Irene Richard
| Title | Associate Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Neurology |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 673
Rochester NY 14642
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| Title | Associate Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Psychiatry |
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| 1985 |
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| Phi Kappa Phi Honor Society | | 1987 |
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| Cornell Presidential Scholar | | 1987 |
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| President, Cornell Honor Society | | 1987 |
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| First Place, Cornell Public Speaking Contest | | 1990 |
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| Rock Sleyster Scholar (Psychiatry) | | 2005 |
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| Elected member
American Neurological Association | | 2011 |
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| Langston Award, Michael J. Fox Foundation |
Dr. Richard's clinical research is aimed at understanding the pathophysiology of and developing effective treatments (medical and surgical) through clinical trials for neurological and psychiatric aspects of movement disorders, with a particular emphasis on depression in Parkinson's disease.
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Leentjens AF, Dujardin K, Marsh L, Martinez-Martin P, Richard IH, Starkstein SE. Anxiety and motor fluctuations in Parkinson's disease: A cross-sectional observational study. Parkinsonism Relat Disord. 2012 Dec; 18(10):1084-8.
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Richard IH, McDermott MP, Kurlan R, Lyness JM, Como PG, Pearson N, Factor SA, Juncos J, Serrano Ramos C, Brodsky M, Manning C, Marsh L, Shulman L, Fernandez HH, Black KJ, Panisset M, Christine CW, Jiang W, Singer C, Horn S, Pfeiffer R, Rottenberg D, Slevin J, Elmer L, Press D, Hyson HC, McDonald W. A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease. Neurology. 2012 Apr 17; 78(16):1229-36.
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LeWitt PA, Rezai AR, Leehey MA, Ojemann SG, Flaherty AW, Eskandar EN, Kostyk SK, Thomas K, Sarkar A, Siddiqui MS, Tatter SB, Schwalb JM, Poston KL, Henderson JM, Kurlan RM, Richard IH, Van Meter L, Sapan CV, During MJ, Kaplitt MG, Feigin A. AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial. Lancet Neurol. 2011 Apr; 10(4):309-19.
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Leentjens AF, Dujardin K, Marsh L, Richard IH, Starkstein SE, Martinez-Martin P. Anxiety rating scales in Parkinson's disease: a validation study of the Hamilton anxiety rating scale, the Beck anxiety inventory, and the hospital anxiety and depression scale. Mov Disord. 2011 Feb 15; 26(3):407-15.
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Leentjens AF, Dujardin K, Marsh L, Martinez-Martin P, Richard IH, Starkstein SE. Symptomatology and markers of anxiety disorders in Parkinson's disease: a cross-sectional study. Mov Disord. 2011 Feb 15; 26(3):484-92.
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Dinomais M, Gambart G, Bruneau A, Bontoux L, Deries X, Tessiot C, Richard I. Social functioning and self-esteem in young people with disabilities participating in adapted competitive sport. Neuropediatrics. 2010 Aug; 41(2):49-54.
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Saoût V, Ombredane MP, Mouillie JM, Marteau C, Mathé JF, Richard I. Patients in a permanent vegetative state or minimally conscious state in the Maine-et-Loire county of France: A cross-sectional, descriptive study. Ann Phys Rehabil Med. 2010 Mar; 53(2):96-104.
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Leentjens AF, Dujardin K, Marsh L, Martinez-Martin P, Richard IH, Starkstein SE, Weintraub D, Sampaio C, Poewe W, Rascol O, Stebbins GT, Goetz CG. Anxiety rating scales in Parkinson's disease: critique and recommendations. Mov Disord. 2008 Oct 30; 23(14):2015-25.
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Leentjens AF, Dujardin K, Marsh L, Martinez-Martin P, Richard IH, Starkstein SE, Weintraub D, Sampaio C, Poewe W, Rascol O, Stebbins GT, Goetz CG. Apathy and anhedonia rating scales in Parkinson's disease: critique and recommendations. Mov Disord. 2008 Oct 30; 23(14):2004-14.
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Bouton C, Roche G, Roquelaure Y, Legrand E, Penneau-Fontbonne D, Dubus V, Bontoux L, Huez JF, Rucay P, Parot-Shinkel E, Fanello S, Richard I. Management of low back pain in primary care prior to multidisciplinary functional restoration: a retrospective study of 72 patients. Ann Readapt Med Phys. 2008 Nov; 51(8):650-6, 656-62.
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Daviss WB, Patel NC, Robb AS, McDermott MP, Bukstein OG, Pelham WE, Palumbo D, Harris P, Sallee FR. Clonidine for attention-deficit/hyperactivity disorder: II. ECG changes and adverse events analysis. J Am Acad Child Adolesc Psychiatry. 2008 Feb; 47(2):189-98.
