URMC Research Network - Robert Notter

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Robert Notter

Title	Professor Emeritus
Institution	School of Medicine and Dentistry
Department	Pediatrics
Address	University of Rochester Medical Center School of Medicine and Dentistry 601 Elmwood Ave, Box 850 Rochester NY 14642

Other Positions


Title	Professor Emeritus
Institution	School of Medicine and Dentistry
Department	Environmental Medicine

Awards And Honors

1962	-	1963	NSF Undergarduate Research Award, Stanford University
1964			Outstanding Senior Chemical Engineer, Stanford University
1964			American Society for Testing Materials Award, Stanford University
1975	-	1976	Outstanding Teacher in College of Engineering, Penn State University, PA
1975	-	1977	NIH Young Investigator (National Lung Institute)
1980	-	2005	Above the 95th percentile for total NIH research funding over the 25 year period 1980 - 2005.
1980			Dinstinction in MD Research, University of Rochester School of Medicine
1981	-	1986	Research Career Development Award, National Lung Institute
1985			Elected to Perinatal Research Society
1989	-	1997	Two time NIH Pulmonary SCOR Director (NHLBI)
2005			Health Leadership Award in Research \| March of Dimes

Overview

Research in the Notter laboratory focuses on lung surfactant, a complex mixture of lipids and proteins that is essential for normal respiratory function. Lung surfactant deficiency in premature infants leads to the neonatal respiratory distress syndrome (NRDS), and surfactant dysfunction (inhibition, inactivation) is important in the pathology of clinical acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) that occur in patients of all ages. The prevalent and lethal syndromes of ALI/ARDS can result from direct pulmonary insults like viral or bacterial pneumonia, gastric or meconium aspiration, lung contusion, hyperoxia, lung transplant, or radiation pneumonitis or from indirect extra-pulmonary causes like sepsis, shock, burn injury, long bone fracture, pancreatitis, or bone marrow transplant. A major focus of our on-going NIH-funded multi-university collaborative research is on developing new highly-active synthetic exogenous surfactants for treating NRDS and direct pulmonary forms of ALI/ARDS. This includes basic and translational NIH Bioengineering Research Partnership (BRP) studies on the molecular design and biophysics of novel amphipathic peptides having structural homology to active surfactant proteins (SP) like SP-B, and the surface and pulmonary activity of synthetic surfactants containing these peptides combined with novel phospholipase-resistant lipids or synthetic biologic lipids. Also studied is the use of exogenous surfactants not just to reverse surfactant dysfunction in ALI/ARDS, but also to deliver added pharmacologic agents or exogenous DNA to concurrently target other aspects of the complex pathology of ALI/ARDS (edema, vascular dysfunction, inflammation). Our research at Rochester over the past three decades helped to develop clinically-significant first-generation surfactant therapy for premature infants with animal-derived drugs, and this is now being extended using sophisticated bioengineering principles to define new fully-synthetic lung surfactants for treating NRDS and direct pulmonary forms of ALI/ARDS.

Selected Publications

Palleboina D, Waring AJ, Notter RH, Booth V, Morrow M. Effects of the lung surfactant protein B construct Mini-B on lipid bilayer order and topography. Eur Biophys J. 2012 Sep; 41(9):755-67.

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Machado-Aranda D, Wang Z, Yu B, Suresh MV, Notter RH, Raghavendran K. Increased phospholipase A(2) and lyso-phosphatidylcholine levels are associated with surfactant dysfunction in lung contusion injury in mice. Surgery. 2013 Jan; 153(1):25-35.

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Holten-Andersen N, Michael Henderson J, Walther FJ, Waring AJ, Ruchala P, Notter RH, Lee KY. KL(4) Peptide Induces Reversible Collapse Structures on Multiple Length Scales in Model Lung Surfactant. Biophys J. 2011 Dec 21; 101(12):2957-65.

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Willson DF, Notter RH. The future of exogenous surfactant therapy. Respir Care. 2011 Sep; 56(9):1369-86; discussion 1386-8.

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Raghavendran K, Willson D, Notter RH. Surfactant therapy for acute lung injury and acute respiratory distress syndrome. Crit Care Clin. 2011 Jul; 27(3):525-59.

