David Yule
| Title | Professor |
|---|
| Institution | School of Medicine and Dentistry |
|---|
| Department | Pharmacology and Physiology |
|---|
| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 711
Rochester NY 14642
|
|---|
|
|
|
| Title | Professor |
|---|
| Institution | University of Rochester Medical Center |
|---|
| Department | Center for Oral Biology |
|---|
|
|
|---|
|
In exocrine acinar cells regulation of intracellular calcium plays a pivotal role in controlling fluid and protein secretion. Exposure of cells to neurotransmitters and hormones results in a rapid elevation of intracellular calcium. This increase in [Ca2+]i carries complex spatial and temporal information important to the physiology of the acinar cell. Research in this laboratory focuses on gaining a better understanding of the mechanisms which underlie these signaling patterns with a primary goal of relating this knowledge to the physiology and pathophysiology of exocrine cells.
Although all Ca2+ mobilizing agonists in pancreatic acinar cells utilize the phosphoinositide-signaling (PI) pathway, stimulation by individual agents results in markedly different temporal and spatial patterns of Ca2+ signaling. One project is designed to understand at the molecular level how the cell effectively "knows" which PI-coupled agonist it is currently exposed to. Given that tremendous molecular diversity is expressed at all levels of this signaling pathway, our working hypothesis is that individual agonists do not couple to the signaling machinery in an identical fashion. This study involves precisely defining by molecular techniques the individual signaling proteins expressed in the acinar cell and then subsequently assessing if individual agonists utilize discrete and different elements of the PI-signaling pathway. We are utilizing fluorescence imaging techniques including high-speed confocal microscopy to monitor [Ca2+]i while manipulating the signaling pathway with neutralizing antibodies and antisense technology.
A further project relates to the organization and regulation of calcium release sites in exocrine cells. These organelles are defined by the expression of receptors for the second messenger Inositol 1,4,5-trisphosphate. In acinar cells the distribution of these receptors is tightly localized to an area associated with the actin cytoskeleton in the apical secretory pole of the cell. This distribution of receptors is the major factor in defining the spatial characteristics of the Ca2+ signal. The nature of the association with the cytoskeleton is being investigated. In addition the regulation of these receptors by phosphorylation and the consequences this may have for Ca2+ signaling are also being studied.
-
Almassy J, Yule DI. Photolysis of caged compounds: studying Ca2+ signaling and activation of Ca2+-dependent ion channels. Cold Spring Harb Protoc. 2013; 2013(1).
-
Almassy J, Yule DI. Studying the activation of epithelial ion channels using global whole-field photolysis. Cold Spring Harb Protoc. 2013; 2013(1).
-
Almassy J, Yule DI. Investigating ion channel distribution using a combination of spatially limited photolysis, Ca2+ imaging, and patch clamp recording. Cold Spring Harb Protoc. 2013; 2013(1).
-
Almassy J, Yule DI. Analyzing Ca2+ dynamics in intact epithelial cells using spatially limited flash photolysis. Cold Spring Harb Protoc. 2013; 2013(1).
-
Gunter TE, Gerstner B, Gunter KK, Malecki J, Gelein R, Valentine WM, Aschner M, Yule DI. Manganese transport via the transferrin mechanism. Neurotoxicology. 2013 Jan; 34:118-27.
-
Siekmann I, Wagner LE, Yule D, Crampin EJ, Sneyd J. A Kinetic Model for Type I and II IP(3)R Accounting for Mode Changes. Biophys J. 2012 Aug 22; 103(4):658-68.
-
Patterson K, Catalán MA, Melvin JE, Yule DI, Crampin EJ, Sneyd J. A quantitative analysis of electrolyte exchange in the salivary duct. Am J Physiol Gastrointest Liver Physiol. 2012 Nov; 303(10):G1153-63.
-
Haun S, Sun L, Hubrack S, Yule D, Machaca K. Phosphorylation of the rat Ins(1,4,5)P 3 receptor at T930 within the coupling domain decreases its affinity to Ins(1,4,5)P 3. Channels (Austin). 2012 Sep 1; 6(5):379-84.