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Palumbo DR, Sallee FR, Pelham WE, Bukstein OG, Daviss WB, McDermott MP. Clonidine for attention-deficit/hyperactivity disorder: I. Efficacy and tolerability outcomes. J Am Acad Child Adolesc Psychiatry. 2008 Feb; 47(2):180-8.
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Richard IH, LaDonna KA, Hartman R, Podgorski C, Kurlan R. The patients' perspective: Results of a survey assessing knowledge about and attitudes toward depression in PD. Neuropsychiatr Dis Treat. 2007 Dec; 3(6):903-6.
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Constantinescu R, Richard I, Kurlan R. Levodopa responsiveness in disorders with parkinsonism: a review of the literature. Mov Disord. 2007 Nov 15; 22(15):2141-8; quiz 2295.
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Biglan KM, Holloway RG, McDermott MP, Richard IH. Risk factors for somnolence, edema, and hallucinations in early Parkinson disease. Neurology. 2007 Jul 10; 69(2):187-95.
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Richard IH. Depression and apathy in Parkinson's disease. Curr Neurol Neurosci Rep. 2007 Jul; 7(4):295-301.
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Kurlan R, Cummings J, Raman R, Thal L. Quetiapine for agitation or psychosis in patients with dementia and parkinsonism. Neurology. 2007 Apr 24; 68(17):1356-63.
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Griggs R, Vihola A, Hackman P, Talvinen K, Haravuori H, Faulkner G, Eymard B, Richard I, Selcen D, Engel A, Carpen O, Udd B. Zaspopathy in a large classic late-onset distal myopathy family. Brain. 2007 Jun; 130(Pt 6):1477-84.
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Kurlan R, Richard IH, Deeley C. Medication tolerance and augmentation in restless legs syndrome: the need for drug class rotation. J Gen Intern Med. 2006 Dec; 21(12):C1-4.
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Richard IH, Kurlan R. The under-recognition of depression in Parkinson's disease. Neuropsychiatr Dis Treat. 2006 Sep; 2(3):349-53.
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Richard IH. Apathy does not equal depression in Parkinson disease: why we should care. Neurology. 2006 Jul 11; 67(1):10-1.
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Marsh L, McDonald WM, Cummings J, Ravina B. Provisional diagnostic criteria for depression in Parkinson's disease: report of an NINDS/NIMH Work Group. Mov Disord. 2006 Feb; 21(2):148-58.
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Richard IH, Frank S, LaDonna KA, Wang H, McDermott MP, Kurlan R. Mood fluctuations in Parkinson's disease: a pilot study comparing the effects of intravenous and oral levodopa administration. Neuropsychiatr Dis Treat. 2005 Sep; 1(3):261-8.
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Udd B, Vihola A, Sarparanta J, Richard I, Hackman P. Titinopathies and extension of the M-line mutation phenotype beyond distal myopathy and LGMD2J. Neurology. 2005 Feb 22; 64(4):636-42.
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Richard IH. Anxiety disorders in Parkinson's disease. Adv Neurol. 2005; 96:42-55.
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Fahn S, Oakes D, Shoulson I, Kieburtz K, Rudolph A, Lang A, Olanow CW, Tanner C, Marek K. Levodopa and the progression of Parkinson's disease. N Engl J Med. 2004 Dec 9; 351(24):2498-508.
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Richard IH, Frank S, McDermott MP, Wang H, Justus AW, LaDonna KA, Kurlan R. The ups and downs of Parkinson disease: a prospective study of mood and anxiety fluctuations. Cogn Behav Neurol. 2004 Dec; 17(4):201-7.
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Bontoux L, Roquelaure Y, Billabert C, Dubus V, Sancho PO, Colin D, Brami L, Moisan S, Fanello S, Penneau-Fontbonne D, Richard I. [Prospective study of the outcome at one year of patients with chronic low back pain in a program of intensive functional restoration and ergonomic intervention. Factors predicting their return to work]. Ann Readapt Med Phys. 2004 Oct; 47(8):563-72.
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Richard IH, McDonald WM. Can "blue" genes affect mood and movement? Neurology. 2004 Aug 24; 63(4):610-1.
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Ismail MS, Richard IH. A reality test: How well do we understand psychosis in Parkinson's disease? J Neuropsychiatry Clin Neurosci. 2004; 16(1):8-18.
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McDonald WM, Richard IH, DeLong MR. Prevalence, etiology, and treatment of depression in Parkinson's disease. Biol Psychiatry. 2003 Aug 1; 54(3):363-75.
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Factor SA, Feustel PJ, Friedman JH, Comella CL, Goetz CG, Kurlan R, Parsa M, Pfeiffer R. Longitudinal outcome of Parkinson's disease patients with psychosis. Neurology. 2003 Jun 10; 60(11):1756-61.