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Walther FJ, Waring AJ, Hernandez-Juviel JM, Gordon LM, Wang Z, Jung CL, Ruchala P, Clark AP, Smith WM, Sharma S, Notter RH. Critical structural and functional roles for the N-terminal insertion sequence in surfactant protein B analogs. PLoS One. 2010; 5(1):e8672.

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Raghavendran K, Davidson BA, Hutson AD, Helinski JD, Nodzo SR, Notter RH, Knight PR. Predictive modeling and inflammatory biomarkers in rats with lung contusion and gastric aspiration. J Trauma. 2009 Dec; 67(6):1182-90.

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Raghavendran K, Notter RH, Davidson BA, Helinski JD, Kunkel SL, Knight PR. Lung contusion: inflammatory mechanisms and interaction with other injuries. Shock. 2009 Aug; 32(2):122-30.

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Yee M, Chess PR, McGrath-Morrow SA, Wang Z, Gelein R, Zhou R, Dean DA, Notter RH, O'Reilly MA. Neonatal oxygen adversely affects lung function in adult mice without altering surfactant composition or activity. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L641-9.

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Schwab U, Rohde KH, Wang Z, Chess PR, Notter RH, Russell DG. Transcriptional responses of Mycobacterium tuberculosis to lung surfactant. Microb Pathog. 2009 Apr; 46(4):185-93.

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Raghavendran K, Davidson BA, Knight PR, Wang Z, Helinski J, Chess PR, Notter RH. Surfactant dysfunction in lung contusion with and without superimposed gastric aspiration in a rat model. Shock. 2008 Nov; 30(5):508-17.

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Raghavendran K, Davidson BA, Huebschmann JC, Helinski JD, Hutson AD, Dayton MT, Notter RH, Knight PR. Superimposed gastric aspiration increases the severity of inflammation and permeability injury in a rat model of lung contusion. J Surg Res. 2009 Aug; 155(2):273-82.

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Willson DF, Chess PR, Notter RH. Surfactant for pediatric acute lung injury. Pediatr Clin North Am. 2008 Jun; 55(3):545-75, ix.

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Raghavendran K, Pryhuber GS, Chess PR, Davidson BA, Knight PR, Notter RH. Pharmacotherapy of acute lung injury and acute respiratory distress syndrome. Curr Med Chem. 2008; 15(19):1911-24.

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Wang Z, Schwab U, Rhoades E, Chess PR, Russell DG, Notter RH. Peripheral cell wall lipids of Mycobacterium tuberculosis are inhibitory to surfactant function. Tuberculosis (Edinb). 2008 May; 88(3):178-86.

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Walther FJ, Waring AJ, Hernandez-Juviel JM, Gordon LM, Schwan AL, Jung CL, Chang Y, Wang Z, Notter RH. Dynamic surface activity of a fully synthetic phospholipase-resistant lipid/peptide lung surfactant. PLoS One. 2007; 2(10):e1039.

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Notter RH, Schwan AL, Wang Z, Waring AJ. Novel phospholipase-resistant lipid/peptide synthetic lung surfactants. Mini Rev Med Chem. 2007 Sep; 7(9):932-44.

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Russo TA, Davidson BA, Beanan JM, Olson R, Holm BA, Notter RH, Knight PR. Capsule and O-antigen from an extraintestinal isolate of Escherichia coli modulate cytokine levels in rat macrophages in vitro and in a rat model of pneumonia. Exp Lung Res. 2007 Sep; 33(7):337-56.

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Wang Z, Chang Y, Schwan AL, Notter RH. Activity and inhibition resistance of a phospholipase-resistant synthetic surfactant in rat lungs. Am J Respir Cell Mol Biol. 2007 Oct; 37(4):387-94.

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Russo TA, Wang Z, Davidson BA, Genagon SA, Beanan JM, Olson R, Holm BA, Knight PR, Chess PR, Notter RH. Surfactant dysfunction and lung injury due to the E. coli virulence factor hemolysin in a rat pneumonia model. Am J Physiol Lung Cell Mol Physiol. 2007 Mar; 292(3):L632-43.

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Notter RH, Wang Z, Wang Z, Davy JA, Schwan AL. Synthesis and surface activity of diether-linked phosphoglycerols: potential applications for exogenous lung surfactants. Bioorg Med Chem Lett. 2007 Jan 1; 17(1):113-7.

