URMC Research Network

Find People
Keyword
Last Name
 
More Search Options

Terry Wright

TitleAssociate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentPediatrics
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester NY 14642
Other Positions
TitleAssociate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentMicrobiology and Immunology

 
 Awards And Honors
1994     American Society for Microbiology Sustaining Membership Travel Award
 
 Overview
Dr. Wright's research interests are:

1) Pneumocystis carinii biology
2) Pathogenesis of lung injury during Pneumocystis carinii pneumonia.

The rapid clearance of bacterial and fungal pathogens is essential to preserve the delicate structure and critical function of the lung. The opportunistic pathogen, Pneumocystis carinii, colonizes the alveolar epithelium of patients suffering from a variety of immunodeficiencies, including AIDS. Dr. Wright's laboratory uses an immunologically-reconstituted scid mouse model of Pneumocystis carinii pneumonia (PCP) to study the host response to infection. Scid mice lack functional lymphocytes and therefore develop active P. carinii infections. However, the adoptive transfer of congenic spleen cells, including CD4+ T lymphocytes, to P. carinii-infected scid mice results in inflammatory cell recruitment to sites of infection and organism clearance. They are now examining the earliest molecular signals (including cytokine and chemokine expression) produced at epithelial sites of P. carinii colonization, to determine which cell types and which soluble mediators are involved in targeting inflammatory cell recruitment. These studies will not only further our understanding of PCP, but may also provide insight into general mechanisms of lung defense.

In addition, they are examining the role of pulmonary inflammation in the pathology of PCP. As stated above, an intense CD4+ T lymphocyte-dependent inflammatory response is mounted at sites of infection in reconstituted scid mice. In many cases this inflammatory response is productive, and serves to resolve the infection. However, under certain circumstances the inflammatory response may actually contribute to the pulmonary injury and respiratory impairment observed in P. carinii pneumonia. They have begun studies using physiological and molecular measurements of lung injury to assess the in vivo role of P. carinii driven inflammation in PCP. They also plan to test specific anti-inflammatory agents to manipulate various aspects of the inflammatory response to determine the effect on lung injury. These studies will help define the role of inflammation in PCP, and further our understanding of pulmonary immunology.