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Richard I, Perrouin-Verbe B, Rome J, Bernat C, Mathé JF. [Pharmacological treatment of post-traumatic behavioural disorders]. Ann Readapt Med Phys. 2003 Feb; 46(1):49-57.
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Richard IH, Papka M, Rubio A, Kurlan R. Parkinson's disease and dementia with Lewy bodies: one disease or two? Mov Disord. 2002 Nov; 17(6):1161-5.
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Richard IH, Justus AW, Greig NH, Marshall F, Kurlan R. Worsening of motor function and mood in a patient with Parkinson's disease after pharmacologic challenge with oral rivastigmine. Clin Neuropharmacol. 2002 Nov-Dec; 25(6):296-9.
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Treatment of ADHD in children with tics: a randomized controlled trial. Neurology. 2002 Feb 26; 58(4):527-36.
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Brockington M, Yuva Y, Prandini P, Brown SC, Torelli S, Benson MA, Herrmann R, Anderson LV, Bashir R, Burgunder JM, Fallet S, Romero N, Fardeau M, Straub V, Storey G, Pollitt C, Richard I, Sewry CA, Bushby K, Voit T, Blake DJ, Muntoni F. Mutations in the fukutin-related protein gene (FKRP) identify limb girdle muscular dystrophy 2I as a milder allelic variant of congenital muscular dystrophy MDC1C. Hum Mol Genet. 2001 Dec 1; 10(25):2851-9.
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Aoki M, Liu J, Richard I, Bashir R, Britton S, Keers SM, Oeltjen J, Brown HE, Marchand S, Bourg N, Beley C, McKenna-Yasek D, Arahata K, Bohlega S, Cupler E, Illa I, Majneh I, Barohn RJ, Urtizberea JA, Fardeau M, Amato A, Angelini C, Bushby K, Beckmann JS, Brown RH. Genomic organization of the dysferlin gene and novel mutations in Miyoshi myopathy. Neurology. 2001 Jul 24; 57(2):271-8.
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Haravuori H, Vihola A, Straub V, Auranen M, Richard I, Marchand S, Voit T, Labeit S, Somer H, Peltonen L, Beckmann JS, Udd B. Secondary calpain3 deficiency in 2q-linked muscular dystrophy: titin is the candidate gene. Neurology. 2001 Apr 10; 56(7):869-77.
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Talim B, Ognibene A, Mattioli E, Richard I, Anderson LV, Merlini L. Normal calpain expression in genetically confirmed limb-girdle muscular dystrophy type 2A. Neurology. 2001 Mar 13; 56(5):692-3.
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Richard IH, Justus AW, Kurlan R. Relationship between mood and motor fluctuations in Parkinson's disease. J Neuropsychiatry Clin Neurosci. 2001; 13(1):35-41.
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Factor SA, Friedman JH, Lannon MC, Oakes D, Bourgeois K. Clozapine for the treatment of drug-induced psychosis in Parkinson's disease: results of the 12 week open label extension in the PSYCLOPS trial. Mov Disord. 2001 Jan; 16(1):135-9.
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Renaud P, Wahab H, Bontoux L, Dauty M, Richard I, Brégeon C. [Total inverted shoulder prosthesis and rotator cuff insufficiency: evaluation and determination of anatomical parameters predictive of good functional outcome in 21 shoulders]. Ann Readapt Med Phys. 2001; 44(5):273-80.
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Richard I, Kurlan R. Commentary to cognitive and behavioral heterogeneity. Neurobiol Aging. 2000 Nov-Dec; 21(6):863-4; discussion 875-7.
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Richard IH, Nutt J. Worsening of motor function in Parkinson's disease: a "typical" response to "atypical" antipsychotic medications. Neurology. 2000 Sep 26; 55(6):748-9.
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Argov Z, Sadeh M, Mazor K, Soffer D, Kahana E, Eisenberg I, Mitrani-Rosenbaum S, Richard I, Beckmann J, Keers S, Bashir R, Bushby K, Rosenmann H. Muscular dystrophy due to dysferlin deficiency in Libyan Jews. Clinical and genetic features. Brain. 2000 Jun; 123 ( Pt 6):1229-37.
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Eymard B, Laforêt P, Tomé FM, Collin H, Leroy JP, Hauw JJ, Richard I, Beckmann J, Fardeau M. [Miyoshi distal myopathy: specific signs and incidence]. Rev Neurol (Paris). 2000 Feb; 156(2):161-8.
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Kurlan R, Richard IH, Papka M, Marshall F. Movement disorders in Alzheimer's disease: more rigidity of definitions is needed. Mov Disord. 2000 Jan; 15(1):24-9.
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Richard I, Bourg N, Marchand S, Alibert O, Eymard B, van der Kooi AJ, Jackson CE, Garcia C, Burgunder JM, Legum C, de Visser M, Fardeau M, Beckmann JS. A diagnostic fluorescent marker kit for six limb girdle muscular dystrophies. Neuromuscul Disord. 1999 Dec; 9(8):555-63.