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Hickman-Davis JM, Wang Z, Fierro-Perez GA, Chess PR, Page GP, Matalon S, Notter RH. Surfactant dysfunction in SP-A-/- and iNOS-/- mice with mycoplasma infection. Am J Respir Cell Mol Biol. 2007 Jan; 36(1):103-13.

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Bruckner L, Gigliotti F, Wright T, Harmsen A, Notter RH, Chess P, Wang Z, Finkelstein J. Pneumocystis carinii infection sensitizes lung to radiation-induced injury after syngeneic marrow transplantation: role of CD4+ T cells. Am J Physiol Lung Cell Mol Physiol. 2006 Jun; 290(6):L1087-96.

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Hutson AD, Davidson BA, Raghavendran K, Chess PR, Tait AR, Holm BA, Notter RH, Knight PR. Statistical prediction of the type of gastric aspiration lung injury based on early cytokine/chemokine profiles. Anesthesiology. 2006 Jan; 104(1):73-9.

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Raghavendran K, Davidson BA, Helinski JD, Marschke CJ, Manderscheid P, Woytash JA, Notter RH, Knight PR. A rat model for isolated bilateral lung contusion from blunt chest trauma. Anesth Analg. 2005 Nov; 101(5):1482-9.

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Chang Y, Wang Z, Schwan AL, Wang Z, Holm BA, Baatz JE, Notter RH. Surface properties of sulfur- and ether-linked phosphonolipids with and without purified hydrophobic lung surfactant proteins. Chem Phys Lipids. 2005 Oct; 137(1-2):77-93.

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Raghavendran K, Davidson BA, Woytash JA, Helinski JD, Marschke CJ, Manderscheid PA, Notter RH, Knight PR. The evolution of isolated bilateral lung contusion from blunt chest trauma in rats: cellular and cytokine responses. Shock. 2005 Aug; 24(2):132-8.

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Elder A, Johnston C, Gelein R, Finkelstein J, Wang Z, Notter R, Oberdörster G. Lung inflammation induced by endotoxin is enhanced in rats depleted of alveolar macrophages with aerosolized clodronate. Exp Lung Res. 2005 Jul-Aug; 31(6):527-46.

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Wang Z, Foye A, Chang Y, Chess PR, Wright TW, Bhagwat S, Gigliotti F, Notter RH. Inhibition of surfactant activity by Pneumocystis carinii organisms and components in vitro. Am J Physiol Lung Cell Mol Physiol. 2005 Jun; 288(6):L1124-31.

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Davidson BA, Knight PR, Wang Z, Chess PR, Holm BA, Russo TA, Hutson A, Notter RH. Surfactant alterations in acute inflammatory lung injury from aspiration of acid and gastric particulates. Am J Physiol Lung Cell Mol Physiol. 2005 Apr; 288(4):L699-708.

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Davidson BA, Stewart CC, Russo TA, Chess PR, Knight PR. Discrimination of resident and infiltrated alveolar macrophages by flow cytometry in influenza A virus-infected mice. Exp Lung Res. 2005 Apr; 31(3):323-39.

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Raghavendran K, Davidson BA, Mullan BA, Hutson AD, Russo TA, Manderscheid PA, Woytash JA, Holm BA, Notter RH, Knight PR. Acid and particulate-induced aspiration lung injury in mice: importance of MCP-1. Am J Physiol Lung Cell Mol Physiol. 2005 Jul; 289(1):L134-43.

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Biswas N, Shanmukh S, Waring AJ, Walther F, Wang Z, Chang Y, Notter RH, Dluhy RA. Structure and properties of phospholipid-peptide monolayers containing monomeric SP-B(1-25) I. Phases and morphology by epifluorescence microscopy. Biophys Chem. 2005 Mar 1; 113(3):223-32.

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Shanmukh S, Biswas N, Waring AJ, Walther FJ, Wang Z, Chang Y, Notter RH, Dluhy RA. Structure and properties of phospholipid-peptide monolayers containing monomeric SP-B(1-25) II. Peptide conformation by infrared spectroscopy. Biophys Chem. 2005 Mar 1; 113(3):233-44.

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Chang Y, Wang Z, Notter RH, Wang Z, Qu L, Schwan AL. Synthesis and interfacial behavior of sulfur-containing analogs of lung surfactant dipalmitoyl phosphatidylcholine. Bioorg Med Chem Lett. 2004 Dec 20; 14(24):5983-6.