-
Wagner LE, Yule DI. Differential regulation of the InsP3 receptor type-1 and -2 single channel properties by InsP3, Ca2+ and ATP. J Physiol. 2012 Jul 15; 590(Pt 14):3245-59.
-
Palk L, Sneyd J, Patterson K, Shuttleworth TJ, Yule DI, Maclaren O, Crampin EJ. Modelling the effects of calcium waves and oscillations on saliva secretion. J Theor Biol. 2012 Jul 21; 305:45-53.
-
Bhattacharya S, Verrill DS, Carbone KM, Brown S, Yule DI, Giovannucci DR. Distinct contributions by ionotropic purinoceptor subtypes to ATP-evoked calcium signals in mouse parotid acinar cells. J Physiol. 2012 Jun 1; 590(Pt 11):2721-37.
-
Almassy J, Won JH, Begenisich TB, Yule DI. Apical Ca2+-activated potassium channels in mouse parotid acinar cells. J Gen Physiol. 2012 Feb; 139(2):121-33.
-
Park HS, Betzenhauser MJ, Zhang Y, Yule DI. Regulation of Ca2+ release through inositol 1,4,5-trisphosphate receptors by adenine nucleotides in parotid acinar cells. Am J Physiol Gastrointest Liver Physiol. 2012 Jan; 302(1):G97-G104.
-
Siekmann I, Wagner LE, Yule D, Fox C, Bryant D, Crampin EJ, Sneyd J. MCMC estimation of Markov models for ion channels. Biophys J. 2011 Apr 20; 100(8):1919-29.
-
Won JH, Zhang Y, Ji B, Logsdon CD, Yule DI. Phenotypic changes in mouse pancreatic stellate cell Ca2+ signaling events following activation in culture and in a disease model of pancreatitis. Mol Biol Cell. 2011 Feb 1; 22(3):421-36.
-
Masuda W, Betzenhauser MJ, Yule DI. InsP3R-associated cGMP kinase substrate determines inositol 1,4,5-trisphosphate receptor susceptibility to phosphoregulation by cyclic nucleotide-dependent kinases. J Biol Chem. 2010 Nov 26; 285(48):37927-38.
-
Betzenhauser MJ, Yule DI. Regulation of inositol 1,4,5-trisphosphate receptors by phosphorylation and adenine nucleotides. Curr Top Membr. 2010; 66C:273-98.
-
Yule DI. Pancreatic acinar cells: molecular insight from studies of signal-transduction using transgenic animals. Int J Biochem Cell Biol. 2010 Nov; 42(11):1757-61.
-
Palk L, Sneyd J, Shuttleworth TJ, Yule DI, Crampin EJ. A dynamic model of saliva secretion. J Theor Biol. 2010 Oct 21; 266(4):625-40.
-
Yule DI, Betzenhauser MJ, Joseph SK. Linking structure to function: Recent lessons from inositol 1,4,5-trisphosphate receptor mutagenesis. Cell Calcium. 2010 Jun; 47(6):469-79.
-
Park KM, Yule DI, Bowers WJ. Impaired TNF-alpha control of IP3R-mediated Ca2+ release in Alzheimer's disease mouse neurons. Cell Signal. 2010 Mar; 22(3):519-26.
-
Ryu SY, Peixoto PM, Won JH, Yule DI, Kinnally KW. Extracellular ATP and P2Y2 receptors mediate intercellular Ca(2+) waves induced by mechanical stimulation in submandibular gland cells: Role of mitochondrial regulation of store operated Ca(2+) entry. Cell Calcium. 2010 Jan; 47(1):65-76.
-
Brown DA, Yule DI. Protein kinase A regulation of P2X(4) receptors: requirement for a specific motif in the C-terminus. Biochim Biophys Acta. 2010 Feb; 1803(2):275-87.
-
Gin E, Wagner LE, Yule DI, Sneyd J. Inositol trisphosphate receptor and ion channel models based on single-channel data. Chaos. 2009 Sep; 19(3):037104.