 
 Selected Publications
List All   |   Timeline
  1. Bello-Irizarry SN, Wang J, Johnston CJ, Gigliotti F, Wright TW. MyD88 Signaling Regulates Both Host Defense and Immunopathogenesis during Pneumocystis Infection. J Immunol. 2014 Jan 1; 192(1):282-92.
    View in: PubMed
  2. Perez-Nazario N, Rangel-Moreno J, O'Reilly MA, Pasparakis M, Gigliotti F, Wright TW. Selective Ablation of Lung Epithelial IKK2 Impairs Pulmonary Th17 Responses and Delays the Clearance of Pneumocystis. J Immunol. 2013 Nov 1; 191(9):4720-30.
    View in: PubMed
  3. Kulkarni AA, Thatcher TH, Hsiao HM, Olsen KC, Kottmann RM, Morrissette J, Wright TW, Phipps RP, Sime PJ. The Triterpenoid CDDO-Me Inhibits Bleomycin-Induced Lung Inflammation and Fibrosis. PLoS One. 2013; 8(5):e63798.
    View in: PubMed
  4. Gigliotti F, Wright TW. Pneumocystis: where does it live? PLoS Pathog. 2012 Nov; 8(11):e1003025.
    View in: PubMed
  5. Bello-Irizarry SN, Wang J, Olsen K, Gigliotti F, Wright TW. The Alveolar Epithelial Cell Chemokine Response to Pneumocystis Requires Adaptor Molecule MyD88 and Interleukin-1 Receptor but Not Toll-Like Receptor 2 or 4. Infect Immun. 2012 Nov; 80(11):3912-20.
    View in: PubMed
  6. Wang J, Wright TW, Gigliotti F. Immune Modulation as Adjunctive Therapy for Pneumocystis pneumonia. Interdiscip Perspect Infect Dis. 2011; 2011:918038.
    View in: PubMed
  7. Montgomery SL, Mastrangelo MA, Habib D, Narrow WC, Knowlden SA, Wright TW, Bowers WJ. Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-a suppressive therapeutic strategies in the brain. Am J Pathol. 2011 Oct; 179(4):2053-70.
    View in: PubMed
  8. Wang J, Gigliotti F, Bhagwat SP, George TC, Wright TW. Immune modulation with sulfasalazine attenuates immunopathogenesis but enhances macrophage-mediated fungal clearance during Pneumocystis pneumonia. PLoS Pathog. 2010; 6(8):e1001058.
    View in: PubMed
  9. Chess PR, Benson RP, Maniscalco WM, Wright TW, O'Reilly MA, Johnston CJ. Murine mechanical ventilation stimulates alveolar epithelial cell proliferation. Exp Lung Res. 2010 Aug; 36(6):331-41.
    View in: PubMed
  10. Desmet EA, Hollenbaugh JA, Sime PJ, Wright TW, Topham DJ, Sant AJ, Takimoto T, Dewhurst S, Maggirwar SB. Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells. Virology. 2010 May 10; 400(2):224-32.
    View in: PubMed
  11. Bhagwat SP, Wright TW, Gigliotti F. Anti-CD3 antibody decreases inflammation and improves outcome in a murine model of Pneumocystis pneumonia. J Immunol. 2010 Jan 1; 184(1):497-502.
    View in: PubMed
  12. Pryhuber GS, Huyck HL, Bhagwat S, O'Reilly MA, Finkelstein JN, Gigliotti F, Wright TW. Parenchymal cell TNF receptors contribute to inflammatory cell recruitment and respiratory failure in Pneumocystis carinii-induced pneumonia. J Immunol. 2008 Jul 15; 181(2):1409-19.
    View in: PubMed
  13. Wang J, Gigliotti F, Bhagwat SP, Maggirwar SB, Wright TW. Pneumocystis stimulates MCP-1 production by alveolar epithelial cells through a JNK-dependent mechanism. Am J Physiol Lung Cell Mol Physiol. 2007 Jun; 292(6):L1495-505.
    View in: PubMed
  14. Gigliotti F, Crow EL, Bhagwat SP, Wright TW. Sensitized CD8+ T cells fail to control organism burden but accelerate the onset of lung injury during Pneumocystis carinii pneumonia. Infect Immun. 2006 Nov; 74(11):6310-6.
    View in: PubMed
  15. Bhagwat SP, Gigliotti F, Xu H, Wright TW. Contribution of T cell subsets to the pathophysiology of Pneumocystis-related immunorestitution disease. Am J Physiol Lung Cell Mol Physiol. 2006 Dec; 291(6):L1256-66.
    View in: PubMed
  16. Yee M, Vitiello PF, Roper JM, Staversky RJ, Wright TW, McGrath-Morrow SA, Maniscalco WM, Finkelstein JN, O'Reilly MA. Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung development. Am J Physiol Lung Cell Mol Physiol. 2006 Nov; 291(5):L1101-11.
    View in: PubMed
