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Robert Dirksen

TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentPharmacology and Physiology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 711
Rochester NY 14642
 
 Awards And Honors
2002     Graduate Student Society Faculty Mentoring Award
2012     Vice-Chair  | Muscle: Excitation-Contraction Coupling Gordon Conference
2015     Chair  | Muscle: Excitation-Contraction Coupling Gordon Conference
 
 Selected Publications
List All   |   Timeline
  1. Wei-Lapierre L, Carrell EM, Boncompagni S, Protasi F, Dirksen RT. Orai1-dependent calcium entry promotes skeletal muscle growth and limits fatigue. Nat Commun. 2013 Nov 18; 4:2805.
    View in: PubMed
  2. Ram R, Wescott AP, Varandas K, Dirksen RT, Blaxall BC. Mena associates with Rac1 and modulates connexin 43 remodeling in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2014 Jan; 306(1):H154-9.
    View in: PubMed
  3. Yarotskyy V, Protasi F, Dirksen RT. Accelerated Activation of SOCE Current in Myotubes from Two Mouse Models of Anesthetic- and Heat-Induced Sudden Death. PLoS One. 2013; 8(10):e77633.
    View in: PubMed
  4. Reifler A, Lenk GM, Li X, Groom L, Brooks SV, Wilson D, Bowerson M, Dirksen RT, Meisler MH, Dowling JJ. Murine Fig4 is dispensable for muscle development but required for muscle function. Skelet Muscle. 2013; 3(1):21.
    View in: PubMed
  5. Wei-Lapierre L, Gong G, Gerstner BJ, Ducreux S, Yule DI, Pouvreau S, Wang X, Sheu SS, Cheng H, Dirksen RT, Wang W. Respective Contribution of Mitochondrial Superoxide and pH to Mitochondria-targeted Circularly Permuted Yellow Fluorescent Protein (mt-cpYFP) Flash Activity. J Biol Chem. 2013 Apr 12; 288(15):10567-77.
    View in: PubMed
  6. Lefebvre R, Legrand C, Groom L, Dirksen RT, Jacquemond V. Ca(2+) Release in Muscle Fibers Expressing R4892W and G4896V Type 1 Ryanodine Receptor Disease Mutants. PLoS One. 2013; 8(1):e54042.
    View in: PubMed
  7. Kraeva N, Zvaritch E, Rossi AE, Goonasekera SA, Zaid H, Frodis W, Kraev A, Dirksen RT, Maclennan DH, Riazi S. Novel excitation-contraction uncoupled RYR1 mutations in patients with central core disease. Neuromuscul Disord. 2013 Feb; 23(2):120-32.
    View in: PubMed
  8. Loy RE, Lueck JD, Mostajo-Radji MA, Carrell EM, Dirksen RT. Allele-specific gene silencing in two mouse models of autosomal dominant skeletal myopathy. PLoS One. 2012; 7(11):e49757.
    View in: PubMed
  9. Yarotskyy V, Dirksen RT. Temperature and RyR1 regulate the activation rate of store-operated Ca²+ entry current in myotubes. Biophys J. 2012 Jul 18; 103(2):202-11.
    View in: PubMed
  10. Wei L, Dirksen RT. Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondrial superoxide flashes: from discovery to new controversies. J Gen Physiol. 2012 Jun; 139(6):425-34.
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  11. Sheu SS, Dirksen RT, Pugh EN. Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondria take center stage. J Gen Physiol. 2012 Jun; 139(6):391-3.
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  12. Lanner JT, Georgiou DK, Dagnino-Acosta A, Ainbinder A, Cheng Q, Joshi AD, Chen Z, Yarotskyy V, Oakes JM, Lee CS, Monroe TO, Santillan A, Dong K, Goodyear L, Ismailov II, Rodney GG, Dirksen RT, Hamilton SL. AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation. Nat Med. 2012 Feb; 18(2):244-51.
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  13. Liu X, Yu L, Wang Q, Pelletier J, Fausther M, Sévigny J, Malmström HS, Dirksen RT, Ren YF. Expression of ecto-ATPase NTPDase2 in human dental pulp. J Dent Res. 2012 Mar; 91(3):261-7.