-
Park KM, Yule DI, Bowers WJ. Tumor necrosis factor-alpha-mediated regulation of the inositol 1,4,5-trisphosphate receptor promoter. J Biol Chem. 2009 Oct 2; 284(40):27557-66.
-
Betzenhauser MJ, Fike JL, Wagner LE, Yule DI. Protein kinase A increases type-2 inositol 1,4,5-trisphosphate receptor activity by phosphorylation of serine 937. J Biol Chem. 2009 Sep 11; 284(37):25116-25.
-
Gin E, Falcke M, Wagner LE, Yule DI, Sneyd J. A kinetic model of the inositol trisphosphate receptor based on single-channel data. Biophys J. 2009 May 20; 96(10):4053-62.
-
Betzenhauser MJ, Wagner LE, Park HS, Yule DI. ATP regulation of type-1 inositol 1,4,5-trisphosphate receptor activity does not require walker A-type ATP-binding motifs. J Biol Chem. 2009 Jun 12; 284(24):16156-63.
-
Gin E, Falcke M, Wagner LE, Yule DI, Sneyd J. Markov chain Monte Carlo fitting of single-channel data from inositol trisphosphate receptors. J Theor Biol. 2009 Apr 7; 257(3):460-74.
-
Betzenhauser MJ, Wagner LE, Won JH, Yule DI. Studying isoform-specific inositol 1,4,5-trisphosphate receptor function and regulation. Methods. 2008 Nov; 46(3):177-82.
-
Park KM, Yule DI, Bowers WJ. Tumor necrosis factor-alpha potentiates intraneuronal Ca2+ signaling via regulation of the inositol 1,4,5-trisphosphate receptor. J Biol Chem. 2008 Nov 28; 283(48):33069-79.
-
Warner JD, Peters CG, Saunders R, Won JH, Betzenhauser MJ, Gunning WT, Yule DI, Giovannucci DR. Visualizing form and function in organotypic slices of the adult mouse parotid gland. Am J Physiol Gastrointest Liver Physiol. 2008 Sep; 295(3):G629-40.
-
Park HS, Betzenhauser MJ, Won JH, Chen J, Yule DI. The type 2 inositol (1,4,5)-trisphosphate (InsP3) receptor determines the sensitivity of InsP3-induced Ca2+ release to ATP in pancreatic acinar cells. J Biol Chem. 2008 Sep 19; 283(38):26081-8.
-
Wagner LE, Joseph SK, Yule DI. Regulation of single inositol 1,4,5-trisphosphate receptor channel activity by protein kinase A phosphorylation. J Physiol. 2008 Aug 1; 586(Pt 15):3577-96.
-
Betzenhauser MJ, Wagner LE, Iwai M, Michikawa T, Mikoshiba K, Yule DI. ATP modulation of Ca2+ release by type-2 and type-3 inositol (1, 4, 5)-triphosphate receptors. Differing ATP sensitivities and molecular determinants of action. J Biol Chem. 2008 Aug 1; 283(31):21579-87.
-
Schug ZT, da Fonseca PC, Bhanumathy CD, Wagner L, Zhang X, Bailey B, Morris EP, Yule DI, Joseph SK. Molecular characterization of the inositol 1,4,5-trisphosphate receptor pore-forming segment. J Biol Chem. 2008 Feb 1; 283(5):2939-48.
-
Won JH, Cottrell WJ, Foster TH, Yule DI. Ca2+ release dynamics in parotid and pancreatic exocrine acinar cells evoked by spatially limited flash photolysis. Am J Physiol Gastrointest Liver Physiol. 2007 Dec; 293(6):G1166-77.
-
Gin E, Crampin EJ, Brown DA, Shuttleworth TJ, Yule DI, Sneyd J. A mathematical model of fluid secretion from a parotid acinar cell. J Theor Biol. 2007 Sep 7; 248(1):64-80.
-
Brown DA, Yule DI. Protein kinase C regulation of P2X3 receptors is unlikely to involve direct receptor phosphorylation. Biochim Biophys Acta. 2007 Feb; 1773(2):166-75.