  17. Vitiello PF, Staversky RJ, Gehen SC, Johnston CJ, Finkelstein JN, Wright TW, O'Reilly MA. p21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growth. Am J Pathol. 2006 Jun; 168(6):1838-47.
    View in: PubMed
  18. Wells J, Haidaris CG, Wright TW, Gigliotti F. Active immunization against Pneumocystis carinii with a recombinant P. carinii antigen. Infect Immun. 2006 Apr; 74(4):2446-8.
    View in: PubMed
  19. Bruckner L, Gigliotti F, Wright T, Harmsen A, Notter RH, Chess P, Wang Z, Finkelstein J. Pneumocystis carinii infection sensitizes lung to radiation-induced injury after syngeneic marrow transplantation: role of CD4+ T cells. Am J Physiol Lung Cell Mol Physiol. 2006 Jun; 290(6):L1087-96.
    View in: PubMed
  20. Wells J, Haidaris CG, Wright TW, Gigliotti F. Complement and Fc function are required for optimal antibody prophylaxis against Pneumocystis carinii pneumonia. Infect Immun. 2006 Jan; 74(1):390-3.
    View in: PubMed
  21. Gigliotti F, Wright TW. Immunopathogenesis of Pneumocystis carinii pneumonia. Expert Rev Mol Med. 2005; 7(26):1-16.
    View in: PubMed
  22. Wang Z, Foye A, Chang Y, Chess PR, Wright TW, Bhagwat S, Gigliotti F, Notter RH. Inhibition of surfactant activity by Pneumocystis carinii organisms and components in vitro. Am J Physiol Lung Cell Mol Physiol. 2005 Jun; 288(6):L1124-31.
    View in: PubMed
  23. Wang J, Gigliotti F, Maggirwar S, Johnston C, Finkelstein JN, Wright TW. Pneumocystis carinii activates the NF-kappaB signaling pathway in alveolar epithelial cells. Infect Immun. 2005 May; 73(5):2766-77.
    View in: PubMed
  24. Disney MD, Stephenson R, Wright TW, Haidaris CG, Turner DH, Gigliotti F. Activity of Hoechst 33258 against Pneumocystis carinii f. sp. muris, Candida albicans, and Candida dubliniensis. Antimicrob Agents Chemother. 2005 Apr; 49(4):1326-30.
    View in: PubMed
  25. Swain SD, Wright TW, Degel PM, Gigliotti F, Harmsen AG. Neither neutrophils nor reactive oxygen species contribute to tissue damage during Pneumocystis pneumonia in mice. Infect Immun. 2004 Oct; 72(10):5722-32.
    View in: PubMed
  26. Wright TW, Pryhuber GS, Chess PR, Wang Z, Notter RH, Gigliotti F. TNF receptor signaling contributes to chemokine secretion, inflammation, and respiratory deficits during Pneumocystis pneumonia. J Immunol. 2004 Feb 15; 172(4):2511-21.
    View in: PubMed
  27. Gigliotti F, Harmsen AG, Wright TW. Characterization of transmission of Pneumocystis carinii f. sp. muris through immunocompetent BALB/c mice. Infect Immun. 2003 Jul; 71(7):3852-6.
    View in: PubMed
  28. Staversky RJ, Watkins RH, Wright TW, Hernady E, LoMonaco MB, D'Angio CT, Williams JP, Maniscalco WM, O'Reilly MA. Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1). Am J Pathol. 2002 Oct; 161(4):1383-93.
    View in: PubMed
  29. Gigliotti F, Haidaris CG, Wright TW, Harmsen AG. Passive intranasal monoclonal antibody prophylaxis against murine Pneumocystis carinii pneumonia. Infect Immun. 2002 Mar; 70(3):1069-74.
    View in: PubMed
  30. Wright TW, Notter RH, Wang Z, Harmsen AG, Gigliotti F. Pulmonary inflammation disrupts surfactant function during Pneumocystis carinii pneumonia. Infect Immun. 2001 Feb; 69(2):758-64.
    View in: PubMed
  31. Lee LH, Gigliotti F, Wright TW, Simpson-Haidaris PJ, Weinberg GA, Haidaris CG. Molecular characterization of KEX1, a kexin-like protease in mouse Pneumocystis carinii. Gene. 2000 Jan 25; 242(1-2):141-50.
    View in: PubMed
  32. Wright TW, Gigliotti F, Finkelstein JN, McBride JT, An CL, Harmsen AG. Immune-mediated inflammation directly impairs pulmonary function, contributing to the pathogenesis of Pneumocystis carinii pneumonia. J Clin Invest. 1999 Nov; 104(9):1307-17.
    View in: PubMed
  33. Wright TW, Johnston CJ, Harmsen AG, Finkelstein JN. Chemokine gene expression during Pneumocystis carinii-driven pulmonary inflammation. Infect Immun. 1999 Jul; 67(7):3452-60.