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  14. Tang ZZ, Yarotskyy V, Wei L, Sobczak K, Nakamori M, Eichinger K, Moxley RT, Dirksen RT, Thornton CA. Muscle weakness in myotonic dystrophy associated with misregulated splicing and altered gating of Ca(V)1.1 calcium channel. Hum Mol Genet. 2012 Mar 15; 21(6):1312-24.
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  15. Sheu SS, Dirksen RT, Pugh EN. The 65th Symposium of the Society for General Physiologists: energizing research in mitochondrial physiology and medicine. J Gen Physiol. 2011 Dec; 138(6):563-7.
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  16. Jhun BS, O-Uchi J, Wang W, Ha CH, Zhao J, Kim JY, Wong C, Dirksen RT, Lopes CM, Jin ZG. Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1. Circ Res. 2012 Jan 6; 110(1):59-70.
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  17. Groom L, Muldoon SM, Tang ZZ, Brandom BW, Bayarsaikhan M, Bina S, Lee HS, Qiu X, Sambuughin N, Dirksen RT. Identical de novo mutation in the type 1 ryanodine receptor gene associated with fatal, stress-induced malignant hyperthermia in two unrelated families. Anesthesiology. 2011 Nov; 115(5):938-45.
    View in: PubMed
  18. Lefebvre R, Legrand C, González-Rodríguez E, Groom L, Dirksen RT, Jacquemond V. Defects in Ca2+ release associated with local expression of pathological ryanodine receptors in mouse muscle fibres. J Physiol. 2011 Nov 15; 589(Pt 22):5361-82.
    View in: PubMed
  19. Huang Z, Zhang W, Fang H, Zheng M, Wang X, Xu J, Cheng H, Gong G, Wang W, Dirksen RT, Sheu SS. Response to "A critical evaluation of cpYFP as a probe for superoxide". Free Radic Biol Med. 2011 Nov 15; 51(10):1937-40.
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  20. Rossi AE, Boncompagni S, Wei L, Protasi F, Dirksen RT. Differential impact of mitochondrial positioning on mitochondrial Ca(2+) uptake and Ca(2+) spark suppression in skeletal muscle. Am J Physiol Cell Physiol. 2011 Nov; 301(5):C1128-39.
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  21. Wei L, Salahura G, Boncompagni S, Kasischke KA, Protasi F, Sheu SS, Dirksen RT. Mitochondrial superoxide flashes: metabolic biomarkers of skeletal muscle activity and disease. FASEB J. 2011 Sep; 25(9):3068-78.
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  22. Ryu SY, Beutner G, Kinnally KW, Dirksen RT, Sheu SS. Single channel characterization of the mitochondrial ryanodine receptor in heart mitoplasts. J Biol Chem. 2011 Jun 17; 286(24):21324-9.
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  23. Tae H, Wei L, Willemse H, Mirza S, Gallant EM, Board PG, Dirksen RT, Casarotto MG, Dulhunty A. The elusive role of the SPRY2 domain in RyR1. Channels (Austin). 2011 Mar-Apr; 5(2):148-60.
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  24. Loy RE, Orynbayev M, Xu L, Andronache Z, Apostol S, Zvaritch E, MacLennan DH, Meissner G, Melzer W, Dirksen RT. Muscle weakness in Ryr1I4895T/WT knock-in mice as a result of reduced ryanodine receptor Ca2+ ion permeation and release from the sarcoplasmic reticulum. J Gen Physiol. 2011 Jan; 137(1):43-57.
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  25. Lueck JD, Rossi AE, Thornton CA, Campbell KP, Dirksen RT. Sarcolemmal-restricted localization of functional ClC-1 channels in mouse skeletal muscle. J Gen Physiol. 2010 Dec; 136(6):597-613.
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  26. Boncompagni S, Loy RE, Dirksen RT, Franzini-Armstrong C. The I4895T mutation in the type 1 ryanodine receptor induces fiber-type specific alterations in skeletal muscle that mimic premature aging. Aging Cell. 2010 Dec; 9(6):958-70.