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Knight PR, Davidson BA, Nader ND, Helinski JD, Marschke CJ, Russo TA, Hutson AD, Notter RH, Holm BA. Progressive, severe lung injury secondary to the interaction of insults in gastric aspiration. Exp Lung Res. 2004 Oct-Nov; 30(7):535-57.

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Elder AC, Gelein R, Oberdörster G, Finkelstein J, Notter R, Wang Z. Efficient depletion of alveolar macrophages using intratracheally inhaled aerosols of liposome-encapsulated clodronate. Exp Lung Res. 2004 Mar; 30(2):105-20.

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Wright TW, Pryhuber GS, Chess PR, Wang Z, Notter RH, Gigliotti F. TNF receptor signaling contributes to chemokine secretion, inflammation, and respiratory deficits during Pneumocystis pneumonia. J Immunol. 2004 Feb 15; 172(4):2511-21.

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Wang Z, Schwan AL, Lairson LL, O'Donnell JS, Byrne GF, Foye A, Holm BA, Notter RH. Surface activity of a synthetic lung surfactant containing a phospholipase-resistant phosphonolipid analog of dipalmitoyl phosphatidylcholine. Am J Physiol Lung Cell Mol Physiol. 2003 Sep; 285(3):L550-9.

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Brockman JM, Wang Z, Notter RH, Dluhy RA. Effect of hydrophobic surfactant proteins SP-B and SP-C on binary phospholipid monolayers: II. Infrared external reflectance-absorption spectroscopy. Biophys J. 2003 Jan; 84(1):326-40.

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Wang Z, Baatz JE, Holm BA, Notter RH. Content-dependent activity of lung surfactant protein B in mixtures with lipids. Am J Physiol Lung Cell Mol Physiol. 2002 Nov; 283(5):L897-906.

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Russo TA, Bartholomew LA, Davidson BA, Helinski JD, Carlino UB, Knight PR, Beers MF, Atochina EN, Notter RH, Holm BA. Total extracellular surfactant is increased but abnormal in a rat model of gram-negative bacterial pneumonia. Am J Physiol Lung Cell Mol Physiol. 2002 Sep; 283(3):L655-63.

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King DM, Wang Z, Palmer HJ, Holm BA, Notter RH. Bulk shear viscosities of endogenous and exogenous lung surfactants. Am J Physiol Lung Cell Mol Physiol. 2002 Feb; 282(2):L277-84.

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Notter RH, Wang Z, Egan EA, Holm BA. Component-specific surface and physiological activity in bovine-derived lung surfactants. Chem Phys Lipids. 2002 Jan; 114(1):21-34.

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Baatz JE, Zou Y, Cox JT, Wang Z, Notter RH. High-yield purification of lung surfactant proteins sp-b and sp-c and the effects on surface activity. Protein Expr Purif. 2001 Oct; 23(1):180-90.

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King DM, Wang Z, Kendig JW, Palmer HJ, Holm BA, Notter RH. Concentration-dependent, temperature-dependent non-Newtonian viscosity of lung surfactant dispersions. Chem Phys Lipids. 2001 Jul; 112(1):11-9.

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Wright TW, Notter RH, Wang Z, Harmsen AG, Gigliotti F. Pulmonary inflammation disrupts surfactant function during Pneumocystis carinii pneumonia. Infect Immun. 2001 Feb; 69(2):758-64.

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Uy IP, Pryhuber GS, Chess PR, Notter RH. Combined-modality therapy with inhaled nitric oxide and exogenous surfactant in term infants with acute respiratory failure. Pediatr Crit Care Med. 2000 Oct; 1(2):107-10.

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Knight PR, Kurek C, Davidson BA, Nader ND, Patel A, Sokolowski J, Notter RH, Holm BA. Acid aspiration increases sensitivity to increased ambient oxygen concentrations. Am J Physiol Lung Cell Mol Physiol. 2000 Jun; 278(6):L1240-7.

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Gernon MD, Turcotte JG, Notter RH, Mu M, Lear Y, Snelgrove JL, Schwan AL. The reaction of thiolates with 2,3-dibromo-1-propanol revisited: application to the synthesis of bis(fattyalkylthio)propanols. Chem Phys Lipids. 1999 Sep; 101(2):215-22.