-
Wagner LE, Betzenhauser MJ, Yule DI. ATP binding to a unique site in the type-1 S2- inositol 1,4,5-trisphosphate receptor defines susceptibility to phosphorylation by protein kinase A. J Biol Chem. 2006 Jun 23; 281(25):17410-9.
-
Won JH, Yule DI. Measurement of Ca2+ signaling dynamics in exocrine cells with total internal reflection microscopy. Am J Physiol Gastrointest Liver Physiol. 2006 Jul; 291(1):G146-55.
-
Sneyd J, Tsaneva-Atanasova K, Reznikov V, Bai Y, Sanderson MJ, Yule DI. A method for determining the dependence of calcium oscillations on inositol trisphosphate oscillations. Proc Natl Acad Sci U S A. 2006 Feb 7; 103(6):1675-80.
-
Khan MT, Wagner L, Yule DI, Bhanumathy C, Joseph SK. Akt kinase phosphorylation of inositol 1,4,5-trisphosphate receptors. J Biol Chem. 2006 Feb 10; 281(6):3731-7.
-
Chen Y, Warner JD, Yule DI, Giovannucci DR. Spatiotemporal analysis of exocytosis in mouse parotid acinar cells. Am J Physiol Cell Physiol. 2005 Nov; 289(5):C1209-19.
-
Mignen O, Thompson JL, Yule DI, Shuttleworth TJ. Agonist activation of arachidonate-regulated Ca2+-selective (ARC) channels in murine parotid and pancreatic acinar cells. J Physiol. 2005 May 1; 564(Pt 3):791-801.
-
Lavé J, Yule D, Sapkota S, Basant K, Madden C, Attal M, Pandey R. Evidence for a great medieval earthquake (~1100 A.D.) in the central Himalayas, Nepal. Science. 2005 Feb 25; 307(5713):1302-5.
-
Melvin JE, Yule D, Shuttleworth T, Begenisich T. Regulation of fluid and electrolyte secretion in salivary gland acinar cells. Annu Rev Physiol. 2005; 67:445-69.
-
Basavappa S, Vulapalli SR, Zhang H, Yule D, Coon S, Sundaram U. Chloride channels in the small intestinal cell line IEC-18. J Cell Physiol. 2005 Jan; 202(1):21-31.
-
Tsaneva-Atanasova K, Yule DI, Sneyd J. Calcium oscillations in a triplet of pancreatic acinar cells. Biophys J. 2005 Mar; 88(3):1535-51.
-
Wagner LE, Li WH, Joseph SK, Yule DI. Functional consequences of phosphomimetic mutations at key cAMP-dependent protein kinase phosphorylation sites in the type 1 inositol 1,4,5-trisphosphate receptor. J Biol Chem. 2004 Oct 29; 279(44):46242-52.
-
Brown DA, Bruce JI, Straub SV, Yule DI. cAMP potentiates ATP-evoked calcium signaling in human parotid acinar cells. J Biol Chem. 2004 Sep 17; 279(38):39485-94.
-
Gunter TE, Yule DI, Gunter KK, Eliseev RA, Salter JD. Calcium and mitochondria. FEBS Lett. 2004 Jun 1; 567(1):96-102.
-
Sneyd J, Tsaneva-Atanasova K, Yule DI, Thompson JL, Shuttleworth TJ. Control of calcium oscillations by membrane fluxes. Proc Natl Acad Sci U S A. 2004 Feb 3; 101(5):1392-6.
-
Straub SV, Wagner LE, Bruce JI, Yule DI. Modulation of cytosolic calcium signaling by protein kinase A-mediated phosphorylation of inositol 1,4,5-trisphosphate receptors. Biol Res. 2004; 37(4):593-602.
-
Bruce JI, Giovannucci DR, Blinder G, Shuttleworth TJ, Yule DI. Modulation of [Ca2+]i signaling dynamics and metabolism by perinuclear mitochondria in mouse parotid acinar cells. J Biol Chem. 2004 Mar 26; 279(13):12909-17.