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  27. Wei L, Dirksen RT. Ryanodinopathies: RyR-Linked Muscle Diseases. Curr Top Membr. 2010; 66C:139-67.
    View in: PubMed
  28. Dirksen RT, Pugh EN. Emerging questions about the macromolecular machines of muscle. J Gen Physiol. 2010 Jul; 136(1):3-5.
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  29. Ryu SY, Beutner G, Dirksen RT, Kinnally KW, Sheu SS. Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels. FEBS Lett. 2010 May 17; 584(10):1948-55.
    View in: PubMed
  30. Zhou H, Lillis S, Loy RE, Ghassemi F, Rose MR, Norwood F, Mills K, Al-Sarraj S, Lane RJ, Feng L, Matthews E, Sewry CA, Abbs S, Buk S, Hanna M, Treves S, Dirksen RT, Meissner G, Muntoni F, Jungbluth H. Multi-minicore disease and atypical periodic paralysis associated with novel mutations in the skeletal muscle ryanodine receptor (RYR1) gene. Neuromuscul Disord. 2010 Mar; 20(3):166-73.
    View in: PubMed
  31. Boncompagni S, Rossi AE, Micaroni M, Hamilton SL, Dirksen RT, Franzini-Armstrong C, Protasi F. Characterization and temporal development of cores in a mouse model of malignant hyperthermia. Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21996-2001.
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  32. Dirksen RT, Bannister RA. The 63rd Symposium of the Society of General Physiologists: "muscles" instead of squid at Woods Hole. J Gen Physiol. 2009 Dec; 134(6):453-5.
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  33. Wheeler TM, Sobczak K, Lueck JD, Osborne RJ, Lin X, Dirksen RT, Thornton CA. Reversal of RNA dominance by displacement of protein sequestered on triplet repeat RNA. Science. 2009 Jul 17; 325(5938):336-9.
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  34. Dirksen RT. Sarcoplasmic reticulum-mitochondrial through-space coupling in skeletal muscle. Appl Physiol Nutr Metab. 2009 Jun; 34(3):389-95.
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  35. Dirksen RT. Checking your SOCCs and feet: the molecular mechanisms of Ca2+ entry in skeletal muscle. J Physiol. 2009 Jul 1; 587(Pt 13):3139-47.
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  36. Fallon JL, Baker MR, Xiong L, Loy RE, Yang G, Dirksen RT, Hamilton SL, Quiocho FA. Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca2+* calmodulins. Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5135-40.
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  37. Andronache Z, Hamilton SL, Dirksen RT, Melzer W. A retrograde signal from RyR1 alters DHP receptor inactivation and limits window Ca2+ release in muscle fibers of Y522S RyR1 knock-in mice. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4531-6.
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  38. Dainese M, Quarta M, Lyfenko AD, Paolini C, Canato M, Reggiani C, Dirksen RT, Protasi F. Anesthetic- and heat-induced sudden death in calsequestrin-1-knockout mice. FASEB J. 2009 Jun; 23(6):1710-20.
    View in: PubMed
  39. Kimura T, Lueck JD, Harvey PJ, Pace SM, Ikemoto N, Casarotto MG, Dirksen RT, Dulhunty AF. Alternative splicing of RyR1 alters the efficacy of skeletal EC coupling. Cell Calcium. 2009 Mar; 45(3):264-74.
    View in: PubMed
  40. Rossi AE, Boncompagni S, Dirksen RT. Sarcoplasmic reticulum-mitochondrial symbiosis: bidirectional signaling in skeletal muscle. Exerc Sport Sci Rev. 2009 Jan; 37(1):29-35.
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  41. Boncompagni S, Rossi AE, Micaroni M, Beznoussenko GV, Polishchuk RS, Dirksen RT, Protasi F. Mitochondria are linked to calcium stores in striated muscle by developmentally regulated tethering structures. Mol Biol Cell. 2009 Feb; 20(3):1058-67.
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  42. Oestreich EA, Malik S, Goonasekera SA, Blaxall BC, Kelley GG, Dirksen RT, Smrcka AV. Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II. J Biol Chem. 2009 Jan 16; 284(3):1514-22.