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Krüger P, Schalke M, Wang Z, Notter RH, Dluhy RA, Lösche M. Effect of hydrophobic surfactant peptides SP-B and SP-C on binary phospholipid monolayers. I. Fluorescence and dark-field microscopy. Biophys J. 1999 Aug; 77(2):903-14.

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Holm BA, Wang Z, Notter RH. Multiple mechanisms of lung surfactant inhibition. Pediatr Res. 1999 Jul; 46(1):85-93.

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Wang Z, Notter RH. Additivity of protein and nonprotein inhibitors of lung surfactant activity. Am J Respir Crit Care Med. 1998 Jul; 158(1):28-35.

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Kendig JW, Ryan RM, Sinkin RA, Maniscalco WM, Notter RH, Guillet R, Cox C, Dweck HS, Horgan MJ, Reubens LJ, Risemberg H, Phelps DL. Comparison of two strategies for surfactant prophylaxis in very premature infants: a multicenter randomized trial. Pediatrics. 1998 Jun; 101(6):1006-12.

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Wang Z, Gurel O, Weinbach S, Notter RH. Primary importance of zwitterionic over anionic phospholipids in the surface-active function of calf lung surfactant extract. Am J Respir Crit Care Med. 1997 Oct; 156(4 Pt 1):1049-57.

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D'Angio CT, Finkelstein JN, Lomonaco MB, Paxhia A, Wright SA, Baggs RB, Notter RH, Ryan RM. Changes in surfactant protein gene expression in a neonatal rabbit model of hyperoxia-induced fibrosis. Am J Physiol. 1997 Apr; 272(4 Pt 1):L720-30.

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Wang Z, Gurel O, Baatz JE, Notter RH. Acylation of pulmonary surfactant protein-C is required for its optimal surface active interactions with phospholipids. J Biol Chem. 1996 Aug 9; 271(32):19104-9.

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Wang Z, Gurel O, Baatz JE, Notter RH. Differential activity and lack of synergy of lung surfactant proteins SP-B and SP-C in interactions with phospholipids. J Lipid Res. 1996 Aug; 37(8):1749-60.

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Holm BA, Wang Z, Egan EA, Notter RH. Content of dipalmitoyl phosphatidylcholine in lung surfactant: ramifications for surface activity. Pediatr Res. 1996 May; 39(5):805-11.

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Wang Z, Hall SB, Notter RH. Roles of different hydrophobic constituents in the adsorption of pulmonary surfactant. J Lipid Res. 1996 Apr; 37(4):790-8.

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Wang Z, Hall SB, Notter RH. Dynamic surface activity of films of lung surfactant phospholipids, hydrophobic proteins, and neutral lipids. J Lipid Res. 1995 Jun; 36(6):1283-93.

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Skita V, Chester DW, Oliver CJ, Turcotte JG, Notter RH. Bilayer characteristics of a diether phosphonolipid analog of the major lung surfactant glycerophospholipid dipalmitoyl phosphatidylcholine. J Lipid Res. 1995 May; 36(5):1116-27.

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Dizon-Co L, Ikegami M, Ueda T, Jobe AH, Lin WH, Turcotte JG, Notter RH, Rider ED. In vivo function of surfactants containing phosphatidylcholine analogs. Am J Respir Crit Care Med. 1994 Oct; 150(4):918-23.

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Hall SB, Wang Z, Notter RH. Separation of subfractions of the hydrophobic components of calf lung surfactant. J Lipid Res. 1994 Aug; 35(8):1386-94.

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Hall SB, Hyde RW, Notter RH. Changes in subphase aggregates in rabbits injured by free fatty acid. Am J Respir Crit Care Med. 1994 May; 149(5):1099-106.

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Hall SB, Bermel MS, Ko YT, Palmer HJ, Enhorning G, Notter RH. Approximations in the measurement of surface tension on the oscillating bubble surfactometer. J Appl Physiol. 1993 Jul; 75(1):468-77.

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Davis JM, Richter SE, Kendig JW, Notter RH. High-frequency jet ventilation and surfactant treatment of newborns with severe respiratory failure. Pediatr Pulmonol. 1992 Jun; 13(2):108-12.

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Hall SB, Lu RZ, Venkitaraman AR, Hyde RW, Notter RH. Inhibition of pulmonary surfactant by oleic acid: mechanisms and characteristics. J Appl Physiol. 1992 May; 72(5):1708-16.