-
Bruce JI, Straub SV, Yule DI. Crosstalk between cAMP and Ca2+ signaling in non-excitable cells. Cell Calcium. 2003 Dec; 34(6):431-44.
-
Yule DI, Straub SV, Bruce JI. Modulation of Ca2+ oscillations by phosphorylation of Ins(1,4,5)P3 receptors. Biochem Soc Trans. 2003 Oct; 31(Pt 5):954-7.
-
Sneyd J, Tsaneva-Atanasova K, Bruce JI, Straub SV, Giovannucci DR, Yule DI. A model of calcium waves in pancreatic and parotid acinar cells. Biophys J. 2003 Sep; 85(3):1392-405.
-
Wagner LE, Li WH, Yule DI. Phosphorylation of type-1 inositol 1,4,5-trisphosphate receptors by cyclic nucleotide-dependent protein kinases: a mutational analysis of the functionally important sites in the S2+ and S2- splice variants. J Biol Chem. 2003 Nov 14; 278(46):45811-7.
-
Brown DA, Melvin JE, Yule DI. Critical role for NHE1 in intracellular pH regulation in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol. 2003 Nov; 285(5):G804-12.
-
Dömötör E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV. Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Blood. 2003 Jun 15; 101(12):4797-801.
-
Bruce JI, Yule DI, Shuttleworth TJ. Ca2+-dependent protein kinase--a modulation of the plasma membrane Ca2+-ATPase in parotid acinar cells. J Biol Chem. 2002 Dec 13; 277(50):48172-81.
-
Straub SV, Giovannucci DR, Bruce JI, Yule DI. A role for phosphorylation of inositol 1,4,5-trisphosphate receptors in defining calcium signals induced by Peptide agonists in pancreatic acinar cells. J Biol Chem. 2002 Aug 30; 277(35):31949-56.
-
Giovannucci DR, Bruce JI, Straub SV, Arreola J, Sneyd J, Shuttleworth TJ, Yule DI. Cytosolic Ca(2+) and Ca(2+)-activated Cl(-) current dynamics: insights from two functionally distinct mouse exocrine cells. J Physiol. 2002 Apr 15; 540(Pt 2):469-84.
-
Bruce JI, Shuttleworth TJ, Giovannucci DR, Yule DI. Phosphorylation of inositol 1,4,5-trisphosphate receptors in parotid acinar cells. A mechanism for the synergistic effects of cAMP on Ca2+ signaling. J Biol Chem. 2002 Jan 11; 277(2):1340-8.
-
Yule DI. Subtype-specific regulation of inositol 1,4,5-trisphosphate receptors: controlling calcium signals in time and space. J Gen Physiol. 2001 May; 117(5):431-4.
-
Beutner G, Sharma VK, Giovannucci DR, Yule DI, Sheu SS. Identification of a ryanodine receptor in rat heart mitochondria. J Biol Chem. 2001 Jun 15; 276(24):21482-8.
-
Giovannucci DR, Groblewski GE, Sneyd J, Yule DI. Targeted phosphorylation of inositol 1,4,5-trisphosphate receptors selectively inhibits localized Ca2+ release and shapes oscillatory Ca2+ signals. J Biol Chem. 2000 Oct 27; 275(43):33704-11.
-
Straub SV, Giovannucci DR, Yule DI. Calcium wave propagation in pancreatic acinar cells: functional interaction of inositol 1,4,5-trisphosphate receptors, ryanodine receptors, and mitochondria. J Gen Physiol. 2000 Oct; 116(4):547-60.
-
Giovannucci DR, Sneyd J, Groblewski GE, Yule DI. Modulation of InsP3 receptor properties by phosphorylation: targeting of PKA to InsP3 receptors shapes oscillatory calcium signals in pancreatic acinar cells. J Korean Med Sci. 2000 Aug; 15 Suppl:S55-6.
-
LeBeau AP, Yule DI, Groblewski GE, Sneyd J. Agonist-dependent phosphorylation of the inositol 1,4,5-trisphosphate receptor: A possible mechanism for agonist-specific calcium oscillations in pancreatic acinar cells. J Gen Physiol. 1999 Jun; 113(6):851-72.