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  43. Lyfenko AD, Dirksen RT. Differential dependence of store-operated and excitation-coupled Ca2+ entry in skeletal muscle on STIM1 and Orai1. J Physiol. 2008 Oct 15; 586(Pt 20):4815-24.
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  44. Wang W, Fang H, Groom L, Cheng A, Zhang W, Liu J, Wang X, Li K, Han P, Zheng M, Yin J, Wang W, Mattson MP, Kao JP, Lakatta EG, Sheu SS, Ouyang K, Chen J, Dirksen RT, Cheng H. Superoxide flashes in single mitochondria. Cell. 2008 Jul 25; 134(2):279-90.
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  45. Durham WJ, Aracena-Parks P, Long C, Rossi AE, Goonasekera SA, Boncompagni S, Galvan DL, Gilman CP, Baker MR, Shirokova N, Protasi F, Dirksen R, Hamilton SL. RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice. Cell. 2008 Apr 4; 133(1):53-65.
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  46. Wheeler TM, Lueck JD, Swanson MS, Dirksen RT, Thornton CA. Correction of ClC-1 splicing eliminates chloride channelopathy and myotonia in mouse models of myotonic dystrophy. J Clin Invest. 2007 Dec; 117(12):3952-7.
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  47. Zvaritch E, Depreux F, Kraeva N, Loy RE, Goonasekera SA, Boncompagni S, Boncompagi S, Kraev A, Gramolini AO, Dirksen RT, Franzini-Armstrong C, Seidman CE, Seidman JG, Maclennan DH. An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18537-42.
    View in: PubMed
  48. Smrcka AV, Oestreich EA, Blaxall BC, Dirksen RT. EPAC regulation of cardiac EC coupling. J Physiol. 2007 Nov 1; 584(Pt 3):1029-31.
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  49. Goonasekera SA, Beard NA, Groom L, Kimura T, Lyfenko AD, Rosenfeld A, Marty I, Dulhunty AF, Dirksen RT. Triadin binding to the C-terminal luminal loop of the ryanodine receptor is important for skeletal muscle excitation contraction coupling. J Gen Physiol. 2007 Oct; 130(4):365-78.
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  50. Rossi D, De Smet P, Lyfenko A, Galli L, Lorenzini S, Franci D, Petrioli F, Orrico A, Angelini C, Tegazzin V, Dirksen R, Sorrentino V. A truncation in the RYR1 gene associated with central core lesions in skeletal muscle fibres. J Med Genet. 2007 Feb; 44(2):e67.
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  51. Kimura T, Pace SM, Wei L, Beard NA, Dirksen RT, Dulhunty AF. A variably spliced region in the type 1 ryanodine receptor may participate in an inter-domain interaction. Biochem J. 2007 Jan 1; 401(1):317-24.
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  52. Lyfenko AD, Ducreux S, Wang Y, Xu L, Zorzato F, Ferreiro A, Meissner G, Treves S, Dirksen RT. Two central core disease (CCD) deletions in the C-terminal region of RYR1 alter muscle excitation-contraction (EC) coupling by distinct mechanisms. Hum Mutat. 2007 Jan; 28(1):61-8.
    View in: PubMed
  53. Oestreich EA, Wang H, Malik S, Kaproth-Joslin KA, Blaxall BC, Kelley GG, Dirksen RT, Smrcka AV. Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes. J Biol Chem. 2007 Feb 23; 282(8):5488-95.
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  54. Lueck JD, Mankodi A, Swanson MS, Thornton CA, Dirksen RT. Muscle chloride channel dysfunction in two mouse models of myotonic dystrophy. J Gen Physiol. 2007 Jan; 129(1):79-94.
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  55. Lueck JD, Lungu C, Mankodi A, Osborne RJ, Welle SL, Dirksen RT, Thornton CA. Chloride channelopathy in myotonic dystrophy resulting from loss of posttranscriptional regulation for CLCN1. Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1291-7.
