurology. 2002 Feb 26; 58(4):527-36.
    View in: PubMed
  40. Brockington M, Yuva Y, Prandini P, Brown SC, Torelli S, Benson MA, Herrmann R, Anderson LV, Bashir R, Burgunder JM, Fallet S, Romero N, Fardeau M, Straub V, Storey G, Pollitt C, Richard I, Sewry CA, Bushby K, Voit T, Blake DJ, Muntoni F. Mutations in the fukutin-related protein gene (FKRP) identify limb girdle muscular dystrophy 2I as a milder allelic variant of congenital muscular dystrophy MDC1C. Hum Mol Genet. 2001 Dec 1; 10(25):2851-9.
    View in: PubMed
  41. Aoki M, Liu J, Richard I, Bashir R, Britton S, Keers SM, Oeltjen J, Brown HE, Marchand S, Bourg N, Beley C, McKenna-Yasek D, Arahata K, Bohlega S, Cupler E, Illa I, Majneh I, Barohn RJ, Urtizberea JA, Fardeau M, Amato A, Angelini C, Bushby K, Beckmann JS, Brown RH. Genomic organization of the dysferlin gene and novel mutations in Miyoshi myopathy. Neurology. 2001 Jul 24; 57(2):271-8.
    View in: PubMed
  42. Haravuori H, Vihola A, Straub V, Auranen M, Richard I, Marchand S, Voit T, Labeit S, Somer H, Peltonen L, Beckmann JS, Udd B. Secondary calpain3 deficiency in 2q-linked muscular dystrophy: titin is the candidate gene. Neurology. 2001 Apr 10; 56(7):869-77.
    View in: PubMed
  43. Talim B, Ognibene A, Mattioli E, Richard I, Anderson LV, Merlini L. Normal calpain expression in genetically confirmed limb-girdle muscular dystrophy type 2A. Neurology. 2001 Mar 13; 56(5):692-3.
    View in: PubMed
  44. Richard IH, Justus AW, Kurlan R. Relationship between mood and motor fluctuations in Parkinson's disease. J Neuropsychiatry Clin Neurosci. 2001; 13(1):35-41.
    View in: PubMed
  45. Factor SA, Friedman JH, Lannon MC, Oakes D, Bourgeois K. Clozapine for the treatment of drug-induced psychosis in Parkinson's disease: results of the 12 week open label extension in the PSYCLOPS trial. Mov Disord. 2001 Jan; 16(1):135-9.
    View in: PubMed
  46. Renaud P, Wahab H, Bontoux L, Dauty M, Richard I, Brégeon C. [Total inverted shoulder prosthesis and rotator cuff insufficiency: evaluation and determination of anatomical parameters predictive of good functional outcome in 21 shoulders]. Ann Readapt Med Phys. 2001; 44(5):273-80.
    View in: PubMed
  47. Richard I, Kurlan R. Commentary to cognitive and behavioral heterogeneity. Neurobiol Aging. 2000 Nov-Dec; 21(6):863-4; discussion 875-7.
    View in: PubMed
  48. Richard IH, Nutt J. Worsening of motor function in Parkinson's disease: a "typical" response to "atypical" antipsychotic medications. Neurology. 2000 Sep 26; 55(6):748-9.
    View in: PubMed
  49. Argov Z, Sadeh M, Mazor K, Soffer D, Kahana E, Eisenberg I, Mitrani-Rosenbaum S, Richard I, Beckmann J, Keers S, Bashir R, Bushby K, Rosenmann H. Muscular dystrophy due to dysferlin deficiency in Libyan Jews. Clinical and genetic features. Brain. 2000 Jun; 123 ( Pt 6):1229-37.
    View in: PubMed
  50. Eymard B, Laforêt P, Tomé FM, Collin H, Leroy JP, Hauw JJ, Richard I, Beckmann J, Fardeau M. [Miyoshi distal myopathy: specific signs and incidence]. Rev Neurol (Paris). 2000 Feb; 156(2):161-8.
    View in: PubMed
  51. Kurlan R, Richard IH, Papka M, Marshall F. Movement disorders in Alzheimer's disease: more rigidity of definitions is needed. Mov Disord. 2000 Jan; 15(1):24-9.
    View in: PubMed
  52. Richard I, Bourg N, Marchand S, Alibert O, Eymard B, van der Kooi AJ, Jackson CE, Garcia C, Burgunder JM, Legum C, de Visser M, Fardeau M, Beckmann JS. A diagnostic fluorescent marker kit for six limb girdle muscular dystrophies. Neuromuscul Disord. 1999 Dec; 9(8):555-63.