-
Wojcikiewicz RJ, Ernst SA, Yule DI. Secretagogues cause ubiquitination and down-regulation of inositol 1, 4,5-trisphosphate receptors in rat pancreatic acinar cells. Gastroenterology. 1999 May; 116(5):1194-201.
-
Yule DI, Baker CW, Williams JA. Calcium signaling in rat pancreatic acinar cells: a role for Galphaq, Galpha11, and Galpha14. Am J Physiol. 1999 Jan; 276(1 Pt 1):G271-9.
-
Giovannucci DR, Yule DI, Stuenkel EL. Optical measurement of stimulus-evoked membrane dynamics in single pancreatic acinar cells. Am J Physiol. 1998 Sep; 275(3 Pt 1):C732-9.
-
Ohnishi H, Samuelson LC, Yule DI, Ernst SA, Williams JA. Overexpression of Rab3D enhances regulated amylase secretion from pancreatic acini of transgenic mice. J Clin Invest. 1997 Dec 15; 100(12):3044-52.
-
Detjen K, Yule D, Tseng MJ, Williams JA, Logsdon CD. CCK-B receptors produce similar signals but have opposite growth effects in CHO and Swiss 3T3 cells. Am J Physiol. 1997 Nov; 273(5 Pt 1):C1449-57.
-
Ohnishi H, Ernst SA, Yule DI, Baker CW, Williams JA. Heterotrimeric G-protein Gq/11 localized on pancreatic zymogen granules is involved in calcium-regulated amylase secretion. J Biol Chem. 1997 Jun 20; 272(25):16056-61.
-
Zhang W, Sarosi G, Barnhart D, Yule DI, Mulholland MW. Endothelin-activated calcium signaling in enteric glia derived from neonatal guinea pig. Am J Physiol. 1997 May; 272(5 Pt 1):G1175-85.
-
Yule DI, Ernst SA, Ohnishi H, Wojcikiewicz RJ. Evidence that zymogen granules are not a physiologically relevant calcium pool. Defining the distribution of inositol 1,4,5-trisphosphate receptors in pancreatic acinar cells. J Biol Chem. 1997 Apr 4; 272(14):9093-8.
-
Westfall MV, Pasyk KA, Yule DI, Samuelson LC, Metzger JM. Ultrastructure and cell-cell coupling of cardiac myocytes differentiating in embryonic stem cell cultures. Cell Motil Cytoskeleton. 1997; 36(1):43-54.
-
Williams JA, Groblewski GE, Ohnishi H, Yule DI. Stimulus-secretion coupling of pancreatic digestive enzyme secretion. Digestion. 1997; 58 Suppl 1:42-5.
-
Yule DI, Stuenkel E, Williams JA. Intercellular calcium waves in rat pancreatic acini: mechanism of transmission. Am J Physiol. 1996 Oct; 271(4 Pt 1):C1285-94.
-
Palmer RK, Yule DI, McEwen EL, Williams JA, Fisher SK. Intra- and intercellular calcium signaling in human neuroepithelioma cells. J Lipid Mediat Cell Signal. 1996 Sep; 14(1-3):169-74.
-
Palmer RK, Yule DI, Shewach DS, Williams JA, Fisher SK. Paracrine mediation of calcium signaling in human SK-N-MCIXC neuroepithelioma cells. Am J Physiol. 1996 Jul; 271(1 Pt 1):C43-53.
-
Kimball BC, Yule DI, Mulholland MW. Extracellular ATP mediates Ca2+ signaling in cultured myenteric neurons via a PLC-dependent mechanism. Am J Physiol. 1996 Apr; 270(4 Pt 1):G587-93.
-
Kimball BC, Yule DI, Mulholland MW. Caffeine- and ryanodine-sensitive Ca2+ stores in cultured guinea pig myenteric neurons. Am J Physiol. 1996 Apr; 270(4 Pt 1):G594-603.