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  56. Aracena-Parks P, Goonasekera SA, Gilman CP, Dirksen RT, Hidalgo C, Hamilton SL. Identification of cysteines involved in S-nitrosylation, S-glutathionylation, and oxidation to disulfides in ryanodine receptor type 1. J Biol Chem. 2006 Dec 29; 281(52):40354-68.
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  57. Kannankeril PJ, Mitchell BM, Goonasekera SA, Chelu MG, Zhang W, Sood S, Kearney DL, Danila CI, De Biasi M, Wehrens XH, Pautler RG, Roden DM, Taffet GE, Dirksen RT, Anderson ME, Hamilton SL. Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy. Proc Natl Acad Sci U S A. 2006 Aug 8; 103(32):12179-84.
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  58. Rossi AE, Dirksen RT. Sarcoplasmic reticulum: the dynamic calcium governor of muscle. Muscle Nerve. 2006 Jun; 33(6):715-31.
    View in: PubMed
  59. Wang H, Oestreich EA, Maekawa N, Bullard TA, Vikstrom KL, Dirksen RT, Kelley GG, Blaxall BC, Smrcka AV. Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy. Circ Res. 2005 Dec 9; 97(12):1305-13.
    View in: PubMed
  60. Chelu MG, Goonasekera SA, Durham WJ, Tang W, Lueck JD, Riehl J, Pessah IN, Zhang P, Bhattacharjee MB, Dirksen RT, Hamilton SL. Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse. FASEB J. 2006 Feb; 20(2):329-30.
    View in: PubMed
  61. Beutner G, Sharma VK, Lin L, Ryu SY, Dirksen RT, Sheu SS. Type 1 ryanodine receptor in cardiac mitochondria: transducer of excitation-metabolism coupling. Biochim Biophys Acta. 2005 Nov 10; 1717(1):1-10.
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  62. Goonasekera SA, Chen SR, Dirksen RT. Reconstitution of local Ca2+ signaling between cardiac L-type Ca2+ channels and ryanodine receptors: insights into regulation by FKBP12.6. Am J Physiol Cell Physiol. 2005 Dec; 289(6):C1476-84.
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  63. Avila G, Dirksen RT. Rapamycin and FK506 reduce skeletal muscle voltage sensor expression and function. Cell Calcium. 2005 Jul; 38(1):35-44.
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  64. Kimura T, Nakamori M, Lueck JD, Pouliquin P, Aoike F, Fujimura H, Dirksen RT, Takahashi MP, Dulhunty AF, Sakoda S. Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1. Hum Mol Genet. 2005 Aug 1; 14(15):2189-200.
    View in: PubMed
  65. Lyfenko AD, Goonasekera SA, Dirksen RT. Dynamic alterations in myoplasmic Ca2+ in malignant hyperthermia and central core disease. Biochem Biophys Res Commun. 2004 Oct 1; 322(4):1256-66.
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  66. Dirksen RT, Avila G. Distinct effects on Ca2+ handling caused by malignant hyperthermia and central core disease mutations in RyR1. Biophys J. 2004 Nov; 87(5):3193-204.
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  67. Du GG, Avila G, Sharma P, Khanna VK, Dirksen RT, MacLennan DH. Role of the sequence surrounding predicted transmembrane helix M4 in membrane association and function of the Ca(2+) release channel of skeletal muscle sarcoplasmic reticulum (ryanodine receptor isoform 1). J Biol Chem. 2004 Sep 3; 279(36):37566-74.
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  68. Weiss RG, O'Connell KM, Flucher BE, Allen PD, Grabner M, Dirksen RT. Functional analysis of the R1086H malignant hyperthermia mutation in the DHPR reveals an unexpected influence of the III-IV loop on skeletal muscle EC coupling. Am J Physiol Cell Physiol. 2004 Oct; 287(4):C1094-102.
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  69. He X, Liu Y, Sharma V, Dirksen RT, Waugh R, Sheu SS, Min W. ASK1 associates with troponin T and induces troponin T phosphorylation and contractile dysfunction in cardiomyocytes. Am J Pathol. 2003 Jul; 163(1):243-51.