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Hall SB, Venkitaraman AR, Whitsett JA, Holm BA, Notter RH. Importance of hydrophobic apoproteins as constituents of clinical exogenous surfactants. Am Rev Respir Dis. 1992 Jan; 145(1):24-30.

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Turcotte JG, Lin WH, Pivarnik PE, Sacco AM, Shirali SS, Bermel MM, Lu Z, Notter RH. Chemical synthesis and surface activity of lung surfactant phospholipid analogs. II. Racemic N-substituted diether phosphonolipids. Biochim Biophys Acta. 1991 Jun 19; 1084(1):1-12.

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Turcotte JG, Lin WH, Motola NC, Pivarnik PE, Bhongle NN, Heyman HR, Shirali SS, Lu Z, Notter RH. Chemical synthesis and surface activity of lung surfactant phospholipid analogs. III. Chiral N-substituted ether-amide phosphonolipids. Chem Phys Lipids. 1991 May-Jun; 58(1-2):81-95.

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Kendig JW, Notter RH, Cox C, Reubens LJ, Davis JM, Maniscalco WM, Sinkin RA, Bartoletti A, Dweck HS, Horgan MJ, et al. A comparison of surfactant as immediate prophylaxis and as rescue therapy in newborns of less than 30 weeks' gestation. N Engl J Med. 1991 Mar 28; 324(13):865-71.

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Venkitaraman AR, Baatz JE, Whitsett JA, Hall SB, Notter RH. Biophysical inhibition of synthetic phospholipid-lung surfactant apoprotein admixtures by plasma proteins. Chem Phys Lipids. 1991 Jan-Feb; 57(1):49-57.

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Auten RL, Notter RH, Kendig JW, Davis JM, Shapiro DL. Surfactant treatment of full-term newborns with respiratory failure. Pediatrics. 1991 Jan; 87(1):101-7.

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Venkitaraman AR, Hall SB, Whitsett JA, Notter RH. Enhancement of biophysical activity of lung surfactant extracts and phospholipid-apoprotein mixtures by surfactant protein A. Chem Phys Lipids. 1990 Dec; 56(2-3):185-94.

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Hall SB, Notter RH, Smith RJ, Hyde RW. Altered function of pulmonary surfactant in fatty acid lung injury. J Appl Physiol. 1990 Sep; 69(3):1143-9.

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Farrell PM, Bourbon JR, Notter RH, Marin L, Nogee LM, Whitsett JA. Relationships among surfactant fraction lipids, proteins and biophysical properties in the developing rat lung. Biochim Biophys Acta. 1990 May 1; 1044(1):84-90.

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Davis JM, Metlay LA, Dickerson B, Penney DP, Notter RH. Early pulmonary changes associated with high-frequency jet ventilation in newborn piglets. Pediatr Res. 1990 May; 27(5):460-5.

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Venkitaraman AR, Hall SB, Notter RH. Hydrophobic homopolymeric peptides enhance the biophysical activity of synthetic lung phospholipids. Chem Phys Lipids. 1990 Mar; 53(2-3):157-64.

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Horowitz S, Shapiro DL, Finkelstein JN, Notter RH, Johnston CJ, Quible DJ. Changes in gene expression in hyperoxia-induced neonatal lung injury. Am J Physiol. 1990 Feb; 258(2 Pt 1):L107-11.

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Holm BA, Venkitaraman AR, Enhorning G, Notter RH. Biophysical inhibition of synthetic lung surfactants. Chem Phys Lipids. 1990 Feb; 52(3-4):243-50.

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Davis JM, Penney DP, Notter RH, Metlay L, Dickerson B, Shapiro DL. Lung injury in the neonatal piglet caused by hyperoxia and mechanical ventilation. J Appl Physiol. 1989 Sep; 67(3):1007-12.

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Horowitz S, Dafni N, Shapiro DL, Holm BA, Notter RH, Quible DJ. Hyperoxic exposure alters gene expression in the lung. Induction of the tissue inhibitor of metalloproteinases mRNA and other mRNAs. J Biol Chem. 1989 May 5; 264(13):7092-5.

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Loewen GM, Holm BA, Milanowski L, Wild LM, Notter RH, Matalon S. Alveolar hyperoxic injury in rabbits receiving exogenous surfactant. J Appl Physiol. 1989 Mar; 66(3):1087-92.