-
Deutsch DE, Williams JA, Yule DI. Halothane and octanol block Ca2+ oscillations in pancreatic acini by multiple mechanisms. Am J Physiol. 1995 Nov; 269(5 Pt 1):G779-88.
-
Yang J, Williams JA, Yule DI, Logsdon CD. Mutation of carboxyl-terminal threonine residues in human m3 muscarinic acetylcholine receptor modulates the extent of sequestration and desensitization. Mol Pharmacol. 1995 Sep; 48(3):477-85.
-
Massa E, Kelly KM, Yule DI, MacDonald RL, Uhler MD. Comparison of fura-2 imaging and electrophysiological analysis of murine calcium channel alpha 1 subunits coexpressed with novel beta 2 subunit isoforms. Mol Pharmacol. 1995 Apr; 47(4):707-16.
-
Simeone DM, Yule DI, Logsdon CD, Williams JA. Ca2+ signaling through secretagogue and growth factor receptors on pancreatic AR42J cells. Regul Pept. 1995 Jan 26; 55(2):197-206.
-
Palmer RK, Yule DI, McEwen EL, Williams JA, Fisher SK. Agonist-specific calcium signaling and phosphoinositide hydrolysis in human SK-N-MCIXC neuroepithelioma cells. J Neurochem. 1994 Dec; 63(6):2099-107.
-
Bode HP, Yule DI, Fehmann HC, Göke B, Williams JA. Spontaneous calcium oscillations in clonal endocrine pancreatic glucagon-secreting cells. Biochem Biophys Res Commun. 1994 Nov 30; 205(1):435-40.
-
Yule DI, Kim ET, Williams JA. Tyrosine kinase inhibitors attenuate "capacitative" Ca2+ influx in rat pancreatic acinar cells. Biochem Biophys Res Commun. 1994 Aug 15; 202(3):1697-704.
-
Blevins GT, van de Westerlo EM, Yule DI, Williams JA. Characterization of cholecystokininA receptor agonist activity by a family of cholecystokininB receptor antagonists. J Pharmacol Exp Ther. 1994 Jun; 269(3):911-6.
-
Duan RD, Wagner AC, Yule DI, Williams JA. Multiple inhibitory effects of genistein on stimulus-secretion coupling in rat pancreatic acini. Am J Physiol. 1994 Feb; 266(2 Pt 1):G303-10.
-
Yule DI, Williams JA. CCK antagonists reveal that CCK-8 and JMV-180 interact with different sites on the rat pancreatic acinar cell CCKA receptor. Peptides. 1994; 15(6):1045-51.
-
Yule DI, Tseng MJ, Williams JA, Logdson CD. A cloned CCK-A receptor transduces multiple signals in response to full and partial agonists. Am J Physiol. 1993 Nov; 265(5 Pt 1):G999-1004.
-
Yule DI, Wu D, Essington TE, Shayman JA, Williams JA. Sphingosine metabolism induces Ca2+ oscillations in rat pancreatic acinar cells. J Biol Chem. 1993 Jun 15; 268(17):12353-8.
-
Yule DI, Essington TE, Williams JA. Pilocarpine and carbachol exhibit markedly different patterns of Ca2+ signaling in rat pancreatic acinar cells. Am J Physiol. 1993 Apr; 264(4 Pt 1):G786-91.
-
Wagner AC, Wishart MJ, Yule DI, Williams JA. Effects of okadaic acid indicate a role for dephosphorylation in pancreatic stimulus-secretion coupling. Am J Physiol. 1992 Dec; 263(6 Pt 1):C1172-80.
-
Yule DI, Blevins GT, Wagner AC, Williams JA. Endothelin increases [Ca2+]i in rat pancreatic acinar cells by intracellular release but fails to increase amylase secretion. Biochim Biophys Acta. 1992 Aug 12; 1136(2):175-80.
-
Yule DI, Williams JA. U73122 inhibits Ca2+ oscillations in response to cholecystokinin and carbachol but not to JMV-180 in rat pancreatic acinar cells. J Biol Chem. 1992 Jul 15; 267(20):13830-5.