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  70. Leuranguer V, Dirksen RT, Beam KG. Potentiated L-type Ca2+ channels rectify. J Gen Physiol. 2003 Jun; 121(6):541-50.
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  71. Avila G, Lee EH, Perez CF, Allen PD, Dirksen RT. FKBP12 binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes. J Biol Chem. 2003 Jun 20; 278(25):22600-8.
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  72. Avila G, O'Connell KM, Dirksen RT. The pore region of the skeletal muscle ryanodine receptor is a primary locus for excitation-contraction uncoupling in central core disease. J Gen Physiol. 2003 Apr; 121(4):277-86.
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  73. Papineni RV, O'Connell KM, Zhang H, Dirksen RT, Hamilton SL. Suramin interacts with the calmodulin binding site on the ryanodine receptor, RYR1. J Biol Chem. 2002 Dec 20; 277(51):49167-74.
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  74. O'Connell KM, Yamaguchi N, Meissner G, Dirksen RT. Calmodulin binding to the 3614-3643 region of RyR1 is not essential for excitation-contraction coupling in skeletal myotubes. J Gen Physiol. 2002 Sep; 120(3):337-47.
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  75. Dirksen RT. Reactive oxygen/nitrogen species and the aged brain: radical impact of ion channel function. Neurobiol Aging. 2002 Sep-Oct; 23(5):837-9; discussion 841-2.
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  76. Dirksen RT, Avila G. Altered ryanodine receptor function in central core disease: leaky or uncoupled Ca(2+) release channels? Trends Cardiovasc Med. 2002 Jul; 12(5):189-97.
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  77. Dirksen RT. Bi-directional coupling between dihydropyridine receptors and ryanodine receptors. Front Biosci. 2002 Mar 1; 7:d659-70.
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  78. Alano CC, Beutner G, Dirksen RT, Gross RA, Sheu SS. Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation. J Neurochem. 2002 Feb; 80(3):531-8.
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  79. Avila G, Dirksen RT. Functional effects of central core disease mutations in the cytoplasmic region of the skeletal muscle ryanodine receptor. J Gen Physiol. 2001 Sep; 118(3):277-90.
    View in: PubMed
  80. Avila G, O'Brien JJ, Dirksen RT. Excitation--contraction uncoupling by a human central core disease mutation in the ryanodine receptor. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):4215-20.
    View in: PubMed
  81. Avila G, O'Connell KM, Groom LA, Dirksen RT. Ca2+ release through ryanodine receptors regulates skeletal muscle L-type Ca2+ channel expression. J Biol Chem. 2001 May 25; 276(21):17732-8.
    View in: PubMed
  82. O'Connell KM, Dirksen RT. Prolonged depolarization promotes fast gating kinetics of L-type Ca2+ channels in mouse skeletal myotubes. J Physiol. 2000 Dec 15; 529 Pt 3:647-59.
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  83. Avila G, Dirksen RT. Functional impact of the ryanodine receptor on the skeletal muscle L-type Ca(2+) channel. J Gen Physiol. 2000 Apr; 115(4):467-80.
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  84. Suda N, Dirksen RT, Gonzalez A, Beam KG. Low serum promotes maturation of excitation-contraction coupling in myotubes. Pflugers Arch. 2000 Mar; 439(5):555-8.
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  85. Snoeck MM, Gielen MJ, Tangerman A, van Egmond J, Dirksen R. Contractures in skeletal muscle of malignant hyperthermia susceptible patients after in vitro exposure to sevoflurane. Acta Anaesthesiol Scand. 2000 Mar; 44(3):334-7.
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  86. Dirksen RT, Beam KG. Role of calcium permeation in dihydropyridine receptor function. Insights into channel gating and excitation-contraction coupling. J Gen Physiol. 1999 Sep; 114(3):393-403.
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  87. Grabner M, Dirksen RT, Suda N, Beam KG. The II-III loop of the skeletal muscle dihydropyridine receptor is responsible for the Bi-directional coupling with the ryanodine receptor. J Biol Chem. 1999 Jul 30; 274(31):21913-9.