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Gleason CA, Jones MD, Traystman RJ, Notter RH. Fetal cerebral responses to ventilation and oxygenation in utero. Am J Physiol. 1988 Dec; 255(6 Pt 2):R1049-54.

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Shapiro DL, Notter RH. Controversies regarding surfactant replacement therapy. Clin Perinatol. 1988 Dec; 15(4):891-902.

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Holm BA, Matalon S, Finkelstein JN, Notter RH. Type II pneumocyte changes during hyperoxic lung injury and recovery. J Appl Physiol. 1988 Dec; 65(6):2672-8.

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Kendig JW, Notter RH, Cox C, Aschner JL, Benn S, Bernstein RM, Hendricks-Munoz K, Maniscalco WM, Metlay LA, Phelps DL, et al. Surfactant replacement therapy at birth: final analysis of a clinical trial and comparisons with similar trials. Pediatrics. 1988 Nov; 82(5):756-62.

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Holm BA, Enhorning G, Notter RH. A biophysical mechanism by which plasma proteins inhibit lung surfactant activity. Chem Phys Lipids. 1988 Nov; 49(1-2):49-55.

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Davis JM, Veness-Meehan K, Notter RH, Bhutani VK, Kendig JW, Shapiro DL. Changes in pulmonary mechanics after the administration of surfactant to infants with respiratory distress syndrome. N Engl J Med. 1988 Aug 25; 319(8):476-9.

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Notter RH. Biophysical behavior of lung surfactant: implications for respiratory physiology and pathophysiology. Semin Perinatol. 1988 Jul; 12(3):180-212.

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Matalon S, Holm BA, Loewen GM, Baker RR, Notter RH. Sublethal hyperoxic injury to the alveolar epithelium and the pulmonary surfactant system. Exp Lung Res. 1988; 14 Suppl:1021-33.

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Wood BP, Sinkin RA, Kendig JW, Notter RH, Shapiro DL. Exogenous lung surfactant: effect on radiographic appearance in premature infants. Radiology. 1987 Oct; 165(1):11-3.

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Holm BA, Notter RH. Effects of hemoglobin and cell membrane lipids on pulmonary surfactant activity. J Appl Physiol. 1987 Oct; 63(4):1434-42.

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Notter RH, Shapiro DL. Lung surfactants for replacement therapy: biochemical, biophysical, and clinical aspects. Clin Perinatol. 1987 Sep; 14(3):433-79.

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Holm BA, Notter RH, Leary JF, Matalon S. Alveolar epithelial changes in rabbits after a 21-day exposure to 60% O2. J Appl Physiol. 1987 Jun; 62(6):2230-6.

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Notter RH, Shapiro DL, Ohning B, Whitsett JA. Biophysical activity of synthetic phospholipids combined with purified lung surfactant 6000 dalton apoprotein. Chem Phys Lipids. 1987 Jun; 44(1):1-17.

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Matalon S, Holm BA, Notter RH. Mitigation of pulmonary hyperoxic injury by administration of exogenous surfactant. J Appl Physiol. 1987 Feb; 62(2):756-61.

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Ross GF, Notter RH, Meuth J, Whitsett JA. Phospholipid binding and biophysical activity of pulmonary surfactant-associated protein (SAP)-35 and its non-collagenous COOH-terminal domains. J Biol Chem. 1986 Oct 25; 261(30):14283-91.

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Leary JF, Finkelstein JN, Notter RH, Shapiro DL. A quantitative study of the development of type II pneumocytes in fetal lung. Cytometry. 1986 Sep; 7(5):431-8.

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Whitsett JA, Ohning BL, Ross G, Meuth J, Weaver T, Holm BA, Shapiro DL, Notter RH. Hydrophobic surfactant-associated protein in whole lung surfactant and its importance for biophysical activity in lung surfactant extracts used for replacement therapy. Pediatr Res. 1986 May; 20(5):460-7.

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Notter RH, Penney DP, Finkelstein JN, Shapiro DL. Adsorption of natural lung surfactant and phospholipid extracts related to tubular myelin formation. Pediatr Res. 1986 Jan; 20(1):97-101.

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Holm BA, Notter RH, Siegle J, Matalon S. Pulmonary physiological and surfactant changes during injury and recovery from hyperoxia. J Appl Physiol. 1985 Nov; 59(5):1402-9.