    View in: PubMed
  34. Simpson-Haidaris PJ, Courtney MA, Wright TW, Goss R, Harmsen A, Gigliotti F. Induction of fibrinogen expression in the lung epithelium during Pneumocystis carinii pneumonia. Infect Immun. 1998 Sep; 66(9):4431-9.
    View in: PubMed
  35. D'Angio CT, Johnston CJ, Wright TW, Reed CK, Finkelstein JN. Chemokine mRNA alterations in newborn and adult mouse lung during acute hyperoxia. Exp Lung Res. 1998 Sep-Oct; 24(5):685-702.
    View in: PubMed
  36. Johnston CJ, Wright TW, Rubin P, Finkelstein JN. Alterations in the expression of chemokine mRNA levels in fibrosis-resistant and -sensitive mice after thoracic irradiation. Exp Lung Res. 1998 May-Jun; 24(3):321-37.
    View in: PubMed
  37. Johnston CJ, Stripp BR, Piedbeouf B, Wright TW, Mango GW, Reed CK, Finkelstein JN. Inflammatory and epithelial responses in mouse strains that differ in sensitivity to hyperoxic injury. Exp Lung Res. 1998 Mar-Apr; 24(2):189-202.
    View in: PubMed
  38. Johnston CJ, Wright TW, Reed CK, Finkelstein JN. Comparison of adult and newborn pulmonary cytokine mRNA expression after hyperoxia. Exp Lung Res. 1997 Nov-Dec; 23(6):537-52.
    View in: PubMed
  39. Wright TW, Johnston CJ, Harmsen AG, Finkelstein JN. Analysis of cytokine mRNA profiles in the lungs of Pneumocystis carinii-infected mice. Am J Respir Cell Mol Biol. 1997 Oct; 17(4):491-500.
    View in: PubMed
  40. Simpson-Haidaris PJ, Wright TW, Earnest BJ, Hui Z, Neroni LA, Courtney MA. Cloning and characterization of a lung-specific cDNA corresponding to the gamma chain of hepatic fibrinogen. Gene. 1995 Dec 29; 167(1-2):273-8.
    View in: PubMed
  41. Wright TW, Gigliotti F, Haidaris CG, Simpson-Haidaris PJ. Cloning and characterization of a conserved region of human and rhesus macaque Pneumocystis carinii gpA. Gene. 1995 Dec 29; 167(1-2):185-9.
    View in: PubMed
  42. Wright TW, Bissoondial TY, Haidaris CG, Gigliotti F, Haidaris PJ. Isoform diversity and tandem duplication of the glycoprotein A gene in ferret Pneumocystis carinii. DNA Res. 1995; 2(2):77-88.
    View in: PubMed
  43. Wright TW, Simpson-Haidaris PJ, Gigliotti F, Harmsen AG, Haidaris CG. Conserved sequence homology of cysteine-rich regions in genes encoding glycoprotein A in Pneumocystis carinii derived from different host species. Infect Immun. 1994 May; 62(5):1513-9.
    View in: PubMed
  44. Lawrence SO, Wright TW, Francis CW, Fay PJ, Haidaris PJ. Purification and functional characterization of homodimeric gamma B-gamma B fibrinogen from rat plasma. Blood. 1993 Oct 15; 82(8):2406-13.
    View in: PubMed
  45. Gigliotti F, Haidaris PJ, Haidaris CG, Wright TW, Van der Meid KR. Further evidence of host species-specific variation in antigens of Pneumocystis carinii using the polymerase chain reaction. J Infect Dis. 1993 Jul; 168(1):191-4.
    View in: PubMed
  46. Haidaris PJ, Wright TW, Gigliotti F, Fallon MA, Whitbeck AA, Haidaris CG. In situ hybridization analysis of developmental stages of Pneumocystis carinii that are transcriptionally active for a major surface glycoprotein gene. Mol Microbiol. 1993 Mar; 7(5):647-56.
    View in: PubMed
  47. Haidaris PJ, Wright TW, Gigliotti F, Haidaris CG. Expression and characterization of a cDNA clone encoding an immunodominant surface glycoprotein of Pneumocystis carinii. J Infect Dis. 1992 Nov; 166(5):1113-23.
    View in: PubMed
  48. Gigliotti F. Antigenic variation of a major surface glycoprotein of Pneumocystis carinii. J Protozool. 1991 Nov-Dec; 38(6):4S-5S.
    View in: PubMed
  49. Haidaris CG, Wright TW, Gigliotti F, Haidaris PJ. Molecular cloning and characterization of ferret Pneumocystis carinii gp120. J Protozool. 1991 Nov-Dec; 38(6):5S-6S.
    View in: PubMed

Visualizations


Wright's Networks

Concepts
_
Co-Authors
_
Similar People
_
Same Department