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  88. Van Rijn CM, Willems-van Bree E, Zwart JP, Rodrigues de Miranda JF, Dirksen R. A molecular model for the synergic interaction between gamma-aminobutyric acid and general anaesthetics. Eur J Pharmacol. 1999 Apr 29; 371(2-3):213-26.
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  89. Grabner M, Dirksen RT, Beam KG. Tagging with green fluorescent protein reveals a distinct subcellular distribution of L-type and non-L-type Ca2+ channels expressed in dysgenic myotubes. Proc Natl Acad Sci U S A. 1998 Feb 17; 95(4):1903-8.
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  90. Jongsma ML, Van Rijn CM, De Bruin EA, Dirksen R, Coenen AM. Time course of chronic diazepam effects on the auditory evoked potential of the rat. Eur J Pharmacol. 1998 Jan 12; 341(2-3):153-60.
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  91. Dirksen RT, Nakai J, Gonzalez A, Imoto K, Beam KG. The S5-S6 linker of repeat I is a critical determinant of L-type Ca2+ channel conductance. Biophys J. 1997 Sep; 73(3):1402-9.
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  92. Wiersema AM, Dirksen R, Oyen WJ, Van der Vliet JA. A method for long duration anaesthesia for a new hindlimb ischaemia-reperfusion model in mice. Lab Anim. 1997 Apr; 31(2):151-6.
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  93. Dirksen RT, Beam KG. Unitary behavior of skeletal, cardiac, and chimeric L-type Ca2+ channels expressed in dysgenic myotubes. J Gen Physiol. 1996 Jun; 107(6):731-42.
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  94. Nakai J, Dirksen RT, Nguyen HT, Pessah IN, Beam KG, Allen PD. Enhanced dihydropyridine receptor channel activity in the presence of ryanodine receptor. Nature. 1996 Mar 7; 380(6569):72-5.
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  95. Vermeulen PM, Lerou JG, Dirksen R, Booij LH, Borm GF. A system model for halothane closed-circuit anesthesia. Structure considerations and performance evaluation. Anesthesiology. 1995 Sep; 83(3):515-27.
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  96. Koopman-Kimenai PM, Vree TB, Booij LH, Dirksen R. The bioavailability of intramuscularly administered nicomorphine (Vilan) with its metabolites and their glucuronide conjugates in surgical patients. Int J Clin Pharmacol Ther. 1995 Aug; 33(8):442-8.
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  97. Dirksen RT, Beam KG. Single calcium channel behavior in native skeletal muscle. J Gen Physiol. 1995 Feb; 105(2):227-47.
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  98. Nagtegaal JE, Siero HL, Dirksen R, Lammers JW, Rodrigues de Miranda JF, Russel FG. Pancuronium masks the prejunctional muscarinic autoreceptor in guinea pig tracheal smooth muscle. Life Sci. 1995; 57(25):2325-33.
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  99. Arreola J, Dirksen RT, Perez-Cornejo P, Piech KM, Sheu SS. Autonomic modulation of action potential and tension in guinea pig papillary muscles. Eur J Pharmacol. 1994 Dec 27; 271(2-3):309-17.
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  100. Koopman-Kimenai PM, Vree TB, Booij LH, Dirksen R. Rectal administration of nicomorphine in patients improves biological availability of morphine and its glucuronide conjugates. Pharm World Sci. 1994 Dec 2; 16(6):248-53.
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  101. Mori Y, Niidome T, Fujita Y, Mynlieff M, Dirksen RT, Beam KG, Iwabe N, Miyata T, Furutama D, Furuichi T, et al. Molecular diversity of voltage-dependent calcium channel. Ann N Y Acad Sci. 1993 Dec 20; 707:87-108.
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  102. Lerou JG, Vermeulen PM, Dirksen R, Booij LH, Borm GF. The predictive performance of a system model for enflurane closed-circuit inhalational anesthesia. Anesthesiology. 1993 Nov; 79(5):932-42.
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  103. Fujita Y, Mynlieff M, Dirksen RT, Kim MS, Niidome T, Nakai J, Friedrich T, Iwabe N, Miyata T, Furuichi T, et al. Primary structure and functional expression of the omega-conotoxin-sensitive N-type calcium channel from rabbit brain. Neuron. 1993 Apr; 10(4):585-98.