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Kwong MS, Egan EA, Notter RH, Shapiro DL. Double-blind clinical trial of calf lung surfactant extract for the prevention of hyaline membrane disease in extremely premature infants. Pediatrics. 1985 Oct; 76(4):585-92.

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Shapiro DL, Notter RH, Morin FC, Deluga KS, Golub LM, Sinkin RA, Weiss KI, Cox C. Double-blind, randomized trial of a calf lung surfactant extract administered at birth to very premature infants for prevention of respiratory distress syndrome. Pediatrics. 1985 Oct; 76(4):593-9.

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Holm BA, Notter RH, Finkelstein JN. Surface property changes from interactions of albumin with natural lung surfactant and extracted lung lipids. Chem Phys Lipids. 1985 Sep; 38(3):287-98.

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Notter RH, Egan EA, Kwong MS, Holm BA, Shapiro DL. Lung surfactant replacement in premature lambs with extracted lipids from bovine lung lavage: effects of dose, dispersion technique, and gestational age. Pediatr Res. 1985 Jun; 19(6):569-77.

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Notter RH, Finkelstein JN. Pulmonary surfactant: an interdisciplinary approach. J Appl Physiol. 1984 Dec; 57(6):1613-24.

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Gallo RL, Wersto RP, Notter RH, Finkelstein JN. Lysophosphatidylcholine cell depolarization: increased membrane permeability for use in the determination of cell membrane potentials. Arch Biochem Biophys. 1984 Dec; 235(2):544-54.

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Gallo RL, Finkelstein JN, Notter RH. Characterization of the plasma and mitochondrial membrane potentials of alveolar type II cells by the use of ionic probes. Biochim Biophys Acta. 1984 Apr 11; 771(2):217-27.

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Bermel MS, McBride JT, Notter RH. Lavaged excised rat lungs as a model of surfactant deficiency. Lung. 1984; 162(2):99-113.

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Egan EA, Notter RH, Kwong MS, Shapiro DL. Natural and artificial lung surfactant replacement therapy in premature lambs. J Appl Physiol. 1983 Sep; 55(3):875-83.

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Marks LB, Notter RH, Oberdorster G, McBride JT. Ultrasonic and jet aerosolization of phospholipids and the effects on surface activity. Pediatr Res. 1983 Sep; 17(9):742-7.

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Notter RH, Finkelstein JN, Taubold RD. Comparative adsorption of natural lung surfactant, extracted phospholipids, and artificial phospholipid mixtures to the air-water interface. Chem Phys Lipids. 1983 Jul; 33(1):67-80.

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Notter RH, Smith S, Taubold RD, Finkelstein JN. Path dependence of adsorption behavior of mixtures containing dipalmitoyl phosphatidylcholine. Pediatr Res. 1982 Jul; 16(7):515-9.

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Notter RH, Taubold R, Mavis RD. Hysteresis in saturated phospholipid films and its potential relevance for lung surfactant function in vivo. Exp Lung Res. 1982 May; 3(2):109-27.

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Leary JF, Finkelstein JN, Notter RH, Shapiro DL. Isolation of type II pneumocytes by laser flow cytometry. Am Rev Respir Dis. 1982 Mar; 125(3):326-30.

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Notter RH, Shapiro DL, Taubold R, Chen J. Bilirubin interactions with phospholipid components of lung surfactant. Pediatr Res. 1982 Feb; 16(2):130-6.

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Notter RH, Shapiro DL. Lung surfactant in an era of replacement therapy. Pediatrics. 1981 Dec; 68(6):781-9.

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Notter RH, Tabak SA, Mavis RD. Surface properties of binary mixtures of some pulmonary surfactant components. J Lipid Res. 1980 Jan; 21(1):10-22.

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Notter RH. Surfactant composition in hyaline-membrane disease. N Engl J Med. 1979 Sep 13; 301(11):612-3.

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Turcotte JG, Sacco AM, Steim JM, Tabak SA, Notter RH. Chemical synthesis and surface properties of an analog of the pulmonary surfactant dipalmitoyl phosphatidylcholine. Biochim Biophys Acta. 1977 Aug 24; 488(2):235-48.

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Notter RH, Morrow PE. Pulmonary surfactant: a surface chemistry viewpoint. Ann Biomed Eng. 1975 Jun; 3(2):119-59.

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