-
Rapoport SI, Pettigrew KD, Schapiro MB. Discordance and concordance of dementia of the Alzheimer type (DAT) in monozygotic twins indicate heritable and sporadic forms of Alzheimer's disease. Neurology. 1991 Oct; 41(10):1549-53.
-
Yule DI, Williams JA. Mastoparan induces oscillations of cytosolic Ca2+ in rat pancreatic acinar cells. Biochem Biophys Res Commun. 1991 May 31; 177(1):159-65.
-
Campistol JM, Montoliu J. Chronic renal failure: causes, diagnosis, and therapy. Compr Ther. 1991 Feb; 17(2):51-62.
-
Yule DI, Lawrie AM, Gallacher DV. Acetylcholine and cholecystokinin induce different patterns of oscillating calcium signals in pancreatic acinar cells. Cell Calcium. 1991 Feb-Mar; 12(2-3):145-51.
-
Petersen OH, Gallacher DV, Wakui M, Yule DI, Petersen CC, Toescu EC. Receptor-activated cytoplasmic Ca2+ oscillations in pancreatic acinar cells: generation and spreading of Ca2+ signals. Cell Calcium. 1991 Feb-Mar; 12(2-3):135-44.
-
Dunne MJ, Yule DI, Gallacher DV, Petersen OH. Effects of alanine on insulin-secreting cells: patch-clamp and single cell intracellular Ca2+ measurements. Biochim Biophys Acta. 1990 Nov 12; 1055(2):157-64.
-
Gallacher DV, Hanley MR, Petersen OH, Roberts ML, Squire-Pollard LG, Yule DI. Substance P and bombesin elevate cytosolic Ca2+ by different molecular mechanisms in a rat pancreatic acinar cell line. J Physiol. 1990 Jul; 426:193-207.
-
Osipchuk YV, Wakui M, Yule DI, Gallacher DV, Petersen OH. Cytoplasmic Ca2+ oscillations evoked by receptor stimulation, G-protein activation, internal application of inositol trisphosphate or Ca2+: simultaneous microfluorimetry and Ca2+ dependent Cl- current recording in single pancreatic acinar cells. EMBO J. 1990 Mar; 9(3):697-704.
-
Dunne MJ, Yule DI, Gallacher DV, Petersen OH. Comparative study of the effects of cromakalim (BRL 34915) and diazoxide on membrane potential, [Ca2+]i and ATP-sensitive potassium currents in insulin-secreting cells. J Membr Biol. 1990 Mar; 114(1):53-60.
-
Dunne MJ, Yule DI, Gallacher DV, Petersen OH. Stimulant-evoked depolarization and increase in [Ca2+]i in insulin-secreting cells is dependent on external Na+. J Membr Biol. 1990 Feb; 113(2):131-8.
-
Petersen OH, Wakui M, Osipchuk Y, Yule D, Gallacher DV. Electrophysiology of pancreatic acinar cells. Methods Enzymol. 1990; 192:300-8.
-
Martin SC, Yule DI, Dunne MJ, Gallacher DV, Petersen OH. Vasopressin directly closes ATP-sensitive potassium channels evoking membrane depolarization and an increase in the free intracellular Ca2+ concentration in insulin-secreting cells. EMBO J. 1989 Dec 1; 8(12):3595-9.
-
Dunne MJ, Yule DI, Gallacher DV, Petersen OH. Cromakalim (BRL 34915) and diazoxide activate ATP-regulated potassium channels in insulin-secreting cells. Pflugers Arch. 1989; 414 Suppl 1:S154-5.
-
Yule DI, Gallacher DV. Oscillations of cytosolic calcium in single pancreatic acinar cells stimulated by acetylcholine. FEBS Lett. 1988 Nov 7; 239(2):358-62.
|
Yule's Networks
Concepts  Derived automatically from this person's publications. _
Co-Authors People in Profiles who have published with this person. _
Similar People People who share similar concepts with this person. _
Same Department
People who are also in this person's primary department.
|