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  104. Koopman-Kimenai PM, Vree TB, Booij LH, Dirksen R, Nijhuis GM. Pharmacokinetics of intravenously administered nicomorphine and its metabolites in man. Eur J Anaesthesiol. 1993 Mar; 10(2):125-32.
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  105. Lerou JG, Dirksen R, Beneken Kolmer HH, Booij LH. A system model for closed-circuit inhalation anesthesia. I. Computer study. Anesthesiology. 1991 Aug; 75(2):345-55.
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  106. Lerou JG, Dirksen R, Beneken Kolmer HH, Booij LH, Borm GF. A system model for closed-circuit inhalation anesthesia. II. Clinical validation. Anesthesiology. 1991 Aug; 75(2):230-7.
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  107. Arreola J, Dirksen RT, Shieh RC, Williford DJ, Sheu SS. Ca2+ current and Ca2+ transients under action potential clamp in guinea pig ventricular myocytes. Am J Physiol. 1991 Aug; 261(2 Pt 1):C393-7.
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  108. Dirksen R, Coenen AM, van Luijtelaar EL. Naloxone enhances epileptogenic and behavioral effects of pentazocine in rats. Pharmacol Biochem Behav. 1991 Jun; 39(2):415-20.
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  109. Duysens J, Inoue M, Van Luijtelaar EL, Dirksen R, Coenen AM. Facilitation of spike-wave activity by the hypnotic etomidate in a rat model for absence epilepsy. Int J Neurosci. 1991 Apr; 57(3-4):213-7.
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  110. Koopman-Kimenai PM, Vree TB, Booij LH, Dirksen R, Nijhuis GM. Pharmacokinetics of intramuscular nicomorphine and its metabolites in man. Eur J Clin Pharmacol. 1991; 41(4):375-8.
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  111. Sheu SS, Sharma VK, Korth M, Moscucci A, Dirksen RT, Jou MJ. Receptor-mediated inotropic effect in heart. Role of sodium-calcium exchange. Ann N Y Acad Sci. 1991; 639:398-407.
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  112. Enyeart JJ, Dirksen RT, Sharma VK, Williford DJ, Sheu SS. Antipsychotic pimozide is a potent Ca2+ channel blocker in heart. Mol Pharmacol. 1990 May; 37(5):752-7.
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  113. Dirksen RT, Sheu SS. Modulation of ventricular action potential by alpha 1-adrenoceptors and protein kinase C. Am J Physiol. 1990 Mar; 258(3 Pt 2):H907-11.
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  114. Dirksen R, Lerou J, Nijhuis GM, Booij LH, Jurna I. Intrathecal somatostatin produces effects dependent on the interval between catheter implantation and drug injection. Life Sci. 1990; 47(15):1347-54.
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  115. Van der Laan JW, Dirksen R. Dipropylacetate-induced shaking behaviour in the rat: a role of spinal alpha 2-adrenoceptors. Eur J Pharmacol. 1988 Aug 2; 152(3):197-205.
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  116. Dirksen R, Rutgers MJ, Coolen JM. Cervical epidural steroids in reflex sympathetic dystrophy. Anesthesiology. 1987 Jan; 66(1):71-3.
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  117. Reichman M, Dirksen R, Abood LG, Gala D. Effects of the affinity ligands 14-beta-chloroacetylnaltrexone and 14-beta-bromoacetamidomorphine on [3H]-dihydromorphine binding sites in rat brain. Biochem Pharmacol. 1986 Nov 15; 35(22):3995-8.
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  118. Yaksh TL, Dirksen R, Harty GJ. Antinociceptive effects of intrathecally injected cholinomimetic drugs in the rat and cat. Eur J Pharmacol. 1985 Oct 29; 117(1):81-8.
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  119. Dirksen R, Nijhuis GM. The relevance of cholinergic transmission at the spinal level to opiate effectiveness. Eur J Pharmacol. 1983 Jul 22; 91(2-3):215-21.
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