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Richard I, Roudaut C, Saenz A, Pogue R, Grimbergen JE, Anderson LV, Beley C, Cobo AM, de Diego C, Eymard B, Gallano P, Ginjaar HB, Lasa A, Pollitt C, Topaloglu H, Urtizberea JA, de Visser M, van der Kooi A, Bushby K, Bakker E, Lopez de Munain A, Fardeau M, Beckmann JS. Calpainopathy-a survey of mutations and polymorphisms. Am J Hum Genet. 1999 Jun; 64(6):1524-40.
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Richard IH, Szegethy E, Lichter D, Schiffer RB, Kurlan R. Parkinson's disease: a preliminary study of yohimbine challenge in patients with anxiety. Clin Neuropharmacol. 1999 May-Jun; 22(3):172-5.
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Low-dose clozapine for the treatment of drug-induced psychosis in Parkinson's disease. The Parkinson Study Group. N Engl J Med. 1999 Mar 11; 340(10):757-63.
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Richard IH, Maughn A, Kurlan R. Do serotonin reuptake inhibitor antidepressants worsen Parkinson's disease? A retrospective case series. Mov Disord. 1999 Jan; 14(1):155-7.
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Kawai H, Akaike M, Kunishige M, Inui T, Adachi K, Kimura C, Kawajiri M, Nishida Y, Endo I, Kashiwagi S, Nishino H, Fujiwara T, Okuno S, Roudaut C, Richard I, Beckmann JS, Miyoshi K, Matsumoto T. Clinical, pathological, and genetic features of limb-girdle muscular dystrophy type 2A with new calpain 3 gene mutations in seven patients from three Japanese families. Muscle Nerve. 1998 Nov; 21(11):1493-501.
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Urtasun M, Sáenz A, Roudaut C, Poza JJ, Urtizberea JA, Cobo AM, Richard I, García Bragado F, Leturcq F, Kaplan JC, Martí Massó JF, Beckmann JS, López de Munain A. Limb-girdle muscular dystrophy in Guipúzcoa (Basque Country, Spain). Brain. 1998 Sep; 121 ( Pt 9):1735-47.
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Richard IH, LaPointe M, Wax P, Risher W. Non-barbiturate, drug-induced reversible loss of brainstem reflexes. Neurology. 1998 Aug; 51(2):639-40.
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Safety and tolerability of the free-radical scavenger OPC-14117 in Huntington's disease. The Huntington Study Group. Neurology. 1998 May; 50(5):1366-73.
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Richard IH, Kurlan R. A survey of antidepressant drug use in Parkinson's disease. Parkinson Study Group. Neurology. 1997 Oct; 49(4):1168-70.
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Richard I, Brenguier L, Dinçer P, Roudaut C, Bady B, Burgunder JM, Chemaly R, Garcia CA, Halaby G, Jackson CE, Kurnit DM, Lefranc G, Legum C, Loiselet J, Merlini L, Nivelon-Chevallier A, Ollagnon-Roman E, Restagno G, Topaloglu H, Beckmann JS. Multiple independent molecular etiology for limb-girdle muscular dystrophy type 2A patients from various geographical origins. Am J Hum Genet. 1997 May; 60(5):1128-38.
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Richard IH, Kurlan R, Tanner C, Factor S, Hubble J, Suchowersky O, Waters C. Serotonin syndrome and the combined use of deprenyl and an antidepressant in Parkinson's disease. Parkinson Study Group. Neurology. 1997 Apr; 48(4):1070-7.
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Fardeau M, Eymard B, Mignard C, Tomé FM, Richard I, Beckmann JS. Chromosome 15-linked limb-girdle muscular dystrophy: clinical phenotypes in Reunion Island and French metropolitan communities. Neuromuscul Disord. 1996 Dec; 6(6):447-53.
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Fardeau M, Hillaire D, Mignard C, Feingold N, Feingold J, Mignard D, de Ubeda B, Collin H, Tome FM, Richard I, Beckmann J. Juvenile limb-girdle muscular dystrophy. Clinical, histopathological and genetic data from a small community living in the Reunion Island. Brain. 1996 Feb; 119 ( Pt 1):295-308.
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Richard IH, Schiffer RB, Kurlan R. Anxiety and Parkinson's disease. J Neuropsychiatry Clin Neurosci. 1996; 8(4):383-92.
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Woods SW, Hegeman IM, Zubal IG, Krystal JH, Koster K, Smith EO, Heninger GR, Hoffer PB. Visual stimulation increases technetium-99m-HMPAO distribution in human visual cortex. J Nucl Med. 1991 Feb; 32(2):210-5.
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