    View in: PubMed
  53. Richard I, Roudaut C, Saenz A, Pogue R, Grimbergen JE, Anderson LV, Beley C, Cobo AM, de Diego C, Eymard B, Gallano P, Ginjaar HB, Lasa A, Pollitt C, Topaloglu H, Urtizberea JA, de Visser M, van der Kooi A, Bushby K, Bakker E, Lopez de Munain A, Fardeau M, Beckmann JS. Calpainopathy-a survey of mutations and polymorphisms. Am J Hum Genet. 1999 Jun; 64(6):1524-40.
    View in: PubMed
  54. Richard IH, Szegethy E, Lichter D, Schiffer RB, Kurlan R. Parkinson's disease: a preliminary study of yohimbine challenge in patients with anxiety. Clin Neuropharmacol. 1999 May-Jun; 22(3):172-5.
    View in: PubMed
  55. Low-dose clozapine for the treatment of drug-induced psychosis in Parkinson's disease. The Parkinson Study Group. N Engl J Med. 1999 Mar 11; 340(10):757-63.
    View in: PubMed
  56. Richard IH, Maughn A, Kurlan R. Do serotonin reuptake inhibitor antidepressants worsen Parkinson's disease? A retrospective case series. Mov Disord. 1999 Jan; 14(1):155-7.
    View in: PubMed
  57. Kawai H, Akaike M, Kunishige M, Inui T, Adachi K, Kimura C, Kawajiri M, Nishida Y, Endo I, Kashiwagi S, Nishino H, Fujiwara T, Okuno S, Roudaut C, Richard I, Beckmann JS, Miyoshi K, Matsumoto T. Clinical, pathological, and genetic features of limb-girdle muscular dystrophy type 2A with new calpain 3 gene mutations in seven patients from three Japanese families. Muscle Nerve. 1998 Nov; 21(11):1493-501.
    View in: PubMed
  58. Urtasun M, Sáenz A, Roudaut C, Poza JJ, Urtizberea JA, Cobo AM, Richard I, García Bragado F, Leturcq F, Kaplan JC, Martí Massó JF, Beckmann JS, López de Munain A. Limb-girdle muscular dystrophy in Guipúzcoa (Basque Country, Spain). Brain. 1998 Sep; 121 ( Pt 9):1735-47.
    View in: PubMed
  59. Richard IH, LaPointe M, Wax P, Risher W. Non-barbiturate, drug-induced reversible loss of brainstem reflexes. Neurology. 1998 Aug; 51(2):639-40.
    View in: PubMed
  60. Safety and tolerability of the free-radical scavenger OPC-14117 in Huntington's disease. The Huntington Study Group. Neurology. 1998 May; 50(5):1366-73.
    View in: PubMed
  61. Richard IH, Kurlan R. A survey of antidepressant drug use in Parkinson's disease. Parkinson Study Group. Neurology. 1997 Oct; 49(4):1168-70.
    View in: PubMed
  62. Richard I, Brenguier L, Dinçer P, Roudaut C, Bady B, Burgunder JM, Chemaly R, Garcia CA, Halaby G, Jackson CE, Kurnit DM, Lefranc G, Legum C, Loiselet J, Merlini L, Nivelon-Chevallier A, Ollagnon-Roman E, Restagno G, Topaloglu H, Beckmann JS. Multiple independent molecular etiology for limb-girdle muscular dystrophy type 2A patients from various geographical origins. Am J Hum Genet. 1997 May; 60(5):1128-38.
    View in: PubMed
  63. Richard IH, Kurlan R, Tanner C, Factor S, Hubble J, Suchowersky O, Waters C. Serotonin syndrome and the combined use of deprenyl and an antidepressant in Parkinson's disease. Parkinson Study Group. Neurology. 1997 Apr; 48(4):1070-7.
    View in: PubMed
  64. Fardeau M, Eymard B, Mignard C, Tomé FM, Richard I, Beckmann JS. Chromosome 15-linked limb-girdle muscular dystrophy: clinical phenotypes in Reunion Island and French metropolitan communities. Neuromuscul Disord. 1996 Dec; 6(6):447-53.
    View in: PubMed
  65. Fardeau M, Hillaire D, Mignard C, Feingold N, Feingold J, Mignard D, de Ubeda B, Collin H, Tome FM, Richard I, Beckmann J. Juvenile limb-girdle muscular dystrophy. Clinical, histopathological and genetic data from a small community living in the Reunion Island. Brain. 1996 Feb; 119 ( Pt 1):295-308.
    View in: PubMed
  66. Richard IH, Schiffer RB, Kurlan R. Anxiety and Parkinson's disease. J Neuropsychiatry Clin Neurosci. 1996; 8(4):383-92.
    View in: PubMed
  67. Woods SW, Hegeman IM, Zubal IG, Krystal JH, Koster K, Smith EO, Heninger GR, Hoffer PB. Visual stimulation increases technetium-99m-HMPAO distribution in human visual cortex. J Nucl Med. 1991 Feb; 32(2):210-5.
    View in: PubMed

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